$257 Cheap Flights from Cusco (CUZ) to Panama City (PTY)

View $257 flight on Mon, Dec 1, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)

Cheap Flights from Cusco to Panama City (CUZ-PTY)

Prices were available within the past 7 days and start at $257 for one-way flights and $564 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Mon, Nov 10 - Thu, Nov 13
CUZ
Cusco
PTY
Panama City
$564 Roundtrip, found 3 days ago
$564
Roundtrip
found 3 days ago
Select avianca flight, departing Mon, Nov 10 from Cusco to Panama City, returning Thu, Nov 13, priced at $564 found 3 days ago
avianca
Fri, May 8 - Tue, May 12
CUZ
Cusco
PTY
Panama City
$583 Roundtrip, found 1 day ago
$583
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, May 8 from Cusco to Panama City, returning Tue, May 12, priced at $583 found 1 day ago
avianca
Thu, Nov 6 - Thu, Nov 13
CUZ
Cusco
PTY
Panama City
$623 Roundtrip, found 3 days ago
$623
Roundtrip
found 3 days ago
Select avianca flight, departing Thu, Nov 6 from Cusco to Panama City, returning Thu, Nov 13, priced at $623 found 3 days ago
avianca
Fri, Sep 5 - Fri, Sep 12
CUZ
Cusco
PTY
Panama City
$630 Roundtrip, found 2 days ago
$630
Roundtrip
found 2 days ago
Select avianca flight, departing Fri, Sep 5 from Cusco to Panama City, returning Fri, Sep 12, priced at $630 found 2 days ago
avianca
Wed, Sep 17 - Tue, Oct 21
CUZ
Cusco
PTY
Panama City
$668 Roundtrip, found 17 hours ago
$668
Roundtrip
found 17 hours ago
Select avianca flight, departing Wed, Sep 17 from Cusco to Panama City, returning Tue, Oct 21, priced at $668 found 17 hours ago
avianca
Sun, Nov 9 - Mon, Nov 10
CUZ
Cusco
PTY
Panama City
$688 Roundtrip, found 3 days ago
$688
Roundtrip
found 3 days ago
Select avianca flight, departing Sun, Nov 9 from Cusco to Panama City, returning Mon, Nov 10, priced at $688 found 3 days ago
avianca
Fri, Sep 5 - Fri, Sep 12
CUZ
Cusco
PTY
Panama City
$771 Roundtrip, found 2 days ago
$771
Roundtrip
found 2 days ago
Select avianca flight, departing Fri, Sep 5 from Cusco to Panama City, returning Fri, Sep 12, priced at $771 found 2 days ago
avianca
Mon, Sep 15 - Tue, Oct 21
CUZ
Cusco
PTY
Panama City
$784 Roundtrip, found 17 hours ago
$784
Roundtrip
found 17 hours ago
Select avianca flight, departing Mon, Sep 15 from Cusco to Panama City, returning Tue, Oct 21, priced at $784 found 17 hours ago
avianca
Fri, Sep 5 - Fri, Sep 12
CUZ
Cusco
PTY
Panama City
$819 Roundtrip, found 2 days ago
$819
Roundtrip
found 2 days ago
Select avianca flight, departing Fri, Sep 5 from Cusco to Panama City, returning Fri, Sep 12, priced at $819 found 2 days ago
avianca
Mon, Sep 1 - Fri, Sep 5
CUZ
Cusco
PTY
Panama City
$852 Roundtrip, found 13 hours ago
$852
Roundtrip
found 13 hours ago
Select avianca flight, departing Mon, Sep 1 from Cusco to Panama City, returning Fri, Sep 5, priced at $852 found 13 hours ago
Flights from Cusco (CUZ) to Panama City (PTY)
Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Tocumen Intl.
Airlines serving
avianca
Roundtrip price
$563
Distance
1643 mi

Cusco to Panama City Flights

The cheapest times to fly from Cusco to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Panama City are during the month of November. You can find some of the cheapest flights from Cusco to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Panama City

Sunday is one of the best days to book for cheap flights from Cusco to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $257 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) cost?
Snag a cheap one-way flight from $257 or cheap return flight from $564 from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
November is the most affordable month to fly from CUZ to PTY. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from CUZ to PTY. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
You'll need to take a flight with a layover if you're traveling from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from CUZ to PTY?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) last-minute?
Booking your plane ticket from CUZ to PTY just before your trip is typically more expensive. But if you're flexible with your travel dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book a CUZ to PTY flight and hotel package?
You'll generally save money by booking a CUZ to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've selected your ideal accommodations and flights, you can add extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
In most instances, you can cancel or reschedule your CUZ to PTY flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

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*Available to One Key members.