Defiance Vacations from $235
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Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance vacation packages
Price found within the past 48 hours. Click for updated prices.
The Knight Center at Washington University
Save 100% on your flight
Price was $322, price is now $235 per person
$235
per person
Oct 16 - Oct 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (627 reviews)
Very nice location. Quiet. University grounds are beautiful.
Reviewed on Jul 26, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $572, price is now $307 per person
$307
per person
Sep 27 - Oct 2
found 6 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,650 reviews)
Very clean and close to everything. When they say "public parking" there is a garage right behind the hotel with a door to the hotel right outside of it. You can use your card to get in and there is an elevator right inside to take to your floor.
Reviewed on Jul 26, 2026
Remodeled and Inviting Free EV
Save 100% on your flight
Price was $930, price is now $556 per person
$556
per person
Sep 27 - Oct 2
found 6 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
10/10 Exceptional! (1 review)
The property was excellent, and the home was very warm and welcoming.
Reviewed on Jun 25, 2026
The Cheshire
Save 100% on your flight
Price was $677, price is now $458 per person
$458
per person
Sep 27 - Oct 2
found 6 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,010 reviews)
The boutique hotel was a very neat experience. The staff was very helpful. It was a central location for the things we wanted to do while in St. Louis.
Reviewed on Jul 26, 2026
Stay near popular Defiance attractions
What to do in Defiance
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
StL's Signature "Sights and Bites" - Private Tour in St. Louis
$165
per adult
Lemp Haunted Neighborhood Walking Tour
$25
per adult
84% of travellers recommend
Defiance Hotel Deals
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $162 total per night from Aug 3 to Aug 4
$162 total
Aug 3 - Aug 4
Total with taxes and fees
8.6/10 Excellent! (2,215 reviews)
"Suite guest, water on our floor didn’t work. Rose petals and ballon trash left over from previous guests. No one was present up front for check in at 1030pm, when someone walked out they looked at us and continued to walk away. The hotel allows kids to stay, but all the restaurants are inside the ..."
Reviewed on Jul 27, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Aug 2 to Aug 3
$109 total
Aug 2 - Aug 3
Total with taxes and fees
7.8/10 Good! (1,475 reviews)
"We stayed here for two nights while attending our daughter’s Irish dance competition. Unfortunately, our experience was overshadowed by finding multiple insects in our room over the course of our stay. We reported the issue to the front desk and were told another guest had recently made a similar ..."
Reviewed on Jul 26, 2026
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $195 total per night from Aug 5 to Aug 6
$195 total
Aug 5 - Aug 6
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Defiance Vacation Packages
Defiance Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 40ºF |
Max Temp Summer | 90ºF |
Top Sights | Augusta Winery, Montelle Winery and Chandler Hill Vineyards |
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Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
