Title: The Best 5 Star Hotels in Isabela Island | Expedia.com [Isabela Island Travel Guide](https://expedia.com/Isabela-Island.dx6085329)[Hotels in Isabela Island](https://expedia.com/Isabela-Island-Hotels.d6085329.Travel-Guide-Hotels)[Vacation Rentals in Isabela Island](https://expedia.com/Isabela-Island-Vacation-Rentals.d6085329.Travel-Guide-VacationRentals)[Flights to Isabela Island](https://expedia.com/Cheap-Flights-To-Isabela-Island.d6085329.Travel-Guide-Flights)[Things to do in Isabela Island](https://expedia.com/Things-To-Do-In-Isabela-Island.d6085329.Travel-Guide-Activities)[Car Rentals in Isabela Island](https://expedia.com/Car-Rentals-In-Isabela-Island.d6085329.Car-Rental-Guide)[Isabela Island Vacation Packages](https://expedia.com/Isabela-Island.d6085329.Destination-Travel-Guides) ![Galapagos islands tourist woman at yellow land iguana on Urbina Bay sand beach panoramic banner. Asian happy girl traveling in Ecuador.](https://images.trvl-media.com/place/6085329/4337a490-733c-45a6-9cff-c3fc0bb8d38d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6085329/4337a490-733c-45a6-9cff-c3fc0bb8d38d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Isabela Island 5 Star Hotels Tonight [Mar 13 - Mar 14](https://www.expedia.com/Hotel-Search?regionId=6085329&startDate=2026-03-13&endDate=2026-03-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 14 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6085329&startDate=2026-03-14&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6085329&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6085329&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Isabela-Island-Hotels.s50-0-d6085329.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Isabela-Island-Hotels.s50-0-d6085329.Travel-Guide-Filter-Hotels) ## Learn more about Isabela Island Head to sights like Galápagos National Park and Puerto Villamil Beach as you discover Isabela Island. [See all hotels in Isabela Island](https://www.expedia.com/Hotel-Search?startDate=2026-03-27&endDate=2026-03-28&adults=2®ionId=6085329) ![Galapagos islands tourist woman at yellow land iguana on Urbina Bay sand beach panoramic banner. Asian happy girl traveling in Ecuador.](https://images.trvl-media.com/place/6085329/4337a490-733c-45a6-9cff-c3fc0bb8d38d.jpg?impolicy=fcrop&w=900&h=300&p=1&q=high) ## Top Isabela Island Hotel Reviews ## Find out more about Isabela Island Why not ask for the best during your trip to Isabela Island? After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Isabela Island so popular in the last year. There's no reason to delay a getaway to Isabela Island any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Our 5-star hotels in Isabela Island are the perfect places to relax in during your next getaway. What are you waiting for? ### Book the Best Isabela Island 5-Star Hotels You'll have a fantastic time at one of these 5-star hotels. Michelin-starred restaurants, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What creature comforts do you want in your lodging? A mud wrap treatment that will leave you feeling like a million bucks? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A Swedish massage to help your cares fall away? Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs. But you aren't going to spend your entire vacation in your room, of course. We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Isabela Island are waiting for you to rest up after an exciting day. ### Your Getaway Starts Today The results are in, and Isabela Island 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. It's time to plan your next great escape -- Expedia can help you land a great deal on accommodation. Opt for one of our Isabela Island 5-star hotels today and settle down in the lap of luxury at your convenience. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Isabela Island? > - Search for the lowest price per night ### What makes a hotel 5 stars in Isabela Island? ### Are there any 5-star all-inclusive resorts in Isabela Island? ## Explore a world of travel with Expedia - Packages - Cars - [Interpretation Center ](https://www.expedia.com/Interpretation-Center-Tomas-de-Berlanga.d553248621532374441.Vacation-Attraction) - [Car rentals near Interpretation Center ](https://www.expedia.com/Car-Rentals-In-Interpretation-Center.d553248621532374441.Car-Rental-Guide)