Find hotels in Northeast Missouri, MO from $74
Upfront pricingOur total price for your stay includes taxes and fees
Treat yourselfSave 10% or more on over 100,000 hotels worldwide with Member PricesLearn about One Key
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Northeast Missouri
Pet friendly
Villa
Cabin
Apartment
Apart hotel
Condo
Cottage
Chalet
Family friendly
Check prices for these dates
Tonight
Sep 6 - Sep 7Tomorrow
Sep 7 - Sep 8Next weekend
Sep 11 - Sep 13In two weeks
Sep 18 - Sep 20Our top choices for Northeast Missouri hotels
1. FairBridge Inn Express, Monroe City
FairBridge Inn Express, Monroe CityMonroe City
Lona
$84 nightly
$91 total
Sep 13 - Sep 14
Total with taxes and fees
2. Super 8 by Wyndham Macon
Super 8 by Wyndham MaconMacon
Austin
$82 nightly
$89 total
Sep 13 - Sep 14
Total with taxes and fees
3. Americas Best Value Inn & Suites Macon at Sunset Dr
Americas Best Value Inn & Suites Macon at Sunset DrMacon
Mary
$71 nightly
$76 total
Oct 2 - Oct 3
Total with taxes and fees
4. Travelier Motel
Travelier MotelMacon
Jessica
$73 nightly
$79 total
Sep 7 - Sep 8
Total with taxes and fees
5. Prairie View Inn
Prairie View InnShelbina
Randy
$91 nightly
$100 total
Sep 7 - Sep 8
Total with taxes and fees
6. Lost Branch Lodge. Complete exterior remodel, spring 2026!
Lost Branch Lodge. Complete exterior remodel, spring 2026!Brashear
Melissa W.
Vacation Rentals in Northeast Missouri
Cabin
Cannon Dam Cabins
Cannon Dam CabinsPerry
"Cozy and well equipped with everything we may have needed"
Aparthotel
The Mercantile on the Katy Trail
The Mercantile on the Katy TrailHermann
"It’s an absolute must do! Such a cool little town right on the Katy Trail!"
Apartment
White House at Grand Central
White House at Grand CentralGrand Center
"Staff was great and accommodating to my needs."
Vacation Home
Remodeled and Inviting Free EV
Remodeled and Inviting Free EVFenton
"It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it"
Cottage
Peaceful Missouri Cabin Rental on 55 Acres!
Peaceful Missouri Cabin Rental on 55 Acres!Canton
"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "
Apartment
Botanical Bliss | JZ Vacation Rentals
Botanical Bliss | JZ Vacation RentalsSouthwest Garden
Apartment
Spacious 3-Bedroom with King Bed
Spacious 3-Bedroom with King BedCentral West End
"Clean room nice area "
Apartment
Landing Furnished Apartments - Central West End
Landing Furnished Apartments - Central West EndCentral West End
"We booked a two bedroom for three people and the 2nd bedroom didn't have a bed! Contacted property, which was very responsive, but they couldn't do anything since we booked through Hotels. com"
Apartment
Lakefront Studio Guest Home on Hermann Wine Trail!
Lakefront Studio Guest Home on Hermann Wine Trail!New Haven
"Loved this property, very clean and well kept! Very pretty, lovely view. "
Vacation Home
Forest Park Oasis | JZ Vacation Rentals
Forest Park Oasis | JZ Vacation RentalsKings Oak
"Great property with plenty of space. Nice sized dining room table for dinner. Beautiful family room and fire place. Nicely decorated. "
Cottage
Updated Missouri Cabin Rental on Large Farm
Updated Missouri Cabin Rental on Large FarmCanton
"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."
Cottage
Close to Vineyards: Updated New Haven Retreat!
Close to Vineyards: Updated New Haven Retreat!New Haven
"Very clean and relaxing environment!! "
Cottage
Walk to Tower Grove Park: St Louis Getaway
Walk to Tower Grove Park: St Louis GetawayTower Grove South
"great place and nice location"
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Northeast Missouri attractions
Photo by Jeff White
St. Louis Zoo
9.2/10 (4,367 reviews)
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Photo by Carl Guttovz
Busch Stadium
9.4/10 (4,850 reviews)
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Enterprise Center
8.8/10 (1,597 reviews)
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.
Dome at America’s Center
8.4/10 (1,229 reviews)
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.
Forest Park
9.2/10 (3,389 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
St. Louis University
8.6/10 (526 reviews)
Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.
City Museum
9.0/10 (3,209 reviews)
This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.
America's Center Convention Complex
8.8/10 (306 reviews)
Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.
Learn more about Northeast Missouri
Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.
See all hotels in Northeast Missouri
Top Northeast Missouri Hotel Reviews
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
10/10 Excellent
"Everyone was nice, room was clean, hotel was clean. Rooftop bar was a vibe. Great location."
Drury Inn & Suites St. Louis Airport
10/10 Excellent
"I loved my stay at the Drury! Check in was easy and the staff was friendly. Room was nice and clean. The shuttle from Lambert Airport to the hotel made it super convenient to get to since we didn't rent a car. Breakfast was good with lots of variety to choose from. Would stay again."
Clayton Plaza Hotel & Extended Stay
10/10 Excellent
"The only issue was the parking garage. One entrance was closed and you had to go around the block to park. I got a little confusing."
