Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
SeaWorld
Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
USS Midway Museum
Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$129
per adult
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
82% of travellers recommend
Introduction Rosarito Day Tour from San Diego
$157
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$116
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$235 nightly
The price is $270 total per night from May 10 to May 11
$270 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,561 reviews)
Found everything outstanding.
Reviewed on Apr 27, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$292 nightly
The price is $339 total per night from May 2 to May 3
$339 total
May 2 - May 3
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,594 reviews)
Pool area was small and a little run down. Rooms were good beds comfortable and the staff was great! My family had a great time even though the Jacuzzi was out of commission! Location was perfect valet parking was $70 per day, which is excessive for a guest to pay!!
Reviewed on Apr 27, 2026
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
$111 nightly
The price is $129 total per night from Apr 29 to Apr 30
$129 total
Apr 29 - Apr 30
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (1,469 reviews)
Rooms were fine and decent location but there was a bar charge on my room that I did not put on my room. So not sure if I’d stay here again.
Reviewed on Apr 28, 2026
The Sofia Hotel
150 W Broadway San Diego CA
$154 nightly
The price is $178 total per night from Apr 30 to May 1
$178 total
Apr 30 - May 1
Total with taxes and fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,970 reviews)
Good location
Reviewed on Apr 28, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$236 nightly
The price is $274 total per night from May 25 to May 26
$274 total
May 25 - May 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,847 reviews)
The Manchester Hyatt always delivers as expected. They have valet and bellhop which is important to me traveling with a special needs child and I need the convenience of having some help moving all of the luggage up to the room and parking the car for us. The room was well appointed and clean. They ...
Reviewed on Apr 25, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$181 nightly
The price is $210 total per night from May 7 to May 8
$210 total
May 7 - May 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,120 reviews)
the hotel was fine and perfect for it's intended use. Soem of the balconies are "childproofed" by screwing the door closed. I'd like to see a childproof lock system installed that would then allow use of the balcnoy regardless of occupant, but that's just my bulidng inspector showing :-)
Reviewed on Apr 28, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other neighborhoods around Otay Mesa
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
4.5/5(8,598 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
4/5(78 area reviews)
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
3.5/5(53 area reviews)
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
4/5(5,069 area reviews)
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
Otay Mesa, CA
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