Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$120
per adult
Introduction Rosarito Day Tour from San Diego
$157
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$135
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$108
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
$130 nightly
The price is $148 total per night from Nov 22 to Nov 23
$148 total
Nov 22 - Nov 23
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Oct 26 to Oct 27
$211 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,349 reviews)
"This is the second time I have stayed there and the rooms are really nice and the view is amazing."
Reviewed on Oct 23, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$194 nightly
The price is $225 total per night from Nov 23 to Nov 24
$225 total
Nov 23 - Nov 24
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,551 reviews)
"Had an excellent stay will be back again!"
Reviewed on Oct 23, 2026
Handlery Hotel
950 Hotel Cir N San Diego CA
$119 nightly
The price is $137 total per night from Nov 16 to Nov 17
$137 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (3,020 reviews)
"o"
Reviewed on Oct 23, 2026
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
$156 nightly
The price is $179 total per night from Nov 17 to Nov 18
$179 total
Nov 17 - Nov 18
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9.2/10 Wonderful! (4,029 reviews)
"Perfect stay. Always a favorite"
Reviewed on Oct 23, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$285 nightly
The price is $328 total per night from Oct 25 to Oct 26
$328 total
Oct 25 - Oct 26
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
Otay Mesa, CA
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