A large eye sculpture in a park surrounded by trees.

Find hotels in Northeast Missouri, MO from $74

  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 2 - Sep 3
Tomorrow
Sep 3 - Sep 4
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Filter by

Star rating

Guest rating

Our top choices for Northeast Missouri hotels

1. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
Monroe City
United States
Darrin J.
$86 nightly
$93 total
Sep 26 - Sep 27
Total with taxes and fees
FairBridge Inn Express, Monroe City

2. Super 8 by Wyndham Macon

Super 8 by Wyndham Macon
Macon
United States
Austin
$82 nightly
$89 total
Sep 13 - Sep 14
Total with taxes and fees
Super 8 by Wyndham Macon

3. Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr
Macon
United States
Mary
$70 nightly
$75 total
Sep 8 - Sep 9
Total with taxes and fees
Americas Best Value Inn & Suites Macon at Sunset Dr

4. Travelier Motel

Travelier Motel
Macon
United States
Jessica
$73 nightly
$79 total
Sep 3 - Sep 4
Total with taxes and fees
Travelier Motel

5. Prairie View Inn

Prairie View Inn
Shelbina
United States
Randy
$93 nightly
$102 total
Sep 3 - Sep 4
Total with taxes and fees
Prairie View Inn

6. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Lost Branch Lodge. Complete exterior remodel, spring 2026!
Brashear
United States
Melissa W.
Lost Branch Lodge. Complete exterior remodel, spring 2026!
View all properties

Vacation Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Cannon Dam Cabins
Perry
"Cozy and well equipped with everything we may have needed"
Cannon Dam Cabins
Aparthotel

Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
"Wonderful place to stay!"
Lighthouse Inn & Suites
Apartment

White House at Grand Central

White House at Grand Central
Grand Center
"Staff was great and accommodating to my needs."
White House at Grand Central
Cottage

Peaceful Missouri Cabin Rental on 55 Acres!

Peaceful Missouri Cabin Rental on 55 Acres!
Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Peaceful Missouri Cabin Rental on 55 Acres!
Apartment

Landing Furnished Apartments - Central West End

Landing Furnished Apartments - Central West End
Central West End
"We booked a two bedroom for three people and the 2nd bedroom didn't have a bed! Contacted property, which was very responsive, but they couldn't do anything since we booked through Hotels. com"
Landing Furnished Apartments - Central West End
Vacation Home

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV
Fenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Remodeled and Inviting Free EV
Cottage

Updated Missouri Cabin Rental on Large Farm

Updated Missouri Cabin Rental on Large Farm
Canton
Updated Missouri Cabin Rental on Large Farm
Cottage

Home w/ Trail Access on 19 Acres in Wright City!

Home w/ Trail Access on 19 Acres in Wright City!
Wright City
"Great house in a beautiful setting. We enjoyed the quiet solitude and woodsy area. Very clean accommodations with every amenity available. "
Home w/ Trail Access on 19 Acres in Wright City!
Cottage

Walk to Tower Grove Park: St Louis Getaway

Walk to Tower Grove Park: St Louis Getaway
Tower Grove South
"great place and nice location"
Walk to Tower Grove Park: St Louis Getaway
Apartment

Near Wineries: Country Condo in Stony Hill

Near Wineries: Country Condo in Stony Hill
New Haven
"Clean and loved original architecture."
Near Wineries: Country Condo in Stony Hill
Apartment

Walk to Carondelet Park: Quiet Couple's Getaway

Walk to Carondelet Park: Quiet Couple's Getaway
Carondelet
"We had a nice stay, close to things we wanted to do"
Walk to Carondelet Park: Quiet Couple's Getaway
Apartment

New Melle Apartment Near Missouri Wine Country

New Melle Apartment Near Missouri Wine Country
Wentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
New Melle Apartment Near Missouri Wine Country
Cottage

St Louis Home < 1 Mi to Forest Park!

St Louis Home < 1 Mi to Forest Park!
Dogtown
"We really enjoyed our stay. A great house in a really fun residential area. Close to an area with a main town st with cool restaurants, bars and shops to walk around. "
St Louis Home < 1 Mi to Forest Park!
Cottage

Home 2 Mi to Dtwn St Louis: Great for Families!

