Title: Top 10 Hotels in Defiance, MO (from $68) 2026 - Competitive Prices | Expedia.com [Defiance Travel Guide](https://expedia.com/Defiance.dx6353634)[Vacation Rentals in Defiance](https://expedia.com/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.com/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Car Rentals in Defiance](https://expedia.com/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.com/Defiance.d6353634.Destination-Travel-Guides) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Defiance Great for families [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&travelerType=family_friendly) Pet-friendly [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&amenities=PETS) Pool [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&amenities=POOL) Cabins [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&lodging=CABIN) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&amenities=HOT_TUB) Cottages [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&lodging=COTTAGE) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&lodging=APARTMENT) Condo [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&lodging=CONDO) Waterpark [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&amenities=WATER_PARK) Chalet [](https://www.expedia.com/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-03-09&d1=2026-03-09&endDate=2026-03-11&d2=2026-03-11&lodging=CHALET) ## Check prices for these dates Tonight [Feb 23 - Feb 24](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-02-23&endDate=2026-02-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 24 - Feb 25](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-02-24&endDate=2026-02-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6353634&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Defiance hotels ![Suite, 1 King Bed, Non Smoking (Upgraded) | In-room safe, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/cc91e017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/a8d86cf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/5b621e3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/860000/855500/855477/390b6bf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham St. Clair MO [](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information) St. Clair 7.2/10 Good (960 reviews) "Room was okay, definitely not the best but good for the price. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mason $64 nightly $70 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-St-Clair-MO.h855477.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/3a1e3bea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking, Refrigerator & Microwave (with Sofabed) | Egyptian cotton sheets, premium bedding, pillowtop beds, desk](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/fecb1b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free full breakfast](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/70eb43b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1080000/1077200/1077183/d4f404b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Washington Hotel [](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information) Washington 9.2/10 Wonderful (662 reviews) "Clean room and hotel with a nice breakfast, have stayed here two times while visiting family." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brooks $129 nightly $147 total Feb 25 - Feb 26 Total with taxes and fees [](https://www.expedia.com/Washington-Hotels-Best-Western-Plus-Washington-Hotel.h1077183.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/280c265a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/67dd4122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/5f015fac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8600/8597/3bf2ff2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Economy Inn Wentzville [](https://www.expedia.com/St-Louis-Hotels-Economy-Inn-Wentzville.h8597.Hotel-Information) Wentzville 6.4/10 (519 reviews) "Really cozy place to stay at!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yufei $60 nightly $68 total Feb 24 - Feb 25 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Economy-Inn-Wentzville.h8597.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/b1b83291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/b8c4dabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/914d7802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, rollaway beds](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489252/f1837aa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Warrenton by IHG [](https://www.expedia.com/Warrenton-Hotels-Holiday-Inn-Express-Warrenton.h1489252.Hotel-Information) Warrenton 9.0/10 Wonderful (522 reviews) "Very helpful and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) TONY $108 nightly $124 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Warrenton-Hotels-Holiday-Inn-Express-Warrenton.h1489252.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/6093d918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/b493e570.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking (2 Queen, 2 Person Sofa Bed) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/68f10652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/159a98ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites St Charles - St Louis [](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) St. Charles 8.4/10 Very Good (1,006 reviews) "Great hotel for the money" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jere $90 nightly $104 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/20625a7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/aa17bcae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/fadbec1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108930000/108922000/108921961/8d754889.