Route one: Tule tree, sixteenth century Dominican church, weavers village and Mezcal distillery. Route two: Villages of wood carvers, black pottery and back strapped looms. Route three: Monte Albán, hand made paper factory, School of Art and Green glazed and terracotta pottery village. Passenger insurance, in an SUV Chevrolet Suburban or Audi sedan with A/C , cold purified water, ice, etc. In case that you want to stop to eat something, I know the best spots. Give you explanations interacting with locals, history, etc. When tourists ask me to stop by the houses of the artisans, I steer away from the most touristy places and stop with true artists and Masters; buying something or not, you can be sure that you will be looking at high-quality craftsmanship or as people say; "the real thing". You can "play it by ear" and stop or skip some places. Normally takes six hours each route at your own pace.