Find hotels in Northeast Missouri, MO from $72
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member PricesLearn about One Key
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Northeast Missouri
Pet friendly
Apartment
Condo
Apart hotel
Cottage
Chalet
Cabin
Family friendly
Waterpark
Check prices for these dates
Tonight
Aug 29 - Aug 30Tomorrow
Aug 30 - Aug 31Next weekend
Sep 4 - Sep 6In two weeks
Sep 11 - Sep 13Our top choices for Northeast Missouri hotels
1. FairBridge Inn Express, Monroe City
FairBridge Inn Express, Monroe CityMonroe City
Darrin J.
$85 nightly
$92 total
Sep 13 - Sep 14
Total with taxes and fees
2. Super 8 by Wyndham Macon
Super 8 by Wyndham MaconMacon
Austin
$82 nightly
$89 total
Aug 30 - Aug 31
Total with taxes and fees
3. Americas Best Value Inn & Suites Macon at Sunset Dr
Americas Best Value Inn & Suites Macon at Sunset DrMacon
Mary
$63 nightly
$67 total
Sep 13 - Sep 14
Total with taxes and fees
4. Travelier Motel
Travelier MotelMacon
Jessica
$73 nightly
$79 total
Aug 31 - Sep 1
Total with taxes and fees
5. Prairie View Inn
Prairie View InnShelbina
Randy
$85 nightly
$93 total
Aug 30 - Aug 31
Total with taxes and fees
6. Lost Branch Lodge. Complete exterior remodel, spring 2026!
Lost Branch Lodge. Complete exterior remodel, spring 2026!Brashear
Melissa W.
Vacation Rentals in Northeast Missouri
Cabin
Cannon Dam Cabins
Cannon Dam CabinsPerry
"Cozy and well equipped with everything we may have needed"
Apartment
White House at Grand Central
White House at Grand CentralGrand Center
"Staff was great and accommodating to my needs."
Cottage
Peaceful Missouri Cabin Rental on 55 Acres!
Peaceful Missouri Cabin Rental on 55 Acres!Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Apartment
Landing Furnished Apartments - Central West End
Landing Furnished Apartments - Central West EndCentral West End
"We booked a two bedroom for three people and the 2nd bedroom didn't have a bed! Contacted property, which was very responsive, but they couldn't do anything since we booked through Hotels. com"
Apartment
Botanical Bliss | JZ Vacation Rentals
Botanical Bliss | JZ Vacation RentalsSouthwest Garden
Apartment
Spacious 3-Bedroom with King Bed
Spacious 3-Bedroom with King BedCentral West End
"Clean room nice area "
Cottage
Updated Missouri Cabin Rental on Large Farm
Updated Missouri Cabin Rental on Large FarmCanton
"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."
Vacation Home
Wine Country Getaway | JZ Vacation Rentals
Wine Country Getaway | JZ Vacation RentalsWashington
"Great communication, had a couple of leaks and shower flooded but the maintenance came right away to fix it. Overall clean, AC/Heat unit in each room, big kitchen, wonderful sitting area and decor."
Cottage
Close to Vineyards: Updated New Haven Retreat!
Close to Vineyards: Updated New Haven Retreat!New Haven
"Very clean and relaxing environment!! "
Apartment
Charming Berger Apt on 42-acre Farm w/ Pool Access
Charming Berger Apt on 42-acre Farm w/ Pool AccessBerger
Cottage
Walk to Tower Grove Park: St Louis Getaway
Walk to Tower Grove Park: St Louis GetawayTower Grove South
Apartment
Walk to Carondelet Park: Quiet Couple's Getaway
Walk to Carondelet Park: Quiet Couple's GetawayCarondelet
"We had a nice stay, close to things we wanted to do"
Apartment
The Merlot Bungalow Defiance Tiny Home on Trail
The Merlot Bungalow Defiance Tiny Home on TrailDefiance
"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"
Apartment
New Melle Apartment Near Missouri Wine Country
New Melle Apartment Near Missouri Wine CountryWentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Northeast Missouri attractions
Photo by Carl Guttovz
Busch Stadium
9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Photo by Jeff White
St. Louis Zoo
9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Dome at America’s Center
8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.
Forest Park
9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
St. Louis University
8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
City Museum
9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
America's Center Convention Complex
8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
Learn more about Northeast Missouri
Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.
See all hotels in Northeast Missouri
Top Northeast Missouri Hotel Reviews
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
8/10 Good
"Clean, great location and staff was very nice."
Pear Tree Inn St. Louis Near Union Station
10/10 Excellent
"perfect!"
Live by Loews - St.Louis
8/10 Good
"Close proximity to Busch stadium."
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
10/10 Excellent
"Great staff, super friendly, loved the waitress at the resturant."
The Royal Sonesta Chase Park Plaza St. Louis
10/10 Excellent
"Always try to stay at CPP when in St. Louis. Familiar, great location, quiet, easy in/out."
