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$109 Cheap Flights from St. Louis (STL) to Panama City (ECP)

View $109 flight on Tue, Oct 20, 2026Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)

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Cheap Flights from St. Louis to Panama City (STL-ECP)

Prices were available within the past 7 days and start at $109 for one-way flights and $217 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$217 Roundtrip, just found
$217
Roundtrip
just found
Select Southwest Airlines flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $217 just found
Southwest Airlines
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$227 Roundtrip, just found
$227
Roundtrip
just found
Select Southwest Airlines flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $227 just found
Southwest Airlines
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$232 Roundtrip, just found
$232
Roundtrip
just found
Select Southwest Airlines flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $232 just found
American Airlines
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$237 Roundtrip, just found
$237
Roundtrip
just found
Select American Airlines flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $237 just found
Delta
Sat, Nov 7 - Mon, Nov 9
STL
St. Louis
ECP
Panama City
$237 Roundtrip, just found
$237
Roundtrip
just found
Select Delta flight, departing Sat, Nov 7 from St. Louis to Panama City, returning Mon, Nov 9, priced at $237 just found
United
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$237 Roundtrip, just found
$237
Roundtrip
just found
Select United flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $237 just found
Delta
Tue, Oct 13 - Tue, Oct 20
STL
St. Louis
ECP
Panama City
$239 Roundtrip, found 4 hours ago
$239
Roundtrip
found 4 hours ago
Select Delta flight, departing Tue, Oct 13 from St. Louis to Panama City, returning Tue, Oct 20, priced at $239 found 4 hours ago
United
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$242 Roundtrip, just found
$242
Roundtrip
just found
Select United flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $242 just found
United
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$250 Roundtrip, just found
$250
Roundtrip
just found
Select United flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $250 just found
United
Tue, Oct 20 - Sat, Oct 24
STL
St. Louis
ECP
Panama City
$255 Roundtrip, just found
$255
Roundtrip
just found
Select United flight, departing Tue, Oct 20 from St. Louis to Panama City, returning Sat, Oct 24, priced at $255 just found

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Northwest Florida Beaches Intl. ECP. Cheapest and Closest option available. Average driving time to city center is 35 minutes. Flights from $495
ECP
Northwest Florida Beaches Intl.
CheapestClosest
Average driving time to city center35 min
Flights from $495

What you need to know for your flight from Lambert-St. Louis Intl. to Northwest Florida Beaches Intl.

St. Louis (STL) to Panama City (ECP) at a glance

Travel between St. Louis (STL) and Panama City (ECP) with a range of airlines on this domestic short-haul route. Discover cheap flights from STL to Panama City as you explore the city's renowned attractions and neighborhoods. Whether you prefer full-service options or low-cost carriers, you can compare itineraries to find one that aligns with your budget and schedule. Check out the essential information for flights departing from Lambert-St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP).

  • Fastest flight duration: around 1h 45m non-stop
  • Route distance: roughly 600 miles (970 km)
  • Flights per week: around 10 departures on average
  • Typical fares (one-way): economy tickets often range from $80–$405, depending on seasonality and how far ahead you book

Flights from Lambert-St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)

Based on the latest traveler bookings, here are the top airlines favored for flights from St. Louis to Panama City, featuring both non-stop and one-stop options. Common layover points include Hartsfield-Jackson Atlanta International Airport (ATL) with a layover of about 1 hour and 30 minutes, Charlotte-Douglas International Airport (CLT) at around 1 hour, and Dallas-Fort Worth International Airport (DFW) also at approximately 1 hour. This variety allows you to compare prices, total travel times, and cabin classes to find the ideal itinerary.

  • Southwest Airlines: This budget-friendly airline provides both non-stop and one-stop options, with one-way fares generally falling between $80 and $405. It operates about 43% of flights on this route, with a typical non-stop flight duration of 1 hour and 45 minutes.
  • Delta: A comprehensive airline that offers one-stop flights, Delta's one-way ticket prices usually range from $90 to $350. It represents approximately 28% of flights on this route, featuring an in-flight duration of 3 hours and 15 minutes, with a total travel time of around 4 hours and 45 minutes, including layover.
  • American Airlines: Another full-service option, American Airlines provides one-stop flights with one-way fares typically between $90 and $330. It makes up roughly 23% of the departures on this route and has an in-flight time of 3 hours and 15 minutes, leading to a total journey of about 4 hours and 45 minutes, factoring in layovers.
  • United: This full-service airline also offers one-stop options, with one-way fares ranging from $100 to $460. United accounts for about 5% of departures on this route, featuring an in-flight duration of 3 hours and 15 minutes, resulting in a total travel time of approximately 4 hours and 45 minutes when including layovers.

