Top 10 Hotels in Lyon, MS (from $86) 2026 - Competitive Prices

Go beyond your typical stay in Lyon

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Our top choices for Lyon hotels

Desk, laptop workspace, blackout drapes, bed sheets

1. Isle Casino Hotel Lula Hotel & Casino - A Caesars Rewards Destination

Lula

Ernest

$85 nightly

$93 total

Aug 18 - Aug 19

Total with taxes and fees

2. Hampton Inn Clarksdale

Clarksdale

James

$132 nightly

$144 total

Aug 30 - Aug 31

Total with taxes and fees

Iron/ironing board, WiFi (surcharge), alarm clocks, bed sheets

3. Quality Inn Clarksdale

Clarksdale

William

$85 nightly

$92 total

Sep 7 - Sep 8

Total with taxes and fees

4. Travelers Hotel

Clarksdale

Amanda

$154 nightly

$168 total

Aug 27 - Aug 28

Total with taxes and fees

Room, 2 Double Beds, Smoking | Desk, soundproofing, iron/ironing board (on request), WiFi (free)

Room, 1 King Bed, Smoking | Desk, soundproofing, iron/ironing board (on request), WiFi (free)

5. Americas Best Value Inn & Suites Clarksdale

Clarksdale

Iesha

$78 nightly

$86 total

Sep 8 - Sep 9

Total with taxes and fees

Premium bedding, in-room safe, desk, iron/ironing board

6. Delta Inn West Helena US 49 AR

West Helena

Yvonne

$58 nightly

$66 total

Aug 19 - Aug 20

Total with taxes and fees

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Where to stay near Lyon

Lyon offers a delightful blend of outdoor adventures and scenic beauty. Explore family-friendly neighborhoods and enjoy romantic strolls amidst nature. Whether hiking, picnicking, or simply soaking in the atmosphere, you'll find plenty of opportunities for unforgettable experiences in and around this charming city.

A colorful car parked in front of a mural on a city street.

A blue guitar with road signs 61 and 49 mounted on top.

A red electric guitar leaning against a speaker in a room with a piano in the background.

A blue guitar leaning against a signpost with route numbers 61 and 49.

A cotton field under a blue sky with scattered clouds.

Clarksdale

Discover Clarksdale, a vibrant destination perfectly suited for cultural enthusiasts and music lovers seeking an authentic Southern experience. Explore the rich heritage at the Delta Blues Museum, enjoy live performances at the iconic Ground Zero Blues Club, and immerse yourself in the local scene around Coahoma Community College. Just about a 2-mile drive from Lyon, Clarksdale offers easy access for visitors. With its unique blend of music, culture, and outdoor activities, Clarksdale is a smart choice for your next getaway.

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Jonestown

Plan your stay in Jonestown, a top-rated choice for families and budget travelers looking for a mix of outdoor adventures and cultural experiences. This charming village offers easy access to attractions like Coahoma Community College and the Rock N' Roll & Blues Heritage Museum, perfect for those wanting to explore the local arts scene. With a drive of about 14 miles from Lyon, Jonestown is a smart choice for your next vacation getaway.

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Coahoma

Make your vacation planning effortless by staying in Coahoma, a haven for family and budget travelers thanks to its diverse attractions. Enjoy the vibrant local culture at the Rock N' Roll & Blues Heritage Museum, relax in the scenic Freedom Park, and explore Coahoma Community College. With its welcoming atmosphere and recreational options, Coahoma is a smart choice for travelers seeking both entertainment and relaxation. Plus, it's only about a 10-mile drive from Lyon, making it easy to reach.

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Alligator

Ideally situated for budget-conscious families and nature enthusiasts, Alligator offers a charming escape just about 16 miles by car from Lyon. Here, visitors can immerse themselves in outdoor adventures, explore the scenic beauty of nearby state parks, and enjoy local landmarks like the Delta Blues Museum and Ground Zero Blues Club. With a blend of education and recreation, Alligator provides a welcoming atmosphere for travelers looking to experience the best of Mississippi's culture and scenery. It's a smart choice for your vacation stay.