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### WoodSpring Suites St Peters-OFallon [](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information) St. Peters 9.0/10 Wonderful (45 reviews) "Super clean , quiet place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Phoenix $91 nightly $105 total Feb 24 - Feb 25 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Woodspring-Suites-St-Peters-Ofallon.h108921961.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/79d56802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/25e461ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/fbaa6227.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7f62e770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel St. Louis St. Charles [](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information) St. Charles 9.6/10 Exceptional (1,004 reviews) "Great hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John Christopher $132 nightly $153 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/9e4f56d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/163dc30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | In-room safe, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/82c13c9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1220000/1216300/1216259/5d4de429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St Peters/St Charles [](https://www.expedia.com/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information) St. Peters 6.2/10 (1,002 reviews) "Room was excellent and clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) catherine $66 nightly $76 total Feb 26 - Feb 27 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Days-Inn-By-Wyndham-St-PetersSt-Charles.h1216259.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/55269a5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/34f8e499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2adbd684.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2edd84af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Foristell [](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) Foristell 8.2/10 Very Good (943 reviews) " Clean room friendly staff easy access" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve $76 nightly $85 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/ac68aac2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/d87b50c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/c8753b6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1140000/1131200/1131105/eaba7c94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton St. Louis St. Charles [](https://www.expedia.com/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information) St. Charles 8.8/10 Excellent (1,001 reviews) "A beautiful hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jon Michael $133 nightly $153 total Mar 19 - Mar 20 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Embassy-Suites-St-Louis-St-Charles.h1131105.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/ff1a33b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/0e791573.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/8d84cb6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/460000/459500/459418/6adb4ce9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Washington [](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information) Washington 8.4/10 Very Good (707 reviews) "The staff was extremely nice & accommodating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda $83 nightly $94 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/Washington-Hotels-Super-8-By-Wyndham-Washington.h459418.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/353d0132.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/9481c58b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/d84a6664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/70000000/69650000/69646200/69646123/8bd53911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites St. Charles Old Town Area [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-Charles-Old-Town-Area.h69646123.Hotel-Information) St. Charles 9.2/10 Wonderful (655 reviews) "Pleasant staff and clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele $98 nightly $118 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Hampton-Inn-Suites-St-Charles-Old-Town-Area.h69646123.Hotel-Information) ![Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/031df354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/72d412b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/0b0d1f69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/56000000/55080000/55078500/55078446/fae8ffd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### River Sirens Hotel [](https://www.expedia.com/Washington-Hotels-Sirens-Hotel.h55078446.Hotel-Information) Washington 9.8/10 Exceptional (190 reviews) "The room was amazing!!! Would definitely stay again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katharine $132 nightly $151 total Mar 4 - Mar 5 Total with taxes and fees [](https://www.expedia.com/Washington-Hotels-Sirens-Hotel.h55078446.