Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$99
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$122
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$92
per adult
Tijuana Walking Street Food Tour with Wild Foodie Tours
$79
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$285 nightly
The price is $328 total per night from Aug 30 to Aug 31
$328 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$250 nightly
The price is $290 total per night from Aug 26 to Aug 27
$290 total
Aug 26 - Aug 27
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,763 reviews)
"Everything was great, location was amazing, property is Beautiful. The only issue was we arrived at 4pm and the room was not ready."
Reviewed on Aug 4, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$180 nightly
The price is $208 total per night from Aug 27 to Aug 28
$208 total
Aug 27 - Aug 28
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,245 reviews)
"Loved it! Close to everything we needed!"
Reviewed on Aug 4, 2026
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$223 nightly
The price is $259 total per night from Aug 13 to Aug 14
$259 total
Aug 13 - Aug 14
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,145 reviews)
"Amazing staff and amazing hotel"
Reviewed on Aug 4, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$287 nightly
The price is $330 total per night from Aug 30 to Aug 31
$330 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Seaport Village are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Riviera Shores Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
Otay Mesa, CA
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