Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$40
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana Walking Street Food Tour with Wild Foodie Tours
$79
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$147
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
$137 nightly
The price is $156 total per night from Oct 1 to Oct 2
$156 total
Oct 1 - Oct 2
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$246 nightly
The price is $285 total per night from Sep 7 to Sep 8
$285 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,834 reviews)
"The room appeared to be newly refurbished and the bathroom was nice. The main lobby looks amazing."
Reviewed on Sep 1, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$180 nightly
The price is $209 total per night from Sep 6 to Sep 7
$209 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,290 reviews)
"This place is in a great location. The free coffee is nice in the morning. The workout rooms are great, and the pool."
Reviewed on Sep 1, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$254 nightly
The price is $292 total per night from Sep 7 to Sep 8
$292 total
Sep 7 - Sep 8
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
$186 nightly
The price is $213 total per night from Sep 2 to Sep 3
$213 total
Sep 2 - Sep 3
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,445 reviews)
"It was a great location with a nice boardwalk! The 2 pools were great - we felt like we were in Hawaii!! The restaurant was excellent!"
Reviewed on Aug 31, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$237 nightly
The price is $274 total per night from Sep 8 to Sep 9
$274 total
Sep 8 - Sep 9
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,285 reviews)
"Room was clean enough, some leftover stains on the sink when we walked in. Shower splashes underneath shower door and spills out. Toilet needs to be pushed a little bit back so it doesn’t keep refilling."
Reviewed on Sep 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
Explore a world of travel with Expedia
- Beach Hotels in San Diego County
- Carlsbad Hotels
- Old Town San Diego Hotels
- Cheap Hotels in San Diego County
- Pacific Beach Hotels
- Hotels near Mission Beach
- Chula Vista Hotels
- Cheap Hotels in San Diego
- Hotels near San Diego Convention Center
- Coronado Hotels
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- Hotels near Hotel Circle
- Hotels with a Lazy River in San Diego County
- Hotels with Free Airport Shuttle in San Diego
- Hotels near San Diego Zoo
- Gaslamp Quarter Hotels
- La Jolla Hotels
- Hotels near Petco Park
- Hotels near LEGOLAND® California
- Extended Stay Hotels in San Diego
- San Diego County Hotels
- Hotels near Mission Bay
- Hotels near San Diego Intl.
- All-Inclusive Resorts in San Diego
- Downtown San Diego Hotels
- Flights from Portland (PDX) to San Diego (SAN)
- Flights from Nashville (BNA) to San Diego (SAN)
- Flights from Chicago (ORD) to San Diego (SAN)
- Flights from Seattle (SEA) to San Diego (SAN)
- Flights from Los Angeles (LAX) to San Diego (SAN)
- Flights from Boston (BOS) to San Diego (SAN)
- Flights from Minneapolis (MSP) to San Diego (SAN)
- Flights from Raleigh (RDU) to San Diego (SAN)
- Flights from Norfolk (ORF) to San Diego (SAN)
- Flights from San Diego Intl.
- Flights from Houston (IAH) to San Diego (SAN)
- Flights from Philadelphia (PHL) to San Diego (SAN)
- Flights from Phoenix (PHX) to San Diego (SAN)
- Flights from Kansas City (MCI) to San Diego (SAN)
- Flights from Austin (AUS) to San Diego (SAN)
- Flights from Orlando (MCO) to San Diego (SAN)
- Flights from San Jose (SJC) to San Diego (SAN)
- Flights from Oakland (OAK) to San Diego (SAN)
- Flights from New York (JFK) to San Diego (SAN)
- Flights from Sacramento (SMF) to San Diego (SAN)
- Flights from Boise (BOI) to San Diego (SAN)
- Flights from Washington (IAD) to San Diego (SAN)
- Flights from Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
- Flights from Detroit (DTW) to San Diego (SAN)
- Flights to San Diego
- Flights from Honolulu (HNL) to San Diego (SAN)
- Flights from Salt Lake City (SLC) to San Diego (SAN)
- Flights from Las Vegas (LAS) to San Diego (SAN)
- Flights from Dallas (DFW) to San Diego (SAN)
- Flights from Denver (DEN) to San Diego (SAN)
- Flights from Tampa (TPA) to San Diego (SAN)
- Flights from Baltimore (BWI) to San Diego (SAN)
- Flights from Fresno (FAT) to San Diego (SAN)
- Flights from San Francisco (SFO) to San Diego (SAN)
- Flights from Charlotte (CLT) to San Diego (SAN)
- Flights from Atlanta (ATL) to San Diego (SAN)
- Visit Spring Valley
- Visit San Diego Coast
- Visit National City
- Visit Otay Mesa West
- Visit Old Town San Diego
- Visit Mission Beach
- Visit Del Mar
- Visit Downtown San Diego
- Visit South San Diego
- Visit Chula Vista
- Visit Dulzura
- Visit Lawrence Welk Resort Village
- Visit Little Italy
- Visit Mission Valley
- Visit Otay
- Visit Bonita
- Visit Coronado
- Visit Liberty Station
- Visit Imperial Beach
- Visit Coronado Cays
- Visit Gaslamp Quarter
- Visit Castle Park
- Visit Bird Rock
- Balboa Park
- Visit San Ysidro
- Visit La Jolla
- Visit Point Loma
- Visit Alpine
- Visit Ocean Beach
- San Diego Vacations
- Visit San Diego
- Visit South Bay