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/da587b35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/660bdaf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/ac681623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Wentzville St Louis West by IHG [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) Wentzville 9.4/10 Exceptional (871 reviews) "Beautiful hotel, friendly staff, good breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erika $135 nightly $161 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/f60ef45e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/744b055b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/4c307556.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/210000/202300/202216/639e641e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites St Louis St Charles by IHG [](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-St-Charles.h202216.Hotel-Information) St. Charles 7.6/10 Good (779 reviews) "The staff was very professional and the room was clean. I will definitely book here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ngozi $75 nightly $86 total Mar 15 - Mar 16 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Towneplace-Suites-By-Marriott-St-Charles.h202216.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/665da1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/9ef66b46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/9b53533a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/7000000/6580000/6575600/6575600/9c369e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Wentzville [](https://www.expedia.com/Wentzville-Hotels-Fairfield-Inn-Suites-Wentzville.h6575600.Hotel-Information) Wentzville 9.0/10 Wonderful (655 reviews) "Hotel staff was friendly and room was very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danielle $128 nightly $146 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/Wentzville-Hotels-Fairfield-Inn-Suites-Wentzville.h6575600.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ee03821d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ab3b2d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/ca22fdb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514757/6809d9b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton St. Charles St. Louis, MO [](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information) St. Charles 8.6/10 Excellent (797 reviews) "Clean, great breakfast options." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristy $114 nightly $132 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Tru-By-Hilton-St-Charles-St-Louis.h22514757.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/001d26f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/0b058bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/ad6cce96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/254f5b60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, St. Charles Historic District [](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) St. Charles Historic District 9.4/10 Exceptional (1,004 reviews) "Wonderful place staff awesome " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chad $121 nightly $139 total Mar 8 - Mar 9 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/b34d85ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/109bb8e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/d5af958a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/1000000/20000/10100/10074/58b9b7e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Near Six Flags St. Louis [](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information) Pacific 8.4/10 Very Good (366 reviews) "Excellent staff & very clean room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen $94 nightly $108 total Feb 24 - Feb 25 Total with taxes and fees [](https://www.expedia.com/Pacific-Hotels-Quality-Inn-Near-Six-Flags-St-Louis.h10074.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/930f8b1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/w3997h2667x0y0-ed67d4f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, Multiple Beds | Desk, iron/ironing board, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/da5fdac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/30000/24200/24101/e68bf536.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott St. Louis St. Peters [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-St-Peters.h24101.Hotel-Information) St. Peters 9.0/10 Wonderful (678 reviews) "Clean spacious room, friendly staff, provided extra pillows upon request. Easy check in and check out! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee $113 nightly $135 total Mar 1 - Mar 2 Total with taxes and fees [](https://www.expedia.com/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-St-Peters.h24101.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-09&endDate=2026-03-10®ionId=6353634&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=HTG_SPRING_PROMO_6353634) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Hotels.d6353634.Travel-Guide-Hotels) ## Stay near popular Defiance attractions ![Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine. ](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg) Photo by Pages of Travel ### Chandler Hill Vineyards This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648567) ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg) ### August A. Busch Memorial Conservation Area This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6160337) ### Historic Daniel Boone Home and Heritage Center Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648566) ### Sugar Creek Winery Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648612) ### Yellow Farmhouse Winery This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648568) ### Matson Hill Park Trailhead Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641530089696399360) ### Broemmelsiek