Find hotels in Texas Medical Center, Houston from $128

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    one key icon
    Treat yourself
    Save instantly and earn perks with One Key
    Learn about One Key
    today icon
    Change your mind
    Book hotels with free cancellation

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Discover 6,231 Texas Medical Center hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Club Quarters Hotel Downtown, Houston
Lobby sitting area
Club Quarters Hotel Downtown, Houston
4.0 star property
8.2 out of 10, Very Good, (4184)
"Self check was awesome "
The price is $129
includes taxes & fees
$110 per night
Aug 5 - Aug 6
Club Quarters Hotel Downtown, Houston
Blossom Hotel Houston
City view
Blossom Hotel Houston
4.0 star property
9.2 out of 10, Wonderful, (2413)
"Haven’t got the room upgrade"
The price is $181
includes taxes & fees
$154 per night
Aug 27 - Aug 28
Blossom Hotel Houston
The Whitehall Houston
City view from property
The Whitehall Houston
4.0 star property
8.2 out of 10, Very Good, (1008)
"Staff was very helpful. Rooms were clean. "
The price is $189
includes taxes & fees
$161 per night
Aug 5 - Aug 6
The Whitehall Houston
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
7.8 out of 10, Good, (1164)
"My stay was fairly well but there was some elevator maintenance going on at the time. This caused kind of a long wait just to get up to my room. Also the parking garage stair lights were completely out which was very scary. I don’t recall seeing any security around the property so anytime I arrived late to the hotel, it caused a slight panic if I had to park and walk down the stairs just to get to the hotel entrance. "
The price is $129
includes taxes & fees
$110 per night
Aug 25 - Aug 26
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Marriott Marquis Houston
2 outdoor pools, open 6:00 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis Houston
4.0 star property
8.8 out of 10, Excellent, (1004)
"Parking and valet is a little too chaotic but convenient. Beautiful hotel "
The price is $335
includes taxes & fees
$287 per night
Aug 23 - Aug 24
Marriott Marquis Houston
Hilton Americas-Houston
Exterior
Hilton Americas-Houston
4.0 star property
9.2 out of 10, Wonderful, (1085)
"Loved staying here. It was nice. I attended the Missy Elliott concert at the Toyota Center so it was waking distance. I was pleasantly surprised to find that the "Trae Day" was being hosted there during the time of my stay. Very nice hotel. "
The price is $239
includes taxes & fees
$204 per night
Aug 4 - Aug 5
Hilton Americas-Houston
Cambria Hotel Houston Downtown Convention Center
Lobby
Cambria Hotel Houston Downtown Convention Center
3.0 star property
8.8 out of 10, Excellent, (1331)
"Great choice for a stay in Houston "
The price is $128
includes taxes & fees
$110 per night
Aug 4 - Aug 5
Cambria Hotel Houston Downtown Convention Center
Hyatt Place Houston Downtown
Lobby sitting area
Hyatt Place Houston Downtown
3.0 star property
9.0 out of 10, Wonderful, (1343)
"Staff is always helpful and accommodating "
The price is $161
includes taxes & fees
$138 per night
Aug 4 - Aug 5
Hyatt Place Houston Downtown
The Royal Sonesta Houston Galleria
Exterior
The Royal Sonesta Houston Galleria
4.0 star property
8.0 out of 10, Very Good, (1005)
"This property made me feel very protected and it was in a good area. "
The price is $204
includes taxes & fees
$174 per night
Aug 25 - Aug 26
The Royal Sonesta Houston Galleria
Hotel Derek
Suite, 1 King Bed, City View | View from room
Hotel Derek
4.0 star property
6.2 out of 10, (2193)
"Good"
The price is $185
includes taxes & fees
$158 per night
Aug 9 - Aug 10
Hotel Derek
Hyatt Regency Houston Downtown
City view
Hyatt Regency Houston Downtown
4.0 star property
9.0 out of 10, Wonderful, (1692)
"This downtown location was close to the venue I was visiting. The Property was clean and very nicely maintained. All staff members were very respectful and kind. I felt safe and it was quiet on my floor. I would definitely stay here again."
The price is $169
includes taxes & fees
$145 per night
Aug 16 - Aug 17
Hyatt Regency Houston Downtown
HYATT house Houston/Galleria
Outdoor pool
HYATT house Houston/Galleria
3.0 star property
8.4 out of 10, Very Good, (2123)
"An older hotel, but kept in good condition. Front desk staff was very pleasant. Convenient location to shopping."
The price is $133
includes taxes & fees
$114 per night
Aug 18 - Aug 19
HYATT house Houston/Galleria
The Post Oak Hotel at Uptown Houston
Outdoor pool, cabanas (surcharge), pool umbrellas
The Post Oak Hotel at Uptown Houston
5.0 star property
9.6 out of 10, Exceptional, (640)
"It was a great experience all around "
The price is $652
includes taxes & fees
$557 per night
Jul 28 - Jul 29
The Post Oak Hotel at Uptown Houston
C. Baldwin, Curio Collection by Hilton
Outdoor banquet area
C. Baldwin, Curio Collection by Hilton
4.0 star property
8.2 out of 10, Very Good, (776)
"Loved our stay, the staff was friendly. The location to the Colombian festival was exceptional. What we did not like we were charged for breakfast and the reservation included breakfast. Other than that we will be returning next year."
The price is $200
includes taxes & fees
$171 per night
Aug 23 - Aug 24
C. Baldwin, Curio Collection by Hilton
Hyatt Place Houston Medical Center
Lobby
Hyatt Place Houston Medical Center
3.0 star property
9.0 out of 10, Wonderful, (869)
"Beautiful hotel, beautiful service, shame the hurricane did some damage, would stay again, their great here."
The price is $146
includes taxes & fees
$125 per night
Aug 2 - Aug 3
Hyatt Place Houston Medical Center
Hyatt Place Houston/Galleria
Lobby
Hyatt Place Houston/Galleria
3.0 star property
8.2 out of 10, Very Good, (1587)
"The hotel was nice but I have stayed at hotels that were nice for less money. I did like the set up of the room. The eating area was not as clean as it should have been after breakfast. There should have been a microwave in all rooms. It defeats the purpose of heating your food in reception and up five floors. It makes no sense."
The price is $159
includes taxes & fees
$136 per night
Aug 4 - Aug 5
Hyatt Place Houston/Galleria
Hyatt Regency Houston/Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria
4.0 star property
8.6 out of 10, Excellent, (1523)
"Great hotel"
The price is $206
includes taxes & fees
$176 per night
Aug 16 - Aug 17
Hyatt Regency Houston/Galleria
Courtyard by Marriott Houston Medical Center/NRG Park
Outdoor pool, pool umbrellas
Courtyard by Marriott Houston Medical Center/NRG Park
3.0 star property
8.6 out of 10, Excellent, (1005)
"The room was really nice as well as the facility. The staff was amazing. Will come back to stay when I am in the area. "
The price is $142
includes taxes & fees
$121 per night
Aug 4 - Aug 5
Courtyard by Marriott Houston Medical Center/NRG Park
Holiday Inn Houston Downtown, an IHG Hotel
Property amenity
Holiday Inn Houston Downtown, an IHG Hotel
3.0 star property
8.4 out of 10, Very Good, (1005)
"Nice hotel"
The price is $157
includes taxes & fees
$134 per night
Jul 29 - Jul 30
Holiday Inn Houston Downtown, an IHG Hotel
InterContinental Houston, an IHG Hotel
International cuisine
InterContinental Houston, an IHG Hotel
4.0 star property
9.4 out of 10, Exceptional, (1004)
"Pool was very dirty, they charge 30 per person for normal 2 star regular hotel breakfast “buffet” which I find ridiculous. Other than that, it’s pretty nice and staff is friendly. "
The price is $168
includes taxes & fees
$146 per night
Aug 2 - Aug 3
InterContinental Houston, an IHG Hotel
Don't see what you're looking for?
See all available properties in Texas Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Texas Medical Center