Home 2 Mi to Dtwn St Louis: Great for Families!
Lafayette Square
"Clean space with so much character!"
Home 2 Mi to Dtwn St Louis: Great for Families!
Cottage

'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
Florissant
"Beautiful well kept secret in a very peaceful setting: we had a large family Thanksgiving week in this beautiful place. There was more than enough rooms for four families to come together and still have enough room for dining visitors. It is beyond well equipped and you should contact the owner before you bring unnecessary items. Great hot tub. Spacious and well equipped baths and showers with all personal supplies and plush towels. Beds were all amazing. There is a great playroom...
'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Northeast Missouri attractions

A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.
Photo by Jeff White

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
See properties
A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
See properties
A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.
See properties
A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
See properties
A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
See properties
A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
See properties

America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
See properties

Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A historic log cabin with a flagpole, hay bales, and autumn pumpkins.

Top Northeast Missouri Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent
"We stayed here again and it's always consistently a wonderful stay!"
Denise 1-night trip
Posted 10 hours ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

8/10 Good
"Staff is always friendlyl"
Doug 1-night trip
Posted 12 hours ago
Pear Tree Inn St. Louis Near Union Station
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

8/10 Good
"No microwave in the room and ice machine only on certain floors was an inconvenience."
James 2-night trip
Posted 17 hours ago
Courtyard by Marriott St. Louis Downtown/Convention Center
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

8/10 Good
"Overall, the hotel was very nice. The restaurant and staff super nice. The hotel had a night club upstairs so if that’s your thing this is the spot for you."
Vosinick 3-night trip
Posted 1 day ago
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

10/10 Excellent
"I recommend this Hotel 10 out of 10 every time I go back home this is where I stay. The staff and the facility. Everything is amazing."
CIERA 2-night trip
Posted 1 day ago
Renaissance St. Louis Airport Hotel
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

10/10 Excellent
"All modern amenities with a touch of old world glam! Across from a beautiful walking/biking park and equipped with a beautiful pool, workout facility, comfortable beds, and several restaurants, all you need to have a wonderful travel experience!"
Eileen 1-night trip
Posted 2 days ago
The Royal Sonesta Chase Park Plaza St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"First time staying at this brand. Loved this stay. In town for couple Cardinals games. Great walkable location, part of Ballpark Village, is right across street from ballpark. Super staff. Awesome indoor/outdoor bar/restaurant/lounge, plus a rooftop bar/lounge. Do have happy hr with reasonable drink prices. Hotel is newer, trendy vibe & decor. Hotel is quiet, heard no one in halls or room doors….don’t get the people who walk out their room and let door slam shut behind em. Doors are slow close which is nice. Bathrooms could use more hooks and maybe couple small shelves. Luggage carts are kept locked, need to ask for one. Def stay here again."
Jessica 1-night trip
Posted 3 days ago
Live by Loews - St.Louis

More cheap stays in Northeast Missouri

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

5781 Campus Ct Hazelwood MO
$60 nightly
$74 total
Oct 1 - Oct 2
Total with taxes and fees
Motel 6 Hazelwood, MO
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
$68 nightly
$79 total
Sep 6 - Sep 7
Total with taxes and fees
4.4/10 (1,004 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO
$75 nightly
$86 total
Sep 17 - Sep 18
Total with taxes and fees
8.4/10 Very Good! (1,107 reviews)
Best Western St. Louis Inn
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

1201 Drury Ln Arnold MO
$90 nightly
$104 total
Sep 7 - Sep 8
Total with taxes and fees
9.4/10 Exceptional! (1,003 reviews)
Pear Tree Inn St. Louis Arnold
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Sep 7 - Sep 8
Total with taxes and fees
Pear Tree Inn St. Louis Airport
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
$98 nightly
$114 total
Sep 9 - Sep 10
Total with taxes and fees
Tru By Hilton St. Louis Downtown

Hotels in Northeast Missouri with star-rating

Explore a world of travel with Expedia