$352 Cheap Flights from Columbus (CMH) to La Crosse (LSE)

View $352 flight on Sat, Oct 4, 2025Opens in a new window

Popular airlines from John Glenn Columbus Intl. Airport (CMH) to La Crosse, WI (LSE-La Crosse Municipal)

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Cheap Flights from Columbus to La Crosse (CMH-LSE)

Prices were available within the past 7 days and start at $352 for one-way flights and $441 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Oct 16 - Sat, Oct 18
CMH
Columbus
LSE
La Crosse
$441 Roundtrip, found 1 day ago
$441
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 16 from Columbus to La Crosse, returning Sat, Oct 18, priced at $441 found 1 day ago
American Airlines
Thu, Oct 16 - Sat, Oct 18
CMH
Columbus
LSE
La Crosse
$447 Roundtrip, found 4 days ago
$447
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 16 from Columbus to La Crosse, returning Sat, Oct 18, priced at $447 found 4 days ago
American Airlines
Thu, Oct 16 - Sat, Oct 18
CMH
Columbus
LSE
La Crosse
$467 Roundtrip, found 1 day ago
$467
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 16 from Columbus to La Crosse, returning Sat, Oct 18, priced at $467 found 1 day ago
American Airlines
Thu, Oct 16 - Sat, Oct 18
CMH
Columbus
LSE
La Crosse
$476 Roundtrip, found 4 days ago
$476
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Oct 16 from Columbus to La Crosse, returning Sat, Oct 18, priced at $476 found 4 days ago
American Airlines
Sat, Oct 4 - Sun, Oct 5
CMH
Columbus
LSE
La Crosse
$477 Roundtrip, found 1 day ago
$477
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Oct 4 from Columbus to La Crosse, returning Sun, Oct 5, priced at $477 found 1 day ago
American Airlines
Thu, Nov 27 - Tue, Dec 2
CMH
Columbus
LSE
La Crosse
$484 Roundtrip, found 2 days ago
$484
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Nov 27 from Columbus to La Crosse, returning Tue, Dec 2, priced at $484 found 2 days ago
American Airlines
Sat, Oct 11 - Sat, Oct 25
CMH
Columbus
LSE
La Crosse
$490 Roundtrip, found 5 days ago
$490
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Oct 11 from Columbus to La Crosse, returning Sat, Oct 25, priced at $490 found 5 days ago
American Airlines
Tue, Sep 30 - Sat, Oct 11
CMH
Columbus
LSE
La Crosse
$494 Roundtrip, found 5 days ago
$494
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Sep 30 from Columbus to La Crosse, returning Sat, Oct 11, priced at $494 found 5 days ago
American Airlines
Wed, Oct 1 - Sat, Oct 4
CMH
Columbus
LSE
La Crosse
$504 Roundtrip, found 1 day ago
$504
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 1 from Columbus to La Crosse, returning Sat, Oct 4, priced at $504 found 1 day ago
American Airlines
Thu, Oct 16 - Sat, Oct 18
CMH
Columbus
LSE
La Crosse
$511 Roundtrip, found 1 day ago
$511
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 16 from Columbus to La Crosse, returning Sat, Oct 18, priced at $511 found 1 day ago

Frequently asked questions

How much does a flight from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE) cost?
Lock in a cheap one-way flight from $352 or cheap return flight from $441 from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE)?
Planning your trip for October may help you find better deals, as it's the cheapest month for flights between CMH and LSE. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from CMH to LSE. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE)?
You'll have to catch a flight with a layover when traveling from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from CMH to LSE?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change depending on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE)?
Book a flight from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE) last-minute?
Holding off until just before your departure to book a ticket from CMH to LSE often results in higher prices. While you may find some last-minute deals, they aren't always guaranteed. Be flexible with your travel plans for the best chance of scoring a bargain.
Is it cheaper to book a CMH to LSE flight and hotel package?
Compared with arranging hotels and flights separately, booking a CMH to LSE flight and hotel package with Expedia could result in significant savings. Better yet, having it all in one place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of stays, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from John Glenn Columbus Intl. Airport (CMH) to La Crosse Municipal Airport (LSE)?
If you booked your CMH to LSE flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

Travel information

Travel information

Origin airport
John Glenn Columbus Intl.
Destination airport
La Crosse Municipal
Airlines serving
American Airlines
Roundtrip price
$441
Distance
506 mi

Book with confidence

Book with confidence

Columbus to La Crosse Flights

The cheapest times to fly from Columbus to La Crosse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Columbus to La Crosse are during the month of October. You can find some of the cheapest flights from Columbus to La Crosse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Columbus to La Crosse

Sunday is one of the best days to book for cheap flights from Columbus to La Crosse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Columbus to La Crosse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Columbus to La Crosse in 2025. You can also book with separate airlines for your outbound and return journeys, from $352 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Columbus to La Crosse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Columbus to La Crosse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Columbus to La Crosse Flights

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*Available to One Key members.