Find hotels in Northeast Missouri, MO from $72
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member PricesLearn about One Key
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Northeast Missouri
Pet friendly
Cabin
Apartment
Condo
Apart hotel
Cottage
Chalet
Family friendly
Waterpark
Check prices for these dates
Tonight
Aug 20 - Aug 21Tomorrow
Aug 21 - Aug 22This weekend
Aug 21 - Aug 23Next weekend
Aug 28 - Aug 30Our top choices for Northeast Missouri hotels
1. FairBridge Inn Express, Monroe City
FairBridge Inn Express, Monroe CityMonroe City
Patricia
$86 nightly
$93 total
Aug 23 - Aug 24
Total with taxes and fees
2. Super 8 by Wyndham Macon
Super 8 by Wyndham MaconMacon
Austin
$82 nightly
$89 total
Aug 23 - Aug 24
Total with taxes and fees
3. Americas Best Value Inn & Suites Macon at Sunset Dr
Americas Best Value Inn & Suites Macon at Sunset DrMacon
William
$72 nightly
$77 total
Sep 4 - Sep 5
Total with taxes and fees
4. Travelier Motel
Travelier MotelMacon
Jessica
$73 nightly
$79 total
Aug 21 - Aug 22
Total with taxes and fees
5. Simple Rewards Inn Shelbina
Simple Rewards Inn ShelbinaShelbina
Randy
$85 nightly
$93 total
Aug 21 - Aug 22
Total with taxes and fees
6. Lost Branch Lodge. Complete exterior remodel, spring 2026!
Lost Branch Lodge. Complete exterior remodel, spring 2026!Brashear
Megan K.
Vacation Rentals in Northeast Missouri
Cabin
Cannon Dam Cabins
Cannon Dam CabinsPerry
"Cozy and well equipped with everything we may have needed"
Aparthotel
The Mercantile on the Katy Trail
The Mercantile on the Katy TrailHermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
Apartment
Lakefront Studio Guest Home on Hermann Wine Trail!
Lakefront Studio Guest Home on Hermann Wine Trail!New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Apartment
White House at Grand Central
White House at Grand CentralGrand Center
"Staff was great and accommodating to my needs."
Apartment
Spacious 3-Bedroom with King Bed
Spacious 3-Bedroom with King BedCentral West End
"Clean room nice area "
Apartment
Near Wineries: Country Condo in Stony Hill
Near Wineries: Country Condo in Stony HillNew Haven
"Clean and loved original architecture."
Apartment
Walk to Carondelet Park: Quiet Couple's Getaway
Walk to Carondelet Park: Quiet Couple's GetawayCarondelet
"We had a nice stay, close to things we wanted to do"
Apartment
St Louis Retreat ~ 1 Mi to Botanical Garden
St Louis Retreat ~ 1 Mi to Botanical GardenShaw
"great location, peaceful and beautiful home!"
Apartment
New Melle Apartment Near Missouri Wine Country
New Melle Apartment Near Missouri Wine CountryWentzville
"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...
Cottage
Home 2 Mi to Dtwn St Louis: Great for Families!
Home 2 Mi to Dtwn St Louis: Great for Families!Lafayette Square
"Clean space with so much character!"
Cottage
'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
'hidden Paradise' on 5 Acres w/ Hot Tub & Deck!Florissant
"Beautiful well kept secret in a very peaceful setting: we had a large family Thanksgiving week in this beautiful place. There was more than enough rooms for four families to come together and still have enough room for dining visitors. It is beyond well equipped and you should contact the owner before you bring unnecessary items. Great hot tub. Spacious and well equipped baths and showers with all personal supplies and plush towels. Beds were all amazing. There is a great playroom...
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Northeast Missouri attractions
Photo by Carl Guttovz
Busch Stadium
9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Photo by Jeff White
St. Louis Zoo
9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Dome at America’s Center
8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's great live music and fascinating museums.
Forest Park
9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
City Museum
9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
St. Louis University
8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its fascinating museums.
America's Center Convention Complex
8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
Learn more about Northeast Missouri
Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.
See all hotels in Northeast Missouri
Top Northeast Missouri Hotel Reviews
Clayton Plaza Hotel & Extended Stay
10/10 Excellent
"Love this place. Will be back"
River City Casino & Hotel
10/10 Excellent
"Great room and friendly staff! Some of the restaurants have strange hours but enjoy having options on site!"
Moonrise Hotel
10/10 Excellent
"Beautiful hotel and great location! Walkable and safe area with a lot to do. Our bartender at the hotel (Ryan) made us feel welcomed, great drinks, and had great recommendations as well. Highly recommend!"
