$139 Cheap Flights from Des Moines (DSM) to Charlotte (CLT)

View $139 flight on Wed, Nov 12, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)

Cheap Flights from Des Moines to Charlotte (DSM-CLT)

Prices were available within the past 7 days and start at $139 for one-way flights and $277 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Nov 12 - Thu, Nov 13
DSM
Des Moines
CLT
Charlotte
$277 Roundtrip, found 2 days ago
$277
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Nov 12 from Des Moines to Charlotte, returning Thu, Nov 13, priced at $277 found 2 days ago
Southwest Airlines
Sat, Oct 18 - Wed, Oct 29
DSM
Des Moines
CLT
Charlotte
$282 Roundtrip, found 5 days ago
$282
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Sat, Oct 18 from Des Moines to Charlotte, returning Wed, Oct 29, priced at $282 found 5 days ago
Southwest Airlines
Wed, Mar 4 - Tue, Mar 10
DSM
Des Moines
CLT
Charlotte
$286 Roundtrip, found 2 days ago
$286
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Mar 4 from Des Moines to Charlotte, returning Tue, Mar 10, priced at $286 found 2 days ago
Southwest Airlines
Wed, Nov 12 - Mon, Nov 17
DSM
Des Moines
CLT
Charlotte
$290 Roundtrip, found 2 days ago
$290
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Nov 12 from Des Moines to Charlotte, returning Mon, Nov 17, priced at $290 found 2 days ago
Southwest Airlines
Wed, Nov 19 - Sat, Nov 22
DSM
Des Moines
CLT
Charlotte
$293 Roundtrip, found 3 days ago
$293
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Wed, Nov 19 from Des Moines to Charlotte, returning Sat, Nov 22, priced at $293 found 3 days ago
American Airlines
Wed, Oct 15 - Sat, Oct 18
DSM
Des Moines
CLT
Charlotte
$295 Roundtrip, found 5 days ago
$295
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 15 from Des Moines to Charlotte, returning Sat, Oct 18, priced at $295 found 5 days ago
Southwest Airlines
Wed, Nov 12 - Mon, Nov 17
DSM
Des Moines
CLT
Charlotte
$300 Roundtrip, found 2 days ago
$300
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Nov 12 from Des Moines to Charlotte, returning Mon, Nov 17, priced at $300 found 2 days ago
American Airlines
Sat, Sep 27 - Wed, Oct 1
DSM
Des Moines
CLT
Charlotte
$301 Roundtrip, found 1 day ago
$301
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 27 from Des Moines to Charlotte, returning Wed, Oct 1, priced at $301 found 1 day ago
Frontier Airlines
Thu, Sep 25 - Thu, Oct 2
DSM
Des Moines
CLT
Charlotte
$306 Roundtrip, found 2 days ago
$306
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Sep 25 from Des Moines to Charlotte, returning Thu, Oct 2, priced at $306 found 2 days ago
United
Sat, Oct 18 - Wed, Oct 22
DSM
Des Moines
CLT
Charlotte
$321 Roundtrip, found 1 day ago
$321
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 18 from Des Moines to Charlotte, returning Wed, Oct 22, priced at $321 found 1 day ago

Find the cheapest month to fly from Des Moines (DSM) to Charlotte (CLT)

October is typically the cheapest month to fly

From $157 - $440 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) cost?
Lock in a cheap one-way flight from $139 or cheap return flight from $277 from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Traveling in November can help you save, as it's the cheapest month for flights between DSM and CLT. You'll usually find the lowest fares during off-peak months.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Jump on a nonstop flight with American Airlines and go straight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT).
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
To find the cheapest airline flying from DSM to CLT, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Every day, an average of 2 nonstop flights operate from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Select the departure date that best suits your plans.
What are the most popular departure times for flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights between DSM and CLT are busiest at 2 PM. If you're after a quieter trip and possibly cheaper prices, look for a departure outside the usual busy windows.
What day of the week has the most flights from DSM to CLT?
Friday offers the most flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Consider taking off on this day and you'll have a greater chance of finding a schedule that works for you.
What is the earliest flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
The first flight of the day out of Des Moines Intl. Airport (DSM) is at around 6:17AM UTC-6. Catch this flight and you'll reach Charlotte-Douglas Intl. Airport (CLT) at approximately 9:52AM UTC-5. The total time in the air is 2h 35m.
How long does it take to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights from DSM to CLT have an average travel time of 2 hours and 20 minutes. The distance between the two airports is 810 mi.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
To touch down at Charlotte-Douglas Intl. Airport (CLT) without delays, pick a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Charlotte from Des Moines Intl. Airport (DSM)?
Charlotte-Douglas Intl. Airport (CLT) is the only airport in Charlotte with direct flights from Des Moines Intl. Airport (DSM). Browse the options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) last-minute?
Last-minute fares from DSM to CLT are usually more expensive. For the cheapest rates, start looking for flights early. That said, if your travel plans are flexible, you may score a cheap fare right before your trip.
Is it cheaper to book a DSM to CLT flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to CLT flight and hotel package with Expedia could result in significant savings. What's more, having everything in one easy place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Usually, it's possible to cancel or reschedule your DSM to CLT flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Charlotte-Douglas Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$276
Distance
813 mi
Average flight time
3 hours 24 mins

Book with confidence

Book with confidence

Des Moines to Charlotte Flights

The cheapest times to fly from Des Moines to Charlotte

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Charlotte are during the month of November. You can find some of the cheapest flights from Des Moines to Charlotte with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Charlotte

Sunday is one of the best days to book for cheap flights from Des Moines to Charlotte: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Charlotte

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Charlotte in 2025. You can also book with separate airlines for your outbound and return journeys, from $139 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Charlotte flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Charlotte airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Charlotte Flights

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*Available to One Key members.