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$175 Cheap Flights from Jacksonville (JAX) to Des Moines (DSM)

View $175 flight on Wed, Oct 28, 2026Opens in a new window

Popular airlines from Jacksonville International Airport (JAX) to Des Moines International Airport (DSM)

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Cheap Flights from Jacksonville to Des Moines (JAX-DSM)

Prices were available within the past 7 days and start at $175 for one-way flights and $355 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Oct 20 - Tue, Oct 27
JAX
Jacksonville
DSM
Des Moines
$355 Roundtrip, found 1 day ago
$355
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 20 from Jacksonville to Des Moines, returning Tue, Oct 27, priced at $355 found 1 day ago
United
Wed, Oct 28 - Wed, Nov 4
JAX
Jacksonville
DSM
Des Moines
$357 Roundtrip, found 2 days ago
$357
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 28 from Jacksonville to Des Moines, returning Wed, Nov 4, priced at $357 found 2 days ago
Delta
Thu, Dec 17 - Mon, Dec 21
JAX
Jacksonville
DSM
Des Moines
$359 Roundtrip, found 22 hours ago
$359
Roundtrip
found 22 hours ago
Select Delta flight, departing Thu, Dec 17 from Jacksonville to Des Moines, returning Mon, Dec 21, priced at $359 found 22 hours ago
Southwest Airlines
Tue, Oct 20 - Tue, Oct 27
JAX
Jacksonville
DSM
Des Moines
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, Oct 20 from Jacksonville to Des Moines, returning Tue, Oct 27, priced at $359 found 1 day ago
Southwest Airlines
Wed, Oct 28 - Wed, Nov 4
JAX
Jacksonville
DSM
Des Moines
$364 Roundtrip, found 2 days ago
$364
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Oct 28 from Jacksonville to Des Moines, returning Wed, Nov 4, priced at $364 found 2 days ago
American Airlines
Fri, Oct 30 - Wed, Nov 4
JAX
Jacksonville
DSM
Des Moines
$373 Roundtrip, found 2 days ago
$373
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Oct 30 from Jacksonville to Des Moines, returning Wed, Nov 4, priced at $373 found 2 days ago
American Airlines
Fri, Jan 8 - Fri, Jan 22
JAX
Jacksonville
DSM
Des Moines
$374 Roundtrip, found 1 day ago
$374
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 8 from Jacksonville to Des Moines, returning Fri, Jan 22, priced at $374 found 1 day ago
Southwest Airlines
Tue, Oct 20 - Tue, Oct 27
JAX
Jacksonville
DSM
Des Moines
$376 Roundtrip, found 1 day ago
$376
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, Oct 20 from Jacksonville to Des Moines, returning Tue, Oct 27, priced at $376 found 1 day ago
Southwest Airlines
Wed, Oct 28 - Wed, Nov 4
JAX
Jacksonville
DSM
Des Moines
$379 Roundtrip, found 2 days ago
$379
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Oct 28 from Jacksonville to Des Moines, returning Wed, Nov 4, priced at $379 found 2 days ago
American Airlines
Fri, Jan 8 - Fri, Jan 22
JAX
Jacksonville
DSM
Des Moines
$381 Roundtrip, found 1 day ago
$381
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 8 from Jacksonville to Des Moines, returning Fri, Jan 22, priced at $381 found 1 day ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $517
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $517

What you need to know for your flight from Jacksonville Intl. to Des Moines Intl.

Jacksonville (JAX) to Des Moines (DSM) at a glance

Travel effortlessly between Jacksonville (JAX) and Des Moines (DSM) with a variety of airlines offering options for this domestic short-haul journey. Compare one-way flights from Jacksonville to Des Moines to discover the best airfare that aligns with your budget and travel schedule. Whether you prefer full-service airlines or low-cost carriers, you’ll find an itinerary that suits your needs as you prepare to explore the vibrant sights and neighborhoods of Des Moines.

  • Fastest flight duration: around 4 hours in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 1,000 miles (1,610 km)
  • Flights per week: around 10 departures on average
  • Typical fares (one-way): economy tickets often range from $130–$490, depending on seasonality and how far ahead you book

Flights from Jacksonville International Airport (JAX) to Des Moines International Airport (DSM)

Based on the latest traveler bookings, here are the top airlines favored for one-stop flights from Jacksonville to Des Moines. Popular layover options include Hartsfield-Jackson Atlanta International Airport (ATL) with around a 1 hour and 15-minute stop, Charlotte-Douglas International Airport (CLT) with a 1-hour layover, and O'Hare International Airport (ORD) offering a 1 hour and 45-minute connection. These choices provide flexibility in terms of pricing, total travel time, and cabin class to help you find the best itinerary.

