Title: Visit Santa Isabel Xiloxoxtla: 2026 Travel Guide for Santa Isabel Xiloxoxtla, Tlaxcala | Expedia.com

[Hotels in Santa Isabel Xiloxoxtla](https://expedia.com/Santa-Isabel-Xiloxoxtla-Hotels.d553248635640641436.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel Xiloxoxtla](https://expedia.com/Santa-Isabel-Xiloxoxtla-Vacation-Rentals.d553248635640641436.Travel-Guide-VacationRentals)[Car Rentals in Santa Isabel Xiloxoxtla](https://expedia.com/Car-Rentals-In-Santa-Isabel-Xiloxoxtla.d553248635640641436.Car-Rental-Guide)[Santa Isabel Xiloxoxtla Vacation Packages](https://expedia.com/Santa-Isabel-Xiloxoxtla.d553248635640641436.Destination-Travel-Guides)

# Santa Isabel Xiloxoxtla

## Travel Guide

## Visit Santa Isabel Xiloxoxtla

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248635640641436)

- Santa Isabel Xiloxoxtla Hotel Deals
- Vacation Rentals in Santa Isabel Xiloxoxtla

![Holiday Inn Express Puebla by IHG](https://images.trvl-media.com/lodging/1000000/1000000/990300/990253/1c0b91c4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Holiday Inn Express Puebla by IHG

Blvd. Hermanos Serdan 45 Puebla PUE

Fully refundableReserve now, pay when you stay

$59 nightly

$70 total

Mar 27 - Mar 28

Total with taxes and fees

Book a stay at this business-friendly hotel in Puebla. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,729 reviews)

Las instalaciones muy deterioradas y no funciono el aire acondicionado del cuarto y pesimo servicio del director me envio ventilador cuando pague precio completo

Reviewed on Mar 12, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F27%2F2026&endDate=3%2F28%2F2026&selected=990253&PinnedHotelID=990253&HadPinnedHotel=true&regionId=553248635640641436)

![Camino Real Puebla Angelopolis](https://images.trvl-media.com/lodging/4000000/3200000/3192000/3191907/474516f8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Camino Real Puebla Angelopolis

Boulevard Atlixcayotl Km 5 San Andrés Cholula PUE

$65 nightly

$77 total

Apr 5 - Apr 6

Total with taxes and fees

Stay at this hotel in San Andrés Cholula. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff in our reviews. ...

8.2/10 Very Good! (2,197 reviews)

Lack of maintenance, shower in waves hot- cold, hard to use it

Reviewed on Mar 5, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=3191907&PinnedHotelID=3191907&HadPinnedHotel=true&regionId=553248635640641436)

![Holiday Inn Express Hotel & Suites Puebla Angelopolis by IHG](https://images.trvl-media.com/lodging/8000000/7670000/7662000/7661913/a98b83a8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Holiday Inn Express Hotel & Suites Puebla Angelopolis by IHG

Perseo N. 2502, Col.San Martinito San Andrés Cholula PUE

$62 nightly

$74 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in San Andrés Cholula. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in ...

9.4/10 Exceptional! (1,050 reviews)

Some things inside the bathroom were not well placed. Looks like it is not having proper maintenance. Swimming pool not working. Breakfast good.

Reviewed on Mar 2, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=7661913&PinnedHotelID=7661913&HadPinnedHotel=true&regionId=553248635640641436)

[See all 658 properties in Santa Isabel Xiloxoxtla](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F16%2F2026&endDate=3%2F17%2F2026&regionId=553248635640641436)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![Pietro Santo](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/603237c8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Pietro Santo

Sta Isa Tetlahuaca Km2 San Miguel Xoxtla Santeagueda TLAX

Stay at this apartment in Tetlatlahuca. Enjoy free WiFi and a 24-hour front desk. Popular attractions Outlet Puebla Premier and Cacaxtla are located nearby.

[](https://expedia.com/Santeagueda-Hotels-Pietro-Santo.h84020693.Hotel-Information)

![Hotel Suites Regente](https://images.trvl-media.com/lodging/122000000/121450000/121440200/121440149/862f5965_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Suites Regente

1618 Av. 5 de Mayo San Andrés Cholula Pue.

Stay at this aparthotel in San Andrés Cholula. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Great Pyramid of Cholula and ...

