Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$150
per adult
Introduction Rosarito Day Tour from San Diego
$157
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$145
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$116
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Oct 25 to Oct 26
$211 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,359 reviews)
"Love this hotel.we always stay here every time we visit San Diego"
Reviewed on Oct 5, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$254 nightly
The price is $292 total per night from Oct 30 to Oct 31
$292 total
Oct 30 - Oct 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,918 reviews)
"The rooms are extremely dated. Phone did not work, nor did the locks. The property and amenities are gorgeous."
Reviewed on Oct 5, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
$103 nightly
The price is $119 total per night from Oct 6 to Oct 7
$119 total
Oct 6 - Oct 7
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,974 reviews)
"One of the worst hotel experiences I’ve ever had. Absolutely disgusting and nowhere near worth the price. The room smelled terrible, the bathtub/shower wouldn’t drain, and there wasn’t even any shower gel. I reported the clogged drain to the front desk and specifically asked for the bathroom to be ..."
Reviewed on Oct 5, 2026
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
$183 nightly
The price is $210 total per night from Oct 25 to Oct 26
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
$175 nightly
The price is $201 total per night from Nov 4 to Nov 5
$201 total
Nov 4 - Nov 5
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (3,977 reviews)
"The room was clean the water pressure is very weak. The front check in staff and restaurant staff we are great. You cannot order or bring your own food to the pool. They said it takes from their restaurant business which is understandable. Just thought I would let others know since I found out the ..."
Reviewed on Oct 5, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$230 nightly
The price is $266 total per night from Nov 5 to Nov 6
$266 total
Nov 5 - Nov 6
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,485 reviews)
"The staff was very friendly and helpful. Anything we asked for, someone was right there to take care if it. Everything was very clean and well kept up."
Reviewed on Oct 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
Otay Mesa, CA
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