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Lambert

Travelers visiting the area often choose Lambert, especially families and outdoor enthusiasts seeking a charming village atmosphere. With attractions like the Hobson Plantation bar, the Coahoma Community College, and the Rock N' Roll & Blues Heritage Museum, Lambert offers a blend of cultural and recreational experiences. Located about 24 miles by car from Lyon, it provides easy access to a peaceful getaway while still being close to urban conveniences. Lambert is a smart choice for those looking to unwind and explore Mississippi's unique offerings.

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Stay near popular attractions around Lyon

Nestled in the heart of Mississippi, Lyon offers a perfect blend of outdoor adventures and cultural experiences. Discover local museums and galleries, and admire beautiful monuments. Whether you seek scenic hikes or family-friendly attractions, Lyon promises an unforgettable getaway for every traveler.

Delta Blues Museum

9.0/10 (83 reviews)

Set the stage for your exploration of American music at the Delta Blues Museum, a vibrant tribute to the rich heritage of blues music. Located about 2 miles by car from Lyon, this museum offers an immersive experience into the culture and history of the Delta blues. Staying nearby makes it easy to soak in the musical legacy of the region.

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Rock N' Roll & Blues Heritage Museum

8.8/10 (19 reviews)

Often cited as a favorite among music lovers, the Rock N' Roll & Blues Heritage Museum in Clarksdale celebrates the rich cultural history of American music. Located about 2 miles by car from Lyon, this museum offers a unique glimpse into the roots of rock and blues, making it a convenient stop for an enriching day out.

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Hambone Art Gallery

9.0/10 (22 reviews)

Ideal for travelers interested in local art and culture, Hambone Art Gallery showcases unique works that reflect the vibrant spirit of the area. Located about 2 miles by car from Lyon, this gallery offers a convenient stop to immerse yourself in the local art scene.

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Carnegie Public Library

10.0/10 (4 reviews)

No trip is complete without a visit to Carnegie Public Library, a charming spot for families and culture seekers. This inviting library offers a welcoming atmosphere and a wealth of resources. It’s about a 2-mile drive from Lyon, making it a convenient stop to enrich your visit.

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The Crossroads

An essential stop for cultural explorers, The Crossroads in Clarksdale, Mississippi, embodies the rich musical heritage of the region. This iconic monument, located about 2 miles by car from Lyon, offers a unique glimpse into the birthplace of blues. Staying nearby allows for easy access to this historic site and the vibrant local scene.

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Top Lyon Hotel Reviews

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

10/10 Excellent

"The home was immaculate, accommodating and accessible. Everything we ever need was available including snacks and beverages."

Auberge Clarksdale Blues Hostel

10/10 Excellent

"My first time in a hostel and was sort of dreading it, but it was lovely. Shared bathroom was more like a locker room. Great location to walk everywhere."

Travelers Hotel

8/10 Good

"Loved this place. The room Did have a smell but it wasn’t horrible. It was clean and nice"

Sunset Log Cabin

10/10 Excellent

"Clean and comfortable accommodation. Great location. reasonable price. I'll be back!"

Hampton Inn Clarksdale

8/10 Good

"Everything was fine."

Quality Inn Clarksdale

8/10 Good

"All good. Staff is a big plus."

Only a mile from historic downtown Clarksdale!

10/10 Excellent

"Great spot. Excellent host"

Americas Best Value Inn & Suites Clarksdale

8/10 Good

"Receptionist at least knew were places were. Rare"

Cottage on riverbank one mile from Clarksdale in gated community

10/10 Excellent

"The property was very clean, comfortable and check in was so easy, the hospitality was amazing, we really enjoyed ourselves and will be visiting again!!!"

More cheap stays in Lyon

Americas Best Value Inn & Suites Clarksdale

350 South State Street Clarksdale MS

$78 nightly

$86 total

Sep 8 - Sep 9

Total with taxes and fees

6/10 (427 reviews)