A large eye sculpture in a park surrounded by trees.

Find hotels in Northeast Missouri, MO from $72

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Our top choices for Northeast Missouri hotels

Cabin
Pet friendly
Hot tub
Dome at America’s Center
Breakfast included

1. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
Monroe City
United States
Patricia
$85 nightly
$92 total
Aug 23 - Aug 24
Total with taxes and fees
FairBridge Inn Express, Monroe City

2. Super 8 by Wyndham Macon

Super 8 by Wyndham Macon
Macon
United States
KARL
$88 nightly
$96 total
Aug 16 - Aug 17
Total with taxes and fees
Super 8 by Wyndham Macon

3. Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr
Macon
United States
William
$72 nightly
$77 total
Sep 1 - Sep 2
Total with taxes and fees
Americas Best Value Inn & Suites Macon at Sunset Dr

4. Travelier Motel

Travelier Motel
Macon
United States
Jessica
$73 nightly
$79 total
Aug 14 - Aug 15
Total with taxes and fees
Travelier Motel

5. Simple Rewards Inn Shelbina

Simple Rewards Inn Shelbina
Shelbina
United States
Jason
$85 nightly
$93 total
Aug 14 - Aug 15
Total with taxes and fees
Simple Rewards Inn Shelbina

6. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Lost Branch Lodge. Complete exterior remodel, spring 2026!
Brashear
United States
Megan K.
Lost Branch Lodge. Complete exterior remodel, spring 2026!
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Vacation Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Cannon Dam Cabins
Perry
"Cozy and well equipped with everything we may have needed"
Cannon Dam Cabins
Aparthotel

The Mercantile on the Katy Trail

The Mercantile on the Katy Trail
Hermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
The Mercantile on the Katy Trail
Aparthotel

Lighthouse Inn & Suites

Lighthouse Inn & Suites
Hannibal
"Wonderful place to stay!"
Lighthouse Inn & Suites
Apartment

Lakefront Studio Guest Home on Hermann Wine Trail!

Lakefront Studio Guest Home on Hermann Wine Trail!
New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Lakefront Studio Guest Home on Hermann Wine Trail!
Apartment

White House at Grand Central

White House at Grand Central
Grand Center
"Staff was great and accommodating to my needs."
White House at Grand Central
Vacation Home

Remodeled and Inviting Free EV

Remodeled and Inviting Free EV
Fenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Remodeled and Inviting Free EV
Apartment

Hidden Gem | JZ Vacation Rentals

Hidden Gem | JZ Vacation Rentals
Central West End
Hidden Gem | JZ Vacation Rentals
Cottage

Home w/ Trail Access on 19 Acres in Wright City!

Home w/ Trail Access on 19 Acres in Wright City!
Wright City
"Great house in a beautiful setting. We enjoyed the quiet solitude and woodsy area. Very clean accommodations with every amenity available. "
Home w/ Trail Access on 19 Acres in Wright City!
Apartment

Lovely Couples Escape on Mississippi River!

Lovely Couples Escape on Mississippi River!
St. Charles
"Amazing place to stay, quiet and relaxing would definitely stay there again"
Lovely Couples Escape on Mississippi River!
Cottage

Walk to Tower Grove Park: St Louis Getaway

Walk to Tower Grove Park: St Louis Getaway
Tower Grove South
"great place and nice location"
Walk to Tower Grove Park: St Louis Getaway
Apartment

The Merlot Bungalow Defiance Tiny Home on Trail

The Merlot Bungalow Defiance Tiny Home on Trail
Defiance
"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"
The Merlot Bungalow Defiance Tiny Home on Trail
Apartment

New Melle Apartment Near Missouri Wine Country

New Melle Apartment Near Missouri Wine Country
Wentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
New Melle Apartment Near Missouri Wine Country
Apartment

'the Ruebling House' Historic Defiance Apartment!

'the Ruebling House' Historic Defiance Apartment!
Defiance
"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."
'the Ruebling House' Historic Defiance Apartment!
Cottage

Home 2 Mi to Dtwn St Louis: Great for Families!

Home 2 Mi to Dtwn St Louis: Great for Families!
Lafayette Square
"Clean space with so much character!"
Home 2 Mi to Dtwn St Louis: Great for Families!
Cottage

Spacious Ozarks Family Home - Private Pool & Grill

Spacious Ozarks Family Home - Private Pool & Grill
Bourbon
"It's perfect 100% recommended."
Spacious Ozarks Family Home - Private Pool & Grill
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Stay near popular Northeast Missouri attractions

A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
Photo by Carl Guttovz

Busch Stadium

9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.
Photo by Jeff White

St. Louis Zoo

9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
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A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
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A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.
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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
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America's Center Convention Complex

8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A historic log cabin with a flagpole, hay bales, and autumn pumpkins.

Top Northeast Missouri Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Great stay overall. No complaints."
Alex 2-night trip
Posted 1 hour ago
Clayton Plaza Hotel & Extended Stay
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Clean and comfortable room. Great staff. Happy hour and breakfast were awesome!"
Brittany 1-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis Union Station
Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"Fantastic stay!"
Royce 2-night trip
Posted 2 hours ago
Live by Loews - St.Louis
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

10/10 Excellent
"It was a great location for us."
Paul 3-night trip
Posted 4 hours ago
Home2 Suites by Hilton St. Louis Downtown
Marriott St. Louis Grand

Marriott St. Louis Grand

8/10 Good
"The hotel was clean. The staff was pleasant. There isn’t much to do around the hotel. The area is a bit rundown."
Kathleen 2-night trip
Posted 4 hours ago
Marriott St. Louis Grand
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

10/10 Excellent
"Staff is amazing, incredibly nice and welcoming. Leah in the bar is a great bartender, kept everything moving even though it was incredibly busy. Only issue is the hotel has a slight musty smell. Excellent location for games. Would stay again."
Rachel 4-night trip
Posted 4 hours ago
Hilton St. Louis at the Ballpark
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

8/10 Good
"This is a classic hotel in St. Louis, we had a nice stay and good service, I would say it could use a little updating, especially in the bathrooms."
Charles 2-night trip
Posted 4 hours ago
The Royal Sonesta Chase Park Plaza St. Louis
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"This hotel is close enough to walk to a lot of activities and also offers a shuttle. Rooms are clean, staff is friendly and helpful. Have stayed here many times already and will continue to book here for future events."
Chrissie 1-night trip
Posted 6 hours ago
Pear Tree Inn St. Louis Near Union Station

More cheap stays in Northeast Missouri

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

5781 Campus Ct Hazelwood MO
$59 nightly
$72 total
Sep 1 - Sep 2
Total with taxes and fees
8.4/10 Very Good! (2,155 reviews)
Motel 6 Hazelwood, MO
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
$67 nightly
$77 total
Sep 3 - Sep 4
Total with taxes and fees
4.4/10 (1,000 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO
$68 nightly
$78 total
Aug 30 - Aug 31
Total with taxes and fees
Best Western St. Louis Inn
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

1201 Drury Ln Arnold MO
$88 nightly
$102 total
Sep 6 - Sep 7
Total with taxes and fees
Pear Tree Inn St. Louis Arnold
Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO
$89 nightly
$105 total
Aug 23 - Aug 24
Total with taxes and fees
Tru By Hilton St. Louis Downtown
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Aug 19 - Aug 20
Total with taxes and fees
Pear Tree Inn St. Louis Airport

Hotels in Northeast Missouri with star-rating

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