Title: Top 10 Hotels in Northeast Missouri from $66 - Competitive Prices | Expedia.com

[Northeast Missouri Travel Guide](https://expedia.com/Northeast-Missouri.dx6058818)[Vacation Rentals in Northeast Missouri](https://expedia.com/Northeast-Missouri-Vacation-Rentals.d6058818.Travel-Guide-VacationRentals)[Flights to Northeast Missouri](https://expedia.com/Cheap-Flights-To-Northeast-Missouri.d6058818.Travel-Guide-Flights)[Things to do in Northeast Missouri](https://expedia.com/Things-To-Do-In-Northeast-Missouri.d6058818.Travel-Guide-Activities)[Car Rentals in Northeast Missouri](https://expedia.com/Car-Rentals-In-Northeast-Missouri.d6058818.Car-Rental-Guide)[Northeast Missouri Vacation Packages](https://expedia.com/Northeast-Missouri.d6058818.Destination-Travel-Guides)

![Grant\'s Farm which includes heritage architecture](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in Northeast Missouri

Pet-friendly

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&amenities=PETS)

Spa

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&amenities=SPA_ON_SITE)

Pool

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&amenities=POOL)

Hot tub

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&amenities=HOT_TUB)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=CABIN)

Great for families

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&travelerType=family_friendly)

Apart hotel

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=APART_HOTEL)

Farm

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=AGRITOURISM)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=COTTAGE)

Apart­ment

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=APARTMENT)

Condo

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=CONDO)

Chalet

[](https://www.expedia.com/Hotel-Search?destination=Northeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058818&latLong=39.356223%2C-91.587801&adults=2&startDate=2026-02-26&d1=2026-02-26&endDate=2026-02-28&d2=2026-02-28&lodging=CHALET)

## Check prices for these dates

Tonight

[Feb 12 - Feb 13](https://www.expedia.com/Hotel-Search?regionId=6058818&startDate=2026-02-12&endDate=2026-02-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 13 - Feb 14](https://www.expedia.com/Hotel-Search?regionId=6058818&startDate=2026-02-13&endDate=2026-02-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=6058818&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=6058818&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Northeast Missouri hotels

![Club Suite, 1 King Bed, Hot Tub | Private spa tub](https://images.trvl-media.com/lodging/2000000/1170000/1161500/1161498/867338f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Traditional Room, 2 Double Beds, Non Smoking | Pillowtop beds, blackout drapes, iron/ironing board, cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1170000/1161500/1161498/8d3ce986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/2000000/1170000/1161500/1161498/a9bed2f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1170000/1161500/1161498/90bd94d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pinemark Inn & Suites

[](https://www.expedia.com/St-Clair-Hotels-Pinemark-Inn-Suites.h1161498.Hotel-Information)

St. Clair

9.6/10

Exceptional

(1,000 reviews)

"The room is always spotless and the staff is always very friendly. The heat lamp in the bathroom is one of y favorite features. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sydney

$115 nightly

$126 total

Feb 13 - Feb 14

Total with taxes and fees

[](https://www.expedia.com/St-Clair-Hotels-Pinemark-Inn-Suites.h1161498.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/6c9e28fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/1817d317.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/0bdc571d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pillowtop beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/44eec777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Depot Inn and Suites

[](https://www.expedia.com/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information)

La Plata

9.8/10

Exceptional

(629 reviews)

"A very pleasant surprise, wonderful decor."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

$77 nightly

$83 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/ff1a33b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/8d84cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/6adb4ce9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/9a9e921d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Washington

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information)

Washington

8.4/10

Very Good

(706 reviews)

"The staff was extremely nice & accommodating."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brenda

$85 nightly

$96 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information)

![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/d6669a71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/ba8e13b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, seasonal outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/74fd9989.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/721fce3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western On The River

[](https://www.expedia.com/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information)

Hannibal

8.6/10

Excellent

(1,001 reviews)

"Everything was great. Will definitely stay again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ethan

$65 nightly

$74 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/863ee254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/f01081f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed with Sofa bed | Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/5a40455a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/5c0eb04d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn & Suites Hannibal West

