$327 Cheap Flights from Quito (UIO) to La Serena (LSC)

View $327 flight on Thu, Aug 21, 2025Opens in a new window

Popular airlines from Mariscal Sucre Intl. Airport (UIO) to La Serena (LSC-La Florida)

Cheap Flights from Quito to La Serena (UIO-LSC)

Prices were available within the past 7 days and start at $327 for one-way flights and $634 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Thu, Aug 21 - Sun, Aug 31
UIO
Quito
LSC
La Serena
$634 Roundtrip, found 4 days ago
$634
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Aug 21 from Quito to La Serena, returning Sun, Aug 31, priced at $634 found 4 days ago
LATAM Airlines Group
Thu, Aug 21 - Sun, Aug 31
UIO
Quito
LSC
La Serena
$644 Roundtrip, found 4 days ago
$644
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Aug 21 from Quito to La Serena, returning Sun, Aug 31, priced at $644 found 4 days ago
LATAM Airlines Group
Fri, Aug 22 - Sun, Aug 31
UIO
Quito
LSC
La Serena
$650 Roundtrip, found 5 days ago
$650
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Fri, Aug 22 from Quito to La Serena, returning Sun, Aug 31, priced at $650 found 5 days ago
LATAM Airlines Group
Tue, Aug 19 - Tue, Sep 2
UIO
Quito
LSC
La Serena
$677 Roundtrip, found 5 days ago
$677
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Aug 19 from Quito to La Serena, returning Tue, Sep 2, priced at $677 found 5 days ago
LATAM Airlines Group
Mon, Aug 18 - Tue, Sep 2
UIO
Quito
LSC
La Serena
$687 Roundtrip, found 5 days ago
$687
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Mon, Aug 18 from Quito to La Serena, returning Tue, Sep 2, priced at $687 found 5 days ago
LATAM Airlines Group
Thu, Aug 21 - Sat, Aug 30
UIO
Quito
LSC
La Serena
$692 Roundtrip, found 4 days ago
$692
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Aug 21 from Quito to La Serena, returning Sat, Aug 30, priced at $692 found 4 days ago
LATAM Airlines Group
Sun, Aug 24 - Tue, Sep 2
UIO
Quito
LSC
La Serena
$694 Roundtrip, found 5 days ago
$694
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Sun, Aug 24 from Quito to La Serena, returning Tue, Sep 2, priced at $694 found 5 days ago
LATAM Airlines Group
Tue, Aug 19 - Sat, Aug 30
UIO
Quito
LSC
La Serena
$696 Roundtrip, found 5 days ago
$696
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Aug 19 from Quito to La Serena, returning Sat, Aug 30, priced at $696 found 5 days ago
LATAM Airlines Group
Thu, Aug 21 - Sun, Aug 31
UIO
Quito
LSC
La Serena
$697 Roundtrip, found 3 days ago
$697
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Aug 21 from Quito to La Serena, returning Sun, Aug 31, priced at $697 found 3 days ago
LATAM Airlines Group
Thu, Aug 21 - Sat, Aug 30
UIO
Quito
LSC
La Serena
$702 Roundtrip, found 4 days ago
$702
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Thu, Aug 21 from Quito to La Serena, returning Sat, Aug 30, priced at $702 found 4 days ago
Flights from Quito (UIO) to La Serena (LSC)
Origin airport
Mariscal Sucre Intl.
Destination airport
La Florida
Roundtrip price
$633
Distance
2111 mi

Quito to La Serena Flights

The cheapest times to fly from Quito to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Quito to La Serena are during the month of August. You can find some of the cheapest flights from Quito to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Quito to La Serena

Sunday is one of the best days to book for cheap flights from Quito to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Quito to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Quito to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $327 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Quito to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Quito to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC) cost?
Get a cheap one-way flight from $327 or cheap return flight from $634 from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC)?
Planning your getaway for August can help you save, as it's the cheapest month for flights between UIO and LSC. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from UIO to LSC. Then, sort your results by "Price (lowest to highest)" to score a great deal.
How many flights per day from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC)?
There aren't any daily nonstop flights available from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from UIO to LSC?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC)?
To reach La Florida Airport (LSC) on time, select a flight that leaves Mariscal Sucre Intl. Airport (UIO) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC) last-minute?
Booking your plane ticket from UIO to LSC just before your trip is generally more expensive. But if you're flexible with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book an UIO to LSC flight and hotel package?
Compared with arranging hotels and flights separately, booking an UIO to LSC flight and hotel package with Expedia could result in significant savings. What's more, managing everything in one place takes the hassle out of travel planning. Just secure your flights and select from our extensive range of stays, then personalize your trip with other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Mariscal Sucre Intl. Airport (UIO) to La Florida Airport (LSC)?
If you reserved your UIO to LSC flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you'd like more information.

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*Available to One Key members.