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    Check prices for these dates, December 15 – 16, 2026

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    Our top choices for Lyon hotels

    1. Isle Casino Hotel Lula Hotel & Casino - A Caesars Rewards Destination

    A modern lobby with a staircase, a reception desk, and two abstract paintings on the wall.

    2. Hampton Inn Clarksdale

    A hotel dining area with a large wooden table, multiple chairs, a television, and wall-mounted lights.

    3. Quality Inn Clarksdale

    A lobby with a chandelier, seating area, and a reception desk.

    4. Travelers Hotel

    A two-story brick building with large windows and a green door, featuring outdoor seating and a signboard.

    5. Americas Best Value Inn & Suites Clarksdale

    A spacious living area with a sofa, armchairs, and a coffee table. Large windows with curtains provide a view of the outdoors.

    6. Delta Inn West Helena US 49 AR

    A lobby with a reception desk, a trash can, a clock on the wall, and a door leading outside.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Where to stay near Lyon

    Lyon offers a delightful blend of outdoor adventures and scenic beauty. Explore family-friendly neighborhoods and enjoy romantic strolls amidst nature. Whether hiking, picnicking, or simply soaking in the atmosphere, you'll find plenty of opportunities for unforgettable experiences in and around this charming city.

    A blue guitar with road signs 61 and 49 mounted on top.

    A colorful car parked in front of a mural on a city street.

    Photo by Alice Andersen

    A red electric guitar leaning against a speaker in a room with a piano in the background.

    A blue guitar leaning against a signpost with route numbers 61 and 49.

    A cotton field under a blue sky with scattered clouds.

    View properties in map for Clarksdale

    Clarksdale

    Discover Clarksdale, a vibrant destination perfectly suited for cultural enthusiasts and music lovers seeking an authentic Southern experience. Explore the rich heritage at the Delta Blues Museum, enjoy live performances at the iconic Ground Zero Blues Club, and immerse yourself in the local scene around Coahoma Community College. Just about a 2-mile drive from Lyon, Clarksdale offers easy access for visitors. With its unique blend of music, culture, and outdoor activities, Clarksdale is a smart choice for your next getaway.

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    Jonestown

    Plan your stay in Jonestown, a top-rated choice for families and budget travelers looking for a mix of outdoor adventures and cultural experiences. This charming village offers easy access to attractions like Coahoma Community College and the Rock N' Roll & Blues Heritage Museum, perfect for those wanting to explore the local arts scene. With a drive of about 14 miles from Lyon, Jonestown is a smart choice for your next vacation getaway.

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    Coahoma

    Make your vacation planning effortless by staying in Coahoma, a haven for family and budget travelers thanks to its diverse attractions. Enjoy the vibrant local culture at the Rock N' Roll & Blues Heritage Museum, relax in the scenic Freedom Park, and explore Coahoma Community College. With its welcoming atmosphere and recreational options, Coahoma is a smart choice for travelers seeking both entertainment and relaxation. Plus, it's only about a 10-mile drive from Lyon, making it easy to reach.

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    Alligator

    Ideally situated for budget-conscious families and nature enthusiasts, Alligator offers a charming escape just about 16 miles by car from Lyon. Here, visitors can immerse themselves in outdoor adventures, explore the scenic beauty of nearby state parks, and enjoy local landmarks like the Delta Blues Museum and Ground Zero Blues Club. With a blend of education and recreation, Alligator provides a welcoming atmosphere for travelers looking to experience the best of Mississippi's culture and scenery. It's a smart choice for your vacation stay.

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    Lambert

    Travelers visiting the area often choose Lambert, especially families and outdoor enthusiasts seeking a charming village atmosphere. With attractions like the Hobson Plantation bar, the Coahoma Community College, and the Rock N' Roll & Blues Heritage Museum, Lambert offers a blend of cultural and recreational experiences. Located about 24 miles by car from Lyon, it provides easy access to a peaceful getaway while still being close to urban conveniences. Lambert is a smart choice for those looking to unwind and explore Mississippi's unique offerings.

