$130 Cheap Flights from Fort Myers (RSW) to Knoxville (TYS)

View $130 flight on Wed, Dec 17, 2025Opens in a new window

Popular airlines from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)

Cheap Flights from Fort Myers to Knoxville (RSW-TYS)

Prices were available within the past 7 days and start at $130 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Jan 21 - Wed, Jan 28
RSW
Fort Myers
TYS
Knoxville
$259 Roundtrip, found 2 hours ago
$259
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Jan 21 from Fort Myers to Knoxville, returning Wed, Jan 28, priced at $259 found 2 hours ago
United
Thu, Sep 4 - Sat, Sep 6
RSW
Fort Myers
TYS
Knoxville
$259 Roundtrip, found 22 hours ago
$259
Roundtrip
found 22 hours ago
Select United flight, departing Thu, Sep 4 from Fort Myers to Knoxville, returning Sat, Sep 6, priced at $259 found 22 hours ago
American Airlines
Tue, Nov 18 - Sat, Nov 22
RSW
Fort Myers
TYS
Knoxville
$259 Roundtrip, found 4 hours ago
$259
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Nov 18 from Fort Myers to Knoxville, returning Sat, Nov 22, priced at $259 found 4 hours ago
Delta
Wed, Jan 21 - Wed, Jan 28
RSW
Fort Myers
TYS
Knoxville
$261 Roundtrip, found 2 hours ago
$261
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Jan 21 from Fort Myers to Knoxville, returning Wed, Jan 28, priced at $261 found 2 hours ago
United
Thu, Sep 4 - Sat, Sep 6
RSW
Fort Myers
TYS
Knoxville
$263 Roundtrip, found 22 hours ago
$263
Roundtrip
found 22 hours ago
Select United flight, departing Thu, Sep 4 from Fort Myers to Knoxville, returning Sat, Sep 6, priced at $263 found 22 hours ago
American Airlines
Wed, Jan 21 - Wed, Jan 28
RSW
Fort Myers
TYS
Knoxville
$264 Roundtrip, found 2 hours ago
$264
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 21 from Fort Myers to Knoxville, returning Wed, Jan 28, priced at $264 found 2 hours ago
Delta
Thu, Nov 27 - Wed, Dec 10
RSW
Fort Myers
TYS
Knoxville
$269 Roundtrip, found 12 hours ago
$269
Roundtrip
found 12 hours ago
Select Delta flight, departing Thu, Nov 27 from Fort Myers to Knoxville, returning Wed, Dec 10, priced at $269 found 12 hours ago
United
Tue, Sep 30 - Wed, Oct 1
RSW
Fort Myers
TYS
Knoxville
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select United flight, departing Tue, Sep 30 from Fort Myers to Knoxville, returning Wed, Oct 1, priced at $274 found 1 day ago
Southwest Airlines
Mon, May 11 - Mon, May 18
RSW
Fort Myers
TYS
Knoxville
$279 Roundtrip, found 6 days ago
$279
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Mon, May 11 from Fort Myers to Knoxville, returning Mon, May 18, priced at $279 found 6 days ago
American Airlines
Tue, Oct 14 - Fri, Oct 17
RSW
Fort Myers
TYS
Knoxville
$281 Roundtrip, found 19 hours ago
$281
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Oct 14 from Fort Myers to Knoxville, returning Fri, Oct 17, priced at $281 found 19 hours ago

Find the cheapest month to fly from Fort Myers (RSW) to Knoxville (TYS)

May is typically the cheapest month to fly

From $198 - $449 per traveler.

Graph displaying average flight prices per month

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $328
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $328
Flights from Fort Myers (RSW) to Knoxville (TYS)
Origin airport
Southwest Florida Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$258
Distance
654 mi

Fort Myers to Knoxville Flights

The cheapest times to fly from Fort Myers to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Fort Myers to Knoxville are during the month of January. You can find some of the cheapest flights from Fort Myers to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Fort Myers to Knoxville

Sunday is one of the best days to book for cheap flights from Fort Myers to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Fort Myers to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Fort Myers to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $130 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Fort Myers to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Fort Myers to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS) cost?
Secure a cheap one-way flight from $130 or cheap return flight from $259 from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from RSW to TYS is January, when demand is low. Off-peak season is generally when airlines offer lower prices between these airports.
Which airlines fly direct from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
Although Fort Myers, FL (RSW-Southwest Florida Intl.) doesn't have any direct flights to McGhee Tyson Airport (TYS), other airports have nonstop options. Jetting off from Charlotte County Airport (PGD) will get you to Knoxville without any layovers.
What is the cheapest airline that flies from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest RSW to TYS flight.
How many flights per day from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
Nonstop flights from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from RSW to TYS?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on various factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on schedule, choose a flight that leaves Southwest Florida Intl. Airport (RSW) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS) last-minute?
Booking your ticket from RSW to TYS just before your trip is generally more expensive. However, if there's some wiggle room with your departure dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a RSW to TYS flight and hotel package?
You'll generally save money by securing a RSW to TYS flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your ideal flights and accommodations, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Southwest Florida Intl. Airport (RSW) to McGhee Tyson Airport (TYS)?
It's usually possible to cancel or reschedule your RSW to TYS flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.