Marriott St. Louis Grand
10/10 Excellent
"This hotel was very nice and the service was outstanding. Biggest negative was that they charge you for your everything. SHAME ON YOU EXPEDIA"
Home2 Suites by Hilton St. Louis Downtown
8/10 Good
"Clean room, staff was great- parking was expensive!"
More cheap stays in Northeast Missouri
Motel 6 Hazelwood, MO
5781 Campus Ct Hazelwood MO
$59 nightly
$72 total
Sep 1 - Sep 2
Total with taxes and fees
8.4/10 Very Good! (2,166 reviews)
Best Western St. Louis Inn
6224 Heimos Industrial Park Dr St. Louis MO
$68 nightly
$78 total
Aug 30 - Aug 31
Total with taxes and fees
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
1970 Craig Rd Maryland Heights MO
$68 nightly
$79 total
Aug 23 - Aug 24
Total with taxes and fees
4.4/10 (1,004 reviews)
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
$90 nightly
$104 total
Aug 25 - Aug 26
Total with taxes and fees
9.4/10 Exceptional! (1,006 reviews)
Tru By Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
$89 nightly
$105 total
Aug 30 - Aug 31
Total with taxes and fees
7.8/10 Good! (934 reviews)
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$90 nightly
$106 total
Aug 25 - Aug 26
Total with taxes and fees
Hotels in Northeast Missouri with star-rating
5 Star Hotels
1 properties
4 Star Hotels
54 properties
3 Star Hotels
186 properties
2 Star Hotels
207 properties
Explore a world of travel with Expedia
- Hotels near Mark Twain State Park
- B&B in Edina
- Hurdland Hotels
- Maywood Hotels
- Palmyra Hotels
- Clarence Hotels
- Hunnewell Hotels
- Cabin Rentals in Knox County
- Cabin Rentals in Shelby County
- Apartments in Shelby County
- B&B in Shelby County
- La Plata Hotels
- Cottages in Shelbyville
- La Quinta Inn & Suites Hotels in Northeast Missouri
- Drury Inn & Suites Hotels in Northeast Missouri
- Family Hotels in Northeast Missouri
- Cheap Hotels in Northeast Missouri
- Lewistown Hotels
- Pet-Friendly Hotels in Northeast Missouri
- Adults Only Resorts & in Northeast Missouri
- Cabin Rentals in Ewing
- Macon Hotels
- 2 Star Hotels in Hunnewell
- Luxury Hotels in Northeast Missouri
- Motels in Bethel
- Cabin Rentals in Edina
- Shelbina Hotels
- Moberly Hotels
- Hotels near La Plata Station
- Monroe City Hotels
- Waterpark Hotels in Northeast Missouri
- Motels in Hunnewell
- Motels in Clarence
- Atlanta Hotels
- Lentner Hotels
- B&B in Northeast Missouri
- 3 Star Hotels in Ewing
- Apartments in Edina
- Excello Hotels
- Cabin Rentals in Knox City
- B&B in Hunnewell
- Cabin Rentals in La Belle
- Cabin Rentals in Northeast Missouri
- Hotels near Long Branch State Park
- Rutledge Hotels
- Paris Hotels
- Bevier Hotels
- Holliday Hotels
- Gay friendly Hotels in Northeast Missouri
- Kirksville Hotels
- Cabin Rentals in Hunnewell
- Hotels with an Indoor Pool in Northeast Missouri
- Farmstay in Shelby County
- Motels in Northeast Missouri
- Cottages in Clarence
- Canton Hotels
- Edina Hotels
- Bethel Hotels
- Historic Hotels in Northeast Missouri
- Motels in Shelbyville
- Farmstay in Ewing
- Shelbyville Hotels
- Hotels with a Pool in Edina
- Hotels & Resorts for Couples in Northeast Missouri
- Motels in Shelbina
- Cabin Rentals in Clarence
- Cabin Rentals in Bethel
- Monticello Hotels
- Casino Hotels in Northeast Missouri
- Hannibal Hotels
- Stoutsville Hotels
- 3 Star Hotels in La Belle
- Resorts in Northeast Missouri
- Hotels near Jackson Street Park
- Ski Vacation Packages Northeast Missouri
- Visit Lentner
- Romantic Vacation Packages Northeast Missouri
- All inclusive Vacation Packages Northeast Missouri
- Pet-Friendly Vacation Packages Northeast Missouri
- Visit La Plata
- Fishing Vacation Packages Northeast Missouri
- Cheap Vacation Packages Northeast Missouri
- Yoga Vacation Packages Northeast Missouri
- Where to stay in Northeast Missouri
- Visit Shelbina
