Otay Mesa, CA
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
94% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
$86
per adult
100% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
Tijuana Walking Street Food Tour with Wild Foodie Tours
$79
per adult
Otay Mesa Hotel Deals
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
$276 nightly
The price is $320 total per night from Sep 13 to Sep 14
$320 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
$182 nightly
The price is $211 total per night from Sep 20 to Sep 21
$211 total
Sep 20 - Sep 21
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,305 reviews)
"Great super location"
Reviewed on Sep 11, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$254 nightly
The price is $292 total per night from Oct 4 to Oct 5
$292 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,852 reviews)
"The first day was terrible. Our room had a bad, moldy smell, and it was hard to breathe. We asked for another room, but they were out of available rooms, so we had to suffer through one night. The next day, they moved us to another room which was much better. However, the overall feel was outdated, ..."
Reviewed on Sep 11, 2026
The Sofia Hotel
150 W Broadway San Diego CA
$172 nightly
The price is $200 total per night from Sep 28 to Sep 29
$200 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,623 reviews)
"Parking was safe but surprising as surface level only. Staff was nice. Room was dated and not great in comparison to options in our timeframe. Free drink does not really cover for it."
Reviewed on Sep 11, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
$237 nightly
The price is $274 total per night from Sep 13 to Sep 14
$274 total
Sep 13 - Sep 14
Total with taxes and fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Handlery Hotel
950 Hotel Cir N San Diego CA
Fully refundable
$118 nightly
The price is $136 total per night from Oct 7 to Oct 8
$136 total
Oct 7 - Oct 8
Total with taxes and fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Lyceum Theatre is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa, CA
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