[](https://www.expedia.com/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information)

Hannibal

9.6/10

Exceptional

(1,002 reviews)

"Desk staff very nice, clean room, very nice facility!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Peg

$98 nightly

$114 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/4e0fe2c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/12a7ffe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/73b1969e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/7d037912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn & Suites Hannibal West

[](https://www.expedia.com/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information)

Hannibal

8.0/10

Very Good

(1,007 reviews)

"Good breakfast selections. Close to a good restaurant. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steve

$68 nightly

$79 total

Feb 19 - Feb 20

Total with taxes and fees

[](https://www.expedia.com/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information)

![Free daily English breakfast](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/d4056513.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/8a16fcd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite, 1 King Bed with Sofa bed, Kitchenette | Living area | 55-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/737d5070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/4fe3b63f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Heritage Hotel Quincy

[](https://www.expedia.com/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information)

Quincy

8.8/10

Excellent

(299 reviews)

"Great hotel clean and quiet "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Danielle

$71 nightly

$81 total

Feb 13 - Feb 14

Total with taxes and fees

[](https://www.expedia.com/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/50b5788d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/660bdaf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/da587b35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Wentzville St Louis West by IHG

[](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

Wentzville

9.4/10

Exceptional

(869 reviews)

"Beautiful hotel, friendly staff, good breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Erika

$122 nightly

$146 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information)

![Indoor spa tub](https://images.trvl-media.com/lodging/2000000/1150000/1145000/1144935/89328cf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pub](https://images.trvl-media.com/lodging/2000000/1150000/1145000/1144935/9342c79e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1150000/1145000/1144935/29099959.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1150000/1145000/1144935/00bdd6be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Stoney Creek Inn Quincy

[](https://www.expedia.com/Quincy-Hotels-Stoney-Creek-Inn-Quincy.h1144935.Hotel-Information)

Quincy

8.8/10

Excellent

(1,000 reviews)

"Easy check-in, clean room, great bathroom. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Donetta S

$130 nightly

$148 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Quincy-Hotels-Stoney-Creek-Inn-Quincy.h1144935.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/159a98ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/897465ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/b493e570.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites St Charles - St Louis

[](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

St. Charles

8.4/10

Very Good

(1,007 reviews)

"Great hotel for the money"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jere

$77 nightly

$89 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/08bb1016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Kirksville-University Area

[](https://www.expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

Kirksville

9.2/10

Wonderful

(168 reviews)

"Great breakfast let me check in early was very nice "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jamie

$64 nightly

$72 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/79d56802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/fbaa6227.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/25e461ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7f62e770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel St. Louis St. Charles

[](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

St. Charles

9.6/10

Exceptional

(1,000 reviews)

"Great hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John Christopher

$132 nightly

$153 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/920000/918800/918798/8e0321ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/920000/918800/918798/b09cecf0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/920000/918800/918798/cacf6eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/920000/918800/918798/8c3bb690.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Union

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Union.h918798.Hotel-Information)

Union

8.2/10

Very Good

(637 reviews)

"Good stay. Clean quiet comfortable"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frances

$79 nightly

$87 total

Feb 19 - Feb 20

Total with taxes and fees

[](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Union.h918798.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40300/40297/446f80a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40300/40297/8664016b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40300/40297/2381e843.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave | Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/50000/40300/40297/d9e74cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus The Charles Hotel

[](https://www.expedia.com/St-Louis-Hotels-Best-Western-Plus-The-Charles-Hotel.h40297.Hotel-Information)

St. Charles

8.2/10

Very Good

(1,000 reviews)

"Amazing experience great staff and nice room "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathy

$75 nightly

$87 total

Feb 16 - Feb 17

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Best-Western-Plus-The-Charles-Hotel.h40297.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ee03821d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ca22fdb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/6809d9b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/12c5eb01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton St. Charles St. Louis, MO

[](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information)

St. Charles

8.6/10

Excellent

(795 reviews)

"Clean, great breakfast options."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristy

$106 nightly

$123 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/8a5baebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/w1021h682x0y0-c9b85e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/b08ddc86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Non Smoking | Down comforters, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/7d76c669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Kirksville

