Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$99
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
$122
per adult
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
$92
per adult
Tijuana Walking Street Food Tour with Wild Foodie Tours
$79
per adult
Otay Mesa Hotel Deals
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$285 nightly
The price is $328 total per night from Aug 30 to Aug 31
$328 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$250 nightly
The price is $290 total per night from Aug 26 to Aug 27
$290 total
Aug 26 - Aug 27
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
9/10 Wonderful! (2,790 reviews)
"Everything was great, location was amazing, property is Beautiful. The only issue was we arrived at 4pm and the room was not ready."
Reviewed on Aug 4, 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Aug 12 to Aug 13
$211 total
Aug 12 - Aug 13
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,295 reviews)
"I’d say book this stay for a budget friendly but rugged stay. Shower bottles were not well maintained, run down furniture, and tissue stuck in a hole in the ceiling rather than a lightbulb installed. Poor bathroom lighting."
Reviewed on Aug 4, 2026
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
$234 nightly
The price is $269 total per night from Sep 1 to Sep 2
$269 total
Sep 1 - Sep 2
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$229 nightly
The price is $265 total per night from Aug 13 to Aug 14
$265 total
Aug 13 - Aug 14
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,139 reviews)
"First time there, we got our room, Which was nice, but the bathroom was dirty, someone exploded the toilet. So gross, called front desk, they sent us to another room, which was old and no upgrades. Very disappointing. Requested our old room back and good thing I saw housekeeping and asked them to ..."
Reviewed on Aug 4, 2026
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
$287 nightly
The price is $330 total per night from Aug 30 to Aug 31
$330 total
Aug 30 - Aug 31
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,317 reviews)
"The location, staff and restaurants were excellent. Room was very dated. Bed too high for handicapped person."
Reviewed on Aug 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Seaport Village are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Riviera Shores Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Spreckels Theater is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
Otay Mesa, CA
Explore a world of travel with Expedia
- Beach Hotels in San Diego County
- Carlsbad Hotels
- Old Town San Diego Hotels
- Cheap Hotels in San Diego County
- Pacific Beach Hotels
- Hotels near Mission Beach
- Chula Vista Hotels
- Cheap Hotels in San Diego
- Hotels near San Diego Convention Center
- Coronado Hotels
- San Diego Hotels
- Hotels near San Ysidro Border Crossing
- Hotels near Hotel Circle
- Hotels with a Lazy River in San Diego County
- Hotels with Free Airport Shuttle in San Diego
- Hotels near San Diego Zoo
- Gaslamp Quarter Hotels
- La Jolla Hotels
- Hotels near Petco Park
- Hotels near LEGOLAND® California
- Extended Stay Hotels in San Diego
- San Diego County Hotels
- Hotels near Mission Bay
- Hotels near San Diego Intl.
- All-Inclusive Resorts in San Diego
- Downtown San Diego Hotels
- Flights from Portland (PDX) to San Diego (SAN)
- Flights from Nashville (BNA) to San Diego (SAN)
- Flights from Chicago (ORD) to San Diego (SAN)
- Flights from Seattle (SEA) to San Diego (SAN)
- Flights from Los Angeles (LAX) to San Diego (SAN)
- Flights from Boston (BOS) to San Diego (SAN)
- Flights from Minneapolis (MSP) to San Diego (SAN)
- Flights from Raleigh (RDU) to San Diego (SAN)
- Flights from Norfolk (ORF) to San Diego (SAN)
- Flights from San Diego Intl.
- Flights from Houston (IAH) to San Diego (SAN)
- Flights from Philadelphia (PHL) to San Diego (SAN)
- Flights from Phoenix (PHX) to San Diego (SAN)
- Flights from Kansas City (MCI) to San Diego (SAN)
- Flights from Austin (AUS) to San Diego (SAN)
- Flights from Orlando (MCO) to San Diego (SAN)
- Flights from San Jose (SJC) to San Diego (SAN)
- Flights from Oakland (OAK) to San Diego (SAN)
- Flights from New York (JFK) to San Diego (SAN)
- Flights from Sacramento (SMF) to San Diego (SAN)
- Flights from Boise (BOI) to San Diego (SAN)
- Flights from Washington (IAD) to San Diego (SAN)
- Flights from Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
- Flights from Detroit (DTW) to San Diego (SAN)
- Flights to San Diego
- Flights from Honolulu (HNL) to San Diego (SAN)
- Flights from Salt Lake City (SLC) to San Diego (SAN)
- Flights from Las Vegas (LAS) to San Diego (SAN)
- Flights from Dallas (DFW) to San Diego (SAN)
- Flights from Denver (DEN) to San Diego (SAN)
- Flights from Tampa (TPA) to San Diego (SAN)
- Flights from Baltimore (BWI) to San Diego (SAN)
- Flights from Fresno (FAT) to San Diego (SAN)
- Flights from San Francisco (SFO) to San Diego (SAN)
- Flights from Charlotte (CLT) to San Diego (SAN)
- Flights from Atlanta (ATL) to San Diego (SAN)
- Visit Spring Valley
- Visit San Diego Coast
- Visit National City
- Visit Otay Mesa West
- Visit Old Town San Diego
- Visit Mission Beach
- Visit Del Mar
- Visit Downtown San Diego
- Visit South San Diego
- Visit Chula Vista
- Visit Dulzura
- Visit Lawrence Welk Resort Village
- Visit Little Italy
- Visit Mission Valley
- Visit Otay
- Visit Bonita
- Visit Coronado
- Visit Liberty Station
- Visit Imperial Beach
- Visit Coronado Cays
- Visit Gaslamp Quarter
- Visit Castle Park
- Visit Bird Rock
- Balboa Park
- Visit San Ysidro
- Visit La Jolla
- Visit Point Loma
- Visit Alpine
- Visit Ocean Beach
- San Diego Vacations
- Visit San Diego
- Visit South Bay
