Top 10 Hotels in Buffalo, SC (from $67) 2026 - Competitive Prices

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Our top choices for Buffalo hotels

A modern hotel lobby with a coffee station, seating area, and a large screen.

1. Quality Inn Union US Hwy 176

Union

Mary

$84 nightly

Nov 16 - Nov 17

Total with taxes and fees

A hotel room with a bed, a sofa, a nightstand, and a small table.

2. Rodeway Inn Union

Union

Dejuana

$61 nightly

Nov 25 - Nov 26

Total with taxes and fees

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

3. The Night Inn

Union

Robert

$75 nightly

Oct 27 - Oct 28

Total with taxes and fees

4. Hampton Inn & Suites Clinton - I-26

Clinton

Andrea

$115 nightly

Nov 15 - Nov 16

Total with taxes and fees

A hotel with a central entrance, multiple floors, and a flag display.

5. Comfort Suites Clinton near Presbyterian College

Clinton

Deanne

$93 nightly

Nov 16 - Nov 17

Total with taxes and fees

A modern living room with a sofa, armchairs, a patterned rug, and a Buddha statue.

6. Days Inn by Wyndham Clinton / Laurens I-26

Clinton

Julian

$68 nightly

Nov 17 - Nov 18

Total with taxes and fees

A modern lobby with a reception desk, seating area, and a television screen.

7. Best Western Spartanburg I-26

Spartanburg

Santhosh

$93 nightly

Nov 8 - Nov 9

Total with taxes and fees

A dining area with tables and chairs, a television mounted on the wall, and a kitchen area with appliances.

8. Rodeway Inn Laurens

Laurens

JAMES

$68 nightly

Nov 21 - Nov 22

Total with taxes and fees

A hotel with a prominent sign, multiple balconies, and well-lit windows.

9. Red Roof Inn Spartanburg - I-85

Spartanburg

Walker

$65 nightly

Oct 27 - Oct 28

Total with taxes and fees

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

10. Hilton Garden Inn Spartanburg

Spartanburg

Patrick

$116 nightly

Nov 19 - Nov 20

Total with taxes and fees

A modern hotel lobby with a seating area, a dining space, and a reception desk.

11. Quality Inn Clinton - Laurens I-26

Clinton

Meridith

$78 nightly

Nov 14 - Nov 15

Total with taxes and fees

An outdoor seating area with sofas, a fire pit, and string lights.

12. Tru by Hilton Spartanburg

Spartanburg

Volodymyr

$106 nightly

Nov 23 - Nov 24

Total with taxes and fees

A hotel room with two beds, a desk, and a kitchenette.

13. Suburban Studios Spartanburg - I-26

Spartanburg

Tammy

$85 nightly

Oct 27 - Oct 28

Total with taxes and fees

A hotel lobby with a curved outdoor seating area, a fire pit, and a pool.

14. Spartanburg Marriott

Spartanburg

Daniel

$118 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

15. Comfort Suites At WestGate Mall

Spartanburg

Willie

$88 nightly

Nov 22 - Nov 23

Total with taxes and fees

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

16. AC Hotel by Marriott Spartanburg

Spartanburg

Willow

$159 nightly

Nov 1 - Nov 2

Total with taxes and fees

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

17. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Deborah

$110 nightly

Nov 1 - Nov 2

Total with taxes and fees

A modern kitchen with a central island, bar stools, and pendant lighting.

18. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Melinda

$108 nightly

Nov 8 - Nov 9

Total with taxes and fees

A modern living room with a stone accent wall, a flat-screen TV, and a blue abstract rug.

19. Fairfield by Marriott Inn & Suites Spartanburg Downtown

Spartanburg

Zachary

$149 nightly

Nov 1 - Nov 2

Total with taxes and fees

A modern breakfast area with a blue-tiled backsplash, a coffee station, and seating with teal cushions.

