Find hotels in Lyon, MS from $68

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Our top choices for Lyon hotels

Travelers Hotel

Travelers Hotel
2.5 star property
Clarksdale
9.8 out of 10, Exceptional, (277)
"Though a bit different, there was a great artsy feel to the hotel. "
United States
T
$146 nightly
The price is $160
Jan 24 - Jan 25, 2026
Total with taxes and fees
Travelers Hotel

Hampton Inn Clarksdale

Hampton Inn Clarksdale
2.5 star property
Clarksdale
8.2 out of 10, Very Good, (334)
"We would stay there again."
United States
Andrew Ray
$136 nightly
The price is $148
Jan 18 - Jan 19, 2026
Total with taxes and fees
Hampton Inn Clarksdale

Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale
2.5 star property
Clarksdale
6.0 out of 10, (405)
"Good location in town"
United States
Samuel
$63 nightly
The price is $68
Jan 10 - Jan 11, 2026
Total with taxes and fees
Americas Best Value Inn & Suites Clarksdale

Quality Inn Clarksdale

Quality Inn Clarksdale
2.5 star property
Clarksdale
7.4 out of 10, Good, (708)
"Room was great! Staff is always nice and sociable."
United States
LaVonda
$80 nightly
The price is $87
Jan 5 - Jan 6, 2026
Total with taxes and fees
Quality Inn Clarksdale

Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel
2.0 star property
Clarksdale
9.6 out of 10, Exceptional, (90)
"Expedia sucks. No email with instructions until after I called directly to the hosts. The hostel was accommodating and friendly. I appreciated our stay. "
United States
Reva
$91 nightly
The price is $97
Jan 1 - Jan 2, 2026
Total with taxes and fees
Auberge Clarksdale Blues Hostel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lyon Hotel Reviews

More cheap stays in Lyon

Hotels in Lyon with star-rating

Frequently asked questions

What is the best area to stay in Lyon?
The best area to stay in Lyon, Mississippi, is near the intersection of Highway 61 and Highway 161, which provides convenient access to local amenities and the surrounding region.

This area is the primary hub for visitors passing through Lyon. It offers easy access to the main roads, making it a practical choice for those exploring the Mississippi Delta. You'll find a few local eateries and essential services concentrated around these major thoroughfares.

For solo travelers or couples on a road trip, this location is ideal.
When is the best time to go to Lyon?
The best time to visit Lyon, Mississippi, is during the spring (March to May) and fall (September to November) months, when the weather is most pleasant for exploring.

Spring offers mild temperatures, typically ranging from the 60s to high 70s Fahrenheit, making it comfortable for outdoor activities and enjoying the natural beauty of the Mississippi Delta. This season is ideal for travelers who appreciate comfortable weather for sightseeing and general exploration without the intense heat of summer.

Similarly, the fall season brings cooler temperatures, generally from the 60s to low 80s Fahrenheit, and lower humidity. This period is superb for those looking to experience the local culture and history in comfort.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Lyon.
How can I save on a Lyon hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Lyon hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Lyon hotel?
Prices for hotels in Lyon often vary, but you can find a great deal from $68 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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