$319 Cheap Flights from Charlotte (CLT) to Florence (FLO)

View $319 flight on Wed, Aug 6, 2025Opens in a new window

Popular airlines from Charlotte-Douglas Intl. Airport (CLT) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Charlotte to Florence (CLT-FLO)

Prices were available within the past 7 days and start at $319 for one-way flights and $327 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Jan 10 - Wed, Jan 14
CLT
Charlotte
FLO
Florence
$327 Roundtrip, found 9 hours ago
$327
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jan 10 from Charlotte to Florence, returning Wed, Jan 14, priced at $327 found 9 hours ago
American Airlines
Wed, Jan 28 - Sun, Feb 1
CLT
Charlotte
FLO
Florence
$347 Roundtrip, found 9 hours ago
$347
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Jan 28 from Charlotte to Florence, returning Sun, Feb 1, priced at $347 found 9 hours ago
American Airlines
Sat, Dec 20 - Wed, Dec 24
CLT
Charlotte
FLO
Florence
$357 Roundtrip, found 3 days ago
$357
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Dec 20 from Charlotte to Florence, returning Wed, Dec 24, priced at $357 found 3 days ago
American Airlines
Fri, Oct 17 - Mon, Oct 20
CLT
Charlotte
FLO
Florence
$367 Roundtrip, found 6 hours ago
$367
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Oct 17 from Charlotte to Florence, returning Mon, Oct 20, priced at $367 found 6 hours ago
American Airlines
Tue, Dec 23 - Sat, Dec 27
CLT
Charlotte
FLO
Florence
$377 Roundtrip, found 9 hours ago
$377
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Dec 23 from Charlotte to Florence, returning Sat, Dec 27, priced at $377 found 9 hours ago
American Airlines
Sat, Jan 10 - Wed, Jan 14
CLT
Charlotte
FLO
Florence
$387 Roundtrip, found 9 hours ago
$387
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jan 10 from Charlotte to Florence, returning Wed, Jan 14, priced at $387 found 9 hours ago
American Airlines
Sat, Sep 20 - Sun, Sep 28
CLT
Charlotte
FLO
Florence
$407 Roundtrip, found 2 days ago
$407
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Sep 20 from Charlotte to Florence, returning Sun, Sep 28, priced at $407 found 2 days ago
American Airlines
Wed, Nov 19 - Sat, Nov 29
CLT
Charlotte
FLO
Florence
$412 Roundtrip, found 3 days ago
$412
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Nov 19 from Charlotte to Florence, returning Sat, Nov 29, priced at $412 found 3 days ago
American Airlines
Tue, Dec 30 - Sat, Jan 3
CLT
Charlotte
FLO
Florence
$417 Roundtrip, found 2 days ago
$417
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Dec 30 from Charlotte to Florence, returning Sat, Jan 3, priced at $417 found 2 days ago
American Airlines
Fri, Oct 17 - Mon, Oct 20
CLT
Charlotte
FLO
Florence
$427 Roundtrip, found 6 hours ago
$427
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Oct 17 from Charlotte to Florence, returning Mon, Oct 20, priced at $427 found 6 hours ago
American Airlines
Tue, Dec 30 - Sat, Jan 3
CLT
Charlotte
FLO
Florence
$429 Roundtrip, found 2 days ago
$429
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Dec 30 from Charlotte to Florence, returning Sat, Jan 3, priced at $429 found 2 days ago
American Airlines
Tue, Dec 23 - Sat, Dec 27
CLT
Charlotte
FLO
Florence
$437 Roundtrip, found 9 hours ago
$437
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Dec 23 from Charlotte to Florence, returning Sat, Dec 27, priced at $437 found 9 hours ago
American Airlines
Wed, Sep 24 - Sun, Sep 28
CLT
Charlotte
FLO
Florence
$438 Roundtrip, found 9 hours ago
$438
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Sep 24 from Charlotte to Florence, returning Sun, Sep 28, priced at $438 found 9 hours ago
American Airlines
Tue, Aug 19 - Sat, Aug 23
CLT
Charlotte
FLO
Florence
$447 Roundtrip, found 9 hours ago
$447
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Aug 19 from Charlotte to Florence, returning Sat, Aug 23, priced at $447 found 9 hours ago
American Airlines
Wed, Dec 3 - Sun, Dec 7
CLT
Charlotte
FLO
Florence
$451 Roundtrip, found 2 days ago
$451
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 3 from Charlotte to Florence, returning Sun, Dec 7, priced at $451 found 2 days ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $458
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $458
Flights from Charlotte (CLT) to Florence (FLO)
Origin airport
Charlotte-Douglas Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$327
Distance
99 mi
Average flight time
1 hour 13 mins

Charlotte to Florence Flights

The cheapest times to fly from Charlotte to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charlotte to Florence are during the month of January. You can find some of the cheapest flights from Charlotte to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charlotte to Florence

Sunday is one of the best days to book for cheap flights from Charlotte to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charlotte to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charlotte to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $319 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charlotte to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charlotte to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) cost?
You'll find affordable return tickets from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) starting from $447. Snag a seat and be on your way. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a American Airlines flight leaving CLT on July 26 2025 and touching down at FLO. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from CLT to FLO?
The cheapest flights from CLT to FLO are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
You can fly straight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) on an American Airlines flight.
What is the cheapest airline that flies from CLT to FLO?
With prices as low as $319 for a one-way flight from CLT to FLO, American Airlines is currently the cheapest carrier for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from CLT on July 26 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
When flying out of Charlotte-Douglas Intl. Airport (CLT), you'll have a choice from an average of 2 daily direct flights to Florence Regional Airport (FLO).
What are the most popular departure times for flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
The 10 PM departures from CLT to FLO are the top choice for many travelers. Greater demand means you'll likely pay more for these departures. If you want to save money, choose a less crowded time to fly.
What day of the week has the most flights from CLT to FLO?
Travel on a Monday if you're searching for the best choice of flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO).
What is the earliest flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
Charlotte-Douglas Intl. Airport (CLT)'s first flight to Florence Regional Airport (FLO) takes off at approximately 9:31AM UTC-5. With a travel time of 1h 12m, you'll arrive at around 10:43AM UTC-5.
How long does it take to fly from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
It usually takes 1 hour and 3 minutes to travel the 100 mi from CLT to FLO.
What airline has the least delays from CLT to FLO?
With 85% of flights generally landing on time, American Airlines has the best on-time performance for direct flights from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO). To keep track of your flight status and receive notifications if anything changes, use the Expedia App.
What is the best time to fly from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
To avoid possible delays on the Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) route, travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Florence from Charlotte-Douglas Intl. Airport (CLT)?
If you're catching a direct flight from Charlotte-Douglas Intl. Airport (CLT) to Florence, you can touch down at either Myrtle Beach Intl. Airport (MYR) or Florence Regional Airport (FLO).
Is it cheaper to buy a plane ticket from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO) last-minute?
Last-minute fares from CLT to FLO are usually more expensive. To lock in the best rates, start looking for flights ahead of time. That being said, if you can play around with your travel dates, it's possible to score a cheap ticket right before your trip.
Is it cheaper to book a CLT to FLO flight and hotel package?
Compared with arranging hotels and flights separately, booking a CLT to FLO flight and hotel package with Expedia could result in significant savings. Better still, having everything in one easy place will take the hassle out of travel planning. Simply pick your flights and select from our wide range of stays, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Charlotte-Douglas Intl. Airport (CLT) to Florence Regional Airport (FLO)?
In most cases, you can cancel or modify your CLT to FLO flight. However, there may be additional fees, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, visit our Customer Service portal.

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*Available to One Key members.