Title: The Best 5 Star Hotels in Wapello, IA from $146 | Expedia.com

[Wapello Travel Guide](https://expedia.com/Wapello.dx3000437669)[Hotels in Wapello](https://expedia.com/Wapello-Hotels.d3000437669.Travel-Guide-Hotels)[Vacation Rentals in Wapello](https://expedia.com/Wapello-Vacation-Rentals.d3000437669.Travel-Guide-VacationRentals)[Flights to Wapello](https://expedia.com/Cheap-Flights-To-Wapello.d3000437669.Travel-Guide-Flights)[Car Rentals in Wapello](https://expedia.com/Car-Rentals-In-Wapello.d3000437669.Car-Rental-Guide)[Wapello Vacation Packages](https://expedia.com/Wapello.d3000437669.Destination-Travel-Guides)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Wapello 5 Star Hotels

Tonight

[Mar 21 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-21&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 22 - Mar 23](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-22&endDate=2026-03-23&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Wapello.

![Evans Holly Grove Inn B&B](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/2bddcaf2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Evans Holly Grove Inn B&B

616 Columbia Street Burlington IA

$130 nightly

$146 total

Mar 28 - Mar 29

Total with taxes and fees

9.6/10 Exceptional! (208 reviews)

[](https://expedia.com/Burlington-Hotels-Evans-Holly-Grove-Inn-Bed-And-Breakfast.h23003876.Hotel-Information)

![The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/22000000/21610000/21600200/21600105/b2245809_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel

119 Mississippi Drive West Muscatine IA

$195 nightly

$218 total

Mar 28 - Mar 29

Total with taxes and fees

[](https://expedia.com/Muscatine-Hotels-The-Merrill-Hotel.h21600105.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Wapello.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&regionId=3000437669&star=50)

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Wapello

Along the banks of the mighty Mississippi, this charming river town invites visitors to explore Chatauqua Park's natural beauty and peaceful surroundings. History buffs and outdoor enthusiasts can venture to nearby Lover's Leap Swinging Bridge or spend an exciting evening watching local races at CJ Speedway.

[See all hotels in Wapello](https://www.expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06&adults=2&regionId=3000437669)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=395&h=400&p=1&q=high)

## Top Wapello Hotel Reviews

## Find out more about Wapello

## Wapello Five Star Hotel Information

If you’re searching for the celebrity treatment, the 5 star hotels in Wapello are your dreams come true. From sprawling resorts to fancy hot spots, theseWapello 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.

Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Wapello, Iowa, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Wapello five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.

Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Wapello 5 star hotels.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Wapello?

> - Search for the lowest price per night from $146

### What makes a hotel 5 stars in Wapello?

### Are there any 5-star all-inclusive resorts in Wapello?

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