Title: The Best 4 Star Hotels in Wapello, IA from $113 | Expedia.com [Wapello Travel Guide](https://expedia.com/Wapello.dx3000437669)[Hotels in Wapello](https://expedia.com/Wapello-Hotels.d3000437669.Travel-Guide-Hotels)[Vacation Rentals in Wapello](https://expedia.com/Wapello-Vacation-Rentals.d3000437669.Travel-Guide-VacationRentals)[Flights to Wapello](https://expedia.com/Cheap-Flights-To-Wapello.d3000437669.Travel-Guide-Flights)[Car Rentals in Wapello](https://expedia.com/Car-Rentals-In-Wapello.d3000437669.Car-Rental-Guide)[Wapello Vacation Packages](https://expedia.com/Wapello.d3000437669.Destination-Travel-Guides) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Wapello 4 Star Hotels Tonight [Mar 8 - Mar 9](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-08&endDate=2026-03-09&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 9 - Mar 10](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-09&endDate=2026-03-10&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=3000437669&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Wapello 4-star hotels ![48-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/22000000/21610000/21600200/21600105/b2245809.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor wedding](https://images.trvl-media.com/lodging/22000000/21610000/21600200/21600105/acc8db95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21610000/21600200/21600105/728aa272.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/22000000/21610000/21600200/21600105/ca75ac05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Merrill Hotel, Muscatine, a Tribute Portfolio Hotel [](https://www.expedia.com/Muscatine-Hotels-The-Merrill-Hotel.h21600105.Hotel-Information) Muscatine 9.6/10 Exceptional (283 reviews) "clean facility, very friendly and helpful staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry $195 nightly $218 total Mar 14 - Mar 15 Total with taxes and fees [](https://www.expedia.com/Muscatine-Hotels-The-Merrill-Hotel.h21600105.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/2bddcaf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Romantic Suite, 1 Queen Bed, Jetted Tub, Courtyard Area | Living room | 40-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/w791h990x2y0-016ea680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/b656603d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Double Room Single Use, 2 Queen Beds, Shared Bathroom, Courtyard Area | Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/24000000/23010000/23003900/23003876/54e3b6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Evans Holly Grove Inn B&B [](https://www.expedia.com/Burlington-Hotels-Evans-Holly-Grove-Inn-Bed-And-Breakfast.h23003876.Hotel-Information) Burlington 9.6/10 Exceptional (203 reviews) "Beautifully furnished historic house that has been well cared for. Grandma Mel was a delight. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Teresa $100 nightly $113 total Mar 14 - Mar 15 Total with taxes and fees [](https://www.expedia.com/Burlington-Hotels-Evans-Holly-Grove-Inn-Bed-And-Breakfast.h23003876.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Wapello-Hotels.s40-0-d3000437669.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Wapello-Hotels.s40-0-d3000437669.Travel-Guide-Filter-Hotels) ## Learn more about Wapello Along the banks of the mighty Mississippi, this charming river town invites visitors to explore Chatauqua Park's natural beauty and peaceful surroundings. History buffs and outdoor enthusiasts can venture to nearby Lover's Leap Swinging Bridge or spend an exciting evening watching local races at CJ Speedway. [See all hotels in Wapello](https://www.expedia.com/Hotel-Search?startDate=2026-03-22&endDate=2026-03-23&adults=2®ionId=3000437669) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=395&h=400&p=1&q=high) ## Top Wapello Hotel Reviews ## Find out more about Wapello ## Wapello Four Star Hotel Information When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Wapello, Iowa are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Wapello 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service. Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Wapello. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Wapello, Iowa, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop. Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Wapello hotels offer everything your heart desires. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Wapello? > - Search for the lowest price from $113 ### What's the difference between 5-star and 4-star hotels in Wapello? ### Does Wapello have any 4-star all-inclusive resorts? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Louisa County Hotels ](https://www.expedia.com/Destinations-In-Louisa-County.d553248635976433104.Hotel-Destinations) - [Grandview Hotels ](https://www.expedia.com/Grandview-Hotels.d553248634983426434.Travel-Guide-Hotels) - [Letts Hotels ](https://www.expedia.com/Letts-Hotels.d553248634983251532.Travel-Guide-Hotels) - [Hotels near CJ Speedway ](https://www.expedia.com/CJ-Speedway-Hotels.0-l553248635974660970-0.Travel-Guide-Filter-Hotels) - [Hotels near Chatauqua Park ](https://www.expedia.com/Chatauqua-Park-Hotels.0-l553248621560669139-0.Travel-Guide-Filter-Hotels) - [Columbus City Hotels ](https://www.expedia.com/Columbus-City-Hotels.d553248634983322241.Travel-Guide-Hotels) - [Columbus Junction Hotels ](https://www.expedia.com/Columbus-Junction-Hotels.d183208.Travel-Guide-Hotels) - [Cabin Rentals in Columbus Junction ](https://www.expedia.com/Columbus-Junction-Cabins.d183208-aaCabins.Travel-Guide-Accommodation) - [B&B in Columbus Junction ](https://www.expedia.com/Columbus-Junction-Bed-And-Breakfast.d183208-aaBedAndBreakfast.Travel-Guide-Accommodation) - [5 Star Hotels in Fruitland ](https://www.expedia.com/5Star-Fruitland-Hotels.s50-0-d3000460880.Travel-Guide-Filter-Hotels) - [Fruitland Hotels ](https://www.expedia.com/Fruitland-Hotels.d3000460880.Travel-Guide-Hotels) - [Hotels near Muscatine Municipal ](https://www.expedia.com/Muscatine-Municipal-Airport-Hotels.0-aMUT-0.Travel-Guide-Filter-Hotels) - [Winfield Hotels ](https://www.expedia.com/Winfield-Hotels.d3000437705.Travel-Guide-Hotels) - [B&B in Winfield ](https://www.expedia.com/Winfield-Bed-And-Breakfast.d3000437705-aaBedAndBreakfast.Travel-Guide-Accommodation) - [5 Star Hotels in Muscatine ](https://www.expedia.com/5Star-Muscatine-Hotels.s50-0-d8837.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Muscatine ](https://www.expedia.com/4Star-Muscatine-Hotels.s40-0-d8837.Travel-Guide-Filter-Hotels) - [Hotels near Riverside Park ](https://www.expedia.com/Riverside-Park-Hotels.0-l6265591-0.Travel-Guide-Filter-Hotels) - [Muscatine Hotels ](https://www.expedia.com/Muscatine-Hotels.d8837.Travel-Guide-Hotels) - [Hotels with an Indoor Pool in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Indoor-Pool.0-0-d8837-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Hotels with Restaurants in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Restaurants.0-0-d8837-tHotelswithRestaurants.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Hot-Tubs.0-0-d8837-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotel Wedding Venues Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Wedding-Hotels.0-0-d8837-tWeddingHotels.