A large eye sculpture in a park surrounded by trees.

Find hotels in Northeast Missouri, MO from $72

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Our top choices for Northeast Missouri hotels

Hotel
Cabin
Breakfast included
Pet friendly
Reserve now, pay later

1. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
Monroe City
United States
Patricia
$86 nightly
$93 total
Aug 23 - Aug 24
Total with taxes and fees
FairBridge Inn Express, Monroe City

2. Super 8 by Wyndham Macon

Super 8 by Wyndham Macon
Macon
United States
Austin
$82 nightly
$89 total
Aug 23 - Aug 24
Total with taxes and fees
Super 8 by Wyndham Macon

3. Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr
Macon
United States
William
$72 nightly
$77 total
Sep 4 - Sep 5
Total with taxes and fees
Americas Best Value Inn & Suites Macon at Sunset Dr

4. Travelier Motel

Travelier Motel
Macon
United States
Jessica
$73 nightly
$79 total
Aug 21 - Aug 22
Total with taxes and fees
Travelier Motel

5. Simple Rewards Inn Shelbina

Simple Rewards Inn Shelbina
Shelbina
United States
Randy
$85 nightly
$93 total
Aug 21 - Aug 22
Total with taxes and fees
Simple Rewards Inn Shelbina

6. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Lost Branch Lodge. Complete exterior remodel, spring 2026!
Brashear
United States
Megan K.
Lost Branch Lodge. Complete exterior remodel, spring 2026!
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Vacation Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Cannon Dam Cabins
Perry
"Cozy and well equipped with everything we may have needed"
Cannon Dam Cabins
Aparthotel

The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
Hermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
The Mercantile on the Katy Trail
Aparthotel

Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
"Wonderful place to stay!"
Lighthouse Inn & Suites
Apartment

Lakefront Studio Guest Home on Hermann Wine Trail!

Lakefront Studio Guest Home on Hermann Wine Trail!
New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Lakefront Studio Guest Home on Hermann Wine Trail!
Apartment

White House at Grand Central

White House at Grand Central
Grand Center
"Staff was great and accommodating to my needs."
White House at Grand Central
Apartment

Hidden Gem | JZ Vacation Rentals

Hidden Gem | JZ Vacation Rentals
Central West End
Hidden Gem | JZ Vacation Rentals
Apartment

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed
Central West End
"Clean room nice area "
Spacious 3-Bedroom with King Bed
Apartment

Near Wineries: Country Condo in Stony Hill

Near Wineries: Country Condo in Stony Hill
New Haven
"Clean and loved original architecture."
Near Wineries: Country Condo in Stony Hill
Apartment

Walk to Carondelet Park: Quiet Couple's Getaway

Walk to Carondelet Park: Quiet Couple's Getaway
Carondelet
"We had a nice stay, close to things we wanted to do"
Walk to Carondelet Park: Quiet Couple's Getaway
Apartment

St Louis Retreat ~ 1 Mi to Botanical Garden

St Louis Retreat ~ 1 Mi to Botanical Garden
Shaw
"great location, peaceful and beautiful home!"
St Louis Retreat ~ 1 Mi to Botanical Garden
Apartment

New Melle Apartment Near Missouri Wine Country

New Melle Apartment Near Missouri Wine Country
Wentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
New Melle Apartment Near Missouri Wine Country
Cottage

Home 2 Mi to Dtwn St Louis: Great for Families!

Home 2 Mi to Dtwn St Louis: Great for Families!
Lafayette Square
"Clean space with so much character!"
Home 2 Mi to Dtwn St Louis: Great for Families!
Cottage

'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!

'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
Florissant
"Beautiful well kept secret in a very peaceful setting: we had a large family Thanksgiving week in this beautiful place. There was more than enough rooms for four families to come together and still have enough room for dining visitors. It is beyond well equipped and you should contact the owner before you bring unnecessary items. Great hot tub. Spacious and well equipped baths and showers with all personal supplies and plush towels. Beds were all amazing. There is a great playroom...
'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
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Stay near popular Northeast Missouri attractions

A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.
Photo by Jeff White

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.
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A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
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America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A historic log cabin with a flagpole, hay bales, and autumn pumpkins.

Top Northeast Missouri Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Love this place. Will be back"
Pavirat 1-night trip
Posted less than an hour ago
Clayton Plaza Hotel & Extended Stay
River City Casino & Hotel

River City Casino & Hotel

10/10 Excellent
"Great room and friendly staff! Some of the restaurants have strange hours but enjoy having options on site!"
Kaitlyn 2-night trip
Posted 11 hours ago
River City Casino & Hotel
Moonrise Hotel

Moonrise Hotel

10/10 Excellent
"Beautiful hotel and great location! Walkable and safe area with a lot to do. Our bartender at the hotel (Ryan) made us feel welcomed, great drinks, and had great recommendations as well. Highly recommend!"
Lindsay 1-night trip
Posted 19 hours ago
Moonrise Hotel
Marriott St. Louis Grand

Marriott St. Louis Grand

10/10 Excellent
"This hotel was very nice and the service was outstanding. Biggest negative was that they charge you for your everything. SHAME ON YOU EXPEDIA"
Deborah 1-night trip
Posted 2 days ago
Marriott St. Louis Grand
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

8/10 Good
"Clean room, staff was great- parking was expensive!"
Peter 1-night trip
Posted 2 days ago
Home2 Suites by Hilton St. Louis Downtown

More cheap stays in Northeast Missouri

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

5781 Campus Ct Hazelwood MO
$59 nightly
$72 total
Sep 1 - Sep 2
Total with taxes and fees
8.4/10 Very Good! (2,166 reviews)
Motel 6 Hazelwood, MO
Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO
$68 nightly
$78 total
Aug 30 - Aug 31
Total with taxes and fees
Best Western St. Louis Inn
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
$68 nightly
$79 total
Aug 23 - Aug 24
Total with taxes and fees
4.4/10 (1,004 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

1201 Drury Ln Arnold MO
$90 nightly
$104 total
Aug 25 - Aug 26
Total with taxes and fees
9.4/10 Exceptional! (1,006 reviews)
Pear Tree Inn St. Louis Arnold
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
$89 nightly
$105 total
Aug 30 - Aug 31
Total with taxes and fees
7.8/10 Good! (934 reviews)
Tru By Hilton St. Louis Downtown
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Aug 25 - Aug 26
Total with taxes and fees
Pear Tree Inn St. Louis Airport

Hotels in Northeast Missouri with star-rating

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