Best time to fly from St. Louis (STL) to Panama City (ECP)

The most popular months for travelers flying from St. Louis to Panama City are March, April, and July, when peak temperatures in Panama City reach up to 82.6°F in July. If you prefer quieter travel, consider November, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 62.4°F. For better deals, October usually offers the lowest average one-way fare around $150. Flight availability peaks in August, with approximately 13 flights per week, making it easier to find convenient departure times. October has the fewest flights, with approximately 7 flights per week.

  • Cheapest time to fly: October usually offers good deals with average one-way fare around $150, roughly 29% cheaper than the yearly average.
  • Most flight options: August has the highest number of flights from St. Louis to Panama City, with approximately 13 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January54.1°F (12.3°C)Low8$206
February57.9°F (14.4°C)Average9$207
March62.8°F (17.1°C)High11$245
April68.4°F (20.2°C)High11$254
May75.0°F (23.9°C)Average10$234
June81.1°F (27.3°C)Average10$210
July82.6°F (28.1°C)High11$217
August82.8°F (28.2°C)Average13$203
September79.5°F (26.4°C)Average10$173
October72.0°F (22.2°C)Average7$150
November62.4°F (16.9°C)Low8$205
December58.1°F (14.5°C)Low8$250

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from St. Louis (STL) to Panama City (ECP)

  • St. Louis to Fort Walton Beach (STL-VPS): Northwest Florida Regional Airport (VPS) lies approximately 46 miles from Northwest Florida Beaches International Airport (ECP). One-way economy prices for this journey generally fall between $85 and $345, influenced by the season and advance booking. Travelers can choose from both non-stop and one-stop flights, with common layover points at Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). Major airlines operating this route include Southwest Airlines (a low-cost carrier) and Delta. First-class service is also offered on this route.

How to find the best prices for flights from St. Louis (STL) to Panama City (ECP)

Getting some of the best deals on flights from St. Louis to Panama City is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Morning departures, from 5 a.m. to 12 p.m., not only offer lower prices but are also the most popular, while flying on Tuesday generally results in cheaper tickets, despite Saturday being the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Northwest Florida Beaches International Airport from Lambert-St. Louis International Airport

Panama City welcomes travelers from St. Louis with a range of transport options based on price, convenience, and proximity. Here's how to reach Panama City efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Panama City, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Northwest Florida Beaches International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Northwest Florida Beaches International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) cost?
You can find cheap one-way flights from $109 and cheap return flights from $217 St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) with Expedia. One-way flights typically cost between $144 and $590, and return flights often range between $333 and $1132. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
September is the cheapest month to fly from St. Louis, MO (STL) to Panama City, FL (ECP), with average return fares around $315. This price is about 20% lower than the average, as fall travel often sees reduced demand. Other budget-friendly months include January and October.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Enter STL to ECP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
To find a cheap flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The best airline to fly with from St. Louis, MO (STL) to Panama City, FL (ECP) will differ from traveler to traveler. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. WN offers the most daily flights from STL to ECP, which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The best time to fly from St. Louis (STL) to Panama City (ECP) is in September and October. September offers return flights at around $315, making it a great choice for budget-conscious travelers. October also provides pleasant weather and reasonable prices, perfect for a fall escape.*Prices based on flights available on Expedia in the last year.
How many flights per day from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
On average, there are around 1 nonstop flights per day from Lambert-St. Louis Intl. (STL) to Northwest Florida Beaches Intl. (ECP). For more options, look at flights that include layovers.
What is the earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The earliest flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is available in November and December, making it a great choice for holiday travelers. An early departure allows you to enjoy a full day at the beach. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
The most popular departure times for flights from St. Louis (STL) to Panama City (ECP) are in the morning, from 6am to 9am. About 45% of passengers prefer this time window. Many major carriers, including American Airlines, Delta Airlines, and United Airlines, offer flights during this window. This timing works well because it allows you to enjoy a full day at your destination.
How long does it take to fly from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
Direct flights from STL to ECP usually take about 1 hour 50 minutes, traveling roughly 635 miles. If you opt for a connecting flight, expect to add around 3 hours 30 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
First class is available on flights from STL to ECP. First class cabins are available on:

  • American Airlines
  • United Airlines
  • Delta Air Lines

How do I earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight with Expedia?
It's easy to earn miles on a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Lambert-St. Louis Intl. (STL)?
From Lambert-St. Louis Intl. (STL), you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP) in Panama City. Some flights may connect through major hubs like O'Hare Intl. (ORD), Charlotte-Douglas Intl. (CLT), Pearson Intl. (YYZ) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) at the last minute?
Typically, booking a last minute flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package?
Securing a St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.)?
If you booked your St. Louis, MO (STL-Lambert-St. Louis Intl.) to Panama City, FL (ECP-Northwest Florida Beaches Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$217
Distance
634 mi
Average flight time
1 hour 47 mins

Book with confidence

St. Louis to Panama City Flights

The cheapest times to fly from St. Louis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Panama City are during the month of October. You can find some of the cheapest flights from St. Louis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Panama City

Sunday is one of the best days to book for cheap flights from St. Louis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $109 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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