$152 Cheap Flights from Des Moines (DSM) to Charlotte (CLT)

View $152 flight on Wed, Oct 15, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)

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Cheap Flights from Des Moines to Charlotte (DSM-CLT)

Prices were available within the past 7 days and start at $152 for one-way flights and $301 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Sep 9 - Sat, Sep 13
DSM
Des Moines
CLT
Charlotte
$301 Roundtrip, found 3 days ago
$301
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Sep 9 from Des Moines to Charlotte, returning Sat, Sep 13, priced at $301 found 3 days ago
Southwest Airlines
Tue, Sep 23 - Wed, Sep 24
DSM
Des Moines
CLT
Charlotte
$303 Roundtrip, found 17 hours ago
$303
Roundtrip
found 17 hours ago
Select Southwest Airlines flight, departing Tue, Sep 23 from Des Moines to Charlotte, returning Wed, Sep 24, priced at $303 found 17 hours ago
Frontier Airlines
Thu, Sep 4 - Sun, Sep 7
DSM
Des Moines
CLT
Charlotte
$306 Roundtrip, found 1 day ago
$306
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 4 from Des Moines to Charlotte, returning Sun, Sep 7, priced at $306 found 1 day ago
Southwest Airlines
Wed, Sep 17 - Sat, Sep 20
DSM
Des Moines
CLT
Charlotte
$309 Roundtrip, found 5 days ago
$309
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Sep 17 from Des Moines to Charlotte, returning Sat, Sep 20, priced at $309 found 5 days ago
American Airlines
Sat, Sep 6 - Sat, Sep 13
DSM
Des Moines
CLT
Charlotte
$311 Roundtrip, found 1 day ago
$311
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 6 from Des Moines to Charlotte, returning Sat, Sep 13, priced at $311 found 1 day ago
United
Sat, Aug 30 - Tue, Sep 2
DSM
Des Moines
CLT
Charlotte
$321 Roundtrip, found 18 hours ago
$321
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Aug 30 from Des Moines to Charlotte, returning Tue, Sep 2, priced at $321 found 18 hours ago
Delta
Sat, Sep 6 - Tue, Sep 9
DSM
Des Moines
CLT
Charlotte
$321 Roundtrip, found 6 hours ago
$321
Roundtrip
found 6 hours ago
Select Delta flight, departing Sat, Sep 6 from Des Moines to Charlotte, returning Tue, Sep 9, priced at $321 found 6 hours ago
United
Sat, Aug 30 - Tue, Sep 2
DSM
Des Moines
CLT
Charlotte
$325 Roundtrip, found 18 hours ago
$325
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Aug 30 from Des Moines to Charlotte, returning Tue, Sep 2, priced at $325 found 18 hours ago
United
Sat, Aug 30 - Tue, Sep 2
DSM
Des Moines
CLT
Charlotte
$326 Roundtrip, found 18 hours ago
$326
Roundtrip
found 18 hours ago
Select United flight, departing Sat, Aug 30 from Des Moines to Charlotte, returning Tue, Sep 2, priced at $326 found 18 hours ago
United
Tue, Sep 23 - Tue, Sep 30
DSM
Des Moines
CLT
Charlotte
$327 Roundtrip, found 5 days ago
$327
Roundtrip
found 5 days ago
Select United flight, departing Tue, Sep 23 from Des Moines to Charlotte, returning Tue, Sep 30, priced at $327 found 5 days ago

Find the cheapest month to fly from Des Moines (DSM) to Charlotte (CLT)

October is typically the cheapest month to fly

From $157 - $405 per traveler.

Graph displaying average flight prices per month

Alternative airports near Charlotte

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Charlotte-Douglas Intl. CLT. Cheapest and Closest option available. Average driving time to city center is 11 minutes. Flights from $369
CLT
Charlotte-Douglas Intl.
CheapestClosest
Average driving time to city center11 min
Flights from $369
Flights from Des Moines (DSM) to Charlotte (CLT)
Origin airport
Des Moines Intl.
Destination airport
Charlotte-Douglas Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$301
Distance
813 mi

Des Moines to Charlotte Flights

The cheapest times to fly from Des Moines to Charlotte

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Charlotte are during the month of September. You can find some of the cheapest flights from Des Moines to Charlotte with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Charlotte

Sunday is one of the best days to book for cheap flights from Des Moines to Charlotte: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Charlotte

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Charlotte in 2025. You can also book with separate airlines for your outbound and return journeys, from $152 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Charlotte flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Charlotte airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) cost?
Lock in a cheap one-way flight from $152 or cheap return flight from $301 from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Traveling in September can help you save, as it's the cheapest month for flights between DSM and CLT. You'll usually find the lowest fares during off-peak months.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Jump on a nonstop flight with American Airlines and go straight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT).
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
To find the cheapest airline flying from DSM to CLT, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Every day, an average of 2 nonstop flights operate from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Select the departure date that best suits your plans.
What are the most popular departure times for flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights between DSM and CLT are busiest at 2 PM. If you're after a quieter trip and possibly cheaper prices, look for a departure outside the usual busy windows.
What day of the week has the most flights from DSM to CLT?
Friday offers the most flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Consider taking off on this day and you'll have a greater chance of finding a schedule that works for you.
What is the earliest flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
The first flight of the day out of Des Moines Intl. Airport (DSM) is at around 6:17AM UTC-6. Catch this flight and you'll reach Charlotte-Douglas Intl. Airport (CLT) at approximately 9:52AM UTC-5. The total time in the air is 2h 35m.
How long does it take to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights from DSM to CLT have an average travel time of 2 hours and 20 minutes. The distance between the two airports is 810 mi.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
To touch down at Charlotte-Douglas Intl. Airport (CLT) without delays, pick a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Charlotte from Des Moines Intl. Airport (DSM)?
Charlotte-Douglas Intl. Airport (CLT) is the only airport in Charlotte with direct flights from Des Moines Intl. Airport (DSM). Browse the options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) last-minute?
Last-minute fares from DSM to CLT are usually more expensive. For the cheapest rates, start looking for flights early. That said, if your travel plans are flexible, you may score a cheap fare right before your trip.
Is it cheaper to book a DSM to CLT flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to CLT flight and hotel package with Expedia could result in significant savings. What's more, having everything in one easy place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Usually, it's possible to cancel or reschedule your DSM to CLT flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.