Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$40
per adult
Introduction Rosarito Day Tour from San Diego
$157
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$118
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$147
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Handlery Hotel
950 Hotel Cir N San Diego CA
$111 nightly
The price is $128 total per night from Sep 21 to Sep 22
$128 total
Sep 21 - Sep 22
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Best Western Seven Seas
411 Hotel Circle South San Diego CA
$85 nightly
The price is $97 total per night from Sep 21 to Sep 22
$97 total
Sep 21 - Sep 22
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$239 nightly
The price is $274 total per night from Oct 4 to Oct 5
$274 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,881 reviews)
"Our stay was great! Everything was easy to get to, and the whole family had a really good time. We will definitely be back. The only downside was the pricing. The food at the BearFoot Bar and Grill was a little expensive, and we felt the General Store was way overpriced. Other than that, we had a ..."
Reviewed on Sep 20, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 28 to Sep 29
$211 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,327 reviews)
"This property seriously needs to be updated. Carpet taped down /c duct tape at the entry to the bathroom. Bathroom mirror had large areas where the mirror and light cover was wearing off. Deck railing had multiple large areas where paint was completely off. Room looked grungy. Not at all the quality ..."
Reviewed on Sep 20, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$286 nightly
The price is $332 total per night from Sep 27 to Sep 28
$332 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,861 reviews)
"Room was not clean found 2 roaches in the room. Staff failed to compensate"
Reviewed on Sep 20, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$229 nightly
The price is $265 total per night from Sep 28 to Sep 29
$265 total
Sep 28 - Sep 29
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Lyceum Theatre is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
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