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    Stay near popular Lyon attractions

    Nestled in the heart of Mississippi, Lyon offers a perfect blend of outdoor adventures and cultural experiences. Discover local museums and galleries, and admire beautiful monuments. Whether you seek scenic hikes or family-friendly attractions, Lyon promises an unforgettable getaway for every traveler.

    Delta Blues Museum

    Rating: 9.0/10 (83 reviews)

    Set the stage for your exploration of American music at the Delta Blues Museum, a vibrant tribute to the rich heritage of blues music. Located about 2 miles by car from Lyon, this museum offers an immersive experience into the culture and history of the Delta blues. Staying nearby makes it easy to soak in the musical legacy of the region.

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    Rock N' Roll & Blues Heritage Museum

    Rating: 8.8/10 (19 reviews)

    Often cited as a favorite among music lovers, the Rock N' Roll & Blues Heritage Museum in Clarksdale celebrates the rich cultural history of American music. Located about 2 miles by car from Lyon, this museum offers a unique glimpse into the roots of rock and blues, making it a convenient stop for an enriching day out.

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    Hambone Art Gallery

    Rating: 9.0/10 (22 reviews)

    Ideal for travelers interested in local art and culture, Hambone Art Gallery showcases unique works that reflect the vibrant spirit of the area. Located about 2 miles by car from Lyon, this gallery offers a convenient stop to immerse yourself in the local art scene.

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    Carnegie Public Library

    Rating: 10.0/10 (4 reviews)

    No trip is complete without a visit to Carnegie Public Library, a charming spot for families and culture seekers. This inviting library offers a welcoming atmosphere and a wealth of resources. It’s about a 2-mile drive from Lyon, making it a convenient stop to enrich your visit.

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    The Crossroads

    An essential stop for cultural explorers, The Crossroads in Clarksdale, Mississippi, embodies the rich musical heritage of the region. This iconic monument, located about 2 miles by car from Lyon, offers a unique glimpse into the birthplace of blues. Staying nearby allows for easy access to this historic site and the vibrant local scene.

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    Top Lyon Hotel Reviews

    Travelers Hotel

    A two-story brick building with large windows and a green door, featuring outdoor seating and a signboard.

    Auberge Clarksdale Blues Hostel

    A bar area with wooden bar stools and shelves with bottles and glasses.

    Hampton Inn Clarksdale

    A hotel dining area with a large wooden table, multiple chairs, a television, and wall-mounted lights.

    Quality Inn Clarksdale

    A lobby with a chandelier, seating area, and a reception desk.

    Frequently Asked Questions

    What is the best area to stay in Lyon?

    The best area to stay in Lyon, Mississippi, is near the intersection of Highway 61 and Highway 161, which provides convenient access to local amenities and the surrounding region.

    This area is the primary hub for visitors passing through Lyon. It offers easy access to the main roads, making it a practical choice for those exploring the Mississippi Delta. You'll find a few local eateries and essential services concentrated around these major thoroughfares.

    For solo travelers or couples on a road trip, this location is ideal.

    When is the best time to go to Lyon?

    The best time to visit Lyon, Mississippi, is during the spring (March to May) and fall (September to November) months, when the weather is most pleasant for exploring.

    Spring offers mild temperatures, typically ranging from the 60s to high 70s Fahrenheit, making it comfortable for outdoor activities and enjoying the natural beauty of the Mississippi Delta. This season is ideal for travelers who appreciate comfortable weather for sightseeing and general exploration without the intense heat of summer.

    Similarly, the fall season brings cooler temperatures, generally from the 60s to low 80s Fahrenheit, and lower humidity. This period is superb for those looking to experience the local culture and history in comfort.

    Can I cancel my hotel reservation on Expedia?

    You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Lyon.

    How much is the nightly rate at a Lyon hotel?

    Prices for hotels in Lyon often vary, but you can find a great deal from $84 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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