$255 Cheap Flights from Myrtle Beach (MYR) to Columbia (COU)

View $255 flight on Sun, Dec 14, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Columbia, MO (COU-Columbia Regional)

Cheap Flights from Myrtle Beach to Columbia (MYR-COU)

Prices were available within the past 7 days and start at $255 for one-way flights and $470 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 31 - Mon, Nov 3
MYR
Myrtle Beach
COU
Columbia
$470 Roundtrip, found 1 day ago
$470
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to Columbia, returning Mon, Nov 3, priced at $470 found 1 day ago
American Airlines
Tue, Nov 18 - Wed, Nov 26
MYR
Myrtle Beach
COU
Columbia
$486 Roundtrip, found 2 days ago
$486
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Nov 18 from Myrtle Beach to Columbia, returning Wed, Nov 26, priced at $486 found 2 days ago
American Airlines
Thu, Nov 27 - Mon, Dec 1
MYR
Myrtle Beach
COU
Columbia
$488 Roundtrip, found 1 day ago
$488
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Nov 27 from Myrtle Beach to Columbia, returning Mon, Dec 1, priced at $488 found 1 day ago
American Airlines
Wed, Nov 19 - Wed, Nov 26
MYR
Myrtle Beach
COU
Columbia
$491 Roundtrip, found 2 days ago
$491
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Nov 19 from Myrtle Beach to Columbia, returning Wed, Nov 26, priced at $491 found 2 days ago
American Airlines
Tue, Nov 18 - Tue, Nov 25
MYR
Myrtle Beach
COU
Columbia
$496 Roundtrip, found 2 days ago
$496
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Nov 18 from Myrtle Beach to Columbia, returning Tue, Nov 25, priced at $496 found 2 days ago
American Airlines
Fri, Oct 31 - Tue, Nov 4
MYR
Myrtle Beach
COU
Columbia
$501 Roundtrip, found 1 day ago
$501
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to Columbia, returning Tue, Nov 4, priced at $501 found 1 day ago
American Airlines
Fri, Nov 21 - Wed, Nov 26
MYR
Myrtle Beach
COU
Columbia
$502 Roundtrip, found 21 hours ago
$502
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Fri, Nov 21 from Myrtle Beach to Columbia, returning Wed, Nov 26, priced at $502 found 21 hours ago
American Airlines
Tue, Oct 28 - Tue, Nov 4
MYR
Myrtle Beach
COU
Columbia
$506 Roundtrip, found 1 day ago
$506
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 28 from Myrtle Beach to Columbia, returning Tue, Nov 4, priced at $506 found 1 day ago
American Airlines
Fri, Nov 21 - Wed, Nov 26
MYR
Myrtle Beach
COU
Columbia
$507 Roundtrip, found 21 hours ago
$507
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Fri, Nov 21 from Myrtle Beach to Columbia, returning Wed, Nov 26, priced at $507 found 21 hours ago
United
Thu, Dec 25 - Mon, Jan 5
MYR
Myrtle Beach
COU
Columbia
$583 Roundtrip, found 2 days ago
$583
Roundtrip
found 2 days ago
Select United flight, departing Thu, Dec 25 from Myrtle Beach to Columbia, returning Mon, Jan 5, priced at $583 found 2 days ago

Alternative airports near Columbia

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Columbia Regional COU. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $506
COU
Columbia Regional
CheapestClosest
Average driving time to city center16 min
Flights from $506

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU) cost?
Lock in a cheap one-way flight from $255 or cheap return flight from $470 from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU)?
The cheapest month to fly from MYR to COU is October, when there's less demand. Off-peak season is usually when better flight deals are available between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll fly you from MYR to COU. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU)?
You'll need to catch a flight with a layover when traveling from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from MYR to COU?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU)?
Opt for a flight from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU) last-minute?
Holding off until just before your departure to book your flight from MYR to COU often results in higher prices. While you might find some last-minute offers, there's no guarantee. Allow some flexibility in your schedule for a better chance of landing a bargain.
Is it cheaper to book a MYR to COU flight and hotel package?
Booking a MYR to COU flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our wide range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Columbia Regional Airport (COU)?
If you reserved your MYR to COU flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Columbia Regional
Airlines serving
American Airlines, United
Roundtrip price
$469
Distance
820 mi

Book with confidence

Myrtle Beach to Columbia Flights

The cheapest times to fly from Myrtle Beach to Columbia

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Columbia are during the month of October. You can find some of the cheapest flights from Myrtle Beach to Columbia with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Columbia

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Columbia: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Columbia

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Columbia in 2025. You can also book with separate airlines for your outbound and return journeys, from $255 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Columbia flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Columbia airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Columbia Flights

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*Available to One Key members.