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Our top choices for Lewis and Clark Interpretive Center hotels

A lobby with a sofa, two armchairs, a coffee table, and a staircase.
A rooftop lounge with large windows, red seating, and a view of the cityscape.
A park with a pathway, trees, and a modern sculpture.
A modern hotel room with a large window, a flat-screen TV mounted on the wall, a round dining table with chairs, and a patterned rug.

1. Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
13 mi from Lewis and Clark Interpretive Center
United States
David
$143 nightly
$169 total
Oct 30 - Oct 31
Total with taxes and fees
Hyatt Regency St. Louis at The Arch
The Clayton Plaza Hotel sign with a stone wall and plants in front.
A living room with a brown leather sofa, a small table, and a chair. There is a window with curtains, a lamp, and a framed picture on the wall.
A hotel room with two beds, a desk, a chair, and a television.
A large conference room with rows of tables and chairs, a podium, and a buffet table with plates and napkins.

2. Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
16.5 mi from Lewis and Clark Interpretive Center
United States
Sivakumar
$94 nightly
$110 total
Oct 25 - Oct 26
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay
A rooftop terrace with wicker furniture, offering a city view.
A lobby with seating areas, a chandelier, and a large pillar.
A hotel room with a large window offering a view of the Gateway Arch and a modern building.
A modern hotel lobby with a bar area, seating arrangements, and a large chandelier.

3. Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
13.1 mi from Lewis and Clark Interpretive Center
United States
Salvatore
$135 nightly
$158 total
Oct 8 - Oct 9
Total with taxes and fees
Drury Plaza Hotel St. Louis at the Arch
A hotel room with a large bathtub, a small table with two chairs, a minibar, and a large mirror.
A lobby with red walls, a clock, seating area, and a reception desk.
A hotel lobby with a desk, computer, and seating area.
A coffee station with Folgers coffee, a coffee machine, and a refrigerator.

4. Econo Lodge Inn & Suites Granite City - St. Louis

Econo Lodge Inn & Suites Granite City - St. Louis
2.9 mi from Lewis and Clark Interpretive Center
United States
Latasha
$66 nightly
$75 total
Oct 25 - Oct 26
Total with taxes and fees
Econo Lodge Inn & Suites Granite City - St. Louis
A motel with two electric vehicle charging stations and a sign indicating it's a budget motel.
A compact room with a wooden desk, a black chair, a round wooden table, a black sofa, a flat-screen TV mounted on the wall, and a microwave on a black cabinet.
A bathroom with a yellow wall, a white sink, a mirror, and a toilet.
A hotel room with two beds, a desk, a chair, a television, and a telephone.

5. Budget Motel Granite City/St Louis Area

Budget Motel Granite City/St Louis Area
2.9 mi from Lewis and Clark Interpretive Center
United States
Pi-Ming
$70 nightly
$76 total
Oct 4 - Oct 5
Total with taxes and fees
Budget Motel Granite City/St Louis Area
A bar area with a central bar, multiple stools, and a chandelier.
A grand lobby with a large chandelier, a bar area, and classical architecture.
A spacious lobby with a high ceiling, ornate chandeliers, and a seating area with sofas and armchairs.
A grand lobby with a bar area, ornate chandeliers, and a staircase.

6. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
12.9 mi from Lewis and Clark Interpretive Center
United States
Carol
$111 nightly
$132 total
Oct 11 - Oct 12
Total with taxes and fees
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
A multi-story hotel with balconies, a parking lot with marked spaces, and a clear sky.
A red door with a prohibition sign against tobacco, e-cigarettes, and cannabis.
A reception desk with a 'NO Pets Allowed' sign, a 'Please ring door bell' sign, and a window with a view of a parking lot.
A long, straight corridor with a series of doors on one side and a black railing on the other.

