Title: Visit Otay Mesa: 2026 Otay Mesa, San Diego Travel Guide | Expedia.com

[Hotels in Otay Mesa](https://expedia.com/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.com/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.com/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Car Rentals in Otay Mesa](https://expedia.com/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.com/Otay-Mesa.d6263723.Destination-Travel-Guides)

# Otay Mesa, CA

## San Diego

![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

## Visit Otay Mesa

Things to do

Hotels

Where to stay

[San Diego Travel Guide](https://expedia.com/San-Diego.dx3073)

---

### Popular places to visit

![San Diego Zoo](https://images.trvl-media.com/place/502547/504b59eb-bcb1-4b86-9adb-3c97368fb431.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

[](https://expedia.com/San-Diego-Zoo-San-Diego.d502547.Vacation-Attraction)

![San Diego Convention Center](https://images.trvl-media.com/place/6125294/2fc00620-42cd-4ab5-9c91-9e9ac3371200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### San Diego Convention Center

Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.

[](https://expedia.com/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Vacation-Attraction)

![Mission Bay](https://images.trvl-media.com/place/6185904/de90e297-f912-4798-a530-b3d83f0907a3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

[](https://expedia.com/Mission-Bay-San-Diego.d6185904.Vacation-Attraction)

![Mission Beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Mission Beach

A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.

[](https://expedia.com/Mission-Beach-Central-Mission-Beach.d506109.Vacation-Attraction)

![SeaWorld](https://images.trvl-media.com/place/3073/8f017bfb-436d-498f-a4c2-881869d60b1d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### SeaWorld

Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.

[](https://expedia.com/SeaWorld-San-Diego.d502548.Vacation-Attraction)

![Balboa Park](https://images.trvl-media.com/place/507458/5c140d77-7130-49d1-ab3d-705937c3610a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Balboa Park

Culture and nature converge in this diverse park located in the heart of the city.

[](https://expedia.com/Balboa-Park-San-Diego.d507458.Vacation-Attraction)

### Things to do

![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/1385617/29d09da0-b871-4eb6-b122-9bf92b9782b7.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Crossing Borders: Tijuana Day Trip from San Diego

$93

per adult

**82%** of travellers recommend

[](https://expedia.com/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a1385617.activity-details)

![ Stand up Paddle Board Lesson on The San Diego Bay ](https://mediaim.expedia.com/localexpert/1246891/0e157c0d-bd34-474b-a551-bd80f218d871.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Stand up Paddle Board Lesson on The San Diego Bay

$25

per adult

**100%** of travellers recommend

[](https://expedia.com/things-to-do/stand-up-paddle-board-lesson-on-the-san-diego-bay.a1246891.activity-details)

![From Tijuana: Valle de Guadalupe Private Winery Tour](https://mediaim.expedia.com/localexpert/4522054/35b19c64-b5ba-448e-82e7-9fa3c08e5eef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### From Tijuana: Valle de Guadalupe Private Winery Tour

$139

per adult

[](https://expedia.com/things-to-do/from-tijuana-valle-de-guadalupe-private-winery-tour.a4522054.activity-details)

![Tijuana Urban Art Walk from San Diego ](https://mediaim.expedia.com/localexpert/3402914/27e36bfb-a851-45d4-a6be-2d4fa7f7a2e9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tijuana Urban Art Walk from San Diego

$80

per adult

[](https://expedia.com/things-to-do/tijuana-urban-art-walk-from-san-diego.a3402914.activity-details)

![San Diego Bay Sail Aboard a French Yacht: Beer and Wine Included ](https://mediaim.expedia.com/localexpert/50788154/00134805-7b12-4136-99e7-27b72339bb83.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### San Diego Bay Sail Aboard a French Yacht: Beer and Wine Included

$239

per adult

[](https://expedia.com/things-to-do/san-diego-bay-sail-aboard-a-french-yacht-beer-and-wine-included.a50788154.activity-details)

![Picture 3 for Activity Tijuana: Guided City Tour with Local Food and Beer Tasting](https://mediaim.expedia.com/localexpert/4568373/f78c81fd-0d24-4ba3-bd5d-102f1e7ef1c3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tijuana: Guided City Tour with Local Food and Beer Tasting

$113

per adult

[](https://expedia.com/things-to-do/tijuana-guided-city-tour-with-local-food-and-beer-tasting.a4568373.activity-details)

[See all activities in San Diego](https://expedia.com/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)

---

## Otay Mesa Hotel Deals

![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

$261 nightly

$300 total

Apr 26 - Apr 27

Total with taxes and fees

Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

8.6/10 Excellent! (2,494 reviews)

clean room nice staff

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F26%2F2026&endDate=4%2F27%2F2026&selected=3731&PinnedHotelID=3731&HadPinnedHotel=true&regionId=6263723)

![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Best Western Seven Seas

411 Hotel Circle South San Diego CA

$82 nightly

$94 total

Apr 5 - Apr 6

Total with taxes and fees

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...

7.8/10 Good! (3,344 reviews)

clean room

Reviewed on Mar 30, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=1734&PinnedHotelID=1734&HadPinnedHotel=true&regionId=6263723)

![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hard Rock Hotel San Diego

207 5th Ave San Diego CA

$248 nightly

$287 total

Apr 2 - Apr 3

Total with taxes and fees

Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...

9/10 Wonderful! (3,463 reviews)

Everything was amazing beginning to end. My kids enjoyed the pool. Staff was extremely friendly and helpful. Breakfast was excellent. Already planning to come back.