[](https://www.expedia.com/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information)

Kirksville

7.6/10

Good

(396 reviews)

"The staff was friendly and provided excellent service!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Don

$72 nightly

$81 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/0b058bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/ad6cce96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/0036679a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, St. Charles Historic District

[](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

St. Charles Historic District

9.4/10

Exceptional

(1,000 reviews)

"Wonderful place staff awesome "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chad

$114 nightly

$131 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/a8acc085.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/4be7f63c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/ee47dad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Kirksville - University Area by IHG

[](https://www.expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

Kirksville

9.2/10

Wonderful

(518 reviews)

"Excellent service and stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Taylor

$110 nightly

$124 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/d446d190.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/41a6853d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/b52a585e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17400000/17395600/17395579/1d29e551.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn St. Louis Wentzville

[](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-By-Hilton-Wentzville.h17395579.Hotel-Information)

Wentzville

9.0/10

Wonderful

(657 reviews)

"Prompt service, quick check in. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily

$126 nightly

$144 total

Feb 26 - Feb 27

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-By-Hilton-Wentzville.h17395579.Hotel-Information)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/70b128db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/502ee41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/w2880h1936x0y0-34b8c827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Nightclub](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/4519749c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ameristar Casino Resort and Spa

[](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

St. Charles

8.4/10

Very Good

(1,001 reviews)

"The room was great. I enjoyed my stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Wanda

$184 nightly

$215 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-26&endDate=2026-02-27&regionId=6058818&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## 

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Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

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## Vacation Rentals in Northeast Missouri

Cabin

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111250000/111246500/111246418/4edef455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111246500/111246418/8888df33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111250000/111246500/111246418/29cf23f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111250000/111246500/111246418/2460a120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cannon Dam Cabins

[](https://www.expedia.com/Perry-Hotels-Cannon-Dam-Cabins.h111246418.Hotel-Information)

Perry

9.2/10

Wonderful

(15 reviews)

"management great, cabins very comfortable and roomy, good location"

[](https://www.expedia.com/Perry-Hotels-Cannon-Dam-Cabins.h111246418.Hotel-Information)

Apartment

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93200000/93198800/93198755/9f8814d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93200000/93198800/93198755/bd4f2df5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93200000/93198800/93198755/ade712ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93200000/93198800/93198755/e6c5f310.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lakefront Studio Guest Home on Hermann Wine Trail!

[](https://www.expedia.com/New-Haven-Hotels-Lakefront-Studio-Guest-Home-On-Hermann-Wine-Trail.h93198755.Hotel-Information)

New Haven

10/10

Exceptional

(3 reviews)

"Loved this property, very clean and well kept! Very pretty, lovely view. "

[](https://www.expedia.com/New-Haven-Hotels-Lakefront-Studio-Guest-Home-On-Hermann-Wine-Trail.h93198755.Hotel-Information)

Aparthotel

![Down comforters, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/0ce65e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jetted tub](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/c020da6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/4063c21a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite | Living area | Smart TV, streaming services](https://images.trvl-media.com/lodging/106000000/105130000/105120300/105120258/1abb1816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lighthouse Inn & Suites

[](https://www.expedia.com/Hannibal-Hotels-Lighthouse-Inn-Suites.h105120258.Hotel-Information)

Hannibal

8.8/10

Excellent

(25 reviews)

"Nice room. Matched the pictures. Exactly what we were looking for."

