Find 4 Star Hotels in Otay Mesa, CA from $128
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Our top choices for Otay Mesa 4-star hotels
Hotel del Coronado, Curio Collection by Hilton
Historic Downtown Coronado
8.4 out of 10, Very Good, (1006)
"Beautiful rooms, great activities, wonderful staff "
Kyle
$389 nightly
The price is $432
Jan 6 - Jan 7, 2026
Total with taxes and fees
Hard Rock Hotel San Diego
Downtown San Diego
9.0 out of 10, Wonderful, (3148)
"Great stay"
Laurence
$210 nightly
The price is $243
Jan 1 - Jan 2, 2026
Total with taxes and fees
DoubleTree by Hilton Hotel San Diego - Mission Valley
Mission Valley
8.4 out of 10, Very Good, (1396)
"Great hotel in a great area - would definitely stay here again."
Bhupinder
$118 nightly
The price is $136
Jan 4 - Jan 5, 2026
Total with taxes and fees
Courtyard by Marriott San Diego Downtown Little Italy
Downtown San Diego
9.0 out of 10, Wonderful, (79)
"It was a nice place to stay at"
Eric
$110 nightly
The price is $128
Dec 18 - Dec 19
Total with taxes and fees
Hilton San Diego Mission Valley
Mission Valley
8.0 out of 10, Very Good, (2238)
"Excelente hotel"
Julio
$118 nightly
The price is $136
Dec 16 - Dec 17
Total with taxes and fees
Legacy Resort Hotel & Spa
Mission Valley
9.2 out of 10, Wonderful, (2957)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
Eric
$152 nightly
The price is $175
Dec 14 - Dec 15
Total with taxes and fees
Wyndham San Diego Bayside
Downtown San Diego
8.4 out of 10, Very Good, (6035)
"Always an amazing stay"
Jana
$160 nightly
The price is $186
Dec 14 - Dec 15
Total with taxes and fees
Embassy Suites by Hilton San Diego Bay Downtown
Downtown San Diego
9.0 out of 10, Wonderful, (1540)
"Clean room, friendly staff, great property. "
MIGUEL
$194 nightly
The price is $226
Dec 19 - Dec 20
Total with taxes and fees
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Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Otay Mesa.
Pendry San Diego
550 J Street San Diego CA
$300 nightly
The price is $348 total per night from Jan 4 to Jan 5
$348 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
9.2/10 Wonderful! (1,005 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Otay Mesa Hotel Reviews
Wyndham San Diego Bayside
10/10 Excellent
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