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Cheap-Hotels.0-0-d8837-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Pet-Friendly-Hotel.0-0-d8837-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Romantic-Hotel.0-0-d8837-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hilton-Hotels.0-0-d8837--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Muscatine County Hotels ](https://www.expedia.com/Destinations-In-Muscatine-County.d553248635976431601.Hotel-Destinations) - [Cabin Rentals in Muscatine ](https://www.expedia.com/Muscatine-Cabins.d8837-aaCabins.Travel-Guide-Accommodation) - [Villas in Muscatine ](https://www.expedia.com/Muscatine-Villas.d8837-aaVillas.Travel-Guide-Accommodation) - [Hotels with Bars in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Bar-Hotel.0-0-d8837-tBarHotel.Travel-Guide-Filter-Hotels) - [Extended Stay Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Extended-Stay-Hotels.0-0-d8837-tExtendedStayHotels.Travel-Guide-Filter-Hotels) - [Resorts & Hotels with Spas in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Spa-Hotel.0-0-d8837-tSpaHotel.Travel-Guide-Filter-Hotels) - [Hotels with Connecting Rooms in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Adjoining-Rooms.0-0-d8837-tHotelswithAdjoiningRooms.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-LGBT-Welcoming-Hotel.0-0-d8837-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Motels in Muscatine ](https://www.expedia.com/Muscatine-Motels.d8837-aaMotels.Travel-Guide-Accommodation) - [Hotels with a Pool in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotel-With-Pool.0-0-d8837-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Luxury-Hotel.0-0-d8837-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [B&B in Muscatine ](https://www.expedia.com/Muscatine-Bed-And-Breakfast.d8837-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels with Air Conditioning in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Air-Conditioning.0-0-d8837-tHotelswithAirConditioning.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Marriott-Hotels-Resorts.0-0-d8837--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Best Western Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Best-Western.0-0-d8837--bBestWestern.Travel-Guide-Filter-Hotels) - [Historic Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Historic-Hotel.0-0-d8837-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels & Resorts for Couples in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Couples-Resorts-Hotels.0-0-d8837-tCouplesResortsHotels.Travel-Guide-Filter-Hotels) - [Cottages in Muscatine ](https://www.expedia.com/Muscatine-Cottages.d8837-aaCottages.Travel-Guide-Accommodation) - [Hotels with an Outdoor Pool in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Hotels-With-Outdoor-Pool.0-0-d8837-tHotelswithOutdoorPool.Travel-Guide-Filter-Hotels) - [Family Hotels in Muscatine ](https://www.expedia.com/Muscatine-Hotels-Family-Hotel.0-0-d8837-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Condo Rentals in Muscatine ](https://www.expedia.com/Muscatine-Condos.d8837-aaCondos.Travel-Guide-Accommodation) - [Crawfordsville Hotels ](https://www.expedia.com/Crawfordsville-Hotels.d553248634983423441.Travel-Guide-Hotels) - [Hotels near Geneva Golf and Country Club ](https://www.expedia.com/Geneva-Golf-And-Country-Club-Hotels.0-l6265586-0.Travel-Guide-Filter-Hotels) - [Flights to Columbus Junction ](https://www.expedia.com/Cheap-Flights-To-Columbus-Junction.d183208.Travel-Guide-Flights) - [Flights from Mediapolis ](https://www.expedia.com/lp/flights/553248634983169755/flights-from-mediapolis) - [Flights to Fruitland ](https://www.expedia.com/Cheap-Flights-To-Fruitland.d3000460880.Travel-Guide-Flights) - [Flights from Muscatine Municipal ](https://www.expedia.com/lp/airports/mut/flights-from-muscatine-municipal-airport) - [Flights from Minneapolis (FCM) to Muscatine (MUT) ](https://www.expedia.com/lp/flights/fcm/mut/minneapolis-to-muscatine) - [Flights to Muscatine Municipal ](https://www.expedia.com/Cheap-Flights-To-Muscatine-Municipal.d553248634328591040.Travel-Guide-Flights) - [Flights to Winfield ](https://www.expedia.com/Cheap-Flights-To-Winfield.d3000437705.Travel-Guide-Flights) - [Flights