$165 Cheap American Airlines flights Knoxville (TYS) to Chicago (ORD)

Make use of the "Price (lowest to highest)" filter on Expedia to search for cheap American Airlines return flights from $189 from TYS to ORD. Affordable one-way options from $165 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

For cheap American Airlines fares from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD), start searching one to three months before your planned departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence how much you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first American Airlines flight from TYS to ORD takes off at 11:43AM UTC-5, touching down at 12:37PM UTC-6. If you prefer to jet off later, the last American Airlines flight leaves TYS at 6:51PM UTC-5 and lands at ORD at 7:50PM UTC-6. Flying early is often a good option as morning and mid-morning flights are less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.