$224 Cheap Flights from Key West (EYW) to St. Louis (STL)

View $224 flight on Wed, Jan 28, 2026Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Key West to St. Louis (EYW-STL)

Prices were available within the past 7 days and start at $224 for one-way flights and $223 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Dec 2 - Tue, Dec 9
EYW
Key West
STL
St. Louis
$223 Roundtrip, found 1 day ago
$223
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 2 from Key West to St. Louis, returning Tue, Dec 9, priced at $223 found 1 day ago
Delta
Thu, Dec 11 - Tue, Dec 16
EYW
Key West
STL
St. Louis
$241 Roundtrip, found 1 day ago
$241
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Dec 11 from Key West to St. Louis, returning Tue, Dec 16, priced at $241 found 1 day ago
American Airlines
Thu, Dec 11 - Sun, Dec 14
EYW
Key West
STL
St. Louis
$259 Roundtrip, found 19 hours ago
$259
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, Dec 11 from Key West to St. Louis, returning Sun, Dec 14, priced at $259 found 19 hours ago
Delta
Wed, May 13 - Mon, May 18
EYW
Key West
STL
St. Louis
$266 Roundtrip, found 1 hour ago
$266
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, May 13 from Key West to St. Louis, returning Mon, May 18, priced at $266 found 1 hour ago
United
Tue, Mar 3 - Tue, Mar 10
EYW
Key West
STL
St. Louis
$267 Roundtrip, found 6 days ago
$267
Roundtrip
found 6 days ago
Select United flight, departing Tue, Mar 3 from Key West to St. Louis, returning Tue, Mar 10, priced at $267 found 6 days ago
United
Tue, Mar 24 - Tue, Mar 31
EYW
Key West
STL
St. Louis
$276 Roundtrip, found 14 hours ago
$276
Roundtrip
found 14 hours ago
Select United flight, departing Tue, Mar 24 from Key West to St. Louis, returning Tue, Mar 31, priced at $276 found 14 hours ago
Delta
Thu, Nov 13 - Tue, Nov 25
EYW
Key West
STL
St. Louis
$284 Roundtrip, found 4 days ago
$284
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Nov 13 from Key West to St. Louis, returning Tue, Nov 25, priced at $284 found 4 days ago
Delta
Wed, May 13 - Mon, May 18
EYW
Key West
STL
St. Louis
$298 Roundtrip, found 1 hour ago
$298
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, May 13 from Key West to St. Louis, returning Mon, May 18, priced at $298 found 1 hour ago
American Airlines
Tue, Apr 14 - Tue, Apr 21
EYW
Key West
STL
St. Louis
$302 Roundtrip, found 6 days ago
$302
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Apr 14 from Key West to St. Louis, returning Tue, Apr 21, priced at $302 found 6 days ago
United
Tue, Mar 3 - Tue, Mar 10
EYW
Key West
STL
St. Louis
$302 Roundtrip, found 6 days ago
$302
Roundtrip
found 6 days ago
Select United flight, departing Tue, Mar 3 from Key West to St. Louis, returning Tue, Mar 10, priced at $302 found 6 days ago

Find the cheapest month to fly from Key West (EYW) to St. Louis (STL)

April is typically the cheapest month to fly

From $204 - $618 per traveler.
Flights from Key West (EYW) to St. Louis (STL)
Origin airport
Key West Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$222
Distance
1102 mi

Key West to St. Louis Flights

The cheapest times to fly from Key West to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to St. Louis are during the month of December. You can find some of the cheapest flights from Key West to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to St. Louis

Sunday is one of the best days to book for cheap flights from Key West to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $224 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL) cost?
Snag a cheap one-way flight from $224 or cheap return flight from $223 from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL)?
Planning your getaway for December is a good way to save, as it's the cheapest month for flights between EYW and STL. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL)?
To find the cheapest airline flying from EYW to STL, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL)?
There are no daily direct flights available from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from EYW to STL?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL) route, fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your departure to book your flight from EYW to STL generally means paying more. While you may find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible to boost your chances of getting a bargain.
Is it cheaper to book an EYW to STL flight and hotel package?
Compared with arranging flights and hotels separately, booking an EYW to STL flight and hotel package with Expedia could result in significant savings. What's more, managing everything in one place will take the stress out of planning your trip. Simply secure your flights and select from our wide range of hotels, then customize your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Lambert-St. Louis Intl. Airport (STL)?
Usually, it's possible to cancel or reschedule your EYW to STL flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.