$596 Cheap Flights from Panama City (PTY) to Lisbon (LIS)

Panama City (PTY) to Lisbon (LIS) at a glance

Embark on an exciting journey from Panama City (PTY) to Lisbon (LIS) with a selection of airlines catering to this international long-haul route. Evaluate various options from full-service carriers to discover the itinerary that perfectly aligns with your budget, schedule, and travel aspirations as you delve into Lisbon's iconic attractions and neighborhoods. Get the essential details for flights departing from Tocumen International Airport (PTY) to Humberto Delgado Airport (LIS).

• Fastest flight duration: around 11h 15m in-flight, plus roughly 1h 45m layover with one stop
• Route distance: roughly 4,800 miles (7,720 km)
• Flights per week: around 7 departures on average
• Typical fares (one-way): economy tickets often range from $385–$1185, depending on seasonality and how far ahead you book

Flights from Tocumen International Airport (PTY) to Humberto Delgado Airport (LIS)

Based on the latest traveler bookings, here are the top airlines favored for flights from Panama City to Lisbon, often selected for their one-stop services. Common layover points include Adolfo Suárez Madrid-Barajas Airport (MAD) with a layover of approximately 1 hour and 45 minutes, Schiphol Airport (AMS) at about 1 hour and 30 minutes, and Roissy-Charles de Gaulle Airport (CDG) with a longer layover of around 3 hours. These options allow you to balance price, total travel time, and cabin class to create your ideal itinerary.

• Air Europa: This full-service airline provides one-stop flights, dominating the route with around 75% of departures. One-way ticket prices generally fall between $385 and $1810. Expect an in-flight duration of 11 hours and 15 minutes, with a total travel time, including layover, of approximately 12 hours and 45 minutes.
• KLM: Representing about 11% of departures, this full-service carrier also offers one-stop services, with one-way fares usually ranging from $750 to $2375. Travelers can anticipate an in-flight time of 11 hours and 15 minutes, culminating in a total journey time of nearly 12 hours and 45 minutes when accounting for layovers.
• Air France: Another full-service option, Air France accounts for about 4% of departures, providing one-stop services with one-way fares typically priced at $425. The in-flight experience lasts approximately 11 hours and 15 minutes, leading to a total travel time of around 12 hours and 45 minutes, including layover.

How to find the best prices for flights from Panama City (PTY) to Lisbon (LIS)

Getting some of the best deals on flights from Panama City to Lisbon is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Evening departures from 6 PM to 12 AM often offer lower prices and are also the most popular times to fly. Additionally, flying on Sunday generally yields cheaper rates, despite Saturday being the busiest travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Lisbon hotel and flight deals.
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Humberto Delgado Airport from Tocumen International Airport

Lisbon welcomes travelers from Panama City with a range of transport options based on price, convenience, and proximity. For departures, Tocumen International Airport is roughly a 20-minute drive (covering about 15 miles) from central Panama City. Here's how to reach Lisbon efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Lisbon, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
• Car rental: Renting a car from Humberto Delgado Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Humberto Delgado Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Humberto Delgado Airport, travelers will find Lisbon Airport Station, a metro station, just a short 0.1-mile walk away, while Oriente Bus Station, a bus station, is located about 1.8 miles from the airport by car. Additionally, Roma-Areeiro Station, a train station, is also approximately 1.8 miles away by car.

Panama City to Lisbon Flights

The cheapest times to fly from Panama City to Lisbon

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Lisbon are during the month of May. You can find some of the cheapest flights from Panama City to Lisbon with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Panama City to Lisbon

Sunday is one of the best days to book for cheap flights from Panama City to Lisbon: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Panama City to Lisbon

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Lisbon in 2026. You can also book with separate airlines for your outbound and return journeys, from $596 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Lisbon flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Lisbon airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.