$706 Cheap Flights from Medellín (MDE) to Johannesburg (JNB)

View $706 flight on Sat, Nov 15, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)

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Cheap Flights from Medellín to Johannesburg (MDE-JNB)

Prices were available within the past 7 days and start at $706 for one-way flights and $1,353 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

KLM
Sat, Nov 22 - Mon, Dec 1
MDE
Medellin
JNB
Johannesburg
$1,353 Roundtrip, found 4 hours ago
$1,353
Roundtrip
found 4 hours ago
Select KLM flight, departing Sat, Nov 22 from Medellin to Johannesburg, returning Mon, Dec 1, priced at $1,353 found 4 hours ago
avianca
Tue, Nov 4 - Wed, Nov 12
MDE
Medellin
JNB
Johannesburg
$1,485 Roundtrip, found 9 hours ago
$1,485
Roundtrip
found 9 hours ago
Select avianca flight, departing Tue, Nov 4 from Medellin to Johannesburg, returning Wed, Nov 12, priced at $1,485 found 9 hours ago
LATAM Airlines Group
Thu, Nov 27 - Thu, Dec 4
MDE
Medellin
JNB
Johannesburg
$1,496 Roundtrip, found 4 hours ago
$1,496
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Thu, Nov 27 from Medellin to Johannesburg, returning Thu, Dec 4, priced at $1,496 found 4 hours ago
KLM
Fri, Nov 7 - Wed, Nov 12
MDE
Medellin
JNB
Johannesburg
$1,529 Roundtrip, found 9 hours ago
$1,529
Roundtrip
found 9 hours ago
Select KLM flight, departing Fri, Nov 7 from Medellin to Johannesburg, returning Wed, Nov 12, priced at $1,529 found 9 hours ago
KLM
Sat, Nov 22 - Wed, Dec 3
MDE
Medellin
JNB
Johannesburg
$1,530 Roundtrip, found 4 hours ago
$1,530
Roundtrip
found 4 hours ago
Select KLM flight, departing Sat, Nov 22 from Medellin to Johannesburg, returning Wed, Dec 3, priced at $1,530 found 4 hours ago
LATAM Airlines Group
Sat, Dec 6 - Thu, Dec 25
MDE
Medellin
JNB
Johannesburg
$1,555 Roundtrip, found 18 hours ago
$1,555
Roundtrip
found 18 hours ago
Select LATAM Airlines Group flight, departing Sat, Dec 6 from Medellin to Johannesburg, returning Thu, Dec 25, priced at $1,555 found 18 hours ago
LATAM Airlines Group
Mon, Nov 24 - Thu, Jan 1
MDE
Medellin
JNB
Johannesburg
$1,562 Roundtrip, found 4 days ago
$1,562
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Nov 24 from Medellin to Johannesburg, returning Thu, Jan 1, priced at $1,562 found 4 days ago
LATAM Airlines Group
Tue, Nov 25 - Tue, Dec 9
MDE
Medellin
JNB
Johannesburg
$1,594 Roundtrip, found 18 hours ago
$1,594
Roundtrip
found 18 hours ago
Select LATAM Airlines Group flight, departing Tue, Nov 25 from Medellin to Johannesburg, returning Tue, Dec 9, priced at $1,594 found 18 hours ago
Turkish Airlines
Sat, Nov 22 - Mon, Nov 24
MDE
Medellin
JNB
Johannesburg
$1,621 Roundtrip, found 4 hours ago
$1,621
Roundtrip
found 4 hours ago
Select Turkish Airlines flight, departing Sat, Nov 22 from Medellin to Johannesburg, returning Mon, Nov 24, priced at $1,621 found 4 hours ago
United
Fri, Nov 21 - Tue, Nov 25
MDE
Medellin
JNB
Johannesburg
$1,766 Roundtrip, found 4 hours ago
$1,766
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Nov 21 from Medellin to Johannesburg, returning Tue, Nov 25, priced at $1,766 found 4 hours ago

Alternative airports near Johannesburg

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O.R. Tambo Intl. JNB. Cheapest option available. Average driving time to city center is 17 minutes. Flights from $1,485
JNB
O.R. Tambo Intl.
Cheapest
Average driving time to city center17 min
Flights from $1,485

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB) cost?
Secure a cheap one-way flight from $706 or cheap return flight from $1,353 from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)?
November is the cheapest month to fly from MDE to JNB. Planning your trip for the off-season is often the key to landing a great deal.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll take you from MDE to JNB. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)?
Direct flights from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDE to JNB?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)?
Choose a flight from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB) that takes off before 3 PM to reduce the risk of cancellations and delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB) last-minute?
Last-minute bookings from MDE to JNB are typically more expensive. To lock in the lowest prices, start looking for flights well ahead of time. That being said, if you're flexible with your travel plans, you may land a cheap fare just before your departure.
Is it cheaper to book a MDE to JNB flight and hotel package?
Compared with arranging flights and hotels separately, booking a MDE to JNB flight and hotel package with Expedia could result in significant savings. What's more, having everything in one convenient place takes the hassle out of planning your trip. Simply secure your flights and select from our wide range of hotels, then personalize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to O.R. Tambo Intl. Airport (JNB)?
In most instances, you can reschedule or cancel your MDE to JNB flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you'd like further details, go to our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
O.R. Tambo Intl.
Airlines serving
Delta, Emirates, KLM, LATAM Airlines Group, Lufthansa, Turkish Airlines, United
Roundtrip price
$1,352
Distance
7251 mi

Book with confidence

Medellín to Johannesburg Flights

The cheapest times to fly from Medellín to Johannesburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Johannesburg are during the month of November. You can find some of the cheapest flights from Medellín to Johannesburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Johannesburg

Sunday is one of the best days to book for cheap flights from Medellín to Johannesburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Johannesburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Johannesburg in 2025. You can also book with separate airlines for your outbound and return journeys, from $706 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Johannesburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Johannesburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Johannesburg Flights

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*Available to One Key members.