Title: Visit Otay Mesa: 2026 Otay Mesa, San Diego Travel Guide | Expedia.com [Hotels in Otay Mesa](https://expedia.com/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Flights to San Diego](https://expedia.com/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.com/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Car Rentals in Otay Mesa](https://expedia.com/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.com/Otay-Mesa.d6263723.Destination-Travel-Guides) # Otay Mesa, CA ## San Diego ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Otay Mesa Things to do Hotels Where to stay [San Diego Travel Guide](https://expedia.com/San-Diego.dx3073) --- ### Popular places to visit ![San Diego Zoo featuring landscape views, zoo animals and a pond](https://images.trvl-media.com/place/502547/504b59eb-bcb1-4b86-9adb-3c97368fb431.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Zoo See nature up-close and personal at one of the country’s largest and most educational zoos. [](https://expedia.com/San-Diego-Zoo-San-Diego.d502547.Vacation-Attraction) ![San Diego Convention Center](https://images.trvl-media.com/place/6125294/2fc00620-42cd-4ab5-9c91-9e9ac3371200.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Diego Convention Center Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs. [](https://expedia.com/San-Diego-Convention-Center-Downtown-San-Diego.d6125294.Vacation-Attraction) ![Mission Bay featuring a sandy beach](https://images.trvl-media.com/place/6185904/de90e297-f912-4798-a530-b3d83f0907a3.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Bay Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park. [](https://expedia.com/Mission-Bay-San-Diego.d6185904.Vacation-Attraction) ![Mission Beach featuring tropical scenes, street scenes and a beach](https://images.trvl-media.com/place/506109/7668844c-8a76-415d-a747-d4762537804f.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Mission Beach A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities. [](https://expedia.com/Mission-Beach-Central-Mission-Beach.d506109.Vacation-Attraction) ![Petco Park](https://images.trvl-media.com/place/6034816/3fd0f316-ed35-46ff-8aa5-88fc867c08a4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Petco Park Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field. [](https://expedia.com/Petco-Park-Downtown-San-Diego.d6034816.Vacation-Attraction) ![Balboa Park which includes a pond](https://images.trvl-media.com/place/507458/5c140d77-7130-49d1-ab3d-705937c3610a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Balboa Park Culture and nature converge in this diverse park located in the heart of the city. [](https://expedia.com/Balboa-Park-San-Diego.d507458.Vacation-Attraction) ### Things to do ![Make your Mexican Meal](https://mediaim.expedia.com/localexpert/3449139/a29ddf94-64f4-4d58-b6ad-b03e71394ba2.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Make your Mexican Meal $93 per adult [](https://expedia.com/things-to-do/make-your-mexican-meal.a3449139.activity-details) ![Crossing Borders: Tijuana Day Trip from San Diego](https://mediaim.expedia.com/localexpert/1385617/3024ad77-520e-43dd-9206-6235bfe2b229.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Crossing Borders: Tijuana Day Trip from San Diego $93 per adult **82%** of travellers recommend [](https://expedia.com/things-to-do/crossing-borders-tijuana-day-trip-from-san-diego.a1385617.activity-details) ![ Stand up Paddle Board Lesson on The San Diego Bay ](https://mediaim.expedia.com/localexpert/1246891/0e157c0d-bd34-474b-a551-bd80f218d871.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Stand up Paddle Board Lesson on The San Diego Bay $25 per adult **100%** of travellers recommend [](https://expedia.com/things-to-do/stand-up-paddle-board-lesson-on-the-san-diego-bay.a1246891.activity-details) ![Tijuana Mexico Coffee Shop hop from San Diego](https://mediaim.expedia.com/localexpert/3423099/4ffc4893-5a05-45e3-a777-37caf46afcbd.