$111 Cheap Flights from Buffalo (BUF) to Knoxville (TYS)

View $111 flight on Sat, Jan 24, 2026Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Buffalo to Knoxville (BUF-TYS)

Prices were available within the past 7 days and start at $111 for one-way flights and $236 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Jan 26 - Sat, Feb 7
BUF
Buffalo
TYS
Knoxville
$236 Roundtrip, found 6 days ago
$236
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Jan 26 from Buffalo to Knoxville, returning Sat, Feb 7, priced at $236 found 6 days ago
Delta
Thu, Nov 27 - Sat, Dec 13
BUF
Buffalo
TYS
Knoxville
$250 Roundtrip, found 6 days ago
$250
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Nov 27 from Buffalo to Knoxville, returning Sat, Dec 13, priced at $250 found 6 days ago
American Airlines
Fri, Feb 20 - Tue, Feb 24
BUF
Buffalo
TYS
Knoxville
$267 Roundtrip, found 2 days ago
$267
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Feb 20 from Buffalo to Knoxville, returning Tue, Feb 24, priced at $267 found 2 days ago
United
Wed, Nov 19 - Mon, Nov 24
BUF
Buffalo
TYS
Knoxville
$270 Roundtrip, found 2 days ago
$270
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 19 from Buffalo to Knoxville, returning Mon, Nov 24, priced at $270 found 2 days ago
American Airlines
Sat, Nov 22 - Thu, Nov 27
BUF
Buffalo
TYS
Knoxville
$275 Roundtrip, found 7 hours ago
$275
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Nov 22 from Buffalo to Knoxville, returning Thu, Nov 27, priced at $275 found 7 hours ago
United
Wed, Nov 19 - Mon, Nov 24
BUF
Buffalo
TYS
Knoxville
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select United flight, departing Wed, Nov 19 from Buffalo to Knoxville, returning Mon, Nov 24, priced at $275 found 2 days ago
Delta
Tue, Nov 11 - Thu, Nov 20
BUF
Buffalo
TYS
Knoxville
$284 Roundtrip, found 2 days ago
$284
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Nov 11 from Buffalo to Knoxville, returning Thu, Nov 20, priced at $284 found 2 days ago
American Airlines
Fri, Feb 20 - Tue, Feb 24
BUF
Buffalo
TYS
Knoxville
$287 Roundtrip, found 2 days ago
$287
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Feb 20 from Buffalo to Knoxville, returning Tue, Feb 24, priced at $287 found 2 days ago
Delta
Thu, Nov 27 - Fri, Dec 12
BUF
Buffalo
TYS
Knoxville
$293 Roundtrip, found 6 days ago
$293
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Nov 27 from Buffalo to Knoxville, returning Fri, Dec 12, priced at $293 found 6 days ago
Southwest Airlines
Mon, May 25 - Sat, May 30
BUF
Buffalo
TYS
Knoxville
$357 Roundtrip, found 6 hours ago
$357
Roundtrip
found 6 hours ago
Select Southwest Airlines flight, departing Mon, May 25 from Buffalo to Knoxville, returning Sat, May 30, priced at $357 found 6 hours ago

Find the cheapest month to fly from Buffalo (BUF) to Knoxville (TYS)

April is typically the cheapest month to fly

From $198 - $469 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $417
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $417

Frequently asked questions

How much does a flight from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS) cost?
Get a cheap one-way flight from $111 or cheap return flight from $236 from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)?
Flying in January is a great way to save, as it's the cheapest month for flights between BUF and TYS. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)?
To find the cheapest airline flying from BUF to TYS, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)?
You'll need to book a flight with a layover when traveling from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from BUF to TYS?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)?
Choose a flight from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS) that takes off before 3 PM to reduce the likelihood of delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS) last-minute?
Holding off until just before your departure to book a ticket from BUF to TYS often results in higher prices. While you may come across some last-minute deals, there's no guarantee. Allow some flexibility in your schedule for a better chance of snagging a bargain.
Is it cheaper to book a BUF to TYS flight and hotel package?
Securing a BUF to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Choose from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to McGhee Tyson Airport (TYS)?
Typically, you can cancel or modify your BUF to TYS flight. However, additional fees may apply, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you need further details, visit our Customer Service portal.

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$235
Distance
566 mi

Book with confidence

Buffalo to Knoxville Flights

The cheapest times to fly from Buffalo to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Knoxville are during the month of January. You can find some of the cheapest flights from Buffalo to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Knoxville

Sunday is one of the best days to book for cheap flights from Buffalo to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $111 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Buffalo to Knoxville Flights

Explore a world of travel with Expedia

*Available to One Key members.