Hotels in top Houston neighborhoods Learn more about Texas Medical Center
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

Frequently asked questions

What is Texas Medical Center like?

Texas Medical Center is a neighborhood that travelers like for its museums, shopping, and zoo. Are you looking for Texas Medical Center travel tips? Be sure to check out Houston Zoo and Hermann Park while you're in the neighborhood.

What's a favorite hotel to stay in Texas Medical Center?

Based on Expedia customer reviews, Hilton Garden Inn Houston Medical Center, TX is the highest ranked property in Texas Medical Center. This hotel offers a restaurant and an outdoor pool. Other favorite options in the area include Home2 Suites by Hilton Houston Medical Center, TX and InterContinental Houston, an IHG Hotel.

How many hotels will I find in the Texas Medical Center area?

Expedia has 252 hotels and other accommodations in Texas Medical Center to choose from, making this an ideal home base for exploring the greater Houston area.

If I need to cancel my hotel reservation in Texas Medical Center, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might still have the option to cancel and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Texas Medical Center.

Where can I learn more about changing or cancelling my trip to Texas Medical Center?

For more information about picking new dates or cancelling your trip to Texas Medical Center, go to https://www.expedia.com/service/.

What can I see and do in this Houston neighborhood?

A few attractions you might want to check out while you're in Texas Medical Center are Houston Zoo and Hermann Park. While you're out sightseeing, NRG Stadium and Reckling Park are a couple of additional sights to visit in Houston.

How can I get around Texas Medical Center and the greater Houston area?

For a quick way to explore the city, catch a ride on metro transit at TMC Transit Center, Dryden/TMC Station, or Smith Lands Station.

Recent reviews of Texas Medical Center hotels

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5/5 Excellent
"My stay was fairly well but there was some elevator maintenance going on at the time. This caused kind of a long wait just to get up to my room. Also the parking garage stair lights were completely out which was very scary. I don’t recall seeing any security around the property so anytime I arrived late to the hotel, it caused a slight panic if I had to park and walk down the stairs just to get to the hotel entrance. "
A verified traveler from Desoto stayed at DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Posted 12 hours ago
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Texas Medical Center Travel Info

Number of reviews
28,918
Location
Houston, United States of America
Similar neighborhoods
Southeast Houston, Houston Central Business District and The Galleria
Accommodation
6,231 hotels
Known landmarks
Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston
Hotels with family-friendly amenities
Motel 6 Houston, TX - Medical Center/NRG Stadium, Americas Best Value Inn NRG Park Medical Center and Scottish Inns & Suites at NRG Park
Lowest price
$128
Highest price
$652