Find hotels in Southern Illinois, IL from $54

Most hotels are fully refundable. Because flexibility matters.

Save an average of 15% on thousands of hotels with Expedia Rewards.

Search over 2.9 million properties and 550 airlines worldwide.

Check Southern Illinois hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Compare 753 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Casino Queen Hotel
3 out of 5
200 South Front Street, East St. Louis, IL, 62201
Fully refundableReserve now, pay when you stay
The price is $99 per night from Mar 29 to Mar 30
$99
per night
Mar 29 - Mar 30
74.44 mi from city center
7.6/10 Good! (1,007 reviews)
"The room was big and clean. Great view of the Arch with the river view room. The pool was a little too cold, but overall good. Close and easy drive to town, plus the casino"

Reviewed on Mar 27, 2023

Casino Queen Hotel
Quality Inn O'Fallon I-64
2.5 out of 5
1409 W US 50, O'Fallon, IL, 62269
Fully refundableReserve now, pay when you stay
The price is $68 per night from Apr 9 to Apr 10
$68
per night
Apr 9 - Apr 10
62.16 mi from city center
7.8/10 Good! (659 reviews)
"Hotel was quiet, clean, and conveniently located. Staff was very nice and helpful."

Reviewed on Mar 24, 2023

Quality Inn O'Fallon I-64
La Quinta Inn & Suites by Wyndham Paducah
2.5 out of 5
3960 Coleman Crossing Cir, Paducah, KY, 42001
Fully refundableReserve now, pay when you stay
The price is $97 per night from Apr 4 to Apr 5
$97
per night
Apr 4 - Apr 5
91.97 mi from city center
8.8/10 Excellent! (1,000 reviews)
"The staff are great! Shout out to Tammy, housekeeper, who goes above and beyond ensuring the cleanliness of the room. The breakfast is well stocked and the gentleman who prepares and monitors the station is friendly and attentive to all. Thank you"

Reviewed on Mar 27, 2023

La Quinta Inn & Suites by Wyndham Paducah

Save an average of 15% on thousands of hotels when you're signed in

Drury Inn & Suites Paducah
3 out of 5
2930 James Sanders Blvd, Paducah, KY, 42001
Fully refundableReserve now, pay when you stay
The price is $126 per night from Apr 2 to Apr 3
$126
per night
Apr 2 - Apr 3
92.63 mi from city center
9.2/10 Wonderful! (1,000 reviews)
"The staff is great. Very friendly. Great food and drinks. Clean we will be back"

Reviewed on Mar 26, 2023

Drury Inn & Suites Paducah
Ramada by Wyndham Effingham
3 out of 5
1606 W Fayette Avenue, Effingham, IL, 62401
Fully refundableReserve now, pay when you stay
The price is $74 per night from Apr 2 to Apr 3
$74
per night
Apr 2 - Apr 3
50.9 mi from city center
8/10 Very Good! (442 reviews)
"Ellen K was absolutely amazing. But for the rest, I wouldn’t probably come back."

Reviewed on Mar 26, 2023

Ramada by Wyndham Effingham
The 1857
3.5 out of 5
210 Kentucky Ave, Paducah, KY, 42001
The price is $89 per night from Apr 2 to Apr 3
$89
per night
Apr 2 - Apr 3
92.43 mi from city center
9.4/10 Exceptional! (601 reviews)
"The room is amazing! The vibe is luxurious and chill. We will definitely be coming back!"

Reviewed on Mar 22, 2023

The 1857
Drury Inn Paducah
3 out of 5
3975 Hinkleville Rd, Paducah, KY, 42001
Fully refundableReserve now, pay when you stay
The price is $121 per night from Apr 2 to Apr 3
$121
per night
Apr 2 - Apr 3
92.41 mi from city center
9/10 Wonderful! (1,001 reviews)
"Under a well overdue renovation. Happy hour was really sad compared to other Drury's I've been to."

Reviewed on Mar 26, 2023

Drury Inn Paducah
Quality Inn & Suites near St. Louis and I-255
2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL, 62206
Fully refundableReserve now, pay when you stay
The price is $71 per night from Apr 9 to Apr 10
$71
per night
Apr 9 - Apr 10
73.07 mi from city center
7.6/10 Good! (987 reviews)
"dining facilities need updating"

Reviewed on Jan 2, 2023

Quality Inn & Suites near St. Louis and I-255
Comfort Inn Paducah I-24
2.5 out of 5
5135 Cairo Rd, Paducah, KY, 42001
Fully refundableReserve now, pay when you stay
The price is $79 per night from Apr 16 to Apr 17
$79
per night
Apr 16 - Apr 17
91.06 mi from city center
8.2/10 Very Good! (1,001 reviews)
"Easy check-in/check-out. The rooms and common areas are clean and really attractive, the breakfast is very appealing, and the staff is amazing in terms of professionalism & friendliness. The area where this Comfort Inn is located is easy to access, and safe. (I've stayed in a few places that were ..."

Reviewed on Mar 21, 2023

Comfort Inn Paducah I-24
La Quinta Inn & Suites by Wyndham Effingham
2.5 out of 5
1103 Avenue Of Mid America, Effingham, IL, 62401
Fully refundableReserve now, pay when you stay
The price is $115 per night from Apr 4 to Apr 5
$115
per night
Apr 4 - Apr 5
52.12 mi from city center
8.8/10 Excellent! (1,006 reviews)
"Friendly staff and clean."

