Find hotels in Northeast Missouri, MO from $76
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Go beyond your typical stay in Northeast Missouri
Pet friendly
Apartment
Condo
Cottage
Chalet
Apart hotel
Cabin
Family friendly
Waterpark
Check prices for these dates
Tonight
Sep 18 - Sep 19Tomorrow
Sep 19 - Sep 20This weekend
Sep 18 - Sep 20Next weekend
Sep 25 - Sep 27Our top choices for Northeast Missouri hotels
1. FairBridge Inn Express, Monroe City
FairBridge Inn Express, Monroe CityMonroe City
Lona
$86 nightly
$93 total
Sep 19 - Sep 20
Total with taxes and fees
2. Super 8 by Wyndham Macon
Super 8 by Wyndham MaconMacon
Austin
$88 nightly
$96 total
Sep 27 - Sep 28
Total with taxes and fees
3. Americas Best Value Inn & Suites Macon at Sunset Dr
Americas Best Value Inn & Suites Macon at Sunset DrMacon
William
$72 nightly
$77 total
Oct 3 - Oct 4
Total with taxes and fees
4. Travelier Motel
Travelier MotelMacon
Jessica
$77 nightly
$83 total
Oct 1 - Oct 2
Total with taxes and fees
5. Prairie View Inn
Prairie View InnShelbina
Randy
$102 nightly
$112 total
Sep 19 - Sep 20
Total with taxes and fees
6. Lost Branch Lodge. Complete exterior remodel, spring 2026!
Lost Branch Lodge. Complete exterior remodel, spring 2026!Brashear
Shadi H.
Vacation Rentals in Northeast Missouri
Cabin
Cannon Dam Cabins
Cannon Dam CabinsPerry
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
Vacation Home
Remodeled and Inviting Free EV
Remodeled and Inviting Free EVFenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Aparthotel
Lighthouse Inn & Suites
Lighthouse Inn & SuitesHannibal
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
Apartment
White House at Grand Central
White House at Grand CentralGrand Center
"Staff was great and accommodating to my needs."
Cottage
Peaceful Missouri Cabin Rental on 55 Acres!
Peaceful Missouri Cabin Rental on 55 Acres!Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Apartment
Spacious 3-Bedroom with King Bed
Spacious 3-Bedroom with King BedCentral West End
"Clean room nice area "
Cottage
Updated Missouri Cabin Rental on Large Farm
Updated Missouri Cabin Rental on Large FarmCanton
"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."
Apartment
Lovely Couples Escape on Mississippi River!
Lovely Couples Escape on Mississippi River!St. Charles
"Amazing place to stay, quiet and relaxing would definitely stay there again"
Cottage
Walk to Tower Grove Park: St Louis Getaway
Walk to Tower Grove Park: St Louis GetawayTower Grove South
"great place and nice location"
Apartment
Walk to Carondelet Park: Quiet Couple's Getaway
Walk to Carondelet Park: Quiet Couple's GetawayCarondelet
"We had a nice stay, close to things we wanted to do"
Cottage
Spacious Ozarks Family Home - Private Pool & Grill
Spacious Ozarks Family Home - Private Pool & GrillBourbon
"It's perfect 100% recommended."
Vacation Home
Wine Country Getaway | JZ Vacation Rentals
Wine Country Getaway | JZ Vacation RentalsWashington
"Great communication, had a couple of leaks and shower flooded but the maintenance came right away to fix it. Overall clean, AC/Heat unit in each room, big kitchen, wonderful sitting area and decor."
Apartment
'the Ruebling House' Historic Defiance Apartment!
'the Ruebling House' Historic Defiance Apartment!Defiance
"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."
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Stay near popular Northeast Missouri attractions
Photo by Jeff White
St. Louis Zoo
9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Photo by Carl Guttovz
Busch Stadium
9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Dome at America’s Center
8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
St. Louis University
8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.
Forest Park
9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
City Museum
9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
America's Center Convention Complex
8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
Learn more about Northeast Missouri
Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.
See all hotels in Northeast Missouri
Photo by Andrew Hershfeld
Top Northeast Missouri Hotel Reviews
Clayton Plaza Hotel & Extended Stay
10/10 Excellent
"This is our go-to place when we're in the St. Louis area. Everyone is extremely nice, everything is very clean and maintained well, and our stay overall couldn't be better!"
Drury Inn & Suites St. Louis Airport
10/10 Excellent
"clean hotel"
Live by Loews - St.Louis
10/10 Excellent
"very enjoyable stay! If you are an older couple, I would recommend getting the valet parking & pay the extra $10 rather than walking to the parking garage, getting your vehicle & driving it around to the loading area. The valet parking gentlemen were very nice & helped us even though we did not order valet parking. Loved the location and the convenience being close to Busch stadium! it was nice being able to walk out of the front of the hotel & across the street into the stadium since I use a walker to walk. hotel staff were all very pleasant & helpful!"
Pear Tree Inn St. Louis Near Union Station
10/10 Excellent
"Great location, breakfast and parking included. Perfect for motorcycle riders."
Hollywood Casino & Hotel St. Louis
8/10 Good
"Convenient location near St Charles and we preferred gambling at the Hollywood Casino. Room linens and bedding was clean. Mattress was okay, pillows very nice, enough towels for the first night, but floors were dirty in the room and corners could be mopped. The toilet was running and we reported to the front desk. Refrigerator had a build up of ice so we defrosted it on day one and were able to use it for our drinks and leftovers on day two. I felt very safe there and even went outside to walk in the middle of the night for some fresh air. Staff is friendly and helpful. I liked the variety of restaurants and the coffee shop right there next to the casino. I would stay there again."
Sonesta ES Suites St. Louis - Chesterfield
8/10 Good
"Big room with full kitchen"
The Cheshire
8/10 Good
"Charming and quaint alternative to a Holiday Inn. It was renovated 10-15 years ago but not much care since then. The pool was allegedly open still (mid September) but when we looked out to go use it, there was debris in it and it wasn’t very inviting. The price was affordable and it was pet friendly, I only wish we could have experienced it during its heyday years ago when it was properly maintained and cleaned."
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
10/10 Excellent
"We will stay here again. Good bkfst, convenient. Nice pool & spa."
Courtyard by Marriott St. Louis Downtown/Convention Center
8/10 Good
"Decent hotel. Friendly staff. Not much for their snack area, but you're near many restaurants."
More cheap stays in Northeast Missouri
Motel 6 Hazelwood, MO
5781 Campus Ct Hazelwood MO
$62 nightly
$76 total
Sep 21 - Sep 22
Total with taxes and fees
Best Western St. Louis Inn
6224 Heimos Industrial Park Dr St. Louis MO
$76 nightly
$87 total
Sep 22 - Sep 23
Total with taxes and fees
8.4/10 Very Good! (1,142 reviews)
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive O'Fallon MO
$82 nightly
$97 total
Oct 11 - Oct 12
Total with taxes and fees
9/10 Wonderful! (1,126 reviews)
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
$90 nightly
$104 total
Sep 23 - Sep 24
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Sep 27 - Sep 28
Total with taxes and fees
Tru By Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
$98 nightly
$114 total
Sep 27 - Sep 28
Total with taxes and fees
Hotels in Northeast Missouri with star-rating
5 Star Hotels
1 properties
4 Star Hotels
54 properties
3 Star Hotels
175 properties
2 Star Hotels
186 properties
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