$541 Cheap Flights from Panama City (PTY) to Reynosa (REX)

View $541 flight on Fri, Dec 5, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Reynosa, Tamaulipas (REX-General Lucio Blanco Intl.)

Cheap Flights from Panama City to Reynosa (PTY-REX)

Prices were available within the past 7 days and start at $541 for one-way flights and $786 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$786 Roundtrip, found 6 days ago
$786
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $786 found 6 days ago
Aeromexico
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$900 Roundtrip, found 6 days ago
$900
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $900 found 6 days ago
Aeromexico
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,040 Roundtrip, found 6 days ago
$1,040
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,040 found 6 days ago
Aeromexico
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,073 Roundtrip, found 6 days ago
$1,073
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,073 found 6 days ago
avianca
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,120 Roundtrip, found 6 days ago
$1,120
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,120 found 6 days ago
avianca
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,131 Roundtrip, found 6 days ago
$1,131
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,131 found 6 days ago
avianca
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,171 Roundtrip, found 6 days ago
$1,171
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,171 found 6 days ago
avianca
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,175 Roundtrip, found 6 days ago
$1,175
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,175 found 6 days ago
avianca
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,181 Roundtrip, found 6 days ago
$1,181
Roundtrip
found 6 days ago
Select avianca flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,181 found 6 days ago
Copa
Mon, Dec 1 - Wed, Dec 31
PTY
Panama City
REX
Reynosa
$1,248 Roundtrip, found 6 days ago
$1,248
Roundtrip
found 6 days ago
Select Copa flight, departing Mon, Dec 1 from Panama City to Reynosa, returning Wed, Dec 31, priced at $1,248 found 6 days ago
Flights from Panama City (PTY) to Reynosa (REX)
Origin airport
Tocumen Intl.
Destination airport
General Lucio Blanco Intl.
Roundtrip price
$786
Distance
1701 mi

Panama City to Reynosa Flights

The cheapest times to fly from Panama City to Reynosa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Reynosa are during the month of December. You can find some of the cheapest flights from Panama City to Reynosa with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Reynosa

Sunday is one of the best days to book for cheap flights from Panama City to Reynosa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Reynosa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Reynosa in 2025. You can also book with separate airlines for your outbound and return journeys, from $541 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Reynosa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Reynosa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX) cost?
Get a cheap one-way flight from $541 or cheap return flight from $786 from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX)?
The cheapest month to fly from PTY to REX is December, when demand is low. Off-peak months are often when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll fly you from PTY to REX. Then, sort your results by "Price (lowest to highest)" to pick up the best deal available.
How many flights per day from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX)?
Direct flights from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to REX?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX)?
Choose a flight from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX) last-minute?
Last-minute fares from PTY to REX are generally more expensive. To secure the best prices, start looking for flights early. That said, if you're flexible with your travel dates, you may find a cheap ticket just before your departure.
Is it cheaper to book a PTY to REX flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to REX flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place will take the hassle out of travel planning. Simply secure your flights and choose from our wide range of stays, then customize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to General Lucio Blanco Intl. Airport (REX)?
Typically, it's possible to reschedule or cancel your PTY to REX flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.