Courtyard by Marriott St. Louis Downtown/Convention Center
10/10 Excellent
"Great location and friendly, helpful staff"
Pear Tree Inn St. Louis Airport
10/10 Excellent
"This property was very clean, staff was very kind and friendly. The continental breakfast was definitely better than most and they have a shuttle to and from the airport that runs 24 hours a day every 20 minutes that is free for guests. Will definitely stay here again."
Hilton St. Louis at the Ballpark
8/10 Good
"Our room was over $300 a night and it had paint chipping everywhere and needed repairs. It was clean just out of date."
Forest Park Hotel by MDR
8/10 Good
"Free parking, clean big room, with microwave and fridge and affordable."
More cheap stays in Northeast Missouri
Motel 6 Hazelwood, MO
5781 Campus Ct Hazelwood MO
$60 nightly
$73 total
Sep 10 - Sep 11
Total with taxes and fees
8.4/10 Very Good! (2,182 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
1970 Craig Rd Maryland Heights MO
$68 nightly
$79 total
Sep 1 - Sep 2
Total with taxes and fees
Best Western St. Louis Inn
6224 Heimos Industrial Park Dr St. Louis MO
$75 nightly
$86 total
Sep 17 - Sep 18
Total with taxes and fees
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
$90 nightly
$104 total
Sep 3 - Sep 4
Total with taxes and fees
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$89 nightly
$104 total
Sep 10 - Sep 11
Total with taxes and fees
9.2/10 Wonderful! (3,206 reviews)
Tru By Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
$98 nightly
$114 total
Sep 6 - Sep 7
Total with taxes and fees
Hotels in Northeast Missouri with star-rating
5 Star Hotels
1 properties
4 Star Hotels
54 properties
3 Star Hotels
186 properties
2 Star Hotels
207 properties
Explore a world of travel with Expedia
- Hotels near Mark Twain State Park
- B&B in Edina
- Hurdland Hotels
- Maywood Hotels
- Palmyra Hotels
- Clarence Hotels
- Hunnewell Hotels
- Cabin Rentals in Knox County
- Cabin Rentals in Shelby County
- Apartments in Shelby County
- B&B in Shelby County
- La Plata Hotels
- Cottages in Shelbyville
- La Quinta Inn & Suites Hotels in Northeast Missouri
- Drury Inn & Suites Hotels in Northeast Missouri
- Family Hotels in Northeast Missouri
- Cheap Hotels in Northeast Missouri
- Lewistown Hotels
- Pet-Friendly Hotels in Northeast Missouri
- Adults Only Resorts & in Northeast Missouri
- Cabin Rentals in Ewing
- Macon Hotels
- 2 Star Hotels in Hunnewell
- Luxury Hotels in Northeast Missouri
- Motels in Bethel
- Cabin Rentals in Edina
- Shelbina Hotels
- Moberly Hotels
- Hotels near La Plata Station
- Monroe City Hotels
- Waterpark Hotels in Northeast Missouri
- Motels in Hunnewell
- Motels in Clarence
- Atlanta Hotels
- Lentner Hotels
- B&B in Northeast Missouri
- 3 Star Hotels in Ewing
- Apartments in Edina
- Excello Hotels
- Cabin Rentals in Knox City
- B&B in Hunnewell
- Cabin Rentals in La Belle
- Cabin Rentals in Northeast Missouri
- Hotels near Long Branch State Park
- Rutledge Hotels
- Paris Hotels
- Bevier Hotels
- Holliday Hotels
- Gay friendly Hotels in Northeast Missouri
- Kirksville Hotels
- Cabin Rentals in Hunnewell
- Hotels with an Indoor Pool in Northeast Missouri
- Farmstay in Shelby County
- Motels in Northeast Missouri
- Cottages in Clarence
- Canton Hotels
- Edina Hotels
- Bethel Hotels
- Historic Hotels in Northeast Missouri
- Motels in Shelbyville
- Farmstay in Ewing
- Shelbyville Hotels
- Hotels with a Pool in Edina
- Hotels & Resorts for Couples in Northeast Missouri
- Motels in Shelbina
- Cabin Rentals in Clarence
- Cabin Rentals in Bethel
- Monticello Hotels
- Casino Hotels in Northeast Missouri
- Hannibal Hotels
- Stoutsville Hotels
- 3 Star Hotels in La Belle
- Resorts in Northeast Missouri
- Hotels near Jackson Street Park
- Ski Vacation Packages Northeast Missouri
- Visit Lentner
- Romantic Vacation Packages Northeast Missouri
- All inclusive Vacation Packages Northeast Missouri
- Pet-Friendly Vacation Packages Northeast Missouri
- Visit La Plata
- Fishing Vacation Packages Northeast Missouri
- Cheap Vacation Packages Northeast Missouri
- Yoga Vacation Packages Northeast Missouri
- Where to stay in Northeast Missouri
- Visit Shelbina