Forest Park Hotel by MDR
8/10 Good
"Parking was an issue"
Pear Tree Inn St. Louis Near Union Station
10/10 Excellent
"Loved staying here. It's within walking distance of the union station restaurants, the aquarium and the observation wheel. We really enjoyed the nightly social hour. Our room had everything we needed and the bed was very comfortable. The bathroom was small but stocked and in good order. The staff was extremely friendly and welcoming. We will be back if we visit STL again."
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
10/10 Excellent
"Very clean and staff was very polite and helpful"
Courtyard by Marriott St. Louis Downtown/Convention Center
10/10 Excellent
"Everything was super excellent"
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
10/10 Excellent
"."
Live by Loews - St.Louis
10/10 Excellent
"This is an amazingly clean and comfortable hotel. It is directly across from the baseball field and there is a parking garage connected to the building for $40. It is a 10min walk to the Gateway Arch and plenty of restaurants to choose from. Right downtown and if there is no game going on it is extremely quiet. Not the loud hussle and bussle of most downtown areas."
More cheap stays in Northeast Missouri
Motel 6 Hazelwood, MO
5781 Campus Ct Hazelwood MO
$74 total
per night
Oct 1 - Oct 2
8.4/10 Very Good! (2,192 reviews)
Best Western St. Louis Inn
6224 Heimos Industrial Park Dr St. Louis MO
$82 total
per night
Sep 13 - Sep 14
8.4/10 Very Good! (1,117 reviews)
Sleep Inn & Suites O'Fallon MO - Technology Drive
1147 Technology Drive O'Fallon MO
$97 total
per night
Sep 27 - Sep 28
Pear Tree Inn St. Louis Arnold
1201 Drury Ln Arnold MO
$103 total
per night
Sep 27 - Sep 28
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
$106 total
per night
Sep 13 - Sep 14
Tru By Hilton St. Louis Downtown
1221 Locus Street St. Louis MO
$114 total
per night
Sep 13 - Sep 14
Hotels in Northeast Missouri with star-rating
5 Star Hotels
1 properties
4 Star Hotels
54 properties
3 Star Hotels
175 properties
2 Star Hotels
186 properties
Explore a world of travel with Expedia
- Hotels near Mark Twain State Park
- B&B in Edina
- Hurdland Hotels
- Maywood Hotels
- Palmyra Hotels
- Clarence Hotels
- Hunnewell Hotels
- Cabin Rentals in Knox County
- Cabin Rentals in Shelby County
- Apartments in Shelby County
- B&B in Shelby County
- La Plata Hotels
- Cottages in Shelbyville
- La Quinta Inn & Suites Hotels in Northeast Missouri
- Drury Inn & Suites Hotels in Northeast Missouri
- Family Hotels in Northeast Missouri
- Cheap Hotels in Northeast Missouri
- Lewistown Hotels
- Pet-Friendly Hotels in Northeast Missouri
- Adults Only Resorts & in Northeast Missouri
- Cabin Rentals in Ewing
- Macon Hotels
- 2 Star Hotels in Hunnewell
- Luxury Hotels in Northeast Missouri
- Motels in Bethel
- Cabin Rentals in Edina
- Shelbina Hotels
- Moberly Hotels
- Hotels near La Plata Station
- Monroe City Hotels
- Waterpark Hotels in Northeast Missouri
- Motels in Hunnewell
- Motels in Clarence
- Atlanta Hotels
- Lentner Hotels
- B&B in Northeast Missouri
- 3 Star Hotels in Ewing
- Apartments in Edina
- Excello Hotels
- Cabin Rentals in Knox City
- B&B in Hunnewell
- Cabin Rentals in La Belle
- Cabin Rentals in Northeast Missouri
- Hotels near Long Branch State Park
- Rutledge Hotels
- Paris Hotels
- Bevier Hotels
- Holliday Hotels
- Gay friendly Hotels in Northeast Missouri
- Kirksville Hotels
- Cabin Rentals in Hunnewell
- Hotels with an Indoor Pool in Northeast Missouri
- Farmstay in Shelby County
- Motels in Northeast Missouri
- Cottages in Clarence
- Canton Hotels
- Edina Hotels
- Bethel Hotels
- Historic Hotels in Northeast Missouri
- Motels in Shelbyville
- Farmstay in Ewing
- Shelbyville Hotels
- Hotels with a Pool in Edina
- Hotels & Resorts for Couples in Northeast Missouri
- Motels in Shelbina
- Cabin Rentals in Clarence
- Cabin Rentals in Bethel
- Monticello Hotels
- Casino Hotels in Northeast Missouri
- Hannibal Hotels
- Stoutsville Hotels
- 3 Star Hotels in La Belle
- Resorts in Northeast Missouri
- Hotels near Jackson Street Park
- Ski Vacation Packages Northeast Missouri
- Visit Lentner
- Romantic Vacation Packages Northeast Missouri
- All inclusive Vacation Packages Northeast Missouri
- Pet-Friendly Vacation Packages Northeast Missouri
- Visit La Plata
- Fishing Vacation Packages Northeast Missouri
- Cheap Vacation Packages Northeast Missouri
- Yoga Vacation Packages Northeast Missouri
- Where to stay in Northeast Missouri
- Visit Shelbina