[](https://www.expedia.com/Hannibal-Hotels-Lighthouse-Inn-Suites.h105120258.Hotel-Information)

Apartment

![Lobby](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/f3c125ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/0920a26c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment | Living area | 42-inch Smart TV with digital channels, TV, Netflix](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/4a627d76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/0bbeb61f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  White House at Grand Central

[](https://www.expedia.com/St-Louis-Hotels-Grand-Center-Apartments.h83121050.Hotel-Information)

Grand Center

8.4/10

Very Good

(127 reviews)

"Very clean and very friendly people "

[](https://www.expedia.com/St-Louis-Hotels-Grand-Center-Apartments.h83121050.Hotel-Information)

Aparthotel

![Comfort Loft, 2 Queen Beds, Bathtub, Garden View | Living area | 45-inch Smart TV with digital channels, books, streaming services](https://images.trvl-media.com/lodging/104000000/103390000/103386000/103385931/2e86baed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Romantic Loft, 1 King Bed, Non Smoking, Bathtub | Private kitchen | Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103390000/103386000/103385931/9b3112da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Loft, 2 Queen Beds, Bathtub, Garden View | In-room dining](https://images.trvl-media.com/lodging/104000000/103390000/103386000/103385931/b543c998.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Romantic Loft, 1 King Bed, Non Smoking, Bathtub | Living area | 45-inch Smart TV with digital channels, books, streaming services](https://images.trvl-media.com/lodging/104000000/103390000/103386000/103385931/100526dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Mercantile on the Katy Trail

[](https://www.expedia.com/Hermann-Hotels-The-Mercantile-On-The-Katy-Trail.h103385931.Hotel-Information)

Hermann

9.8/10

Exceptional

(28 reviews)

"Great place, fully stocked and clean!"

[](https://www.expedia.com/Hermann-Hotels-The-Mercantile-On-The-Katy-Trail.h103385931.Hotel-Information)

Apartment

![1 bedroom, individually decorated, individually furnished, free WiFi](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335703/bd9372e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch TV with cable channels, fireplace](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335703/c08783b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch TV with cable channels, fireplace](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335703/cac8e009.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335703/9c2868fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hidden Gem | JZ Vacation Rentals

[](https://www.expedia.com/St-Louis-Hotels-Charming-Studio-In-CWE-JZ-Vacation-Rentals.h99335703.Hotel-Information)

Central West End

8.0/10

Very Good

(1 review)

[](https://www.expedia.com/St-Louis-Hotels-Charming-Studio-In-CWE-JZ-Vacation-Rentals.h99335703.Hotel-Information)

Cottage

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93550000/93546000/93545930/5c5a75bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/94000000/93550000/93546000/93545930/4c282423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93550000/93546000/93545930/c859cadc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93550000/93546000/93545930/289ea009.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful Guest Home w/ Patio on 152-acre Farm

[](https://www.expedia.com/Berger-Hotels-Peaceful-Guest-Home-W-Patio-On-152-Acre-Farm.h93545930.Hotel-Information)

Berger

10/10

Exceptional

(2 reviews)

"Very clean,family friendly, even though it was 7 miles out of town they were very Accommodating,they came to puck us up at the train station and there's a van that will take you into town and you can take the trolley to all the wineries,shopping, we all loved our stay,i would definitely recommend to anyone who enjoys the fram life, they have lots of history, and animals, thank you Susan and Mike for all that you did to make our stay memorable, we would definitely come back. "

[](https://www.expedia.com/Berger-Hotels-Peaceful-Guest-Home-W-Patio-On-152-Acre-Farm.h93545930.Hotel-Information)

Cottage

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93210000/93203900/93203821/98d234a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93210000/93203900/93203821/bc9a2c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93210000/93203900/93203821/eed8bfcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93210000/93203900/93203821/1248965d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hillside Cabin on 43 Acres w/ Private Lake & View!

[](https://www.expedia.com/Defiance-Hotels-Hillside-Cabin-On-43-Acres-W-Private-Lake-View.h93203821.Hotel-Information)

Defiance

10/10

Exceptional

(1 review)

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

[](https://www.expedia.com/Defiance-Hotels-Hillside-Cabin-On-43-Acres-W-Private-Lake-View.h93203821.Hotel-Information)

Apartment

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/119000000/118120000/118110800/118110776/63d1798c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/119000000/118120000/118110800/118110776/cfb6d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/119000000/118120000/118110800/118110776/9e6c3e9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/119000000/118120000/118110800/118110776/2d3556bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walk to Mississippi River: Grafton Townhome!

