Title: The Best 5 Star Hotels in Florida Keys from $448 | Expedia.com

[Florida Keys Travel Guide](https://expedia.com/Florida-Keys.dx6023765)[Hotels in Florida Keys](https://expedia.com/Florida-Keys-Hotels.d6023765.Travel-Guide-Hotels)[Vacation Rentals in Florida Keys](https://expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)[Flights to Florida Keys](https://expedia.com/Cheap-Flights-To-Florida-Keys.d6023765.Travel-Guide-Flights)[Things to do in Florida Keys](https://expedia.com/Things-To-Do-In-Florida-Keys.d6023765.Travel-Guide-Activities)[Car Rentals in Florida Keys](https://expedia.com/Car-Rentals-In-Florida-Keys.d6023765.Car-Rental-Guide)[Florida Keys Vacation Packages](https://expedia.com/Florida-Keys.d6023765.Destination-Travel-Guides)

![Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Florida Keys 5 Star Hotels

Tonight

[Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=6023765&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=6023765&startDate=2026-03-11&endDate=2026-03-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6023765&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6023765&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Florida Keys 5-star hotels

![Balcony](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/4608d7e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/981feca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside bar](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/387633fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/4cbd70d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cheeca Lodge & Spa

[](https://www.expedia.com/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information)

Matecumbe

9.2/10

Wonderful

(1,307 reviews)

"Great staff and beautiful property "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie

$460 nightly

$518 total

Mar 12 - Mar 13

Total with taxes and fees

[](https://www.expedia.com/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information)

![On the beach, sun loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f6566b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/02a3a50c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/5a054f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/9f64224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Isla Bella Beach Resort & Spa

[](https://www.expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information)

Marathon

9.2/10

Wonderful

(1,105 reviews)

"great resort "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Niki

$630 nightly

$709 total

Mar 12 - Mar 13

Total with taxes and fees

[](https://www.expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.

![Hawks Cay Resort](https://images.trvl-media.com/lodging/1000000/10000/6100/6068/8671ba74_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL

$503 nightly

$565 total

Mar 22 - Mar 23

Total with taxes and fees

8/10 Very Good! (1,015 reviews)

[](https://expedia.com/Marathon-Hotels-Hawks-Cay-Resort.h6068.Hotel-Information)

![Reefhouse Resort & Marina](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/e9f2dff3_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL

$439 nightly

$489 total

Mar 15 - Mar 16

Total with taxes and fees

9.4/10 Exceptional! (1,405 reviews)

[](https://expedia.com/Key-Largo-Hotels-Reefhouse-Resort-Marina.h3427.Hotel-Information)

![Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort](https://images.trvl-media.com/lodging/1000000/20000/11900/11864/4671ebc2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

84001 Overseas Hwy Islamorada FL

$398 nightly

$448 total

Mar 23 - Mar 24

Total with taxes and fees

9/10 Wonderful! (166 reviews)

[](https://expedia.com/Islamorada-Hotels-Three-Waters-Resort-And-Marina.h11864.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Florida Keys.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F11%2F2026&endDate=3%2F12%2F2026&regionId=6023765&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

[See all hotels in Florida Keys](https://www.expedia.com/Hotel-Search?startDate=2026-03-24&endDate=2026-03-25&adults=2&regionId=6023765)

![Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people](https://images.trvl-media.com/place/6246822/f00ad239-b8ad-4f0c-b162-acc6426db1e2.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Florida Keys Hotel Reviews

![Isla Bella Beach Resort & Spa](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/f6566b0f_y.jpg)

### Isla Bella Beach Resort & Spa

8/10 Good

"All rooms have an ocean view-beautiful for sure!"

[](https://expedia.com/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information)

![Cheeca Lodge & Spa](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/4608d7e2_y.jpg)

### Cheeca Lodge & Spa

10/10 Excellent

"Terrific staff, room, amenities. 100% heavenly "

[](https://expedia.com/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information)

## Find out more about Florida Keys

Ready for an incredible adventure? Add an extra layer of luxury on your next trip to Florida Keys by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Florida Keys so popular in the last year. There's no reason to delay a getaway to Florida Keys any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Florida Keys and get ready to be pampered like never before. Don't wait any longer!

### Get a Great Deal on 5-Star Hotels in Florida Keys

You'll have a fantastic time at one of these 5-star hotels. Exceptional service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. What creature comforts do you want in your lodging? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A reflexology treatment that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. 

Ready for experiences outside your hotel room? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Florida Keys are waiting for you to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs. 

### Your Getaway Starts Today

Numerous visitors make Florida Keys the place to vacation. Why not join their ranks? If you've been dreaming about a vacation set here, then go ahead and book it. A surge in interest means these great hotel rooms will go quickly. Your great getaway is just a mouse-click away. Choose one of Expedia's Florida Keys 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Florida Keys?

> - Search for the lowest price per night from $448

### What makes a hotel 5 stars in Florida Keys?

### Are there any 5-star all-inclusive resorts in Florida Keys?