$106 Cheap Flights from Des Moines (DSM) to Charlotte (CLT)

View $106 flight on Mon, Sep 8, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)

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Cheap Flights from Des Moines to Charlotte (DSM-CLT)

Prices were available within the past 7 days and start at $106 for one-way flights and $200 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Mon, Sep 8 - Thu, Sep 11
DSM
Des Moines
CLT
Charlotte
$200 Roundtrip, found 15 hours ago
$200
Roundtrip
found 15 hours ago
Select Southwest Airlines flight, departing Mon, Sep 8 from Des Moines to Charlotte, returning Thu, Sep 11, priced at $200 found 15 hours ago
Southwest Airlines
Wed, Aug 20 - Mon, Aug 25
DSM
Des Moines
CLT
Charlotte
$205 Roundtrip, found 14 hours ago
$205
Roundtrip
found 14 hours ago
Select Southwest Airlines flight, departing Wed, Aug 20 from Des Moines to Charlotte, returning Mon, Aug 25, priced at $205 found 14 hours ago
Southwest Airlines
Tue, Aug 5 - Tue, Aug 12
DSM
Des Moines
CLT
Charlotte
$216 Roundtrip, found 4 days ago
$216
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Tue, Aug 5 from Des Moines to Charlotte, returning Tue, Aug 12, priced at $216 found 4 days ago
Southwest Airlines
Mon, Aug 18 - Sat, Aug 23
DSM
Des Moines
CLT
Charlotte
$217 Roundtrip, found 2 days ago
$217
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Mon, Aug 18 from Des Moines to Charlotte, returning Sat, Aug 23, priced at $217 found 2 days ago
Southwest Airlines
Tue, Aug 12 - Thu, Aug 14
DSM
Des Moines
CLT
Charlotte
$222 Roundtrip, found 4 days ago
$222
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Tue, Aug 12 from Des Moines to Charlotte, returning Thu, Aug 14, priced at $222 found 4 days ago
Southwest Airlines
Fri, Sep 5 - Mon, Sep 8
DSM
Des Moines
CLT
Charlotte
$230 Roundtrip, found 20 hours ago
$230
Roundtrip
found 20 hours ago
Select Southwest Airlines flight, departing Fri, Sep 5 from Des Moines to Charlotte, returning Mon, Sep 8, priced at $230 found 20 hours ago
American Airlines
Thu, Sep 18 - Tue, Sep 23
DSM
Des Moines
CLT
Charlotte
$234 Roundtrip, found 1 day ago
$234
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 18 from Des Moines to Charlotte, returning Tue, Sep 23, priced at $234 found 1 day ago
Southwest Airlines
Thu, Aug 21 - Sun, Aug 24
DSM
Des Moines
CLT
Charlotte
$234 Roundtrip, found 3 days ago
$234
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Aug 21 from Des Moines to Charlotte, returning Sun, Aug 24, priced at $234 found 3 days ago
United
Thu, Sep 4 - Mon, Sep 8
DSM
Des Moines
CLT
Charlotte
$327 Roundtrip, just found
$327
Roundtrip
just found
Select United flight, departing Thu, Sep 4 from Des Moines to Charlotte, returning Mon, Sep 8, priced at $327 just found
Delta
Sat, Aug 16 - Tue, Aug 19
DSM
Des Moines
CLT
Charlotte
$393 Roundtrip, found 1 hour ago
$393
Roundtrip
found 1 hour ago
Select Delta flight, departing Sat, Aug 16 from Des Moines to Charlotte, returning Tue, Aug 19, priced at $393 found 1 hour ago

Find the cheapest month to fly from Des Moines (DSM) to Charlotte (CLT)

October is typically the cheapest month to fly

From $157 - $401 per traveler.

Graph displaying average flight prices per month

Alternative airports near Charlotte

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Charlotte-Douglas Intl. CLT. Cheapest and Closest option available. Average driving time to city center is 11 minutes. Flights from $540
CLT
Charlotte-Douglas Intl.
CheapestClosest
Average driving time to city center11 min
Flights from $540
Flights from Des Moines (DSM) to Charlotte (CLT)
Origin airport
Des Moines Intl.
Destination airport
Charlotte-Douglas Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$200
Distance
813 mi
Average flight time
3 hours 24 mins

Des Moines to Charlotte Flights

The cheapest times to fly from Des Moines to Charlotte

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Charlotte are during the month of September. You can find some of the cheapest flights from Des Moines to Charlotte with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Charlotte

Sunday is one of the best days to book for cheap flights from Des Moines to Charlotte: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Charlotte

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Charlotte in 2025. You can also book with separate airlines for your outbound and return journeys, from $106 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Charlotte flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Charlotte airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) cost?
Cheap return fares from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) start from $373. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a American Airlines flight leaving DSM on August 2 2025 and touching down at CLT. The price was last updated on July 6 2025 and has not changed since.
What is the cheapest month to fly from DSM to CLT?
The cheapest flights from DSM to CLT are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Jump on a nonstop flight with American Airlines and go straight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT).
What is the cheapest airline that flies from DSM to CLT?
With prices starting from $253 for a one-way journey from DSM to CLT, American Airlines is currently the cheapest airline flying this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from DSM on September 3 2025. Prices were last updated on July 6 2025 and have not changed since.
How many flights per day from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Every day, an average of 2 nonstop flights operate from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Select the departure date that best suits your plans.
What are the most popular departure times for flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights between DSM and CLT are busiest at 2 PM. If you're after a quieter trip and possibly cheaper prices, look for a departure outside the usual busy windows.
What day of the week has the most flights from DSM to CLT?
Friday offers the most flights from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT). Consider taking off on this day and you'll have a greater chance of finding a schedule that works for you.
What is the earliest flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
The first flight of the day out of Des Moines Intl. Airport (DSM) is at around 6:17AM UTC-6. Catch this flight and you'll reach Charlotte-Douglas Intl. Airport (CLT) at approximately 9:52AM UTC-5. The total time in the air is 2h 35m.
How long does it take to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Flights from DSM to CLT have an average travel time of 2 hours and 20 minutes. The distance between the two airports is 810 mi.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
To touch down at Charlotte-Douglas Intl. Airport (CLT) without delays, pick a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Charlotte from Des Moines Intl. Airport (DSM)?
Charlotte-Douglas Intl. Airport (CLT) is the only airport in Charlotte with direct flights from Des Moines Intl. Airport (DSM). Browse the options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT) last-minute?
Last-minute fares from DSM to CLT are usually more expensive. For the cheapest rates, start looking for flights early. That said, if your travel plans are flexible, you may score a cheap fare right before your trip.
Is it cheaper to book a DSM to CLT flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to CLT flight and hotel package with Expedia could result in significant savings. What's more, having everything in one easy place will take the hassle out of travel planning. Just secure your flights and choose from our wide range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Charlotte-Douglas Intl. Airport (CLT)?
Usually, it's possible to cancel or reschedule your DSM to CLT flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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