$154 Cheap American Airlines flights New York (LGA) to Knoxville (TYS)

Landing cheap one-way American Airlines flights from LGA to TYS from $154 on Expedia is easy — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly round-trip fares from $183 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find cheap American Airlines fares from LaGuardia Airport (LGA) to McGhee Tyson Airport (TYS), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact the price you pay. Sunday is typically the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from LGA to TYS with American Airlines leaves at 8:28AM UTC-5. You'll touch down at 10:52AM UTC-5. The final American Airlines flight of the day takes off at 6:44PM UTC-5 and arrives at 9:09PM UTC-5. With approximately 20% fewer cancellations for morning departures, beginning your travel day early is often the wisest option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.