[](https://www.expedia.com/Grafton-Hotels-Walk-To-Mississippi-River-Grafton-Townhome.h118110776.Hotel-Information)

Grafton

10/10

Exceptional

(1 review)

"The property exceeded our expectations and was perfect for our stay!"

[](https://www.expedia.com/Grafton-Hotels-Walk-To-Mississippi-River-Grafton-Townhome.h118110776.Hotel-Information)

Apartment

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537800/93537800/2bc9887f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537800/93537800/781e702f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537800/93537800/fffa75b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (0 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537800/93537800/9a29db2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lovely Couples Escape on Mississippi River!

[](https://www.expedia.com/St-Charles-Hotels-Lovely-Couples-Escape-On-Mississippi-River.h93537800.Hotel-Information)

St. Charles

10/10

Exceptional

(2 reviews)

"Amazing place to stay, quiet and relaxing would definitely stay there again"

[](https://www.expedia.com/St-Charles-Hotels-Lovely-Couples-Escape-On-Mississippi-River.h93537800.Hotel-Information)

Cottage

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537498/8d018067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537498/954630bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537498/82409c69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537498/dba34dbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Reubling House - Modern-rustic Cabin!

[](https://www.expedia.com/Defiance-Hotels-The-Reubling-House-Modern-Rustic-Cabin.h93537498.Hotel-Information)

Defiance

10/10

Exceptional

(1 review)

[](https://www.expedia.com/Defiance-Hotels-The-Reubling-House-Modern-Rustic-Cabin.h93537498.Hotel-Information)

Apartment

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537597/a36c69b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537597/c5839981.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537597/1bba0290.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537597/5b044396.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Berger Apt on 42-acre Farm w/ Pool Access

[](https://www.expedia.com/Berger-Hotels-Charming-Berger-Apt-On-42-Acre-Farm-Wpool-Access.h93537597.Hotel-Information)

Berger

10/10

Exceptional

(1 review)

[](https://www.expedia.com/Berger-Hotels-Charming-Berger-Apt-On-42-Acre-Farm-Wpool-Access.h93537597.Hotel-Information)

Cottage

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98547000/98546909/1a7ecc40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98547000/98546909/bbdaa1a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98547000/98546909/5f0525bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98547000/98546909/c7094b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Downtown Hermann Vacation Home Near Wineries!

[](https://www.expedia.com/Hermann-Hotels-Downtown-Hermann-Vacation-Home-Near-Wineries.h98546909.Hotel-Information)

Hermann

10/10

Exceptional

(1 review)

"This is a very cute little house on the end of a quiet street. It's within easy walking distance of all the shops, restaurants, wineries, distilleries, and bars between 1st Street and 5th Street. If you don't mind a longer, hillier walk you could also go further south to City Park or to Stone Hill winery. But there's also easy transportation on the Trolley or local ride services. We were happy to find there were more beds than pictured (3 queen size downstairs between 2 bedrooms, and 2 queens...

[](https://www.expedia.com/Hermann-Hotels-Downtown-Hermann-Vacation-Home-Near-Wineries.h98546909.Hotel-Information)

Apartment

![Apartment (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94540000/94537900/94537855/e81d3075.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/95000000/94540000/94537900/94537855/8e7f9af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94540000/94537900/94537855/001a7597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94540000/94537900/94537855/9a15cd1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 'the Ruebling House' Historic Defiance Apartment!

[](https://www.expedia.com/Defiance-Hotels-The-Ruebling-House-Historic-Defiance-Apartment.h94537855.Hotel-Information)

Defiance

10/10

Exceptional

(1 review)

"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."

[](https://www.expedia.com/Defiance-Hotels-The-Ruebling-House-Historic-Defiance-Apartment.h94537855.Hotel-Information)

Cottage

![House (5 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94500000/94496800/94496740/43fade66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (5 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94500000/94496800/94496740/442c326a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (5 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94500000/94496800/94496740/b3b83dfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (5 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94500000/94496800/94496740/d67a983a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

[](https://www.expedia.com/St-Louis-Hotels-Hidden-Paradise-On-5-Acres-Outdoor-Pool-Deck.h94496740.Hotel-Information)

Florissant

10/10

Exceptional

(1 review)

"Beautiful well kept secret in a very peaceful setting: we had a large family Thanksgiving week in this beautiful place. There was more than enough rooms for four families to come together and still have enough room for dining visitors. It is beyond well equipped and you should contact the owner before you bring unnecessary items. Great hot tub. Spacious and well equipped baths and showers with all personal supplies and plush towels. Beds were all amazing. There is a great playroom...

