$301 Cheap Flights from Des Moines (DSM) to Zacatecas (ZCL)

View $301 flight on Tue, Apr 28, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Zacatecas, Zacatecas (ZCL-General Leobardo C. Ruiz Intl.)

Cheap Flights from Des Moines to Zacatecas (DSM-ZCL)

Prices were available within the past 7 days and start at $301 for one-way flights and $523 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Mon, Nov 17 - Wed, Dec 3
DSM
Des Moines
ZCL
Zacatecas
$523 Roundtrip, found 5 days ago
$523
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Nov 17 from Des Moines to Zacatecas, returning Wed, Dec 3, priced at $523 found 5 days ago
Aeromexico
Tue, Apr 28 - Wed, May 13
DSM
Des Moines
ZCL
Zacatecas
$535 Roundtrip, found 2 days ago
$535
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Tue, Apr 28 from Des Moines to Zacatecas, returning Wed, May 13, priced at $535 found 2 days ago
Delta
Mon, Jan 19 - Tue, Feb 3
DSM
Des Moines
ZCL
Zacatecas
$535 Roundtrip, just found
$535
Roundtrip
just found
Select Delta flight, departing Mon, Jan 19 from Des Moines to Zacatecas, returning Tue, Feb 3, priced at $535 just found
Frontier Airlines
Mon, Nov 17 - Thu, Dec 4
DSM
Des Moines
ZCL
Zacatecas
$544 Roundtrip, found 5 days ago
$544
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Nov 17 from Des Moines to Zacatecas, returning Thu, Dec 4, priced at $544 found 5 days ago
Aeromexico
Wed, Apr 29 - Thu, May 14
DSM
Des Moines
ZCL
Zacatecas
$555 Roundtrip, found 2 days ago
$555
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Wed, Apr 29 from Des Moines to Zacatecas, returning Thu, May 14, priced at $555 found 2 days ago
Delta
Mon, Jan 19 - Sat, Feb 7
DSM
Des Moines
ZCL
Zacatecas
$555 Roundtrip, just found
$555
Roundtrip
just found
Select Delta flight, departing Mon, Jan 19 from Des Moines to Zacatecas, returning Sat, Feb 7, priced at $555 just found
Delta
Mon, Jan 19 - Mon, Feb 9
DSM
Des Moines
ZCL
Zacatecas
$556 Roundtrip, just found
$556
Roundtrip
just found
Select Delta flight, departing Mon, Jan 19 from Des Moines to Zacatecas, returning Mon, Feb 9, priced at $556 just found
Frontier Airlines
Wed, Nov 26 - Thu, Dec 11
DSM
Des Moines
ZCL
Zacatecas
$570 Roundtrip, found 3 days ago
$570
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Nov 26 from Des Moines to Zacatecas, returning Thu, Dec 11, priced at $570 found 3 days ago
Delta
Fri, May 1 - Thu, May 14
DSM
Des Moines
ZCL
Zacatecas
$575 Roundtrip, found 2 days ago
$575
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, May 1 from Des Moines to Zacatecas, returning Thu, May 14, priced at $575 found 2 days ago
American Airlines
Sun, Nov 23 - Thu, Dec 11
DSM
Des Moines
ZCL
Zacatecas
$600 Roundtrip, found 3 days ago
$600
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Nov 23 from Des Moines to Zacatecas, returning Thu, Dec 11, priced at $600 found 3 days ago

Find the cheapest month to fly from Des Moines (DSM) to Zacatecas (ZCL)

March is typically the cheapest month to fly

From $529 - $2,071 per traveler.

Alternative airports near Zacatecas

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to General Leobardo C. Ruiz Intl. ZCL. Cheapest and Closest option available. Average driving time to city center is 24 minutes. Flights from $523
ZCL
General Leobardo C. Ruiz Intl.
CheapestClosest
Average driving time to city center24 min
Flights from $523

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL) cost?
Get a cheap one-way flight from $301 or cheap return flight from $523 from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
The cheapest month to fly from DSM to ZCL is November, when demand is low. Off-peak season is usually when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest DSM to ZCL flight.
How many flights per day from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Nonstop flights from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to ZCL?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
To land at General Leobardo C. Ruiz Intl. Airport (ZCL) on time, choose a flight that leaves Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL) last-minute?
Booking your plane ticket from DSM to ZCL just before your trip is typically more expensive. But if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a DSM to ZCL flight and hotel package?
Securing a DSM to ZCL flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our extensive range of accommodations and then add car rentals, activities and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
If you reserved your DSM to ZCL flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Des Moines Intl.
Destination airport
General Leobardo C. Ruiz Intl.
Airlines serving
Aeromexico, American Airlines, Delta
Roundtrip price
$523
Distance
1389 mi

Book with confidence

Des Moines to Zacatecas Flights

The cheapest times to fly from Des Moines to Zacatecas

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Zacatecas are during the month of November. You can find some of the cheapest flights from Des Moines to Zacatecas with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Zacatecas

Sunday is one of the best days to book for cheap flights from Des Moines to Zacatecas: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Zacatecas

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Zacatecas in 2025. You can also book with separate airlines for your outbound and return journeys, from $301 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Zacatecas flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Zacatecas airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Zacatecas Flights

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*Available to One Key members.