from Conesville ](https://www.expedia.com/lp/flights/553248634983429190/flights-from-conesville) - [Flights to Muscatine ](https://www.expedia.com/Cheap-Flights-To-Muscatine.d8837.Travel-Guide-Flights) - [Flights from Muscatine ](https://www.expedia.com/lp/flights/8837/flights-from-muscatine) - [San Antonio to Muscatine ](https://www.expedia.com/lp/flights/178303/8837/san-antonio-to-muscatine) - [Charlotte to Muscatine ](https://www.expedia.com/lp/flights/178247/8837/charlotte-to-muscatine) - [Las Vegas to Muscatine ](https://www.expedia.com/lp/flights/178276/8837/las-vegas-to-muscatine) - [Cj Speedway ](https://www.expedia.com/CJ-Speedway-Columbus-Junction.d553248635974660970.Vacation-Attraction) - [Visit Columbus Junction ](https://www.expedia.com/Columbus-Junction.dx183208) - [Columbus Junction Public Library ](https://www.expedia.com/Columbus-Junction-Public-Library-Columbus-Junction.d553248621560669140.Vacation-Attraction) - [Visit Fruitland ](https://www.expedia.com/Fruitland.dx3000460880) - [Visit Winfield ](https://www.expedia.com/Winfield.dx3000437705) - [Riverside Park ](https://www.expedia.com/Riverside-Park-Muscatine.d6265591.Vacation-Attraction) - [Visit Muscatine ](https://www.expedia.com/Muscatine.dx8837) - [Muscatine Vacations ](https://www.expedia.com/Muscatine.d8837.Destination-Travel-Guides) - [Muscatine Art Center ](https://www.expedia.com/Muscatine-Art-Center-Muscatine.d553248621532649142.Vacation-Attraction) - [Geneva Golf and Country Club ](https://www.expedia.com/Geneva-Golf-And-Country-Club-Muscatine.d6265586.Vacation-Attraction) - [Muscatine Aquatic Center ](https://www.expedia.com/Muscatine-Aquatic-Center-Muscatine.d6265596.Vacation-Attraction) - [Car rentals near Fredonia ](https://www.expedia.com/Car-Rentals-In-Fredonia.d553248634983395503.Car-Rental-Guide) - [Car rentals near Columbus City ](https://www.expedia.com/Car-Rentals-In-Columbus-City.d553248634983322241.Car-Rental-Guide) - [Car rentals near Columbus Junction ](https://www.expedia.com/Car-Rentals-In-Columbus-Junction.d183208.Car-Rental-Guide) - [Car rentals near Columbus Junction Public Library ](https://www.expedia.com/Car-Rentals-In-Columbus-Junction-Public-Library.d553248621560669140.Car-Rental-Guide) - [Car rentals near Fruitland ](https://www.expedia.com/Car-Rentals-In-Fruitland.d3000460880.Car-Rental-Guide) - [Car rentals near Winfield ](https://www.expedia.com/Car-Rentals-In-Winfield.d3000437705.Car-Rental-Guide) - [Car rentals near Cotter ](https://www.expedia.com/Car-Rentals-In-Cotter.d553248634983191207.Car-Rental-Guide) - [Car rentals near Muscatine ](https://www.expedia.com/Car-Rentals-In-Muscatine.d8837.Car-Rental-Guide) - [Van Car Rentals in Muscatine ](https://www.expedia.com/Van-Car-Rentals-In-Muscatine.d8837-tVan.Car-Rental-Guide-Class) - [Budget Rental Cars in Muscatine ](https://www.expedia.com/Budget-Car-Rentals-In-Muscatine.d8837-c39.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Muscatine ](https://www.expedia.com/Avis-Car-Rentals-In-Muscatine.d8837-c41.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Muscatine ](https://www.expedia.com/Hertz-Car-Rentals-In-Muscatine.d8837-c40.Car-Rental-Guide-Suppliers) - [Sicily By Car Rental Cars in Muscatine ](https://www.expedia.com/Sicily-By-Car-Car-Rentals-In-Muscatine.d8837-c1048.Car-Rental-Guide-Suppliers) - [Alamo Rent A Car Rental Cars in Muscatine ](https://www.expedia.com/Alamo-Rent-A-Car-Car-Rentals-In-Muscatine.d8837-c6.Car-Rental-Guide-Suppliers) - [Car rentals near Olds ](https://www.expedia.com/Car-Rentals-In-Olds.d553248634983084933.Car-Rental-Guide) - [Columbus Junction Vacation Rentals ](https://www.expedia.com/Columbus-Junction-Vacation-Rentals.d183208.Travel-Guide-VacationRentals) - [Muscatine Vacation Rentals ](https://www.expedia.com/Muscatine-Vacation-Rentals.d8837.Travel-Guide-VacationRentals)