$104 Cheap Flights from St. Louis (STL) to Panama City (ECP)

View $104 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)

Cheap Flights from St. Louis to Panama City (STL-ECP)

Prices were available within the past 7 days and start at $104 for one-way flights and $177 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Dec 12 - Mon, Dec 15
STL
St. Louis
ECP
Panama City
$177 Roundtrip, found 6 days ago
$177
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Dec 12 from St. Louis to Panama City, returning Mon, Dec 15, priced at $177 found 6 days ago
Delta
Fri, Dec 12 - Sun, Dec 21
STL
St. Louis
ECP
Panama City
$187 Roundtrip, found 4 days ago
$187
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Dec 12 from St. Louis to Panama City, returning Sun, Dec 21, priced at $187 found 4 days ago
Southwest Airlines
Wed, Dec 3 - Mon, Dec 8
STL
St. Louis
ECP
Panama City
$207 Roundtrip, found 5 hours ago
$207
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Wed, Dec 3 from St. Louis to Panama City, returning Mon, Dec 8, priced at $207 found 5 hours ago
American Airlines
Wed, Dec 3 - Mon, Dec 8
STL
St. Louis
ECP
Panama City
$207 Roundtrip, found 5 hours ago
$207
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Wed, Dec 3 from St. Louis to Panama City, returning Mon, Dec 8, priced at $207 found 5 hours ago
Southwest Airlines
Wed, Dec 3 - Mon, Dec 8
STL
St. Louis
ECP
Panama City
$207 Roundtrip, found 5 hours ago
$207
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Wed, Dec 3 from St. Louis to Panama City, returning Mon, Dec 8, priced at $207 found 5 hours ago
American Airlines
Sat, Dec 13 - Wed, Dec 17
STL
St. Louis
ECP
Panama City
$209 Roundtrip, found 4 days ago
$209
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Dec 13 from St. Louis to Panama City, returning Wed, Dec 17, priced at $209 found 4 days ago
Southwest Airlines
Sat, Dec 13 - Wed, Dec 17
STL
St. Louis
ECP
Panama City
$212 Roundtrip, found 4 days ago
$212
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Sat, Dec 13 from St. Louis to Panama City, returning Wed, Dec 17, priced at $212 found 4 days ago
Southwest Airlines
Sat, Dec 13 - Wed, Dec 17
STL
St. Louis
ECP
Panama City
$215 Roundtrip, found 4 days ago
$215
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Sat, Dec 13 from St. Louis to Panama City, returning Wed, Dec 17, priced at $215 found 4 days ago
Delta
Tue, Nov 18 - Wed, Nov 19
STL
St. Louis
ECP
Panama City
$227 Roundtrip, found 1 day ago
$227
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 18 from St. Louis to Panama City, returning Wed, Nov 19, priced at $227 found 1 day ago
United
Thu, Dec 4 - Sun, Dec 7
STL
St. Louis
ECP
Panama City
$252 Roundtrip, found 3 days ago
$252
Roundtrip
found 3 days ago
Select United flight, departing Thu, Dec 4 from St. Louis to Panama City, returning Sun, Dec 7, priced at $252 found 3 days ago

Find the cheapest month to fly from St. Louis (STL) to Panama City (ECP)

September is typically the cheapest month to fly

From $152 - $415 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Northwest Florida Beaches Intl. ECP. Cheapest and Closest option available. Average driving time to city center is 35 minutes. Flights from $488
ECP
Northwest Florida Beaches Intl.
CheapestClosest
Average driving time to city center35 min
Flights from $488

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) cost?
Lock in a cheap one-way flight from $104 or cheap return flight from $177 from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
The cheapest month to fly from STL to ECP is December, when demand is low. Off-peak season is typically when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest STL to ECP flight.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
Nonstop flights from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from STL to ECP?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
To touch down at Northwest Florida Beaches Intl. Airport (ECP) on time, select a flight that leaves Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP) last-minute?
Booking your ticket from STL to ECP just before your trip is generally more expensive. But if there's some wiggle room with your departure dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a STL to ECP flight and hotel package?
Compared with arranging flights and hotels separately, booking a STL to ECP flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one convenient place will take the hassle out of travel planning. Simply pick your flights and select from our extensive range of stays, then customize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Northwest Florida Beaches Intl. Airport (ECP)?
Typically, you can cancel or reschedule your STL to ECP flight. However, additional fees may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you need further information, go to our Customer Service portal.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Northwest Florida Beaches Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$176
Distance
634 mi
Average flight time
1 hour 45 mins

Book with confidence

St. Louis to Panama City Flights

The cheapest times to fly from St. Louis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Panama City are during the month of December. You can find some of the cheapest flights from St. Louis to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Panama City

Sunday is one of the best days to book for cheap flights from St. Louis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $104 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Panama City Flights

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*Available to One Key members.