$146 Cheap Flights from Cusco (CUZ) to Medellín (MDE)

View $146 flight on Wed, Jan 28, 2026Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)

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Cheap Flights from Cusco to Medellín (CUZ-MDE)

Prices were available within the past 7 days and start at $146 for one-way flights and $317 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Sun, Mar 1 - Mon, Mar 16
CUZ
Cusco
MDE
Medellin
$317 Roundtrip, found 6 days ago
$317
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sun, Mar 1 from Cusco to Medellin, returning Mon, Mar 16, priced at $317 found 6 days ago
Jetsmart SPA
Tue, Apr 7 - Thu, Apr 23
CUZ
Cusco
MDE
Medellin
$320 Roundtrip, found 6 days ago
$320
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Tue, Apr 7 from Cusco to Medellin, returning Thu, Apr 23, priced at $320 found 6 days ago
Jetsmart SPA
Tue, May 12 - Tue, May 26
CUZ
Cusco
MDE
Medellin
$322 Roundtrip, found 6 days ago
$322
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Tue, May 12 from Cusco to Medellin, returning Tue, May 26, priced at $322 found 6 days ago
Jetsmart SPA
Tue, Feb 24 - Wed, Mar 11
CUZ
Cusco
MDE
Medellin
$324 Roundtrip, found 6 days ago
$324
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Tue, Feb 24 from Cusco to Medellin, returning Wed, Mar 11, priced at $324 found 6 days ago
Jetsmart SPA
Tue, Feb 24 - Sat, Mar 7
CUZ
Cusco
MDE
Medellin
$327 Roundtrip, found 6 days ago
$327
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Tue, Feb 24 from Cusco to Medellin, returning Sat, Mar 7, priced at $327 found 6 days ago
LATAM Airlines Group
Wed, Feb 11 - Sat, Feb 21
CUZ
Cusco
MDE
Medellin
$329 Roundtrip, found 6 days ago
$329
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Feb 11 from Cusco to Medellin, returning Sat, Feb 21, priced at $329 found 6 days ago
Jetsmart SPA
Wed, Jan 28 - Sun, Feb 8
CUZ
Cusco
MDE
Medellin
$331 Roundtrip, found 6 days ago
$331
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Wed, Jan 28 from Cusco to Medellin, returning Sun, Feb 8, priced at $331 found 6 days ago
Jetsmart SPA
Sun, Jan 25 - Fri, Feb 6
CUZ
Cusco
MDE
Medellin
$334 Roundtrip, found 6 days ago
$334
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Sun, Jan 25 from Cusco to Medellin, returning Fri, Feb 6, priced at $334 found 6 days ago
Jetsmart SPA
Fri, Feb 27 - Sat, Mar 14
CUZ
Cusco
MDE
Medellin
$338 Roundtrip, found 6 days ago
$338
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Fri, Feb 27 from Cusco to Medellin, returning Sat, Mar 14, priced at $338 found 6 days ago
avianca
Sun, Feb 1 - Sat, Feb 7
CUZ
Cusco
MDE
Medellin
$451 Roundtrip, found 3 days ago
$451
Roundtrip
found 3 days ago
Select avianca flight, departing Sun, Feb 1 from Cusco to Medellin, returning Sat, Feb 7, priced at $451 found 3 days ago

Find the cheapest month to fly from Cusco (CUZ) to Medellín (MDE)

November is typically the cheapest month to fly

From $341 - $660 per traveler.

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE) cost?
Get a cheap one-way flight from $146 or cheap return flight from $317 from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)?
March is the cheapest month to fly from CUZ to MDE. Planning your trip for the off-season is often the key to finding better fares.
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from CUZ to MDE. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)?
You'll need to book a flight with a layover if you're traveling from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from CUZ to MDE?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)?
To avoid potential delays on the Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE) route, aim to travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Booking your ticket from CUZ to MDE shortly before your journey is usually more expensive. But if you're flexible with your departure times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a CUZ to MDE flight and hotel package?
Securing a CUZ to MDE flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Jose Maria Cordova Intl. Airport (MDE)?
If you reserved your CUZ to MDE flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
José María Córdova Intl.
Roundtrip price
$317
Distance
1382 mi

Book with confidence

Cusco to Medellín Flights

The cheapest times to fly from Cusco to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Medellín are during the month of March. You can find some of the cheapest flights from Cusco to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Medellín

Sunday is one of the best days to book for cheap flights from Cusco to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $146 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Medellín Flights

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*Available to One Key members.