$285 Cheap Flights from Minneapolis (MSP) to La Crosse (LSE)

View $285 flight on Fri, Sep 12, 2025Opens in a new window

Popular airlines from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Minneapolis to La Crosse (MSP-LSE)

Prices were available within the past 7 days and start at $285 for one-way flights and $445 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Nov 6 - Sat, Nov 8
MSP
Minneapolis
LSE
La Crosse
$445 Roundtrip, found 17 hours ago
$445
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Thu, Nov 6 from Minneapolis to La Crosse, returning Sat, Nov 8, priced at $445 found 17 hours ago
American Airlines
Wed, Nov 19 - Wed, Dec 3
MSP
Minneapolis
LSE
La Crosse
$533 Roundtrip, found 3 days ago
$533
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 19 from Minneapolis to La Crosse, returning Wed, Dec 3, priced at $533 found 3 days ago
American Airlines
Tue, Sep 16 - Wed, Sep 24
MSP
Minneapolis
LSE
La Crosse
$549 Roundtrip, found 1 day ago
$549
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Minneapolis to La Crosse, returning Wed, Sep 24, priced at $549 found 1 day ago
American Airlines
Wed, Nov 19 - Thu, Nov 27
MSP
Minneapolis
LSE
La Crosse
$553 Roundtrip, found 3 days ago
$553
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 19 from Minneapolis to La Crosse, returning Thu, Nov 27, priced at $553 found 3 days ago
American Airlines
Tue, Sep 16 - Sat, Sep 27
MSP
Minneapolis
LSE
La Crosse
$560 Roundtrip, found 4 days ago
$560
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Sep 16 from Minneapolis to La Crosse, returning Sat, Sep 27, priced at $560 found 4 days ago
American Airlines
Wed, Sep 10 - Fri, Sep 26
MSP
Minneapolis
LSE
La Crosse
$562 Roundtrip, found 4 days ago
$562
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Sep 10 from Minneapolis to La Crosse, returning Fri, Sep 26, priced at $562 found 4 days ago
American Airlines
Tue, Sep 16 - Sat, Sep 27
MSP
Minneapolis
LSE
La Crosse
$568 Roundtrip, found 1 day ago
$568
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Minneapolis to La Crosse, returning Sat, Sep 27, priced at $568 found 1 day ago
American Airlines
Tue, Sep 16 - Sun, Sep 21
MSP
Minneapolis
LSE
La Crosse
$569 Roundtrip, found 1 day ago
$569
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Minneapolis to La Crosse, returning Sun, Sep 21, priced at $569 found 1 day ago
American Airlines
Thu, Nov 20 - Thu, Nov 27
MSP
Minneapolis
LSE
La Crosse
$573 Roundtrip, found 3 days ago
$573
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Nov 20 from Minneapolis to La Crosse, returning Thu, Nov 27, priced at $573 found 3 days ago
American Airlines
Tue, Sep 16 - Fri, Sep 26
MSP
Minneapolis
LSE
La Crosse
$578 Roundtrip, found 1 day ago
$578
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 16 from Minneapolis to La Crosse, returning Fri, Sep 26, priced at $578 found 1 day ago

Alternative airports near La Crosse

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Crosse Municipal LSE. Cheapest and Closest option available. Average driving time to city center is 12 minutes. Flights from $727
LSE
La Crosse Municipal
CheapestClosest
Average driving time to city center12 min
Flights from $727
Flights from Minneapolis (MSP) to La Crosse (LSE)
Origin airport
Minneapolis - St. Paul Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$444
Distance
118 mi

Minneapolis to La Crosse Flights

The cheapest times to fly from Minneapolis to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Minneapolis to La Crosse are during the month of November. You can find some of the cheapest flights from Minneapolis to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Minneapolis to La Crosse

Sunday is one of the best days to book for cheap flights from Minneapolis to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Minneapolis to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Minneapolis to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $285 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Minneapolis to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Minneapolis to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE) cost?
Get a cheap one-way flight from $285 or cheap return flight from $445 from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE)?
Planning your getaway for November is a great way to save, as it's the cheapest month for flights between MSP and LSE. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE)?
To find the cheapest airline flying from MSP to LSE, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE)?
There aren't any daily direct flights from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from MSP to LSE?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary based on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE)?
Opt for a flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE) last-minute?
Last-minute fares from MSP to LSE are typically more expensive. To secure the lowest prices, start looking for flights well ahead of time. That being said, if you're flexible with your travel plans, you may score a cheap fare right before your journey.
Is it cheaper to book a MSP to LSE flight and hotel package?
Booking a MSP to LSE flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our impressive range of hotels and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Crosse Municipal Airport (LSE)?
In most cases, you can cancel or modify your MSP to LSE flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like more information, go to our Customer Service portal.

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*Available to One Key members.