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Tijuana Mexico Coffee Shop Hop from San Diego $93 per adult [](https://expedia.com/things-to-do/tijuana-mexico-coffee-shop-hop-from-san-diego.a3423099.activity-details) ![Tijuana Urban Art Walk from San Diego ](https://mediaim.expedia.com/localexpert/3402914/27e36bfb-a851-45d4-a6be-2d4fa7f7a2e9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Tijuana Urban Art Walk from San Diego $80 per adult [](https://expedia.com/things-to-do/tijuana-urban-art-walk-from-san-diego.a3402914.activity-details) ![From Tijuana: Valle de Guadalupe Private Winery Tour](https://mediaim.expedia.com/localexpert/4522054/35b19c64-b5ba-448e-82e7-9fa3c08e5eef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### From Tijuana: Valle de Guadalupe Private Winery Tour $145 per adult [](https://expedia.com/things-to-do/from-tijuana-valle-de-guadalupe-private-winery-tour.a4522054.activity-details) [See all activities in San Diego](https://expedia.com/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities) --- ## Otay Mesa Hotel Deals ![Paradise Point Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/3800/3731/d0f041ab_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Paradise Point Resort & Spa 1404 Vacation Rd San Diego CA $302 nightly $347 total Mar 25 - Mar 26 Total with taxes and fees Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ... 8.8/10 Excellent! (2,458 reviews) Wonderful place to stay. There were little things here and there (like a tear in our couch) that made me take a 2nd look. But besides that, it was a great trip. We will visit again. Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F25%2F2026&endDate=3%2F26%2F2026&selected=3731&PinnedHotelID=3731&HadPinnedHotel=true®ionId=6263723) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Seven Seas 411 Hotel Circle South San Diego CA $76 nightly $87 total Mar 29 - Mar 30 Total with taxes and fees Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ... 7.8/10 Good! (3,299 reviews) The receptionist was very helpful Reviewed on Mar 16, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F29%2F2026&endDate=3%2F30%2F2026&selected=1734&PinnedHotelID=1734&HadPinnedHotel=true®ionId=6263723) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hard Rock Hotel San Diego 207 5th Ave San Diego CA $237 nightly $274 total Apr 5 - Apr 6 Total with taxes and fees Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ... 9/10 Wonderful! (3,430 reviews) They charged $100 more than it was showing on hotels.com. Said it is mandatory resort fees. We were given a handicap room which was fine until showering. The floor design completely floods the entire bathroom floor. Front desk staff were rude when we asked about the extra charges. We will not stay ... Reviewed on Mar 17, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=1731557&PinnedHotelID=1731557&HadPinnedHotel=true®ionId=6263723) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/c491024e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Days Inn by Wyndham San Diego Hotel Circle 543 Hotel Circle S San Diego CA $107 nightly $123 total Mar 23 - Mar 24 Total with taxes and fees Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ... 8/10 Very Good! (2,555 reviews) Was pleased with early check in and room was wonderful!! Reviewed on Mar 16, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F23%2F2026&endDate=3%2F24%2F2026&selected=19220&PinnedHotelID=19220&HadPinnedHotel=true®ionId=6263723) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/8cec183d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Handlery Hotel 950 Hotel Cir N San Diego CA $110 nightly $126 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ... 8.2/10 Very Good! (2,341 reviews) Nice hotel Reviewed on Mar 16, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=8374&PinnedHotelID=8374&HadPinnedHotel=true®ionId=6263723) ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The DEXTRO Little Italy, BW Premier Collection 1617 1st Avenue San Diego CA $130 nightly $150 total Apr 5 - Apr 6 Total with taxes and fees Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ... 