Park This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621561876810) ### Hamburg Trail Trailhead This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641529175733194752) ## Learn more about Defiance Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside. [See all hotels in Defiance](https://www.expedia.com/Hotel-Search?startDate=2026-03-09&endDate=2026-03-10&adults=2®ionId=6353634) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Defiance Hotel Reviews ![Crowne Plaza St. Louis Airport by IHG](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/45ba14e8_y.jpg) ### Crowne Plaza St. Louis Airport by IHG 10/10 Excellent "Yes" [](https://expedia.com/St-Louis-Hotels-Crowne-Plaza-St-Louis-Airport.h3010.Hotel-Information) ![Drury Plaza Hotel St. Louis Chesterfield](https://images.trvl-media.com/lodging/2000000/1350000/1346800/1346760/c1fcfc39_y.jpg) ### Drury Plaza Hotel St. Louis Chesterfield 10/10 Excellent "Room was clean and comfortable. Front desk staff was friendly and helpful. Very nice hotel. " [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-Chesterfield.h1346760.Hotel-Information) ![Drury Plaza Hotel St. Louis St. Charles](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7efb516b_y.jpg) ### Drury Plaza Hotel St. Louis St. Charles 10/10 Excellent "Everything and everyone is great. Check in is akways fast and painless, free drinks and happy hour food is a GREAT added value, rooms always are clean and smell clean and breakfast always offers many options which is helpful for me and my wife given our different eating plans." [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information) ![Drury Plaza Hotel St. Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/80000/74700/74657/3c4503ce_y.jpg) ### Drury Plaza Hotel St. Louis Creve Coeur 10/10 Excellent "My husband and i stayed 5 nights. i never usually leave reviews but this place was outstanding, staff was amazing and the rooms were very clean. i seriously had no complaints. food was good and the pool/ spa was amazing. would definitely come back and i recommend if you’re in the area to book this hotel!! " [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Creve-Coeur.h74657.Hotel-Information) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg) ### The Wildwood Hotel 10/10 Excellent "Friendly staff, room was clean, comfortable, and smelled great! " [](https://expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg) ### Country Inn & Suites by Radisson, St. Charles Historic District 10/10 Excellent "Hotel is outstanding....clean and up-to-date furnishings......staff very friendly and helpful.....continental breakfast was outstanding....this is the place to stay in Old St. Charles" [](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ![Best Western Plus St. Louis West-Westport](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25_y.jpg) ### Best Western Plus St. Louis West-Westport 10/10 Excellent "Great bed and clean room " [](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information) ![Drury Inn & Suites St. Louis St. Peters](https://images.trvl-media.com/lodging/1000000/50000/41500/41453/cf4e5d0d_y.jpg) ### Drury Inn & Suites St. Louis St. Peters 10/10 Excellent "Staff was very friendly and service at both the hospitality hour and breakfast were wonderful. Room was clean and had everything we needed. Only issue is that the location near the freeway and train tracks were very loud up in the room." [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-St-Peters.h41453.Hotel-Information) ![Drury Inn & Suites Southwest St. Louis](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/416a6a90_y.jpg) ### Drury Inn & Suites Southwest St. Louis 10/10 Excellent "The room was great no" [](https://expedia.com/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information) ## More cheap stays in Defiance ![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Relax Inn Saint Charles 3800 Harry S Truman Blvd St. Charles MO $61 nightly $71 total Feb 24 - Feb 25 Total with taxes and fees 6.6/10 (1,005 reviews) [](https://expedia.com/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information) ![Best Western Plus St. Louis West-Westport](https://images.trvl-media.com/lodging/1000000/50000/41500/41448/00255b25_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus St. Louis West-Westport 12220 Dorsett Rd Maryland Heights MO $79 nightly $92 total Mar 1 - Mar 2 Total with taxes and fees 7.8/10 Good! (1,048 reviews) [](https://expedia.com/St-Louis-Hotels-Best-Western-Plus-St-Louis-West-Westport.h41448.Hotel-Information) ![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/55d0714b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Suites St Charles - St Louis 1400 S 5th St St. Charles MO $90 nightly $104 total Feb 26 - Feb 27 Total with taxes and fees 8.2/10 Very Good! (1,004 reviews) [](https://expedia.com/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information) ![Americas Best Value Inn & Suites St. Louis, St. Charles Inn](https://images.trvl-media.com/lodging/1000000/70000/68200/68132/c17520b0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Americas Best Value Inn & Suites St. Louis, St. Charles Inn 1310 Bass Pro Drive St. Charles MO $90 nightly $104 total Feb 24 - Feb 25 Total with taxes and fees 5.6/10 (1,004 reviews) [](https://expedia.com/St-Louis-Hotels-Americas-Best-Value-Inn-Suites-St-Louis.h68132.Hotel-Information) ![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn St. Charles St. Peters 3720 W Clay St St. Charles MO $98 nightly $112 total Mar 8 - Mar 9 Total with taxes and fees 8/10 Very Good! (1,001 reviews) [](https://expedia.com/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Country Inn & Suites by Radisson, St. Charles Historic District 1190 S Main St St. Charles MO $121 nightly $139 total Mar 8 - Mar 9 Total with taxes and fees 9.4/10 Exceptional! (1,002 reviews) [](https://expedia.com/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ## Hotels in Defiance with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 7 properties [](https://expedia.com/4Star-Defiance-Hotels.s40-0-d6353634.