Find hotels in Lyon, MS from $79

The best area to stay in Lyon, Mississippi, is near the intersection of Highway 61 and Highway 161, which provides convenient access to local amenities and the surrounding region.This area is the primary hub for visitors passing through Lyon. It offers easy access to the main roads, making it a practical choice for those exploring the Mississippi Delta. You'll find a few local eateries and essential services concentrated around these major thoroughfares.For solo travelers or couples on a road trip, this location is ideal.

The best time to visit Lyon, Mississippi, is during the spring (March to May) and fall (September to November) months, when the weather is most pleasant for exploring.Spring offers mild temperatures, typically ranging from the 60s to high 70s Fahrenheit, making it comfortable for outdoor activities and enjoying the natural beauty of the Mississippi Delta. This season is ideal for travelers who appreciate comfortable weather for sightseeing and general exploration without the intense heat of summer.Similarly, the fall season brings cooler temperatures, generally from the 60s to low 80s Fahrenheit, and lower humidity. This period is superb for those looking to experience the local culture and history in comfort.

With Expedia, you earn OneKeyCash™* on eligible Lyon hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.