Find hotels in Northeast Missouri, MO from $71
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member PricesLearn about One Key
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Northeast Missouri
Pet friendly
Villa
Apartment
Apart hotel
Condo
Cottage
Chalet
Family friendly
Check prices for these dates
Tonight
Aug 10 - Aug 11Tomorrow
Aug 11 - Aug 12This weekend
Aug 14 - Aug 16Next weekend
Aug 21 - Aug 23Our top choices for Northeast Missouri hotels
1. FairBridge Inn Express, Monroe City
FairBridge Inn Express, Monroe CityMonroe City
Patricia
$83 nightly
$91 total
Sep 3 - Sep 4
Total with taxes and fees
2. Super 8 by Wyndham Macon
Super 8 by Wyndham MaconMacon
KARL
$87 nightly
$95 total
Sep 5 - Sep 6
Total with taxes and fees
3. Americas Best Value Inn & Suites Macon at Sunset Dr
Americas Best Value Inn & Suites Macon at Sunset DrMacon
William
$68 nightly
$73 total
Aug 25 - Aug 26
Total with taxes and fees
4. Travelier Motel
Travelier MotelMacon
Jessica
$73 nightly
$79 total
Aug 11 - Aug 12
Total with taxes and fees
5. Simple Rewards Inn Shelbina
Simple Rewards Inn ShelbinaShelbina
Jason
$83 nightly
$91 total
Aug 17 - Aug 18
Total with taxes and fees
6. Lost Branch Lodge. Complete exterior remodel, spring 2026!
Lost Branch Lodge. Complete exterior remodel, spring 2026!Brashear
Megan K.
Vacation Rentals in Northeast Missouri
Cabin
Cannon Dam Cabins
Cannon Dam CabinsPerry
"Cozy and well equipped with everything we may have needed"
Aparthotel
The Mercantile on the Katy Trail
The Mercantile on the Katy TrailHermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
Apartment
White House at Grand Central
White House at Grand CentralGrand Center
"Staff was great and accommodating to my needs."
Apartment
Lakefront Studio Guest Home on Hermann Wine Trail!
Lakefront Studio Guest Home on Hermann Wine Trail!New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Vacation Home
Remodeled and Inviting Free EV
Remodeled and Inviting Free EVFenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Cottage
Spacious Owensville Getaway w/ Winery On-site!
Spacious Owensville Getaway w/ Winery On-site!Rosebud
"I don't even know where to start with this rental. We live in the country, this farmhouse was right up our alley!! I have stayed in a lot of rental properties, this one was like being at home. I could have stayed forever. The pond served as a wonderful experience for my daughter, she loves to fish and caught many fish. My husband enjoyed watching the sunrise every morning with his cup of coffee. The restaurant was in a league of it's own, the food was spectacular. The owner was VERY responsive,...
Vacation Home
Wine Country Getaway | JZ Vacation Rentals
Wine Country Getaway | JZ Vacation RentalsWashington
"Great communication, had a couple of leaks and shower flooded but the maintenance came right away to fix it. Overall clean, AC/Heat unit in each room, big kitchen, wonderful sitting area and decor."
Apartment
Charming Berger Apt on 42-acre Farm w/ Pool Access
Charming Berger Apt on 42-acre Farm w/ Pool AccessBerger
Cottage
Home w/ Trail Access on 19 Acres in Wright City!
Home w/ Trail Access on 19 Acres in Wright City!Wright City
"Great house in a beautiful setting. We enjoyed the quiet solitude and woodsy area. Very clean accommodations with every amenity available. "
Apartment
Lovely Couples Escape on Mississippi River!
Lovely Couples Escape on Mississippi River!St. Charles
"Amazing place to stay, quiet and relaxing would definitely stay there again"
Apartment
The Merlot Bungalow Defiance Tiny Home on Trail
The Merlot Bungalow Defiance Tiny Home on TrailDefiance
"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"
Cottage
Peaceful Guest Home w/ Patio on 152-acre Farm
Peaceful Guest Home w/ Patio on 152-acre FarmBerger
"Very clean,family friendly, even though it was 7 miles out of town they were very Accommodating,they came to puck us up at the train station and there's a van that will take you into town and you can take the trolley to all the wineries,shopping, we all loved our stay,i would definitely recommend to anyone who enjoys the fram life, they have lots of history, and animals, thank you Susan and Mike for all that you did to make our stay memorable, we would definitely come back. "
Apartment
New Melle Apartment Near Missouri Wine Country
New Melle Apartment Near Missouri Wine CountryWentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Northeast Missouri attractions
Photo by Carl Guttovz
Busch Stadium
9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Photo by Jeff White
St. Louis Zoo
9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Dome at America’s Center
8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
Forest Park
9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
City Museum
9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
St. Louis University
8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
America's Center Convention Complex
8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed theater scene and great live music.
Learn more about Northeast Missouri
Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.
See all hotels in Northeast Missouri
Top Northeast Missouri Hotel Reviews
Live by Loews - St.Louis
10/10 Excellent
"Loved the closest to going to a game and the hotel was very nice! Would stay here again!"
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
10/10 Excellent
"I love the hotel! The location, the interesting artwork, the rooftop bar. The colors are vibrant and fun. It feels full of life. I will go back."
