Otay Mesa, CA
San Diego
Popular places to visit
San Diego Zoo
4.5/5(3,633 reviews)
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Bay
4.5/5(2,416 reviews)
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
4.5/5(1,324 reviews)
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
Mission Beach
4.5/5(4,995 reviews)
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Balboa Park
4.5/5(3,784 reviews)
Culture and nature converge in this diverse park located in the heart of the city.
SeaWorld
4.5/5(2,465 reviews)
Visit one of the world’s largest marine parks for talented and amazing and animals, electrifying rides, conservation education and seasonal events.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
82% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
San Diego Bay Sail Aboard a French Yacht: Beer and Wine Included
$239
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$139
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
$113
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$235 nightly
The price is $270 total per night from May 10 to May 11
$270 total
May 10 - May 11
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,543 reviews)
Fun location. Lots of amenities. Great pools. Food options on sight. Great s
Reviewed on Apr 12, 2026
Best Western Seven Seas
411 Hotel Circle South San Diego CA
$82 nightly
The price is $94 total per night from Apr 21 to Apr 22
$94 total
Apr 21 - Apr 22
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,384 reviews)
The room was musty smelling. NO Shampoo nor Conditioner in bathroom. Noise coming from parking structures.
Reviewed on Apr 12, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$266 nightly
The price is $308 total per night from Apr 15 to Apr 16
$308 total
Apr 15 - Apr 16
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,535 reviews)
Was all good other than being disappointed for not really feeling welcomed or get the perks as a VIP member of Orbitz. I showed them my VIP membership and asked for a complementary late checkout and got an extra hour. No mention of other complementary service or drinks, nothing. I had to comeback ...
Reviewed on Apr 11, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
$129 nightly
The price is $148 total per night from Apr 13 to Apr 14
$148 total
Apr 13 - Apr 14
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,413 reviews)
Front desk staff was very helpful. The pool bar staff was very friendly and made great drinks!
Reviewed on Apr 11, 2026
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
$127 nightly
The price is $147 total per night from May 11 to May 12
$147 total
May 11 - May 12
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (1,362 reviews)
Nice hotel. Convenient to the cruise port. Restaurant had a limited menu.
Reviewed on Apr 11, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from May 3 to May 4
$211 total
May 3 - May 4
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,150 reviews)
Check in is way to late. Couldn’t even use the restroom or try to shower until almost 5pm. Ended up booking a different hotel and never even checked in. Will never stay here
Reviewed on Apr 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other neighborhoods around Otay Mesa
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Downtown San Diego
4.5/5(8,598 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
North Park
4/5(78 area reviews)
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Little Italy
Little Italy is popular for its captivating waterfront views. Explore top sights like Maritime Museum of San Diego and San Diego Bay, and you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
3.5/5(53 area reviews)
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
4/5(5,069 area reviews)
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
Otay Mesa, CA
Explore a world of travel with Expedia
- Flights to San Diego
- Flights from Brown Field Municipal
- Flights from Ensenada (ESE) to San Diego (SDM)
