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Find all hotels by Ayres Collection in La Mesa, CA from $160

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Compare rooms and suites by Ayres Collection in La Mesa with rates, reviews, and availability. Most hotels are fully refundable.

"I stay at this hotel to see my cousin who stays here on business trips. It’s a nice, modern hotel. The area has grown and there are a lot of great shops and chain restaurants nearby. The staff is friendly. It’s not too far from Seaport Village, Gaslamp and other San Diego attractions. It has a decent breakfast and bar but there is no restaurant."

$205 total

includes taxes & fees

May 7 - May 8

"very nice clean place"

$173 total

includes taxes & fees

May 12 - May 13

Ayres Collection La Mesa Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Ayres Collection hotels in La Mesa, California. Known for well-appointed rooms and friendly, personalized service, each of the top Ayres Collection La Mesa hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some La Mesa Ayres Collection locations may even offer extra little benefits and discounts for frequent travelers.