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Our top choices for Northeast Missouri hotels

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

1. Depot Inn and Suites

La Plata

JERROD

$89 nightly

Nov 8 - Nov 9

Total with taxes and fees

A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

2. FairBridge Inn Express, Monroe City

Monroe City

Ron

$90 nightly

Nov 21 - Nov 22

Total with taxes and fees

A hotel room with a bed, a sofa, a desk, a chair, and a small table.

3. Super 8 by Wyndham Macon

Macon

Brian

$82 nightly

Nov 5 - Nov 6

Total with taxes and fees

A reception area with a counter, a trash bin, and a seating area with chairs.

4. Travelier Motel

Macon

Dovey

$63 nightly

Nov 7 - Nov 8

Total with taxes and fees

A compact kitchen with wooden cabinets, a coffee machine, and a dining area with metal chairs.

5. Americas Best Value Inn & Suites Macon at Sunset Dr

Macon

Brian

$72 nightly

Nov 24 - Nov 25

Total with taxes and fees

A neatly made bed with a white quilt, a dark wooden headboard, a bedside lamp, a red chair, and a wall decoration.

6. Prairie View Inn

Shelbina

Connie

$85 nightly

Dec 1 - Dec 2

Total with taxes and fees

A spacious living room with a high ceiling, wooden beams, a fireplace, and a dining area with a table and chairs.

7. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Brashear

Shadi H.

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Vacation Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

The Mercantile on the Katy Trail

Hermann

"We loved this place- very unique! Clean and great communication from hosts."

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

Spacious 3-Bedroom with King Bed

Central West End

"Had a great stay! I hosted a birthday dinner for my best friend! Everything was clean and looked great"

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

Landing Furnished Apartments - Central West End

Central West End

"Parking was behind a large mechanical gate which did not always work. Could sometimes be noisy outside in the evening due to college clientele. Had to park on the street most of the time because of gate issues."

Cottage

Peaceful Missouri Cabin Rental on Large Property

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A house with a stone staircase, a balcony, and a garden with pink flowers.

Augusta Studio at Halcyon Spa Bed & Breakfast

Augusta

"Everything was great with this place"

Apartment

A covered outdoor patio with wooden flooring, metal chairs, tables, and ceiling fans.

Studio Stay w/ Deck in Missouri Wine Country

New Haven

"It is a clean efficiency with modern amenities but with a touch of country flair! Sara is the property manager and is absolutely wonderful! Based on their availability, I would absolutely stay there again!!!!! Even if I can't stay there, I am definitely going to get some of thar great ice cream and home cooking at the restaurant in the same building!"

Apartment

A red building with a yellow door, a wooden deck, and a chair.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Cottage

A spacious room with a wooden interior, a staircase, a sofa, a table, and a cabinet.

Hillside Cabin on 43 Acres w/ Private Lake & View!

Defiance

"We had a wonderful stay. The property is beautiful and well maintained, and the cabin is cute, comfortable, and well equipped. Nick is a very courteous host. We couldn’t have hoped for a better Thanksgiving getaway!"

Apartment

A kitchen with white cabinetry, wooden countertops, a dining table with checkered chairs, and a view of greenery outside.

'the Ruebling House' Historic Defiance Apartment!

Defiance

"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

A large eye sculpture in a park surrounded by trees.

Top Northeast Missouri Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"Everything was perfect. Check in was smooth, parking is available, walking distance to union station. All in all good choice. Will definitely stay here next time I’m in St. Louis."