Biscayne Vacations from $322

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Your Biscayne Vacation

Book a Biscayne vacation package and experience the way of life and rhythm of this sought-after neighborhood. With all your travel plans taken care of, the only thing you need to focus on here is having the time of your life. When it's time to explore the sights, you'll find a lot of awesome attractions nearby including Florida State College North Campus, Anheuser-Busch Brewery and Bethesda Park. Tick off one or all during your trip to Biscayne. Stop dreaming and start doing. When it's time to lock in your ideal vacation to Biscayne, Expedia will help get you there.

The Latest Biscayne Vacation Packages

Price found within the past 48 hours. Click for updated prices.
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
Downtown Jacksonville
Price was $455, price is now $322 per person
$322
per person
Dec 5 - Dec 8
found 2 days ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
6.8/10 (1,408 reviews)
our room was very hot which made it uncomfortable throughout the nights . I couldn't change the the thermostat it was stuck . It so was so hot it made me sick.

Reviewed on Oct 26, 2025

Hammock Beach Golf Resort & Spa

Hammock Beach Golf Resort & Spa

4 out of 5
Save 100% on your flight
Price was $942, price is now $648 per person
$648
per person
Jan 15 - Jan 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Daytona Beach (DAB)
8.6/10 Excellent! (1,004 reviews)
place is just fine. a bit dated but great location. nice people

Reviewed on Oct 20, 2025

The Ritz-Carlton, Amelia Island

The Ritz-Carlton, Amelia Island

5 out of 5
Amelia City
Save 100% on your flight
Price was $1,622, price is now $1,134 per person
$1,134
per person
Jan 9 - Jan 12
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
9.2/10 Wonderful! (372 reviews)
Leticia at the front desk was fantastic! I had a health related attack on the way back from Atlanta and we decided to stay at the Ritz so I could rest. We stayed at this Ritz on our honeymoon over 30 years ago, had my 50th birthday party at Salt with guests for a weekend, stayed there for our 30th wedding anniversary and had dinner at Salt also (I highly recommend Salt), stayed many holidays with our children and friends, car shows, and it is still such a wonderful resort. You cannot go wrong staying at this beautiful resort. We have loved it for over 30 years and hope to keep going there for many more years to come. All of the staff is great, but a special shout out to Leticia. Thank you for helping us.

Reviewed on Sep 6, 2025

Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
Save 100% on your flight
Price was $730, price is now $511 per person
$511
per person
Jan 9 - Jan 12
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Jacksonville (JAX)
8.6/10 Excellent! (1,008 reviews)
Very cool self contained resort

Reviewed on Oct 23, 2025

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3 out of 5
Save 100% on your flight
Price was $1,048, price is now $735 per person
$735
per person
Dec 30 - Jan 4
found 1 day ago
Roundtrip non-stop flight included
New York (LGA) to Jacksonville (JAX)
9.2/10 Wonderful! (2,500 reviews)
Upgraded to oceanfront. Bathroom needs updating but everything else in the the room was great. Where do we buy those awesome pillows?? Stephen Mcinninch and Eric at the front desk were so helpful.

Reviewed on Oct 27, 2025

Where to stay in Biscayne

Find the best Biscayne areas and neighborhoods for the activities you enjoy most. Learn more about Biscayne
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Southside

1 out of top 10 points of interest in this area
4/5(912 area reviews)

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

Find hotels in Southside

Biscayne Hotel Deals

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $165 total per night from Nov 23 to Nov 24
$165 total
Nov 23 - Nov 24
Total with taxes and fees
8.8/10 Excellent! (1,347 reviews)
Everything was amazing. We got a room with the river view and loved it!

Reviewed on Oct 26, 2025

Hyatt Regency Jacksonville
DoubleTree by Hilton Hotel Jacksonville Riverfront

DoubleTree by Hilton Hotel Jacksonville Riverfront

4 out of 5
1201 Riverplace Boulevard, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$92 nightly
The price is $104 total per night from Nov 26 to Nov 27
$104 total
Nov 26 - Nov 27
Total with taxes and fees
6.6/10 (1,407 reviews)
.

Reviewed on Oct 26, 2025

DoubleTree by Hilton Hotel Jacksonville Riverfront
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

3 out of 5
14565 Duval Rd, Jacksonville, FL
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Nov 16 to Nov 17
$106 total
Nov 16 - Nov 17
Total with taxes and fees
8.8/10 Excellent! (2,152 reviews)
Will be returning

Reviewed on Oct 24, 2025

Hyatt Place Jacksonville Airport
See all 2,992 properties in Biscayne
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Biscayne

Pretty

Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

Mayo Clinic Florida
Jacksonville Naval Air Station

Jacksonville Naval Air Station

After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.

Jacksonville Naval Air Station
EverBank Field which includes a lake or waterhole

EverBank Stadium

Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.

EverBank Stadium

Things to do

Chocolate Bar Class

Chocolate Bar Class - Hands on class

$20
per adult
Chocolate Bar Class - Hands on class
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports

$140
per traveler
90% of travellers recommend
1 Hour Jet Ski Rental in Jacksonville, FL Evolution Jetsports
Architecture and History Tour in San Marco

Architecture and History Tour in San Marco

$96
per adult
Architecture and History Tour in San Marco
See all activities in Jacksonville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.