[](https://www.expedia.com/St-Louis-Hotels-Hidden-Paradise-On-5-Acres-Outdoor-Pool-Deck.h94496740.Hotel-Information)

[See all vacation rentals](https://expedia.com/Hotel-Search?startDate=2026-03-12&endDate=2026-03-15&regionId=6058818&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true)

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## Stay near popular Central United States attractions

![Busch Stadium](https://images.trvl-media.com/place/3284/670cccfc-c300-4998-a42c-96757eeed295.jpg)

Photo by Kelsey Fotovich

### Busch Stadium

4.6/5 (2,624 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502872)

![Caption---- Penguins at The St. Louis, MO Zoo](https://images.trvl-media.com/place/502878/d236ddaf-a463-4f53-858a-6c1f9c4e02c5.jpg)

### St. Louis Zoo

4.6/5 (2,379 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502878)

![Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.](https://images.trvl-media.com/place/502873/da730472-6151-40a1-b074-013a6c50d0f4.jpg)

### Enterprise Center

4.3/5 (835 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502873)

![Saint Louis is a City and Urban Center is Missouri with the Iconic Arch](https://images.trvl-media.com/place/6058090/0265bc5b-4681-44d3-90f6-25e6868a0534.jpg)

### Dome at America’s Center

4.1/5 (804 reviews)

Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and great live music. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6058090)

![Dark blue hour](https://images.trvl-media.com/place/3284/04b315ae-9f95-42cd-a17d-2221fbcbadcb.jpg)

Photo by Rayna Kinley

### City Museum

4.5/5 (2,067 reviews)

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6069375)

![Grand Basin looking from top of Art Hill in Forest Park, St. Louis, Missouri](https://images.trvl-media.com/place/6005687/6a48afd8-f12d-4336-91f1-21e5f7dcf5c4.jpg)

### Forest Park

4.6/5 (2,094 reviews)

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6005687)

![St. Louis, Missouri - 08.22.2021 - Brookings Hall on the Danforth Campus of Washington University in St. Louis.](https://images.trvl-media.com/place/502875/5ca38745-4153-4e94-ab7e-09c532468b9f.jpg)

### St. Louis University

4.4/5 (308 reviews)

Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its great live music. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=502875)

### America's Center Convention Complex

4.4/5 (256 reviews)

Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and great live music. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6170694)

## Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Union Station to Busch Stadium—explore Northeast Missouri, a family-friendly destination also known for its theaters.

[See all hotels in Northeast Missouri](https://www.expedia.com/Hotel-Search?startDate=2026-02-26&endDate=2026-02-27&adults=2&regionId=6058818)

![Grant\'s Farm which includes heritage architecture](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Northeast Missouri Hotel Reviews

![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/0bb9dbf3_y.jpg)

### Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"The room was terrific, loved the hot tub, drinks, snacks, and the Coke bar."

[](https://expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information)

![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg)

### Pear Tree Inn St. Louis Airport

10/10 Excellent

"Great experience "

[](https://expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information)

![Live by Loews - St.Louis](https://images.trvl-media.com/lodging/40000000/39170000/39161300/39161277/4c39e93f_y.jpg)

### Live by Loews - St.Louis

10/10 Excellent

"Everything was great. Very nice staff and hotel. "

[](https://expedia.com/St-Louis-Hotels-Live-By-Lowes-StLouis.h39161277.Hotel-Information)

![Embassy Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/5000000/4540000/4531500/4531472/d41360b0_y.jpg)

### Embassy Suites by Hilton St. Louis Downtown

10/10 Excellent

"Excellent stay"

[](https://expedia.com/St-Louis-Hotels-Embassy-Suites-By-Hilton-St-Louis-Downtown.h4531472.Hotel-Information)

![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg)

### Ameristar Casino Resort and Spa

10/10 Excellent

"Great job"

[](https://expedia.com/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/bfca870c_y.jpg)

### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"Lovely hotel, clean with friendly staff and a hot breakfast although limited. I really like the location. Lots of places to eat nearby or at a short walk. Highly tecommmwnd Bandanas one building over. Easy parking. "

[](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg)

### Hollywood Casino & Hotel St. Louis

10/10 Excellent

"Everything was very, very nice. The casino smoke was unfortunate, but was not noticable in the room, of course."