9/10 Wonderful! (1,203 reviews) Expensive parking! Reviewed on Mar 16, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F5%2F2026&endDate=4%2F6%2F2026&selected=170338&PinnedHotelID=170338&HadPinnedHotel=true®ionId=6263723) [See all 4,877 properties in Otay Mesa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F18%2F2026&endDate=3%2F19%2F2026®ionId=6263723) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Otay Mesa hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-03-17&endDate=2026-03-18)[Mar 17 - Mar 18](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-03-17&endDate=2026-03-18) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-03-18&endDate=2026-03-19)[Mar 18 - Mar 19](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=2026-03-18&endDate=2026-03-19) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026)[Mar 20 - Mar 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=3%2F20%2F2026&endDate=3%2F22%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6263723&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) --- ### Other neighborhoods around Otay Mesa ![Petco Park featuring a statue or sculpture](https://images.trvl-media.com/place/6034816/3b5523cf-9fe3-4419-a57d-df61b6834ac5.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### East Village Travelers choose East Village for its lively bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park. [](https://expedia.com/San-Diego-East-Village.dx553248633849130034) ![Gaslamp Quarter showing signage, night scenes and street scenes](https://images.trvl-media.com/place/6130021/5158ce24-3077-4ad7-bf7d-46fd554e646d.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Gaslamp Quarter Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street. [](https://expedia.com/San-Diego-Gaslamp-Quarter.dx6130021) ![US Grant Hotel](https://images.trvl-media.com/place/800123/772b9d6a-cdc3-400e-b3ed-61d10adc7912.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Downtown San Diego 4.5/5(8,497 area reviews) Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options. [](https://expedia.com/San-Diego-Downtown-San-Diego.dx800123) ![SanDiego_NorthPark_6346499_001](https://images.trvl-media.com/place/6346499/6374335e-0d00-4eb7-8271-3d9bb2afaf80.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### North Park 4/5(78 area reviews) North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum. [](https://expedia.com/San-Diego-North-Park.dx6346499) ![Little Italy](https://images.trvl-media.com/place/6161280/027d3836-740c-44f0-bb0a-a8fb158f401a.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Little Italy Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station. [](https://expedia.com/San-Diego-Little-Italy.dx6161280) ![Gossip Grill](https://images.trvl-media.com/place/6191797/60a250a8-62f2-4c0b-8601-b05dd917f234.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Hillcrest 3.5/5(53 area reviews) Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop. [](https://expedia.com/San-Diego-Hillcrest.dx6191797) [See our Where To Stay guide](https://expedia.com/San-Diego.dx3073.Where-To-Stay?rfrr=TG.LP.Dest.Neigh.Neighborhoods) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Otay Mesa, CA ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [San Diego County Hotels ](https://www.expedia.com/Destinations-In-San-Diego-County.d178304.Hotel-Destinations) - [Hotels near Brown Field Municipal ](https://www.expedia.com/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Hotels near North Island Credit Union Amphitheatre ](https://www.expedia.com/North-Island-Credit-Union-Amphitheatre-Hotels.0-l6128061-0.Travel-Guide-Filter-Hotels) - [Hotels near White Water Canyon ](https://www.expedia.com/White-Water-Canyon-Hotels.0-l553248621532638602-0.Travel-Guide-Filter-Hotels) - 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(OAX) to San Diego (SDM) ](https://www.expedia.com/lp/flights/oax/sdm/oaxaca-intl-to-san-diego) - [Flights from Fort Lauderdale (FLL) to San Diego (SDM) ](https://www.expedia.com/lp/flights/fll/sdm/fort-lauderdale-to-san-diego) - [Flights from Long Beach (LGB) to San Diego (SDM) ](https://www.expedia.com/lp/flights/lgb/sdm/long-beach-to-san-diego) - [Flights from Detroit (DTW) to San Diego (SDM) ](https://www.expedia.com/lp/flights/dtw/sdm/detroit-to-san-diego) - [Flights from Minneapolis (MSP) to San Diego (SDM) ](https://www.expedia.com/lp/flights/msp/sdm/minneapolis-to-san-diego) - [Flights to Brown Field Municipal ](https://www.expedia.com/Cheap-Flights-To-Brown-Field-Municipal.d6031787.Travel-Guide-Flights) - [Flights from New York (NYC) to San Diego (SDM) ](https://www.expedia.com/lp/flights/nyc/sdm/new-york-to-san-diego) - [Flights from Beaumont (BMT) to San Diego (SDM) ](https://www.expedia.com/lp/flights/bmt/sdm/beaumont-to-san-diego) - [Flights from New York (JFK) to San Diego (SDM) ](https://www.expedia.com/lp/flights/jfk/sdm/new-york-to-san-diego) - 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