  • Delta: This full-service airline provides one-stop travel options, with one-way ticket prices generally falling between $140 and $490. Delta represents around 38% of all departures on this route, featuring a flight duration of 4 hours and a total travel time of approximately 5 hours and 15 minutes, including layovers.
  • American Airlines: As a full-service carrier, American Airlines offers one-stop services with one-way fares typically ranging from $130 to $465. It makes up about 36% of the departures on this route, with an in-flight time of 4 hours and a total journey lasting around 5 hours and 15 minutes, layover included.
  • United: Offering one-stop service, United is a full-service airline with one-way fares generally priced between $160 and $485. Approximately 14% of the departures on this route are operated by United, featuring a flight time of 4 hours and a total travel duration of roughly 5 hours and 15 minutes, accounting for layovers.
  • Southwest Airlines: This low-cost carrier provides one-stop services, with one-way fares typically spanning from $130 to $490. Southwest Airlines comprises about 12% of the departures on this route, with an in-flight duration of 4 hours and a complete journey time of roughly 5 hours and 15 minutes, including layover periods.

Travelers flying from Jacksonville to Des Moines can opt for an upgrade, as Delta provides premium economy class service on this route.

Best time to fly from Jacksonville (JAX) to Des Moines (DSM)

The most popular months for travelers flying from Jacksonville to Des Moines are March, April, and May, when peak temperatures in Des Moines reach up to 61.3°F in May. If you prefer quieter travel, consider October, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 53.2°F. For better deals, August usually offers the lowest average one-way fare around $187. Flight availability peaks in May, with approximately 12 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: August usually offers good deals with average one-way fare around $187, roughly 26% cheaper than the yearly average.
  • Another budget-friendly time to fly: October typically offers an average one-way fare of around $204.
  • Most flight options: May has the highest number of flights from Jacksonville to Des Moines, with approximately 12 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January21.7°F (-5.7°C)Average9$263
February24.1°F (-4.4°C)Average9$283
March39.6°F (4.2°C)High10$341
April50.2°F (10.1°C)High10$274
May61.3°F (16.3°C)High12$250
June71.8°F (22.1°C)Average8$259
July74.8°F (23.8°C)Low9$253
August73.4°F (23.0°C)Average10$187
September66.9°F (19.4°C)Low10$252
October53.2°F (11.8°C)Low8$204
November40.5°F (4.7°C)Average10$261
December29.3°F (-1.5°C)Average10$250

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Jacksonville (JAX) to Des Moines (DSM)

  • Gainesville to Des Moines (GNV-DSM): Gainesville Regional Airport (GNV) is located approximately 66 miles from Jacksonville International Airport (JAX). One-way economy prices for this route generally fall between $195 and $445, influenced by the season and timing of the booking. Travelers can expect primarily one-stop services, with common layover points at Hartsfield-Jackson Atlanta International Airport (ATL) and Charlotte-Douglas International Airport (CLT). Major airlines operating on this route include Delta and American Airlines. Additionally, first-class service is offered for those seeking a more premium experience.

How to find the best prices for flights from Jacksonville (JAX) to Des Moines (DSM)

Getting some of the best deals on flights from Jacksonville to Des Moines is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Evening departures (6 PM-12 AM) often offer lower prices, although morning flights (5 AM-12 PM) are the most popular. Additionally, flying on Saturday typically results in cheaper rates, while Monday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Des Moines International Airport from Jacksonville International Airport

Des Moines welcomes travelers from Jacksonville with a range of transport options based on price, convenience, and proximity. Here's how to reach Des Moines efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Des Moines, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Des Moines International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Des Moines International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $175 and cheap return flights from $355 Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights generally range between $165 and $702, and roundtrip flights usually range from $356 to $1149. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from JAX to DSM is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter JAX to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Jacksonville International Airport (JAX) to Des Moines International Airport (DSM) typically departs at around 5:00 AM local time, operated by American Airlines. This is a seasonal service active in November, and catching an early flight can help you make the most of your time in Des Moines. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The most popular departure times for flights from Jacksonville (JAX) to Des Moines (DSM) are in the early morning, from 6am to 9am. About 34% of passengers prefer this time window. Many major carriers, including Delta Air Lines, American Airlines and United Airlines, offer flights during this window. This timing is favored because it allows you to arrive in Des Moines with plenty of time to start your day.
How long does it take to fly from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Flying from JAX to DSM with a connection usually takes about 6 hours 20 minutes, traveling roughly 1,012 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
You can fly first class between JAX and DSM. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Jacksonville Intl. (JAX)?
If you're planning to travel to Des Moines from Jacksonville Intl. (JAX), you can fly into Des Moines Intl. (DSM) Some flights may connect through major hubs like George Bush Intercontinental (IAH), Washington Dulles Intl. (IAD), Liberty Intl. (EWR) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Jacksonville, FL (JAX-Jacksonville Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Jacksonville Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$355
Distance
1012 mi

Book with confidence

Jacksonville to Des Moines Flights

The cheapest times to fly from Jacksonville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Jacksonville to Des Moines are during the month of October. You can find some of the cheapest flights from Jacksonville to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Jacksonville to Des Moines

Sunday is one of the best days to book for cheap flights from Jacksonville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Jacksonville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Jacksonville to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $175 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Jacksonville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Jacksonville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Jacksonville to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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