20. Sleep Inn Spartanburg Southwest

Spartanburg

Michael

$67 nightly

Nov 26 - Nov 27

Total with taxes and fees

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Where to stay near Buffalo

Buffalo offers a charming blend of outdoor adventures and scenic beauty. Explore lush parks, enjoy romantic lakeside strolls, or indulge in wellness retreats. Nearby towns provide a friendly atmosphere, perfect for family outings and cultural experiences, making it an ideal getaway for relaxation and rejuvenation.

A neoclassical courthouse with a dome and columns, a flagpole, and a parked car in front.

Union

For travelers seeking a blend of nature and history, Union is the perfect base to explore the charm of South Carolina. This welcoming city offers access to the scenic Rose Hill Plantation State Historic Site, the tranquil Veterans Memorial Park, and the engaging Union County Museum, ensuring a rich experience for families and nature enthusiasts alike. Located about 4 miles from Buffalo, Union provides a smart choice for those looking to immerse themselves in local culture while enjoying outdoor activities.

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Monarch Mill

Plan your stay in Monarch Mill, a great choice for travelers seeking a blend of business, family, and outdoor adventures. This charming village is near attractions like Veterans Memorial Park, perfect for relaxation, and the Union County Museum, where history comes alive. For a taste of local heritage, don’t miss the Rose Hill Plantation State Historic Site. Located about 6 miles from Buffalo, Monarch Mill is an ideal spot for a memorable getaway.

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Jonesville

If you are a family or nature enthusiast, look no further than Jonesville, a charming city known for its inviting parks and recreational activities. Enjoy the serene landscapes at Croft State Park or unwind at the urban charm of Veterans Memorial Park, both perfect for outdoor adventures. With easy access to local shopping and golf courses, you’ll find plenty to explore. Located about 8 miles from Buffalo, Jonesville is an ideal choice for a delightful stay.

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Pauline

Immerse yourself in Pauline, where travelers with a penchant for family outings and nature adventures can easily access scenic spots and recreational activities. Enjoy the rich history at Walnut Grove Plantation, explore the natural beauty of Croft State Park, and unwind at Tyger-10 Nature Park. With its charm and variety, Pauline serves as a delightful base for your exploration of the surrounding area. Located about 10 miles from Buffalo, it’s a smart choice for your next getaway.

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Cross Anchor

Travelers looking for a charming getaway will find Cross Anchor to be the ideal base for their vacation, featuring a blend of family-friendly activities and beautiful natural scenery. This welcoming city is perfect for those seeking outdoor adventures and romantic escapes, with highlights like the Musgrove Mill State Historic Site and the nearby lake for leisurely days. With Cross Anchor just about 11 miles from Buffalo, it offers a smart choice for a budget-friendly stay while enjoying local attractions and experiences.

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Stay near popular attractions around Buffalo

Buffalo, South Carolina, offers a delightful blend of outdoor adventures and romantic scenery. Explore the charming urban parks, historic houses, and a welcoming library. Whether you're seeking family fun or a serene city experience, Buffalo is the perfect base for unforgettable memories and exploration.

Musgrove Mill State Historic Site

8.6/10 (19 reviews)

A fascinating mix of history and nature awaits outdoor enthusiasts at Musgrove Mill State Historic Site. This National Park features scenic landscapes and opportunities for adventure, showcasing the site’s rich Revolutionary War heritage. Located about 13 miles from Buffalo, it’s a convenient stop for a memorable day trip.

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Rose Hill Plantation State Historic Site

8.8/10 (6 reviews)

Ideal for travelers interested in history and culture, Rose Hill Plantation State Historic Site offers a glimpse into South Carolina's rich past. Located about 8 miles from Buffalo, visitors can explore its beautifully preserved grounds and learn about plantation life, making it a convenient and enriching stop on your journey.

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Battle of Blackstock Marker

8.0/10 (2 reviews)

Visitors often appreciate how this spot delivers a glimpse into the rich history of the Revolutionary War. The Battle of Blackstock marker commemorates a significant clash between American patriots and British forces, offering cultural insights. Located about 9 miles from Buffalo, it provides easy access for those eager to explore the region's heritage.

