Clayton, MO
St. Louis
Visit Clayton
Stay near popular Clayton attractions
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
$15
per traveler
Forest Park E-Bike Tour with Optional Saint Louis Zoo Visit
$105
per adult
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
$60
per adult
St Louis: Fun Sushi Making Class at a Trendy Local Café
$75
per adult
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
$94 nightly
The price is $110 total per night from Oct 4 to Oct 5
$110 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,408 reviews)
"Omelette cook was a joy. Breakfast was great. We slept well and thoroughly enjoyed our stay"
Reviewed on Sep 18, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
$128 nightly
The price is $150 total per night from Sep 27 to Sep 28
$150 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
9.2/10 Wonderful! (401 reviews)
"At this hotel, you only have one person work in valet and it’s really hard when people are needing to get their car and they have to wait in a line of 20 to get their car but you paid $32 for valet. It’s not fair. The kid that was working ballet was doing his very best and he did a very good job ..."
Reviewed on Sep 18, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
$152 nightly
The price is $179 total per night from Oct 4 to Oct 5
$179 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave St. Louis MO
$130 nightly
The price is $154 total per night from Sep 27 to Sep 28
$154 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the helpful staff ...
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
$152 nightly
The price is $179 total per night from Oct 1 to Oct 2
$179 total
Oct 1 - Oct 2
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (4,287 reviews)
"I would recommend going somewhere else"
Reviewed on Sep 18, 2026
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$90 nightly
The price is $106 total per night from Sep 27 to Sep 28
$106 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Learn more about Clayton
Downtown St. Louis
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.
Central West End
The ample dining options and lush forests are just a few popular features of the neighborhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
St. Charles Historic District
St. Charles Historic District is known for its abundant dining options, and you can plan a trip to Historic Main Street and Missouri River while you're in town.
Photo by Terry Eaves
Open Photo by Terry Eaves
Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and Enterprise Center are top sights worth seeing.
Clayton, MO
Explore a world of travel with Expedia
- St. Louis Hotels
- Casino Hotels in St. Louis
- Downtown St. Louis Hotels
- Hotels with Free Breakfast in St. Louis
- Motels in St. Louis
- Hotels near Lambert-St. Louis Intl.
- Hotels near Enterprise Center
- Clayton Hotels
- Hotels with Free Airport Shuttle in St. Louis
- Hotels near Hollywood Casino Amphitheatre
- Cheap Hotels in St. Louis
- Chesterfield Hotels
- Hotels near Dome at America’s Center
- Hotels near St. Louis Zoo
- Cabin Rentals in St. Louis
- Hotels with Hot Tubs in St. Louis
- Pet-Friendly Hotels in St. Louis
- Hotels near Barnes Jewish Hospital
- Hotels near Gateway Arch
- Hotels near Busch Stadium
- Hotels with an Indoor Pool in St. Louis
- St. Charles Hotels
- Extended Stay Hotels in St. Louis
- Flights from Portland (PDX) to St. Louis (STL)
- Flights from Springfield (SGF) to St. Louis (STL)
- Flights from Austin (AUS) to St. Louis (STL)
- Flights from Kansas City (MCI) to St. Louis (STL)
- Flights from Charlotte (CLT) to St. Louis (STL)
- Flights from Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
- Flights from Tampa (TPA) to St. Louis (STL)
- Flights from New York (LGA) to St. Louis (STL)
- Flights from New York (JFK) to St. Louis (STL)
- Flights from Baltimore (BWI) to St. Louis (STL)
- Flights from Los Angeles (LAX) to St. Louis (STL)
- Flights from Cincinnati (CVG) to St. Louis (STL)
- Flights from San Diego (SAN) to St. Louis (STL)
- Flights from Orlando (MCO) to St. Louis (STL)
- Flights from Hartford (BDL) to St. Louis (STL)
- Flights from Phoenix (PHX) to St. Louis (STL)
- Flights from Chicago (ORD) to St. Louis (STL)
- Flights from Washington (DCA) to St. Louis (STL)
- Flights from Cleveland (CLE) to St. Louis (STL)
- Flights from Nashville (BNA) to St. Louis (STL)
- Flights from Minneapolis (MSP) to St. Louis (STL)
- Flights from San Francisco (SFO) to St. Louis (STL)
- Flights from Fort Lauderdale (FLL) to St. Louis (STL)
- Flights from Philadelphia (PHL) to St. Louis (STL)
- Flights from Indianapolis (IND) to St. Louis (STL)
- Flights from Detroit (DTW) to St. Louis (STL)
- Flights from Atlanta (ATL) to St. Louis (STL)
- Flights from Seattle (SEA) to St. Louis (STL)
- Flights from Las Vegas (LAS) to St. Louis (STL)
- Flights from Miami (MIA) to St. Louis (STL)
- Flights to St. Louis
- Flights from Denver (DEN) to St. Louis (STL)
- Flights from Lambert-St. Louis Intl.
- Flights from Boston (BOS) to St. Louis (STL)
- Flights from Houston (IAH) to St. Louis (STL)
- Flights from Memphis (MEM) to St. Louis (STL)
- Flights from Pittsburgh (PIT) to St. Louis (STL)
- Flights from Washington (IAD) to St. Louis (STL)
- Flights from Dallas (DFW) to St. Louis (STL)
- Flights from Salt Lake City (SLC) to St. Louis (STL)
- Flights from Raleigh (RDU) to St. Louis (STL)
- Visit Compton Heights
- Visit Downtown St. Louis
- Visit Bridgeton
- Visit Central West End
- Visit Ladue
- Visit Brentwood
- Visit Kirkwood
- Visit Des Peres
- Visit St. John
- St. Louis Vacations
- Visit Florissant
- Visit Woodson Terrace
- Visit Tesson Ferry
- Visit Edmundson
- Visit Sunset Hills
- Visit St. Louis
- Visit Ferguson
- Visit Lafayette Square
- Visit Richmond Heights
- Visit Earth City
- Visit Grand Center
- Visit Creve Coeur
- Visit Town and Country
- Visit University City
- Visit Lindenwood Park
- Visit Soulard
- Visit Maryland Heights
- Visit Sappington
- Visit Downtown West
- Visit Berkeley
- Visit Castle Point
- Jewel Box
- St. Louis Zoo