9.6/10 Exceptional! (12 reviews)

Cuarto limpio,personal muy amable, parking con seguridad 24?horas parking con cancel en la noche. Es un hotel nuevo. Planeamos una noche y nos quedamos 2 por la comodidad de sus camas y la amabilidad de el personal.

Reviewed on Feb 24, 2026

[](https://expedia.com/Puebla-Hotels-Hotel-Suites-Regente.h121440149.Hotel-Information)

![Casa Tlaxcalli by Beddo Hoteles](https://images.trvl-media.com/lodging/100000000/99480000/99472200/99472163/9cd9ee3d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Casa Tlaxcalli by Beddo Hoteles

Av. 20 de Noviembre Tlaxcala TLAX

Stay at this aparthotel in Tlaxcala. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions Art Museum of Tlaxcala and Museo de la Memoria ...

9/10 Wonderful! (58 reviews)

Excellent

Reviewed on Dec 31, 2025

[](https://expedia.com/Tlaxcala-Hotels-Casa-Tlaxcalli-By-Beddo-Hoteles.h99472163.Hotel-Information)

[See all properties in Santa Isabel Xiloxoxtla](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=553248635640641436&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Santa Isabel Xiloxoxtla hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=2026-03-15&endDate=2026-03-16)[Mar 15 - Mar 16](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=2026-03-15&endDate=2026-03-16)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=2026-03-16&endDate=2026-03-17)[Mar 16 - Mar 17](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=2026-03-16&endDate=2026-03-17)

[Next weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=553248635640641436&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)

## Cities near Santa Isabel Xiloxoxtla

![If you come to Tlaxcala make sure that these stairs are on your list of places to visit.](https://images.trvl-media.com/place/6345209/585eac43-b1ac-45c1-842f-4029642fef07.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Tlaxcala

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- [Museo de la Memoria ](https://www.expedia.com/Museo-De-La-Memoria-Tlaxcala.d553248621532976761.Vacation-Attraction)
- [Constitution Square ](https://www.expedia.com/Constitution-Square-Tlaxcala.d553248621532976756.Vacation-Attraction)
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- [Centro de Convenciones de Tlaxcala ](https://www.expedia.com/Centro-De-Convenciones-De-Tlaxcala-Tlaxcala.d553248621592397531.Vacation-Attraction)
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- [Tlaxcala Vacation Rentals ](https://www.expedia.com/Tlaxcala-Vacation-Rentals.d6345209.Travel-Guide-VacationRentals)
- [Tlaxcala Vacation Rentals ](https://www.expedia.com/Destinations-In-Tlaxcala.d9498.Vacation-Rental-Destinations)
- [Apizaco Vacation Rentals ](https://www.expedia.com/Apizaco-Vacation-Rentals.d6023383.Travel-Guide-VacationRentals)
- [Huamantla Vacation Rentals ](https://www.expedia.com/Huamantla-Vacation-Rentals.d6024106.Travel-Guide-VacationRentals)

- [Things to do in Tlaxcala ](https://www.expedia.com/Things-To-Do-In-Tlaxcala.d6345209.Travel-Guide-Activities)
- [Things to do in Huamantla ](https://www.expedia.com/Things-To-Do-In-Huamantla.d6024106.Travel-Guide-Activities)

- Cities near Santa Isabel Xiloxoxtla
- Places of interest

[Tlaxcala](https://expedia.com/Tlaxcala.dx6345209)

- [Angelopolis Commercial Center ](https://expedia.com/Angelopolis-Commercial-Center-Angelopolis.d6302860.Vacation-Attraction)
- [Great Pyramid of Cholula ](https://expedia.com/Great-Pyramid-Of-Cholula-Cholula.d6165713.Vacation-Attraction)
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- [Xicotencatl National Park ](https://expedia.com/Xicotencatl-National-Park-Tlaxcala.d6113704.Vacation-Attraction)

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