Title: Top Independent in Wapello, IA - Expedia.com [Wapello Travel Guide](https://expedia.com/Wapello.dx3000437669)[Hotels in Wapello](https://expedia.com/Wapello-Hotels.d3000437669.Travel-Guide-Hotels)[Vacation Rentals in Wapello](https://expedia.com/Wapello-Vacation-Rentals.d3000437669.Travel-Guide-VacationRentals)[Flights to Wapello](https://expedia.com/Cheap-Flights-To-Wapello.d3000437669.Travel-Guide-Flights)[Car Rentals in Wapello](https://expedia.com/Car-Rentals-In-Wapello.d3000437669.Car-Rental-Guide)[Wapello Vacation Packages](https://expedia.com/Wapello.d3000437669.Destination-Travel-Guides) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 5 - Mar 6](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-05&endDate=2026-03-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 6 - Mar 7](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-06&endDate=2026-03-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FWapello-Hotels-Independent.0-0-d3000437669--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FWapello-Hotels-Independent.0-0-d3000437669--bIndependent.Travel-Guide-Filter-Hotels) ## Top Wapello Hotel Reviews ![AmericInn by Wyndham Muscatine](https://images.trvl-media.com/lodging/1000000/980000/972800/972723/7a83a55f_y.jpg) ### AmericInn by Wyndham Muscatine 10/10 Excellent "Everything is good 👍" [](https://expedia.com/Muscatine-Hotels-AmericInn-By-Wyndham-Muscatine.h972723.Hotel-Information) ![AmericInn by Wyndham West Burlington](https://images.trvl-media.com/lodging/1000000/560000/550600/550579/dc2defbe_y.jpg) ### AmericInn by Wyndham West Burlington 10/10 Excellent "The staff is amazing, so very helpful, and the cleaning crew is amazing and friendly! Thank you for a pleasant stay!" [](https://expedia.com/Burlington-Hotels-AmericInn-By-Wyndham-West-Burlington.h550579.Hotel-Information) ![Holiday Inn Express Hotel & Suites Burlington by IHG](https://images.trvl-media.com/lodging/1000000/30000/23100/23041/12350ef3_y.jpg) ### Holiday Inn Express Hotel & Suites Burlington by IHG 8/10 Good "Room was clean and staff was excellent. Noisy people in the halls and parking lot early in the morning" [](https://expedia.com/Burlington-Hotels-Holiday-Inn-Express-Hotel-Suites-Burlington.h23041.Hotel-Information) ![AmericInn by Wyndham Mount Pleasant](https://images.trvl-media.com/lodging/1000000/130000/124500/124480/21fbbb57_y.jpg) ### AmericInn by Wyndham Mount Pleasant 10/10 Excellent "Very nice experience " [](https://expedia.com/Burlington-Hotels-AmericInn-By-Wyndham-Mount-Pleasant.h124480.Hotel-Information) ![Hampton Inn Muscatine](https://images.trvl-media.com/lodging/4000000/3890000/3886300/3886256/w3840h2385x0y0-ea97f528_y.jpg) ### Hampton Inn Muscatine 10/10 Excellent "The hotel and the room was very clean friendly staff" [](https://expedia.com/Muscatine-Hotels-Hampton-Inn-Muscatine.h3886256.Hotel-Information) ![The Catfish Bend Inn & Spa](https://images.trvl-media.com/lodging/40000000/39220000/39213700/39213685/274a5133_y.jpg) ### The Catfish Bend Inn & Spa 10/10 Excellent "EVERYTHING WAS GREAT!" [](https://expedia.com/Burlington-Hotels-The-Catfish-Bend-Inn-Spa.h39213685.Hotel-Information) ![Quality Inn & Suites Mount Pleasant](https://images.trvl-media.com/lodging/1000000/70000/68200/68135/b3c42063_y.jpg) ### Quality Inn & Suites Mount Pleasant 10/10 Excellent "Beautiful room" [](https://expedia.com/Burlington-Hotels-Quality-Inn-Suites.h68135.Hotel-Information) ![Best Western Mt. Pleasant Inn](https://images.trvl-media.com/lodging/1000000/60000/50100/50061/f895586a_y.jpg) ### Best Western Mt. Pleasant Inn 8/10 Good "Great breakfast. Rooms could use some updating. " [](https://expedia.com/Burlington-Hotels-Best-Western-Mt-Pleasant-Inn.h50061.Hotel-Information) ![Evans Holly Grove Inn B&B](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/2bddcaf2_y.jpg) ### Evans Holly Grove Inn B&B 10/10 Excellent "The room was better than the photos, but the service was simply amazing!!!!" [](https://expedia.com/Burlington-Hotels-Evans-Holly-Grove-Inn-Bed-And-Breakfast.h23003876.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Louisa County Hotels ](https://www.expedia.com/Destinations-In-Louisa-County.d553248635976433104.Hotel-Destinations) - [Grandview Hotels ](https://www.expedia.com/Grandview-Hotels.d553248634983426434.Travel-Guide-Hotels) - [Letts Hotels ](https://www.expedia.com/Letts-Hotels.d553248634983251532.Travel-Guide-Hotels) - [Hotels near CJ Speedway ](https://www.expedia.com/CJ-Speedway-Hotels.0-l553248635974660970-0.Travel-Guide-Filter-Hotels) - [Hotels near Chatauqua Park ](https://www.expedia.com/Chatauqua-Park-Hotels.0-l553248621560669139-0.Travel-Guide-Filter-Hotels) - [Columbus City Hotels ](https://www.expedia.com/Columbus-City-Hotels.d553248634983322241.Travel-Guide-Hotels) - [Columbus Junction Hotels ](https://www.expedia.com/Columbus-Junction-Hotels.d183208.Travel-Guide-Hotels) - 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