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 114 properties [](https://expedia.com/3Star-Defiance-Hotels.s30-0-d6353634.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 156 properties [](https://expedia.com/2Star-Defiance-Hotels.s20-0-d6353634.Travel-Guide-Filter-Hotels) ## Find out more about Defiance ### Top reasons to visit Defiance - **Outdoor Adventures:** Defiance offers scenic recreational areas with hiking trails, perfect for nature enthusiasts. - **Charming Downtown:** Stroll through downtown Defiance, featuring charming shops and local eateries that embody small-town charm. - **Family-Friendly Attractions:** Enjoy a mix of state parks and amusement parks, catering to family fun and entertainment. - **Romantic Escapes:** Ideal for couples seeking peaceful retreats and memorable outdoor experiences. - **Diverse Accommodations:** A variety of inviting hotels, including pet-friendly and LGBTQIA-welcoming options, enhance your stay. ### Find great hotels near Defiance Discover a range of inviting hotel accommodations in Defiance, Missouri, perfect for every type of traveler. Whether you're seeking business-friendly amenities, pet-friendly options, or an LGBTQIA-welcoming atmosphere, you'll find a variety of choices to enhance your stay. Explore the top hotels and available options that ensure a memorable vacation experience in this charming destination. - **[Sonesta ES Suites St. Louis - Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Sonesta-ES-Suites-St-Louis-Chesterfield.h422.Hotel-Information)** This welcoming 3-star hotel is an ideal choice for pet lovers looking to explore the charming region of Defiance. Located 12 miles away, Sonesta ES Suites offers a home-like atmosphere with spacious suites featuring full kitchens, making it perfect for extended stays. The pet-friendly policy allows for a worry-free experience, as pets are permitted with certain restrictions. Guests appreciate the complimentary amenities, including free breakfast, Wi-Fi, and access to on-site fitness facilities. With a warm and inviting environment, this hotel ensures a comfortable and enjoyable vacation for both you and your furry friends. - **[The Wildwood Hotel: ](https://www.expedia.com/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)** A unique blend of nature and business, The Wildwood Hotel is a stylish 3.5-star lodging located 9 miles from Defiance. This stunning hotel is perfect for nature enthusiasts and business travelers alike, offering a serene escape with its rustic decor and lush surroundings. With a range of business amenities such as a 24-hour business center and multiple meeting rooms, this hotel caters to corporate needs while providing a tranquil retreat. The pet-friendly policy allows guests to bring their four-legged companions along, ensuring a memorable stay surrounded by nature's beauty. - **[Hyatt Place St. Louis/Chesterfield: ](https://www.expedia.com/St-Louis-Hotels-Hyatt-Place-St-LouisChesterfield.h6583788.Hotel-Information)** This family-friendly 3-star hotel, situated 12 miles from Defiance, is a perfect choice for travelers looking for comfort and convenience. Hyatt Place St. Louis/Chesterfield features spacious rooms equipped with modern amenities and offers a variety of services for business guests, including a 24-hour business center and flexible meeting spaces. Families will appreciate the kid-friendly services, while pet owners can enjoy a welcoming atmosphere for their dogs. With complimentary breakfast and a convenient location, this hotel promises a delightful and hassle-free stay for all. ### Where to stay near Defiance Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes, perfect for any traveler. Stroll through downtown Defiance, where charming shops and local eateries await. Enjoy leisurely walks that showcase the area's historical vibes and family-friendly atmosphere. Whether you're seeking a relaxing break or an adventurous outing, Defiance and its nearby regions promise memorable experiences that capture the essence of small-town charm and community spirit. - **[Chesterfield: ](https://www.expedia.com/Chesterfield-Hotels.d9530.Travel-Guide-Hotels)** Located 12 miles from Defiance, Chesterfield is a vibrant city that offers a delightful mix of family-friendly entertainment and urban experiences. Known for its seasonal visitor peaks in April and from June to July, Chesterfield boasts attractions such as an arcade adventure zone, a local theater, and a bustling amusement park. The area is also home to a variety of popular landmarks, including a theme park and a stadium, making it an ideal destination for those seeking a fun-filled getaway. - **[O'Fallon: ](https://www.expedia.com/OFallon-Hotels.d140195.Travel-Guide-Hotels)** Situated 13 miles away from Defiance, O'Fallon is another great city perfect for family outings and outdoor adventures. Like Chesterfield, O'Fallon sees a surge in visitors around April and during the summer months. The city features an array of entertainment options, including