$247 Cheap Flights from Guayaquil (GYE) to Santiago (STI)

View $247 flight on Sat, Jan 24, 2026Opens in a new window

Popular airlines from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)

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Cheap Flights from Guayaquil to Santiago (GYE-STI)

Prices were available within the past 7 days and start at $247 for one-way flights and $416 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Jan 19 - Sat, Jan 24
GYE
Guayaquil
STI
Santiago de los Caballeros
$416 Roundtrip, found 1 day ago
$416
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 19 from Guayaquil to Santiago de los Caballeros, returning Sat, Jan 24, priced at $416 found 1 day ago
Copa
Mon, Jan 19 - Sat, Jan 24
GYE
Guayaquil
STI
Santiago de los Caballeros
$428 Roundtrip, found 1 day ago
$428
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 19 from Guayaquil to Santiago de los Caballeros, returning Sat, Jan 24, priced at $428 found 1 day ago
Copa
Sat, Jan 31 - Thu, Feb 5
GYE
Guayaquil
STI
Santiago de los Caballeros
$440 Roundtrip, found 1 day ago
$440
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Jan 31 from Guayaquil to Santiago de los Caballeros, returning Thu, Feb 5, priced at $440 found 1 day ago
Copa
Mon, Jan 19 - Sat, Jan 24
GYE
Guayaquil
STI
Santiago de los Caballeros
$461 Roundtrip, found 1 day ago
$461
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 19 from Guayaquil to Santiago de los Caballeros, returning Sat, Jan 24, priced at $461 found 1 day ago
Copa
Mon, Jan 19 - Sat, Jan 24
GYE
Guayaquil
STI
Santiago de los Caballeros
$473 Roundtrip, found 1 day ago
$473
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 19 from Guayaquil to Santiago de los Caballeros, returning Sat, Jan 24, priced at $473 found 1 day ago
Copa
Mon, Mar 23 - Mon, Apr 6
GYE
Guayaquil
STI
Santiago de los Caballeros
$497 Roundtrip, found 11 hours ago
$497
Roundtrip
found 11 hours ago
Select Copa flight, departing Mon, Mar 23 from Guayaquil to Santiago de los Caballeros, returning Mon, Apr 6, priced at $497 found 11 hours ago
Copa
Mon, Jan 19 - Sat, Jan 24
GYE
Guayaquil
STI
Santiago de los Caballeros
$500 Roundtrip, found 1 day ago
$500
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 19 from Guayaquil to Santiago de los Caballeros, returning Sat, Jan 24, priced at $500 found 1 day ago
Copa
Mon, Mar 23 - Mon, Apr 6
GYE
Guayaquil
STI
Santiago de los Caballeros
$509 Roundtrip, found 11 hours ago
$509
Roundtrip
found 11 hours ago
Select Copa flight, departing Mon, Mar 23 from Guayaquil to Santiago de los Caballeros, returning Mon, Apr 6, priced at $509 found 11 hours ago
JetBlue Airways
Mon, Oct 13 - Sat, Oct 25
GYE
Guayaquil
STI
Santiago de los Caballeros
$673 Roundtrip, found 1 day ago
$673
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Mon, Oct 13 from Guayaquil to Santiago de los Caballeros, returning Sat, Oct 25, priced at $673 found 1 day ago
American Airlines
Wed, Nov 26 - Tue, Dec 16
GYE
Guayaquil
STI
Santiago de los Caballeros
$1,153 Roundtrip, found 1 day ago
$1,153
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 26 from Guayaquil to Santiago de los Caballeros, returning Tue, Dec 16, priced at $1,153 found 1 day ago

Find the cheapest month to fly from Guayaquil (GYE) to Santiago de los Caballeros (STI)

November is typically the cheapest month to fly

From $450 - $1,231 per traveler.

Graph displaying average flight prices per month

Flights from Guayaquil (GYE) to Santiago (STI)
Origin airport
Jose Joaquin de Olmedo Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Copa, JetBlue Airways
Roundtrip price
$415
Distance
1616 mi

Guayaquil to Santiago Flights

The cheapest times to fly from Guayaquil to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Guayaquil to Santiago are during the month of January. You can find some of the cheapest flights from Guayaquil to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Guayaquil to Santiago

Sunday is one of the best days to book for cheap flights from Guayaquil to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Guayaquil to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Guayaquil to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $247 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Guayaquil to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Guayaquil to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) cost?
Lock in a cheap one-way flight from $247 or cheap return flight from $416 from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
January is the most affordable month to fly from GYE to STI. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
To find the cheapest airline flying from GYE to STI, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
Direct flights from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from GYE to STI?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
To land at Cibao Intl. Airport (STI) on time, book a flight that takes off from Jose Joaquin de Olmedo Intl. Airport (GYE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI) last-minute?
Holding off until just before your trip to book a ticket from GYE to STI often results in higher prices. Although you may find some last-minute deals, they're not always guaranteed. Allow some flexibility in your schedule to maximize your chances of getting a bargain.
Is it cheaper to book a GYE to STI flight and hotel package?
Compared with arranging flights and hotels separately, booking a GYE to STI flight and hotel package with Expedia could result in significant savings. What's more, having everything in one place will take the stress out of travel planning. Just pick your flights and choose from our wide range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Jose Joaquin de Olmedo Intl. Airport (GYE) to Cibao Intl. Airport (STI)?
If you reserved your GYE to STI flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for further details.

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*Available to One Key members.