Clayton, MO

St. Louis

Clayton
Photo by Najib Tecle
Photo by kirk allen
Photo by Sarah Mather

Popular places to visit

Things to do


Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
$90 nightly
The price is $105 total per night from Jan 30 to Jan 31
$105 total
Jan 30 - Jan 31
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (3,076 reviews)
All the employees were friendly and welcoming. The breakfast is amazing

Reviewed on Jan 18, 2026

Clayton Plaza Hotel & Extended Stay
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza St. Louis MO
$499 nightly
The price is $583 total per night from Jan 25 to Jan 26
$583 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the room ...
9.2/10 Wonderful! (556 reviews)
Very courteo

Reviewed on Jan 13, 2026

The Ritz-Carlton, St. Louis
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave St. Louis MO
$122 nightly
The price is $144 total per night from Jan 23 to Jan 24
$144 total
Jan 23 - Jan 24
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (929 reviews)
The breakfast was fresh. LOts of great options.. I do wish there were a few more meat choices and egg choices. BUt you have a great variety and very friendly kitchen help!! Also the bar had great Service and bartender was super nice.. A few more options and price lowered and it wouldve been perfect.. ...

Reviewed on Jan 12, 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
$135 nightly
The price is $158 total per night from Jan 25 to Jan 26
$158 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
9/10 Wonderful! (236 reviews)
My room was spotless and very well put together.

Reviewed on Jan 9, 2026

AC Hotel St. Louis Clayton
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
$148 nightly
The price is $173 total per night from Feb 9 to Feb 10
$173 total
Feb 9 - Feb 10
Total with taxes and fees
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,560 reviews)
Great hotel! Art, food and drinks were fantastic

Reviewed on Jan 18, 2026

21C Museum Hotel St Louis
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
$149 nightly
The price is $176 total per night from Jan 20 to Jan 21
$176 total
Jan 20 - Jan 21
Total with taxes and fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (4,046 reviews)
There was still an old coffee pod in the coffee maker. Hotels are creepy and weird. This one wasn’t any different. The view was nice. The beds and bathroom were clean.

Reviewed on Jan 19, 2026

Hyatt Regency St. Louis at The Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighborhoods around Clayton

New Loop Trolley at Delmar St Louis

University City

Noted for its shopping and restaurants, there's plenty to explore in University City. Top attractions like Museum of Transportation and Center of Creative Arts are major draws, and you can hop on the metro at Forsyth Station or U City Big Bend Station to see more of the city.

University City
#lifeatexpedia

Dogtown

If you're looking for some top things to see and do in Dogtown and surrounding area, you can visit St. Louis Zoo and St. Louis Art Museum.

Dogtown
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Ladue

The restaurants and churches are a few reasons travelers visit Ladue. Though there aren't many top sights in the neighborhood, you can visit Saint Louis Galleria Mall and St. Louis Art Museum, a few notable attractions nearby.

Ladue
Fantastic toasted ravioli, a quintessential St. Louis dish. Excellent restaurant located on the Hill, a large Italian neighborhood.
#localgem #Delicious

The Hill

If you're looking for some top things to see and do in The Hill and surrounding area, you can visit St. Louis Science Center and Missouri Botanical Gardens and Arboretum.

The Hill
Central West End

Central West End

4.5/5(450 area reviews)

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Central West End
Not just bars but also loft apartments are lit in rainbow lights for Pride weekend in the Grove neighborhood in St. Louis! #LifeAtExpedia

The Grove

The Grove might not have many top sights, but St. Louis Science Center and Missouri Botanical Gardens and Arboretum are two attractions nearby that you can check out.

The Grove


Clayton, MO

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