Reviewed on Mar 25, 2023

La Quinta Inn & Suites by Wyndham Effingham
Quality Inn & Suites Caseyville - St. Louis
2.5 out of 5
2180 Patricia Dr, Caseyville, IL, 62232
Fully refundableReserve now, pay when you stay
The price is $68 per night from Apr 10 to Apr 11
$68
per night
Apr 10 - Apr 11
67.39 mi from city center
6/10 (307 reviews)
"Not bad and like extra room attached to our room. But refrigerator and hair dryer in room did not work at all."

Reviewed on Jan 1, 2023

Quality Inn & Suites Caseyville - St. Louis
Holiday Inn Express Hotel & Suites Paducah West, an IHG Hotel
2.5 out of 5
3996 Hinkleville Road, Paducah, KY, 42001
Fully refundable
The price is $132 per night from Apr 3 to Apr 4
$132
per night
Apr 3 - Apr 4
92.55 mi from city center
9.6/10 Exceptional! (562 reviews)
"Very clean rooms. Comfy beds. The equipment in the gym was great. Pretty good breakfast in the morning including a pancake machine. Helpful staff."

Reviewed on Mar 22, 2023

Holiday Inn Express Hotel & Suites Paducah West, an IHG Hotel
Comfort Suites Mount Vernon
2.5 out of 5
404 South 44th Street, Mount Vernon, IL, 62864
Fully refundableReserve now, pay when you stay
The price is $113 per night from Apr 10 to Apr 11
$113
per night
Apr 10 - Apr 11
9.64 mi from city center
8.8/10 Excellent! (1,005 reviews)
"Nice hotel. Bed was very comfortable. Lots of people there the night we stayed and had no issues with noise. Kids loved the indoor pool"

Reviewed on Mar 26, 2023

Comfort Suites Mount Vernon
Country Inn & Suites by Radisson, Paducah, KY
2.5 out of 5
145 Mcbride Ln, Paducah, KY, 42001
The price is $93 per night from Apr 12 to Apr 13
$93
per night
Apr 12 - Apr 13
92.75 mi from city center
7.8/10 Good! (1,005 reviews)
"The hotel was solid. It meet all my needs."

Reviewed on Mar 24, 2023

Country Inn & Suites by Radisson, Paducah, KY
Best Western Saluki Inn
2.5 out of 5
801 N Giant City Rd, Carbondale, IL, 62902
The price is $76 per night from Apr 11 to Apr 12
$76
per night
Apr 11 - Apr 12
50.76 mi from city center
8/10 Very Good! (1,000 reviews)
"Friendly staff could work in coffee"

Reviewed on Mar 27, 2023

Best Western Saluki Inn
Holiday Inn Express & Suites Mount Vernon, an IHG Hotel
2.5 out of 5
300 Potomac Blvd, Mount Vernon, IL, 62864
Fully refundable
The price is $125 per night from Apr 3 to Apr 4
$125
per night
Apr 3 - Apr 4
9.64 mi from city center
9.2/10 Wonderful! (648 reviews)
"Courteous and friendly staff"

Reviewed on Mar 23, 2023

Holiday Inn Express & Suites Mount Vernon, an IHG Hotel
Super 8 by Wyndham Carbondale
2 out of 5
1180 E Main St, Carbondale, IL, 62901
Fully refundableReserve now, pay when you stay
The price is $54 per night from Apr 2 to Apr 3
$54
per night
Apr 2 - Apr 3
51.24 mi from city center
7/10 Good! (1,000 reviews)
Super 8 Carbondale, IL
"The computer kept crashing so it made it harder to check in. The beds are a bit too firm. However, for the 8 hours we were here, it was a good buy for sleep. They offer a free breakfast, but it is not worth your time. They just offered raisin bran and frosted flakes and really bad coffee."

Reviewed on Mar 25, 2023

Super 8 by Wyndham Carbondale
Days Inn by Wyndham Collinsville
2.5 out of 5
12 Commerce Drive, I-55/70 and IL 157, Collinsville, IL, 62234
Fully refundableReserve now, pay when you stay
The price is $64 per night from Apr 3 to Apr 4
$64
per night
Apr 3 - Apr 4
66.85 mi from city center
7/10 Good! (1,001 reviews)
"Very friendly, room was spacious and clean"

Reviewed on Feb 20, 2023

Days Inn by Wyndham Collinsville
Quality Inn & Suites
2.5 out of 5
4922 Paradise Rd, Mattoon, IL, 61938
Fully refundableReserve now, pay when you stay
The price is $76 per night from Apr 10 to Apr 11
$76
per night
Apr 10 - Apr 11
74.34 mi from city center
8.4/10 Very Good! (466 reviews)
Decent stay minus the breakfast.
"Breakfast wasn't as good as the pictures showed. Most people put something on their toast but the hotel didn't have any butter or jam/jelly. The only thing to put on the toast was spray butter which was a fair amount of time to spritz the toast. The one working the food area was the one working the ..."

Reviewed on Mar 23, 2023

Quality Inn & Suites
Holiday Inn Express Hotel & Suites Marion Northeast, an IHG Hotel
2.5 out of 5
2609 Blue Heron Drive, Marion, IL, 62959
Fully refundable
The price is $124 per night from Apr 3 to Apr 4
$124
per night
Apr 3 - Apr 4
46.68 mi from city center
9/10 Wonderful! (727 reviews)
"Friendly staff and easy access from highway"

Reviewed on Feb 23, 2023

Holiday Inn Express Hotel & Suites Marion Northeast, an IHG Hotel
Don't see what you're looking for?
See all available properties in Southern Illinois
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore, discover, and save

Stay near popular Southern Illinois attractions

Southern Illinois hotels information

Number of reviews
16,425
Accommodation
753 hotels
Lowest Price
$54
Highest Price
$132

Recent reviews of Southern Illinois hotels
Expedia verified reviews