Home2 Suites by Hilton St. Louis Downtown
8/10 Good
"Hotel was a bit awkward to get to because of construction nearby but the Valet service was good. The room had a full size fridge, which was very much appreciated, but the bed and pillows were very soft. Breakfast had lots of variety but quality varied from one day to the next. Overall, happy with our stay and would stay there again if in the area."
Pear Tree Inn St. Louis Near Union Station
8/10 Good
"Loved the happy hour and breakfast. Building and room need some updating. Staff friendly."
River City Casino & Hotel
10/10 Excellent
"Fantastic trip! Super clean and nice staff!"
Moonrise Hotel
10/10 Excellent
"Great staff; clean room."
The Royal Sonesta Chase Park Plaza St. Louis
10/10 Excellent
"Nice clean hotel nice weekend trip"
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
10/10 Excellent
"Great place to stay !"
Renaissance St. Louis Airport Hotel
10/10 Excellent
"It was a great stay. A little confused about the parking but it was great"
More cheap stays in Northeast Missouri
Motel 6 Hazelwood, MO
5781 Campus Ct Hazelwood MO
$58 nightly
$71 total
Sep 8 - Sep 9
Total with taxes and fees
8.4/10 Very Good! (2,149 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
1970 Craig Rd Maryland Heights MO
$68 nightly
$79 total
Aug 25 - Aug 26
Total with taxes and fees
Best Western St. Louis Inn
6224 Heimos Industrial Park Dr St. Louis MO
$75 nightly
$86 total
Aug 16 - Aug 17
Total with taxes and fees
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
$90 nightly
$104 total
Aug 16 - Aug 17
Total with taxes and fees
9.4/10 Exceptional! (1,021 reviews)
Tru By Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
$89 nightly
$105 total
Aug 18 - Aug 19
Total with taxes and fees
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Aug 17 - Aug 18
Total with taxes and fees
Hotels in Northeast Missouri with star-rating
5 Star Hotels
1 properties
4 Star Hotels
54 properties
3 Star Hotels
186 properties
2 Star Hotels
207 properties
Explore a world of travel with Expedia
- Hotels near Mark Twain State Park
- B&B in Edina
- Hurdland Hotels
- Maywood Hotels
- Palmyra Hotels
- Clarence Hotels
- Hunnewell Hotels
- Cabin Rentals in Knox County
- Cabin Rentals in Shelby County
- Apartments in Shelby County
- B&B in Shelby County
- La Plata Hotels
- Cottages in Shelbyville
- La Quinta Inn & Suites Hotels in Northeast Missouri
- Drury Inn & Suites Hotels in Northeast Missouri
- Family Hotels in Northeast Missouri
- Cheap Hotels in Northeast Missouri
- Lewistown Hotels
- Pet-Friendly Hotels in Northeast Missouri
- Adults Only Resorts & in Northeast Missouri
- Cabin Rentals in Ewing
- Macon Hotels
- 2 Star Hotels in Hunnewell
- Luxury Hotels in Northeast Missouri
- Motels in Bethel
- Cabin Rentals in Edina
- Shelbina Hotels
- Moberly Hotels
- Hotels near La Plata Station
- Monroe City Hotels
- Waterpark Hotels in Northeast Missouri
- Motels in Hunnewell
- Motels in Clarence
- Atlanta Hotels
- Lentner Hotels
- B&B in Northeast Missouri
- 3 Star Hotels in Ewing
- Apartments in Edina
- Excello Hotels
- Cabin Rentals in Knox City
- B&B in Hunnewell
- Cabin Rentals in La Belle
- Cabin Rentals in Northeast Missouri
- Hotels near Long Branch State Park
- Rutledge Hotels
- Paris Hotels
- Bevier Hotels
- Holliday Hotels
- Gay friendly Hotels in Northeast Missouri
- Kirksville Hotels
- Cabin Rentals in Hunnewell
- Hotels with an Indoor Pool in Northeast Missouri
- Farmstay in Shelby County
- Motels in Northeast Missouri
- Cottages in Clarence
- Canton Hotels
- Edina Hotels
- Bethel Hotels
- Historic Hotels in Northeast Missouri
- Motels in Shelbyville
- Farmstay in Ewing
- Shelbyville Hotels
- Hotels with a Pool in Edina
- Hotels & Resorts for Couples in Northeast Missouri
- Motels in Shelbina
- Cabin Rentals in Clarence
- Cabin Rentals in Bethel
- Monticello Hotels
- Casino Hotels in Northeast Missouri
- Hannibal Hotels
- Stoutsville Hotels
- 3 Star Hotels in La Belle
- Resorts in Northeast Missouri
- Hotels near Jackson Street Park
- Ski Vacation Packages Northeast Missouri
- Visit Lentner
- Romantic Vacation Packages Northeast Missouri
- All inclusive Vacation Packages Northeast Missouri
- Pet-Friendly Vacation Packages Northeast Missouri
- Visit La Plata
- Fishing Vacation Packages Northeast Missouri
- Cheap Vacation Packages Northeast Missouri
- Yoga Vacation Packages Northeast Missouri
- Where to stay in Northeast Missouri
- Visit Shelbina