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F2%2F2026&endDate=4%2F3%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true&regionId=6263723)

![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/8cec183d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Handlery Hotel

950 Hotel Cir N San Diego CA

Fully refundableReserve now, pay when you stay

$129 nightly

$148 total

Apr 13 - Apr 14

Total with taxes and fees

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

8.4/10 Very Good! (2,364 reviews)

Love the pool

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F13%2F2026&endDate=4%2F14%2F2026&selected=8374&PinnedHotelID=8374&HadPinnedHotel=true&regionId=6263723)

![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

The DEXTRO Little Italy, BW Premier Collection

1617 1st Avenue San Diego CA

$135 nightly

$157 total

Apr 23 - Apr 24

Total with taxes and fees

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...

8.8/10 Excellent! (1,289 reviews)

Parking is almost $40 per night. No WiFi(system down). Room dirty. Still waiting to get my deposit back after almost a week. Room is tiny.

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F23%2F2026&endDate=4%2F24%2F2026&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true&regionId=6263723)

![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/c491024e_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Days Inn by Wyndham San Diego Hotel Circle

543 Hotel Circle S San Diego CA

$107 nightly

$123 total

Apr 26 - Apr 27

Total with taxes and fees

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...

8/10 Very Good! (2,586 reviews)

Heated pool. Convenient location. Kitchenettes. Perfect for families

Reviewed on Mar 31, 2026

[](https://expedia.com/Hotel-Search?startDate=4%2F26%2F2026&endDate=4%2F27%2F2026&selected=19220&PinnedHotelID=19220&HadPinnedHotel=true&regionId=6263723)

[See all 4,883 properties in Otay Mesa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=4%2F1%2F2026&endDate=4%2F2%2F2026&regionId=6263723)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Otay Mesa hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=2026-03-31&endDate=2026-04-01)[Mar 31 - Apr 1](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=2026-03-31&endDate=2026-04-01)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=2026-04-01&endDate=2026-03-02)[Apr 1 - Apr 2](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=2026-04-01&endDate=2026-03-02)

[This weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)

[Next weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)[Apr 10 - Apr 12](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6263723&startDate=4%2F10%2F2026&endDate=4%2F12%2F2026)

---

### Other neighborhoods around Otay Mesa

![Gaslamp Quarter](https://images.trvl-media.com/place/6130021/5158ce24-3077-4ad7-bf7d-46fd554e646d.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Gaslamp Quarter

 Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street. 

[](https://expedia.com/San-Diego-Gaslamp-Quarter.dx6130021)

![Downtown San Diego](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Downtown San Diego

4.5/5(8,598 area reviews)

 Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options. 

[](https://expedia.com/San-Diego-Downtown-San-Diego.dx800123)

![North Park sign at sunset, in San Diego, California](https://images.trvl-media.com/place/6346499/b86dcf12-1068-4f1b-98f0-547974936805.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### North Park

4/5(78 area reviews)

 North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum. 

[](https://expedia.com/San-Diego-North-Park.dx6346499)

![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Little Italy

 Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station. 

[](https://expedia.com/San-Diego-Little-Italy.dx6161280)

![Gossip Grill](https://images.trvl-media.com/place/6191797/60a250a8-62f2-4c0b-8601-b05dd917f234.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Hillcrest

3.5/5(53 area reviews)

 Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop. 

[](https://expedia.com/San-Diego-Hillcrest.dx6191797)

![Mission San Diego de Alcala With Century Plant,San Diego, California, USA](https://images.trvl-media.com/place/800124/3acb7c99-e1a9-4421-ac6d-8b056ecd511f.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Mission Valley

4/5(5,069 area reviews)

 Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line. 

[](https://expedia.com/San-Diego-Mission-Valley.dx800124)

[See our Where To Stay guide](https://expedia.com/San-Diego.dx3073.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods)

---

---

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# Otay Mesa, CA

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- [Flights to Brown Field Municipal ](https://www.expedia.com/Cheap-Flights-To-Brown-Field-Municipal.d6031787.Travel-Guide-Flights)
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- [Flights from New York (JFK) to San Diego (SDM) ](https://www.expedia.com/lp/flights/jfk/sdm/new-york-to-san-diego)
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- [Flights from Cleveland (CLE) to San Diego (SDM) ](https://www.expedia.com/lp/flights/cle/sdm/cleveland-to-san-diego)
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- [Flights from Hong Kong (HKG) to San Diego (SDM) ](https://www.expedia.com/lp/flights/hkg/sdm/hong-kong-to-san-diego)
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- [North Island Credit Union Amphitheatre ](https://www.expedia.com/North-Island-Credit-Union-Amphitheatre-Chula-Vista.d6128061.Vacation-Attraction)
- [White Water Canyon ](https://www.expedia.com/White-Water-Canyon-Chula-Vista.d553248621532638602.Vacation-Attraction)

- [Car rental San Diego Airport (SDM) ](https://www.expedia.com/Car-Rentals-In-Brown-Field-Municipal.d6031787.Car-Rental-Guide)
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- [Car rentals near North Island Credit Union Amphitheatre ](https://www.expedia.com/Car-Rentals-In-North-Island-Credit-Union-Amphitheatre.d6128061.Car-Rental-Guide)
- [Car rentals near San Ysidro Border Crossing ](https://www.expedia.com/Car-Rentals-In-San-Ysidro-Border-Crossing.d553248621551385128.Car-Rental-Guide)

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