Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana Walking Street Food Tour with Wild Foodie Tours
$79
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$145
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Oct 25 to Oct 26
$211 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$239 nightly
The price is $274 total per night from Nov 1 to Nov 2
$274 total
Nov 1 - Nov 2
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,928 reviews)
"We paid a pretty penny for this place because of all the amenities, however, you have to pay another pretty penny just to use them."
Reviewed on Oct 10, 2026
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
$183 nightly
The price is $210 total per night from Oct 25 to Oct 26
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Handlery Hotel
950 Hotel Cir N San Diego CA
$114 nightly
The price is $131 total per night from Oct 15 to Oct 16
$131 total
Oct 15 - Oct 16
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,989 reviews)
"Staff was helpful and welcoming. The room was clean and quiet. Would go back again!"
Reviewed on Oct 10, 2026
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
$177 nightly
The price is $203 total per night from Nov 10 to Nov 11
$203 total
Nov 10 - Nov 11
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (3,996 reviews)
"The staff were amazing. Zijon at the front desk was extremely friendly and helpful. The food and drinks were excellent. We were 3 80 year old ladies who graduated high school together in 1965 and everyone at the hotel were so kind to us. We plan on coming back every year."
Reviewed on Oct 10, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$230 nightly
The price is $266 total per night from Nov 5 to Nov 6
$266 total
Nov 5 - Nov 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,500 reviews)
"Excellent staff, excellent room. Great amenities. I would stay there again. I was impressed."
Reviewed on Oct 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
Otay Mesa, CA
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