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Discover 1,771 Downtown Clayton hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

AC Hotel St. Louis Clayton
AC Hotel St. Louis Clayton

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay

Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis

Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
Where to stay in Downtown Clayton

Downtown St. Louis
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Recent reviews of Downtown Clayton hotels
Recent reviews of Downtown Clayton hotels

The Arch Convention Hotel
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