7. Bel Air Motel

Bel Air Motel
3.9 mi from Lewis and Clark Interpretive Center
United States
Tai
$80 nightly
$89 total
Oct 4 - Oct 5
Total with taxes and fees
Bel Air Motel
A rooftop terrace with outdoor seating, string lights, and a city skyline view.
A modern hotel room with a large window, a bathtub, and a unique eye-themed pillow.
A multi-story hotel with a classic architectural style, featuring a prominent entrance and a series of uniformly lit windows.
A woman sitting on a green sofa in a modern lobby with a staircase and a large framed artwork on the wall.

8. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
13.2 mi from Lewis and Clark Interpretive Center
United States
Skylee
$122 nightly
$144 total
Oct 4 - Oct 5
Total with taxes and fees
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
A modern lounge with a central fire feature, comfortable seating, and large windows offering a city view.
A bar area with wooden bar stools, a high counter, and a seating area with cushioned sofas and tables.
A rooftop bar with a glass railing, yellow bar stools, and a large umbrella.
A rooftop terrace with a glass table, cushioned seating, and a view of the cityscape.

9. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
13.1 mi from Lewis and Clark Interpretive Center
United States
Xuehui
$147 nightly
$175 total
Oct 15 - Oct 16
Total with taxes and fees
Hilton St. Louis at the Ballpark
A modern outdoor lounge area with seating, a bar, and a view of a cityscape.
The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.
A modern bar area with a central fire feature, bar stools, and seating.
A restaurant with tables set for dining, a kitchen in the background, and hanging light fixtures.

10. Live by Loews - St.Louis

Live by Loews - St.Louis
13.2 mi from Lewis and Clark Interpretive Center
United States
Molly
$159 nightly
$189 total
Oct 4 - Oct 5
Total with taxes and fees
Live by Loews - St.Louis
A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.
An indoor swimming pool area with lounge chairs, a small table, and potted plants.
A bar area with a long counter, multiple stools, and a television mounted on the wall.
A spacious lobby with striped chairs, a central coffee table, and large potted plants.

11. Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
12.8 mi from Lewis and Clark Interpretive Center
United States
Karen
$114 nightly
$136 total
Oct 18 - Oct 19
Total with taxes and fees
Embassy Suites by Hilton St. Louis Downtown
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.

12. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
13 mi from Lewis and Clark Interpretive Center
United States
Zane
$148 nightly
$173 total
Oct 25 - Oct 26
Total with taxes and fees
21C Museum Hotel St Louis
A modern living room with a stone fireplace, a reception desk, and a large window.
A modern lobby with a blue sofa, a white coffee table, and a reception desk in the background.
A modern living room with a stone fireplace, green and beige sofas, a round coffee table, and large windows offering a view of trees.
An indoor swimming pool with clear blue water, surrounded by lounge chairs and tables, large windows with a view of trees, and a tiled floor.

13. Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
3.9 mi from Lewis and Clark Interpretive Center
United States
Sabra
$112 nightly
$124 total
Oct 12 - Oct 13
Total with taxes and fees
Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.
A hotel lobby with a bar area, seating, and a large window.
A compact minibar with a refrigerator, coffee maker, and beverage dispensers.
A hotel with a prominent arch structure in the background, a sign for Hampton Inn, and a TGI Friday's restaurant.

14. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
12.7 mi from Lewis and Clark Interpretive Center
United States
Andy
$106 nightly
$124 total
Oct 26 - Oct 27
Total with taxes and fees
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.
A modern living room with a grey sofa, a round wooden coffee table, and a large window with a city view.
A modern restaurant interior with high tables, chairs, and a central bar area.
A lobby with wooden paneling, a green wall, and two armchairs.

15. The Westin St. Louis

The Westin St. Louis
13.3 mi from Lewis and Clark Interpretive Center
United States
Stacy
$131 nightly
$153 total
Oct 18 - Oct 19
Total with taxes and fees
The Westin St. Louis
A modern interior with hanging chairs and ottomans, large windows with a view of the street.
A hallway with four elevators, each with a marble frame and a gold door.
A pool table in a modern lounge area with a colorful geometric wall art and a gray sofa with patterned ottomans.
A modern kitchen with a hexagonal tile backsplash, built-in appliances, and a central island.

16. Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown
12.9 mi from Lewis and Clark Interpretive Center
United States
Erik
$98 nightly
$114 total
Oct 11 - Oct 12
Total with taxes and fees
Home2 Suites by Hilton St. Louis Downtown
A cozy lounge area with leather seating, a wooden coffee table, and a fireplace.
A hotel lobby with a beverage fridge, a television, and a seating area with a sofa and armchairs.
A hotel room with a bed, a sofa, a desk, and a chair.
An indoor swimming pool with lounge chairs and tables, large windows, and a ceiling with exposed beams.

17. Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach
4.2 mi from Lewis and Clark Interpretive Center
United States
Timothy
$103 nightly
$115 total
Oct 11 - Oct 12
Total with taxes and fees
Best Western Plus Pontoon Beach
A spacious lobby with high arched ceilings, ornate columns, and a central fountain.
A multi-level hotel lobby with a grand staircase, a reception desk, and a seating area.
A spacious lobby with a high arched ceiling, multiple seating areas, and a central decorative column.
A restaurant with tables and chairs, large windows, and a view of the street.

18. St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
13.2 mi from Lewis and Clark Interpretive Center
United States
Mirjana
$163 nightly
$194 total
Oct 30 - Oct 31
Total with taxes and fees
St. Louis Union Station Hotel, Curio Collection by Hilton
A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.
A hotel lobby with a checkered floor, bar area, and seating with lamps.
A modern hotel lobby with a large sofa, a television, and a bar area.
A lobby with a checkered floor, red and grey seating, and a staircase.

19. Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center
12.8 mi from Lewis and Clark Interpretive Center
United States
Kristy
$97 nightly
$115 total
Oct 31 - Nov 1
Total with taxes and fees
Courtyard by Marriott St. Louis Downtown/Convention Center
A multi-story hotel with a prominent 'Marriott' sign, featuring a classic architectural style with a red brick facade and large windows.
Lobby
A spacious lobby with a high ceiling, a bar area, multiple seating arrangements, and a large screen displaying a sports event.
A grand hall with rows of chairs arranged for an event, a central floral arrangement, and a large chandelier.

20. Marriott St. Louis Grand

Marriott St. Louis Grand
12.8 mi from Lewis and Clark Interpretive Center
United States
Andrew
$152 nightly
$181 total
Oct 10 - Oct 11
Total with taxes and fees
Marriott St. Louis Grand
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Compare popular hotels close to Lewis and Clark Interpretive Center

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
An indoor swimming pool with a lifeguard chair, a lifebuoy, and a mural of a beach scene.
Super 8 by Wyndham Troy IL/St. Louis Area
8.2
Very good
1,001 reviews
View
A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.
Drury Inn & Suites St. Louis Collinsville
9.6
Exceptional
1,000 reviews
View
A hotel lobby with blue seating, a flat-screen TV, and a fireplace.
Comfort Inn Edwardsville - St. Louis
8.4
Very good
956 reviews
View
A hotel room with a bed, a desk with a television, a chair, a desk lamp, and a wall-mounted rack with keys.
Red Roof Inn St Louis - Troy, IL
7.8
Good
1,003 reviews
View
A modern living room with a stone fireplace, a reception desk, and a large window.
Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City
9.2
Wonderful
532 reviews
View

Top Lewis and Clark Interpretive Center Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"Very friendly and helpful staff. Good breakfast and clean room."
Donnie 1-night trip
Posted 4 hours ago
Pear Tree Inn St. Louis Near Union Station
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Very friendly staff."
Steve 1-night trip
Posted 9 hours ago
Pear Tree Inn St. Louis Airport
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

10/10 Excellent
"The hotel was very nice and friendly. I liked everyone in front desk during the morning afternoon evening. They were great. It was good but the ballet sucked. He was very rude and that was at 5 PM on Wednesday, September 30, 2026"
Denise 1-night trip
Posted 11 hours ago
Tru By Hilton St. Louis Downtown
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"It was a great hotel located in a very neat part of town. It was clean and fit our needs perfectly."
Miranda 1-night trip
Posted 12 hours ago
Drury Plaza Hotel St. Louis Union Station
Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown

10/10 Excellent
"everything"
Arlyn Morales 4-night trip
Posted 16 hours ago
Embassy Suites by Hilton St. Louis Downtown
Casino Queen Hotel

Casino Queen Hotel

8/10 Good
"Plenty of parking. Staff were friendly. Rooms are spacious. Easy access to the Metro."
Patti 2-night trip
Posted 1 day ago
Casino Queen Hotel
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent
"Paula at the front desk was amazing! Felt save in the private parking garage. Everything needed a key to get in, to keep random outsiders from entering."
Missy 1-night trip
Posted 2 days ago
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

8/10 Good
"TV on in room when we arrived. There was no remote to turn tv off. Called down to"
Dr. EvaRee 2-night trip
Posted 2 days ago
Courtyard by Marriott St. Louis Downtown/Convention Center
21C Museum Hotel St Louis

21C Museum Hotel St Louis

10/10 Excellent
"Room clean. Staff friendly."
Jane 2-night trip
Posted 2 days ago
21C Museum Hotel St Louis

Other attractions near Lewis and Clark Interpretive Center

Lewis and Clark Confluence Tower

Bring a camera when you climb this tower, which offers fantastic views across the Mississippi River and provides insight into a fascinating piece of history.
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Lewis and Clark State Memorial Park

Explore the great outdoors at Lewis and Clark State Memorial Park, a lovely green space in Hartford. Discover the area's museums and monuments.
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Hartford Park

After visiting Hartford Park, make a plan to see the other sights and activities in Hartford. Discover the area's museums and monuments.
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Hartford City Hall

Hartford City Hall is just one of the places to see in Hartford, so why not enjoy the other things to explore during your travels? Amble around the area's riverfront or experience its museums.
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Jones-Confluence Point State Park

You can take time to visit Jones-Confluence Point State Park during your travels to West Alton. You can attend a sporting event while in the area.
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Dads Club Park

Explore the great outdoors at Dads Club Park, a lovely green space in South Roxana.
See properties

South Roxana Dad's Club Park

South Roxana Dad's Club Park is just one of the places to see in South Roxana, so why not enjoy the other things to explore during your travels?
See properties

