$326 Cheap Flights from Indianapolis (IND) to Florence (FLO)

View $326 flight on Fri, Mar 27, 2026Opens in a new window

Popular airlines from Indianapolis Intl. Airport (IND) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Indianapolis to Florence (IND-FLO)

Prices were available within the past 7 days and start at $326 for one-way flights and $461 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$461 Roundtrip, found 9 hours ago
$461
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $461 found 9 hours ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$466 Roundtrip, found 9 hours ago
$466
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $466 found 9 hours ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$472 Roundtrip, found 9 hours ago
$472
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $472 found 9 hours ago
American Airlines
Sat, May 23 - Sun, May 24
IND
Indianapolis
FLO
Florence
$488 Roundtrip, found 6 days ago
$488
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 23 from Indianapolis to Florence, returning Sun, May 24, priced at $488 found 6 days ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$491 Roundtrip, found 9 hours ago
$491
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $491 found 9 hours ago
American Airlines
Sat, May 23 - Sun, May 24
IND
Indianapolis
FLO
Florence
$493 Roundtrip, found 6 days ago
$493
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 23 from Indianapolis to Florence, returning Sun, May 24, priced at $493 found 6 days ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$496 Roundtrip, found 9 hours ago
$496
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $496 found 9 hours ago
American Airlines
Sat, May 23 - Sun, May 24
IND
Indianapolis
FLO
Florence
$499 Roundtrip, found 6 days ago
$499
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, May 23 from Indianapolis to Florence, returning Sun, May 24, priced at $499 found 6 days ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$502 Roundtrip, found 9 hours ago
$502
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $502 found 9 hours ago
American Airlines
Sat, Jul 11 - Sat, Jul 18
IND
Indianapolis
FLO
Florence
$520 Roundtrip, found 1 day ago
$520
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 11 from Indianapolis to Florence, returning Sat, Jul 18, priced at $520 found 1 day ago

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Frequently asked questions

How much does a flight from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO) cost?
Secure a cheap one-way flight from $326 or cheap return flight from $461 from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO)?
The cheapest month to fly from IND to FLO is July, when there's less demand. Off-peak months are generally when better flight deals are available between these airports.
What is the cheapest airline that flies from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest IND to FLO flight.
How many flights per day from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO)?
You'll have to book a flight with a layover if you're traveling from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from IND to FLO?
Generally you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO)?
To avoid possible delays on the Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO) last-minute?
Booking your flight from IND to FLO just before your getaway is generally more expensive. But if you're flexible with your departure dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book an IND to FLO flight and hotel package?
Opting for an IND to FLO flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our extensive range of accommodations and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Indianapolis Intl. Airport (IND) to Florence Regional Airport (FLO)?
Usually, it's possible to reschedule or cancel your IND to FLO flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Indianapolis Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$460
Distance
526 mi

Book with confidence

Indianapolis to Florence Flights

The cheapest times to fly from Indianapolis to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Indianapolis to Florence are during the month of July. You can find some of the cheapest flights from Indianapolis to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Indianapolis to Florence

Sunday is one of the best days to book for cheap flights from Indianapolis to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Indianapolis to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Indianapolis to Florence in 2026. You can also book with separate airlines for your outbound and return journeys, from $326 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Indianapolis to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Indianapolis to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Indianapolis to Florence Flights

*Flight schedules are subject to change.

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