an arena entertainment facility, an arcade adventure zone, and a shopping mall center. With its urban parks and sports facilities, O'Fallon offers a dynamic blend of relaxation and excitement for visitors of all ages. - **[Saint Albans: ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels)** Just 4 miles from Defiance, Saint Albans is a charming city that invites travelers to immerse themselves in outdoor adventures and family activities. Peak tourist seasons occur in April, July, and September, with visitors drawn to attractions like an arcade adventure zone, an amusement park, and a shopping center. The area is also notable for its scenic landmarks, including a beautiful lake and a convention center, making it a picturesque spot for both relaxation and exploration. ### Things to do in and around Defiance Defiance, Missouri, is perfect for a romantic and adventurous getaway, offering a range of outdoor activities for an unforgettable experience. You can explore its scenic recreational areas, enjoy the hiking trails, and immerse yourself in nature. Whether you're looking for a peaceful retreat or an active vacation, Defiance provides the ideal backdrop for memorable moments in the great outdoors. **Shopping** The nearest shopping destination is [St. Louis Premium Outlets](https://www.expedia.com/St-Louis-Premium-Outlets-Hotels.0-l553248621561876860-0.Travel-Guide-Filter-Hotels), located 7 miles away, offering a variety of entertainment, shopping, and family-friendly vibes. If you're up for a drive, check out [Taubman Prestige Outlets](https://www.expedia.com/Taubman-Prestige-Outlets-Hotels.0-l553248621561876633-0.Travel-Guide-Filter-Hotels), 10 miles away, or the [Wentzville Flea Market](https://www.expedia.com/Wentzville-Flea-Market-Hotels.0-l553248621561876812-0.Travel-Guide-Filter-Hotels), 13 miles away, for unique finds. **Recreation** Catch a live show at [The Factory](https://www.expedia.com/The-Factory-Hotels.0-l769870834915799040-0.Travel-Guide-Filter-Hotels) for vibrant entertainment just 10 miles from Defiance. Enjoy a round of golf at [Missouri Bluffs Golf Course](https://www.expedia.com/Missouri-Bluffs-Golf-Course-Hotels.0-l553248621532648614-0.Travel-Guide-Filter-Hotels), surrounded by scenic landscapes, located 7 miles away. For relaxation, unwind at [Broemmelsiek Park](https://www.expedia.com/Broemmelsiek-Park-Hotels.0-l553248621561876810-0.Travel-Guide-Filter-Hotels), where wellness and tranquility await right in Defiance. **Adventure** At [Hidden Valley Ski Resort](https://www.expedia.com/Hidden-Valley-Ski-Resort-Hotels.0-l553248621592827639-0.Travel-Guide-Filter-Hotels), located 9 miles from Defiance, enjoy thrilling skiing adventures amid beautiful snowy landscapes. [Hurricane Harbor](https://www.expedia.com/Hurricane-Harbor-Hotels.0-l553248621532648581-0.Travel-Guide-Filter-Hotels), 10 miles away, offers water-based fun with slides and attractions perfect for family entertainment. Explore the scenic Matson Hill Park Trailhead right in Defiance for hiking and outdoor experiences. **Nightlife** Experience the excitement at [Chesterfield Sports Fusion](https://www.expedia.com/Chesterfield-Sports-Fusion-Hotels.0-l553248621532648590-0.Travel-Guide-Filter-Hotels), an arcade adventure zone 9 miles from Defiance. For a cultural night out, catch a show at the [New Jewish Theatre](https://www.expedia.com/New-Jewish-Theatre-Hotels.0-l553248621561876895-0.Travel-Guide-Filter-Hotels), 20 miles away. Don't miss Sky Zone Indoor Trampoline Park, an adventure zone 10 miles from Defiance for a fun evening. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Defiance To save money on your trip to Defiance, Missouri, consider visiting during the off-peak months of December to February, when prices are lower. Booking your stay on a Monday can also help you save, as Saturday is the most expensive day. Use Expedia to compare hotel prices, and consider booking a package that includes flights and activities for better deals. Joining Expedia's One Key membership can unlock exclusive discounts and allow you to earn rewards for future bookings. Look for free activities in the area to enhance your travel experience without breaking the bank. - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia's search tool to narrow down your options based on your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by booking a package with Expedia that combines your Defiance hotel with flights and activities. - **Become a One Key member:** Join [Expedia's One Key membership](https://www.expedia.com/welcome-one-key) program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels. ### Find the best attractions in and around Defiance Defiance, Missouri, offers a delightful mix of outdoor adventures and romantic escapes. Visitors can explore local attractions such as state and urban parks, as well as amusement parks, perfect for family fun. Whether you're seeking a nature hike, a thrilling ride, or a peaceful picnic, Defiance caters to travelers looking for both city experiences and serene landscapes, making it an ideal destination for entertainment-themed vacations. - **[Six Flags St. Louis: ](https://www.expedia.com/Six-Flags-St-Louis-Hotels.0-l6147083-0.Travel-Guide-Filter-Hotels)** Experience the thrill of exhilarating rides and family-friendly entertainment at this vibrant amusement park, located 10 miles from Defiance. With a variety of attractions, it offers an adventurous atmosphere perfect for creating lasting memories. - **[August A. Busch Memorial Conservation Area: ](https://www.expedia.com/August-A-Busch-Memorial-Conservation-Area-Hotels.0-l6160337-0.Travel-Guide-Filter-Hotels)** Nestled within Defiance, this beautiful reserve features scenic trails and friendly wildlife. It's an ideal spot for family outings and excursions, making it a perfect place to enjoy nature and connect with the outdoors. - **[Purina Farms: ](https://www.expedia.com/Purina-Farms-Hotels.0-l553248621532648557-0.Travel-Guide-Filter-Hotels)** Located 10 miles away, this charming farm showcases beautiful scenery and offers interactive experiences with animals. It’s a delightful destination for animal lovers and families looking to enjoy a relaxing day in the countryside. ### Best time to go to Defiance The best time to visit Defiance is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly cloudy with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 31.6°F (-0.2°C) | Light Rain | Mostly Cloudy | Moderately Low | Slightly Low | | February | 34.7°F (1.5°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | March | 46.4°F (8.0°C) | Light Rain | Mostly Sunny | Average | Average | | April | 55.9°F (13.3°C) | Light Rain | Mostly Sunny | Moderately High | Average | | May | 66.2°F (19.0°C) | Light Rain | Mostly Sunny | Average | Slightly High | | June | 75.9°F (24.4°C) | Light Rain | Mostly Sunny | Average | Slightly High | | July | 79.0°F (26.1°C) | Light Rain | Mostly Sunny | Moderately High | Slightly High | | August | 77.2°F (25.1°C) | Light Rain | Mostly Sunny | Average | Average | | September | 70.9°F (21.6°C) | Light Rain | Mostly Sunny | Moderately High | Average | | October | 58.5°F (14.7°C) | Light Rain | Mostly Sunny | Average | Average | | November | 46.2°F (7.9°C) | Light Rain | Mostly Sunny | Moderately Low | Average | | December | 37.6°F (3.1°C) | Light Rain | Mostly Sunny | Moderately Low | Slightly Low | ### The nearest major airports for your trip to Defiance When visiting Defiance, Missouri, you have convenient access to two major airports. St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)) is approximately 23 miles away and offers a variety of nearby hotels, including the 5-star Ritz-Carlton, St. Louis, and the 4.5-star Royal Sonesta Chase Park Plaza, both within 9 miles. The Spirit of St. Louis Airport ([SUS](https://www.expedia.com/Spirit-Of-St-Louis-Airport-Hotels.0-aSUS-0.Travel-Guide-Filter-Hotels)) is closer at about 7 miles from Defiance, with excellent accommodations such as the 4-star [DoubleTree by Hilton Hotel St. Louis - Chesterfield](https://www.expedia.com/St-Louis-Hotels-DoubleTree-By-Hilton-Hotel-St-Louis-Chesterfield.h3258.Hotel-Information) just 4 miles away. These hotels provide easy transportation options to both airports, ensuring a smooth start to your vacation. ## Frequently asked questions ### What is the best area to stay in Defiance? > The village of Defiance is small and picturesque, centered around its historic general store and a few local eateries. Hotels here are typically smaller, independently owned establishments or bed and breakfasts, providing a personalized experience. The Katy Trail, a popular walking and cycling path, runs directly through the village, making it an excellent base for outdoor enthusiasts. > > > Couples looking for a relaxing getaway will appreciate staying in this area. It's quiet and offers direct access to scenic walks and bike rides along the Missouri River. ### When is the best time to go to Defiance? > These seasons offer pleasant weather conditions, with comfortable temperatures that are ideal for outdoor activities like cycling or exploring the Katy Trail. In spring, the local vineyards begin to bloom, and in autumn, the changing leaves provide scenic views along the Missouri River. Traveling during these times also allows you to enjoy local events and festivals without the peak summer crowds. > > > For travelers looking to experience the region's natural beauty and participate in outdoor recreation, spring and fall provide the most agreeable climate. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Defiance hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Defiance hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - [Hotels near Yellow Farmhouse Winery ](https://www.expedia.com/Yellow-Farmhouse-Winery-Hotels.0-l553248621532648568-0.Travel-Guide-Filter-Hotels) - [Hotels near Chandler Hill Vineyards ](https://www.expedia.com/Chandler-Hill-Vineyards-Hotels.0-l553248621532648567-0.Travel-Guide-Filter-Hotels) - [Hotels near Sugar Creek Winery ](https://www.expedia.com/Sugar-Creek-Winery-Hotels.0-l553248621532648612-0.Travel-Guide-Filter-Hotels) - [Hamburg Hotels ](https://www.expedia.com/Hamburg-Hotels.d553248635975869538.Travel-Guide-Hotels) - [Saint Albans Hotels ](https://www.expedia.com/Saint-Albans-Hotels.d3000445473.Travel-Guide-Hotels) - [Villas in Saint Albans ](https://www.expedia.com/Saint-Albans-Villas.d3000445473-aaVillas.Travel-Guide-Accommodation) - [Vacation Homes in Saint Albans ](https://www.expedia.com/Saint-Albans-Private-Vacation-Homes.d3000445473-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cottages in Saint Albans ](https://www.expedia.com/Saint-Albans-Cottages.d3000445473-aaCottages.Travel-Guide-Accommodation) - [Hotels near Historic Daniel Boone Home and Heritage Center ](https://www.expedia.com/Historic-Daniel-Boone-Home-And-Heritage-Center-Hotels.0-l553248621532648566-0.Travel-Guide-Filter-Hotels) - [Hotels near Babler State Park ](https://www.expedia.com/Babler-State-Park-Hotels.0-l6293012-0.Travel-Guide-Filter-Hotels) - [Hotels near Dr. Edmund A. 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