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Croft State Park

7.0/10 (2 reviews)

Discover the appeal of Croft State Park, a fantastic destination for nature lovers seeking adventure and scenic beauty. Located about 13 miles from Buffalo, this park offers a variety of outdoor experiences amid its picturesque landscapes, making it an ideal spot for relaxation and exploration. Staying nearby allows easy access to its natural charm.

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Top Buffalo Hotel Reviews

Tru by Hilton Spartanburg

8/10 Good

"slightly noisy near the highway but overall good place to stay, I would recommend this hotel, thanks ."

Best Western Spartanburg I-26

8/10 Good

"The bed was very comfortable! Slept like a rock. The room was very cleanThe bathroom sink was located outside the bathroom, which I always hate. The breakfast had a little pancake maker and a yogurt machine. There were eggs and bacon. The eggs were cold though. Lots of juice options, toast and bagels. Would recommend"

Quality Inn Clinton - Laurens I-26

8/10 Good

"This is a fine accommodation for those road warriors stopping to rest for a night. The local seafood restaurant next door is a local favorite with good value and great food. We were disappointed when the front desk staff didn’t offer up any information on breakfast times or location of the breakfast room. They also neglected to tell us of the Wi-Fi info ie. password etc. sadly the desk clerk also placed us in the least desirable room at the stairwell by the ice machine. We also had some road crew workers hanging out late into the evening. You guessed it sitting on the staircase smoking and drinking. Oh what fun. Staff could have been more considerate to us given we are retirees and often retire early so a more quiet local would have been appreciated."

More cheap stays in Buffalo

Days Inn by Wyndham Clinton / Laurens I-26

12374 Highway 56 N Clinton SC

$68 nightly

$76 total

Nov 17 - Nov 18

Total with taxes and fees

Hotels in Buffalo with star-rating

Frequently asked questions

What is the best area to stay in Buffalo?

The best area to stay in Buffalo, South Carolina, is the downtown area, particularly around Main Street, for convenient access to local amenities and a central location.

Downtown Buffalo is the commercial and social center of the town. While not a large city, this area offers the most options for dining and shopping within walking distance. Main Street is the primary thoroughfare, connecting various local businesses and community gathering spots.

For solo travelers or couples looking for a relaxed stay with easy access to local services, downtown is the ideal choice.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Buffalo.

How much is the nightly rate at a Buffalo hotel?

Prices for hotels in Buffalo often vary, but you can find a great deal from $67 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Things to do in Upstate South Carolina

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Our top choices for Buffalo hotels

1. Quality Inn Union US Hwy 176

2. Rodeway Inn Union

3. The Night Inn

4. Hampton Inn & Suites Clinton - I-26

5. Comfort Suites Clinton near Presbyterian College

6. Days Inn by Wyndham Clinton / Laurens I-26

7. Best Western Spartanburg I-26

8. Rodeway Inn Laurens

9. Red Roof Inn Spartanburg - I-85

10. Hilton Garden Inn Spartanburg

11. Quality Inn Clinton - Laurens I-26

12. Tru by Hilton Spartanburg

13. Suburban Studios Spartanburg - I-26

14. Spartanburg Marriott

15. Comfort Suites At WestGate Mall

16. AC Hotel by Marriott Spartanburg

17. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

18. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

19. Fairfield by Marriott Inn & Suites Spartanburg Downtown

20. Sleep Inn Spartanburg Southwest

Where to stay near Buffalo

Union

Monarch Mill

Jonesville

Pauline

Cross Anchor

Stay near popular attractions around Buffalo

Musgrove Mill State Historic Site

Top Buffalo Hotel Reviews

Tru by Hilton Spartanburg

More cheap stays in Buffalo

Days Inn by Wyndham Clinton / Laurens I-26

Hotels in Buffalo with star-rating

Frequently asked questions

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