Midtown Vacations from $259

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Your Midtown Vacation

Lose yourself in the wonder of this commercial neighborhood with a Midtown vacation package. From its nightlife and bars and pubs to its dining, there's something for every type of traveler. Want to see the sights during your trip to Midtown? Be sure to check out nearby attractions like Toyota Center, Minute Maid Park and Houston Zoo. Don't just think about it — turn it into a reality! Book your ideal Midtown vacation with Expedia and experience travel your way.

The Latest Midtown Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hilton Houston North
Luxury 3BR for Families Nurses and Group
Experience a First Class Stay - 2 BDRM
Tx Home Group- Houston

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most. Learn more about Midtown

Midtown Hotel Deals

Grand Tuscany Hotel

Grand Tuscany Hotel

4 out of 5
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $122 total per night from Jul 19 to Jul 20
$122 total
Jul 19 - Jul 20
Total with taxes and fees
8/10 Very Good! (169 reviews)
"Beautiful hotel. Good amenities. If breakfast was complimentary this would be a 5-star easily! Will definitely book again."

Reviewed on Jul 14, 2026

Grand Tuscany Hotel
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $118 total per night from Jul 24 to Jul 25
$118 total
Jul 24 - Jul 25
Total with taxes and fees
8.4/10 Very Good! (2,038 reviews)
"I usually don’t leave reviews, but I had to leave one. I just went to Houston for the Dreamcon convention and the next time I come back for next year, I will be also staying at this hotel! The staff are extremely nice and friendly. The rooms are spacious, and the beds are very comfortable! There’s ..."

Reviewed on Jul 14, 2026

Hilton Houston Plaza/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Aug 14 to Aug 15
$109 total
Aug 14 - Aug 15
Total with taxes and fees
8.6/10 Excellent! (4,328 reviews)
"Our room’s walls could have been wiped a bit better, there were odd beverage splatters, and there were used coffee pods in the nespresso drawer, but honestly besides those super minor things, we had an amazing experience. I think it would have been amazing if there was free onsite parking for customers ..."

Reviewed on Jul 14, 2026

Club Quarters Hotel Downtown, Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Midtown attractions

Things to do

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.