- Flights from Seattle (SEA) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Tijuana (TIJ) to San Diego (SDM)
- Flights from Phoenix (PHX) to San Diego (SDM)
- Flights from Fresno (FAT) to San Diego (SDM)
- Flights from Compton (CPM) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Baltimore (BWI) to San Diego (SDM)
- Flights from Philadelphia (PHL) to San Diego (SDM)
- Flights from Austin (AUS) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Henderson (HSH) to San Diego (SDM)
- Flights from Pasco (PSC) to San Diego (SDM)
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Oakland (OAK) to San Diego (SDM)
- Flights from Omaha (OMA) to San Diego (SDM)
- Flights from New Orleans (MSY) to San Diego (SDM)
- Flights from Orange County (SNA) to San Diego (SDM)
- Flights from Salt Lake City (SLC) to San Diego (SDM)
- Flights from Cincinnati (CVG) to San Diego (SDM)
- Flights from Sacramento (SMF) to San Diego (SDM)
- Flights from San Jose (SJC) to San Diego (SDM)
- Flights from Raleigh (RDU) to San Diego (SDM)
- Flights from Oklahoma City (OKC) to San Diego (SDM)
- Flights from Charlotte (CLT) to San Diego (SDM)
- Flights from San Antonio (SAT) to San Diego (SDM)
- Flights from Washington (DCA) to San Diego (SDM)
- Flights from Honolulu (HNL) to San Diego (SDM)
- Flights from Burbank (BUR) to San Diego (SDM)
- Flights from Kansas City (MCI) to San Diego (SDM)
- Flights from Jacksonville (JAX) to San Diego (SDM)
- Flights from Miami (MIA) to San Diego (SDM)
- Flights from Dallas (DFW) to San Diego (SDM)
- Flights from Houston (IAH) to San Diego (SDM)
- Flights from Oaxaca Intl. (OAX) to San Diego (SDM)
- Flights from Fort Lauderdale (FLL) to San Diego (SDM)
- Flights from Long Beach (LGB) to San Diego (SDM)
- Flights from Detroit (DTW) to San Diego (SDM)
- Flights from Minneapolis (MSP) to San Diego (SDM)
- Flights to Brown Field Municipal
- Flights from New York (NYC) to San Diego (SDM)
- Flights from Beaumont (BMT) to San Diego (SDM)
- Flights from New York (JFK) to San Diego (SDM)
- Flights from Pittsburgh (PIT) to San Diego (SDM)
- Flights from Winnemucca (WMC) to San Diego (SDM)
- Flights from Lake Tahoe (TVL) to San Diego (SDM)
- Flights from Orlando (MCO) to San Diego (SDM)
- Flights from San Juan (SJU) to San Diego (SDM)
- Flights from Atlanta (ATL) to San Diego (SDM)
- Flights from Reno (RNO) to San Diego (SDM)
- Flights from Portland (PDX) to San Diego (SDM)
- Flights from León (BJX) to San Diego (SDM)
- Flights from Hartford (BDL) to San Diego (SDM)
- Flights from Milwaukee (MKE) to San Diego (SDM)
- Flights from Chicago (ORD) to San Diego (SDM)
- Flights from Syracuse (SYR) to San Diego (SDM)
- Flights from Eugene (EUG) to San Diego (SDM)
- Flights from Monterey (MRY) to San Diego (SDM)
- Flights from Albuquerque (ABQ) to San Diego (SDM)
- Flights from Tampa (TPA) to San Diego (SDM)
- Flights from Cleveland (CLE) to San Diego (SDM)
- Flights from Tucson (TUS) to San Diego (SDM)
- Flights from Sioux Falls (FSD) to San Diego (SDM)
- Flights from Sacramento (SAC) to San Diego (SDM)
- Flights from Auckland (AKL) to San Diego (SDM)
- Flights from Huntsville (HSV) to San Diego (SDM)
- Flights from Colorado Springs (COS) to San Diego (SDM)
- Flights from Guadalajara (GDL) to San Diego (SDM)
- Flights from Columbus (CMH) to San Diego (SDM)
- Flights from Tulsa (TUL) to San Diego (SDM)
- Flights from El Paso (ELP) to San Diego (SDM)
- Flights from Nashville (BNA) to San Diego (SDM)
- Flights from Norfolk (ORF) to San Diego (SDM)
- Flights from Barstow (DAG) to San Diego (SDM)
- Flights from Paris (CDG) to San Diego (SDM)
- Flights from Bellingham (BLI) to San Diego (SDM)
- Flights from Indianapolis (IND) to San Diego (SDM)
- Flights from Bakersfield (BFL) to San Diego (SDM)
- Flights from Vancouver (YVR) to San Diego (SDM)
- Flights from Boise (BOI) to San Diego (SDM)
- Flights from New York (LGA) to San Diego (SDM)
- Flights from Hong Kong (HKG) to San Diego (SDM)
- Flights from Des Moines (DSM) to San Diego (SDM)