Frequently asked questions

What are the top-rated hotels near Lewis and Clark Interpretive Center?
Discover the top-rated hotels near Lewis and Clark Interpretive Center, perfect for a comfortable and enjoyable stay in Hartford, Illinois.Bel Air MotelBel Air Motel boasts a solid review rating of 8.8 and is a cozy 3.5-star hotel located just 4.4 miles from Lewis and Clark Interpretive Center. Guests will appreciate the convenience of early check-in and late check-out options. The motel features essential amenities such as free toiletries and air conditioning, ensuring a comfortable stay. Additionally, travelers can enjoy the benefit of free self-parking during their visit.Red Lion Inn & Suites Pontoon BeachRated 8.0 by travelers, Red Lion Inn & Suites Pontoon Beach is situated 4.8 miles from Lewis and Clark Interpretive Center. This hotel offers a range of amenities including complimentary breakfast served daily and free self-parking. Guests can unwind in the private hot tub and enjoy the comfort of air conditioning in their rooms. The hotel is also equipped with mini-refrigerators, ensuring that travelers have everything they need for a pleasant stay.Econo Lodge & Suites Granite CityEcono Lodge & Suites Granite City has a review rating of 6.2 and is conveniently located just 3.6 miles from Lewis and Clark Interpretive Center. This hotel offers a continental breakfast to start the day right, along with free self-parking. Guests can enjoy the spacious suites featuring separate living rooms and premium bedding for added comfort. The hotel also provides daily housekeeping and free toiletries, making it a practical choice for travelers.
How much is a hotel near Lewis and Clark Interpretive Center?
Staying near Lewis and Clark Interpretive Center is a treat, with plenty of hotels from $69 offering incredible amenities. If you're leaning toward a little luxury, prices can rise, especially in peak season. Be sure to book in advance to enjoy more options and potentially better rates, especially if you're planning a vacation during weekends or around public holidays.
What are the most popular family-friendly hotels near Lewis and Clark Interpretive Center?
For families looking to explore the Lewis and Clark Interpretive Center, there are several top-rated family-friendly hotels just a short drive away, ensuring a comfortable and convenient stay for all ages.Red Lion Inn & Suites Pontoon BeachRed Lion Inn & Suites Pontoon Beach is a welcoming family-friendly hotel located just 4.8 miles from the Lewis and Clark Interpretive Center, featuring a solid travelers' rating of 8.0. Families will appreciate the convenience of complimentary cribs and a mini-refrigerator in every room. Guests can also enjoy free continental breakfast and relax in the hot tub. Additional amenities include free parking, air conditioning, and early check-in to make your family trip even smoother.Econo Lodge & Suites Granite CityEcono Lodge & Suites Granite City offers a budget-friendly stay just 3.6 miles from the Lewis and Clark Interpretive Center, with a review rating of 6.2. This family-friendly hotel provides daily housekeeping and free accommodations for children, ensuring a straightforward experience. Guests can benefit from amenities such as a microwave in each room, free continental breakfast, and spacious suites with premium bedding, making it an ideal choice for families.
What are the best affordable hotels near Lewis and Clark Interpretive Center?
For an affordable stay close to the Lewis and Clark Interpretive Center, these top-rated hotels offer great amenities without breaking the bank.Red Lion Inn & Suites Pontoon BeachRed Lion Inn & Suites Pontoon Beach is a cozy 3-star hotel located just 4.8 miles from the Lewis and Clark Interpretive Center, a solid travelers' rating of 8.0. This family-friendly hotel offers free daily breakfast, complimentary Wi-Fi, and self-parking, ensuring a comfortable stay for all travelers. Enjoy the convenience of air-conditioned rooms equipped with mini-refrigerators and the option for early check-in, making it an ideal choice for families on a budget.Econo Lodge & Suites Granite CityEcono Lodge & Suites Granite City is a budget-friendly hotel situated only 3.6 miles from the Lewis and Clark Interpretive Center, with a review rating of 6.2. This hotel features essential amenities like free continental breakfast, Wi-Fi, and self-parking, making it a practical choice for travelers. Guests can enjoy spacious suites with separate living areas and daily housekeeping, ensuring a pleasant stay for families and groups alike.
What are the best pet-friendly hotels near Lewis and Clark Interpretive Center?
For travelers looking for the best pet-friendly hotels near the Lewis and Clark Interpretive Center, these accommodations provide a welcoming atmosphere for you and your furry friends.Red Lion Inn & Suites Pontoon BeachRed Lion Inn & Suites Pontoon Beach is a welcoming 3-star hotel located just 4.8 miles from the Lewis and Clark Interpretive Center. With a review rating of 8.0, this hotel is perfect for travelers traveling with pets, as it offers amenities such as pet-friendly rooms and services. Guests can enjoy free continental breakfast, early check-in, and access to a hot tub. Additional features include air conditioning, mini-refrigerators, and free self-parking.Econo Lodge & Suites Granite CityEcono Lodge & Suites Granite City is situated only 3.6 miles from the Lewis and Clark Interpretive Center, making it a convenient choice for travelers. Rated 6.2 by travelers, this hotel provides a comfortable stay with pet-friendly policies. Guests will appreciate the complimentary continental breakfast, daily housekeeping, and the convenience of in-room microwaves. The hotel also features suites with separate living rooms, allowing for extra space during your stay.
Can I book a fully refundable hotel close to Lewis and Clark Interpretive Center?
Most bookings on Expedia are refundable if canceled within 24-48 hours of arrival, though this depends on the hotel's individual cancellation policy, which you should check in your booking confirmation. If free cancellation is available, you can cancel directly through your Expedia account by going to "My Trips" and selecting your reservation. To find fully refundable hotel options, simply enter "Lewis and Clark Interpretive Center", set your travel dates, and use the "Fully refundable" filter under "Deals & Discounts" on the results page. Alternatively, explore deals with free cancellation options on Expedia.

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