[](https://expedia.com/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information)

![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758_y.jpg)

### 21C Museum Hotel St Louis 

10/10 Excellent

"Everything was great i can’t wait to stay again "

[](https://expedia.com/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information)

![Marriott St. Louis Grand](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/4c313173_y.jpg)

### Marriott St. Louis Grand

10/10 Excellent

"Room was very nice. Beds super comfy. Hotel lobby provided a great space to gather with friends."

[](https://expedia.com/St-Louis-Hotels-Marriott-St-Louis-Grand.h904712.Hotel-Information)

## More cheap stays in Northeast Missouri

![Motel 6 Hazelwood, MO](https://images.trvl-media.com/lodging/1000000/10000/500/457/82f143a9_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Hazelwood, MO

5781 Campus Ct Hazelwood MO

$54 nightly

$66 total

Feb 15 - Feb 16

Total with taxes and fees

8.4/10 Very Good! (1,756 reviews)

[](https://expedia.com/St-Louis-Hotels-Motel-6-Hazelwood.h457.Hotel-Information)

![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Relax Inn Saint Charles 

3800 Harry S Truman Blvd St. Charles MO

$61 nightly

$71 total

Feb 14 - Feb 15

Total with taxes and fees

6.6/10 (1,000 reviews)

[](https://expedia.com/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information)

![Americas Best Value Inn & Suites St. Louis, St. Charles Inn](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/c17520b0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive St. Charles MO

$71 nightly

$83 total

Feb 15 - Feb 16

Total with taxes and fees

5.6/10 (1,010 reviews)

[](https://expedia.com/St-Louis-Hotels-Americas-Best-Value-Inn-Suites-St-Louis.h68132.Hotel-Information)

![Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave ](https://images.trvl-media.com/lodging/1000000/30000/24500/24411/3904d866_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

5823 Wilson Avenue St. Louis MO

$78 nightly

$91 total

Feb 16 - Feb 17

Total with taxes and fees

5.8/10 (1,001 reviews)

[](https://expedia.com/St-Louis-Hotels-Red-Roof-Inn-PLUS-St-Louis-Forest-Park-Hampton-Ave.h24411.Hotel-Information)

![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

$90 nightly

$106 total

Feb 17 - Feb 18

Total with taxes and fees

9.2/10 Wonderful! (2,812 reviews)

[](https://expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information)

![Wingate by Wyndham St. Louis Airport](https://images.trvl-media.com/lodging/1000000/20000/18200/18172/f94bc4e7_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Wingate by Wyndham St. Louis Airport

10820 Pear Tree Lane St. Ann MO

$97 nightly

$114 total

Feb 19 - Feb 20

Total with taxes and fees

9.2/10 Wonderful! (1,519 reviews)

[](https://expedia.com/St-Louis-Hotels-Wingate-By-Wyndham-St-Louis-Airport.h18172.Hotel-Information)

## Hotels in Northeast Missouri with star-rating

![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg)

5 Star Hotels

1 properties

[](https://expedia.com/5Star-Northeast-Missouri-Hotels.s50-0-d6058818.Travel-Guide-Filter-Hotels)

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

65 properties

[](https://expedia.com/4Star-Northeast-Missouri-Hotels.s40-0-d6058818.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

197 properties

[](https://expedia.com/3Star-Northeast-Missouri-Hotels.s30-0-d6058818.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

307 properties

[](https://expedia.com/2Star-Northeast-Missouri-Hotels.s20-0-d6058818.Travel-Guide-Filter-Hotels)

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