$101 Cheap American Airlines flights Tampa (TPA) to Key West (EYW)

You’ll find cheap return American Airlines flights from $162 from TPA to EYW by filtering your results from “Price (lowest to highest)” on Expedia. Or search for deals from $101 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

September is one of the cheapest months to jet off to Key West with American Airlines. You could also find fantastic deals on return and one-way fares in August.

Search for cheap American Airlines flights from Tampa Intl. Airport (TPA) to Key West Intl. Airport (EYW) one to three months ahead of your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the ideal day to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use our “Nonstop” filter when browsing for direct American Airlines flights from TPA to EYW. It’s also a great way to compare other airlines offering the same nonstop route.

To find the earliest departures from TPA to EYW with American Airlines, sort your results by “Early Morning” and “Morning.” Choosing an early flight usually means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Tampa Intl. Airport (TPA) to Key West land at Key West Intl. Airport (EYW). This is the main gateway here.

Depending on your ticket type, a fee is typically charged if you cancel or reschedule your flight more than 24 hours after it has been confirmed. To find tickets with more flexibility, select our “Changes included” or “No cancel fee” filter while searching for flights. For more information on changing or canceling your reservation, head to “Trips,” select your flight and click on “Manage Booking.”