$79 Cheap Flights from St. Louis (STL) to Panama City (ECP)

View $79 flight on Mon, Sep 29, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)

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Cheap Flights from St. Louis to Panama City (STL-ECP)

Prices were available within the past 7 days and start at $79 for one-way flights and $157 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Thu, Aug 14 - Wed, Aug 20
STL
St. Louis
ECP
Panama City
$157 Roundtrip, found 11 hours ago
$157
Roundtrip
found 11 hours ago
Select Southwest Airlines flight, departing Thu, Aug 14 from St. Louis to Panama City, returning Wed, Aug 20, priced at $157 found 11 hours ago
Delta
Wed, Aug 20 - Wed, Aug 27
STL
St. Louis
ECP
Panama City
$162 Roundtrip, found 10 hours ago
$162
Roundtrip
found 10 hours ago
Select Delta flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Wed, Aug 27, priced at $162 found 10 hours ago
Delta
Wed, Aug 20 - Mon, Aug 25
STL
St. Louis
ECP
Panama City
$163 Roundtrip, found 9 hours ago
$163
Roundtrip
found 9 hours ago
Select Delta flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Mon, Aug 25, priced at $163 found 9 hours ago
American Airlines
Wed, Aug 20 - Mon, Aug 25
STL
St. Louis
ECP
Panama City
$167 Roundtrip, found 9 hours ago
$167
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Mon, Aug 25, priced at $167 found 9 hours ago
Delta
Wed, Aug 20 - Wed, Aug 27
STL
St. Louis
ECP
Panama City
$167 Roundtrip, found 10 hours ago
$167
Roundtrip
found 10 hours ago
Select Delta flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Wed, Aug 27, priced at $167 found 10 hours ago
Delta
Sat, Sep 6 - Wed, Sep 10
STL
St. Louis
ECP
Panama City
$167 Roundtrip, found 2 hours ago
$167
Roundtrip
found 2 hours ago
Select Delta flight, departing Sat, Sep 6 from St. Louis to Panama City, returning Wed, Sep 10, priced at $167 found 2 hours ago
Delta
Sun, Aug 24 - Thu, Aug 28
STL
St. Louis
ECP
Panama City
$168 Roundtrip, found 23 hours ago
$168
Roundtrip
found 23 hours ago
Select Delta flight, departing Sun, Aug 24 from St. Louis to Panama City, returning Thu, Aug 28, priced at $168 found 23 hours ago
Southwest Airlines
Mon, Sep 29 - Fri, Oct 3
STL
St. Louis
ECP
Panama City
$172 Roundtrip, just found
$172
Roundtrip
just found
Select Southwest Airlines flight, departing Mon, Sep 29 from St. Louis to Panama City, returning Fri, Oct 3, priced at $172 just found
American Airlines
Sun, Aug 24 - Thu, Aug 28
STL
St. Louis
ECP
Panama City
$173 Roundtrip, found 23 hours ago
$173
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sun, Aug 24 from St. Louis to Panama City, returning Thu, Aug 28, priced at $173 found 23 hours ago
United
Tue, Aug 26 - Sat, Aug 30
STL
St. Louis
ECP
Panama City
$193 Roundtrip, found 4 days ago
$193
Roundtrip
found 4 days ago
Select United flight, departing Tue, Aug 26 from St. Louis to Panama City, returning Sat, Aug 30, priced at $193 found 4 days ago

Find the cheapest month to fly from St. Louis (STL) to Panama City (ECP)

September is typically the cheapest month to fly

From $176 - $477 per traveler.

Graph displaying average flight prices per month

Flights from St. Louis (STL) to Panama City (ECP)
Origin airport
Lambert-St. Louis Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$157
Distance
634 mi
Average flight time
1 hour 46 mins

St. Louis to Panama City Flights

The cheapest times to fly from St. Louis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Panama City are during the month of August. You can find some of the cheapest flights from St. Louis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Panama City

Sunday is one of the best days to book for cheap flights from St. Louis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $79 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) cost?
Pick up cheap return fares starting from $157 from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Southwest Airlines flight leaving STL on July 15 2025 and touching down at ECP. The price was last updated on June 30 2025 and has not changed since.
What is the cheapest month to fly from STL to ECP?
Look for direct flights from STL to ECP in September to take advantage of cheaper fares. You can find a one-way Southwest Airlines flight for $79 leaving on September 1 2025. This price is based on the cheapest direct flight found on Expedia for this route in the next 330 days. The price was last updated on June 30 2025 and remains unchanged.
What is the cheapest airline that flies from STL to ECP?
With fares starting at $79 for a one-way flight from STL to ECP, Southwest Airlines is currently the cheapest airline flying this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from STL on September 1 2025. Prices were last updated on June 30 2025 and have not changed since.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
Nonstop flights from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from STL to ECP?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
To touch down at Northwest Florida Beaches Intl. Airport (ECP) on time, select a flight that leaves Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) last-minute?
Booking your ticket from STL to ECP just before your trip is generally more expensive. But if there's some wiggle room with your departure dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a STL to ECP flight and hotel package?
Compared with arranging flights and hotels separately, booking a STL to ECP flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one convenient place will take the hassle out of travel planning. Simply pick your flights and select from our extensive range of stays, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
Typically, you can cancel or reschedule your STL to ECP flight. However, additional fees may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you need further information, go to our Customer Service portal.

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*Available to One Key members.