$45 Car Rental Defiance, MO

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Top Car Deals in Defiance

* Price found within the past 6 days. Click for updated prices.

Compact

Nissan Versa Note
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Nissan Versa Note

$45

includes taxes & fees
$33 per day
found 6 hours ago
Compact Nissan Versa Note

Economy

Chevrolet Spark
  • 4 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Chevrolet Spark

$45

includes taxes & fees
$33 per day
found 6 hours ago
Economy Chevrolet Spark

Midsize

Toyota Corolla
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Toyota Corolla

$47

includes taxes & fees
$35 per day
found 4 hours ago
Midsize Toyota Corolla

Special

Managers Special
  • 4 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Managers Special

$52

includes taxes & fees
$39 per day
found 6 hours ago
Special Managers Special

Fullsize

Nissan Altima
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Nissan Altima

$53

includes taxes & fees
$40 per day
found 6 hours ago
Fullsize Nissan Altima

Standard

Volkswagen Jetta
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Volkswagen Jetta

$58

includes taxes & fees
$44 per day
found 6 hours ago
Standard Volkswagen Jetta

Midsize Elite

Tesla Short Range Model 3
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Tesla Short Range Model 3

$73

includes taxes & fees
$56 per day
found 6 hours ago
Midsize Elite Tesla Short Range Model 3

Standard Elite Special

Ford Mustang Mach-E
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Ford Mustang Mach-E

$81

includes taxes & fees
$63 per day
found 4 hours ago
Standard Elite Special Ford Mustang Mach-E

Premium Crossover

Dodge Durango
  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Dodge Durango

$89

includes taxes & fees
$70 per day
found 6 hours ago
Premium Crossover Dodge Durango

Mini Van

Chrysler Pacifica
  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Chrysler Pacifica

$125

includes taxes & fees
$100 per day
found 4 hours ago
Mini Van Chrysler Pacifica

Luxury SUV

Jeep Grand Wagoneer
  • 7 people
  • Unlimited mileage
St Louis, Missouri, USA
Jeep Grand Wagoneer

$139

includes taxes & fees
$108 per day
found 6 hours ago
Luxury SUV Jeep Grand Wagoneer

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Lowest prices found within the past 6 hours. Prices and availability subject to change. Additional terms may apply.

What you need to know for your Defiance car rental

Reasons to book a car rental in and around Defiance

Renting a car in Defiance offers you the freedom and flexibility to explore the area at your own pace. With a rental vehicle, you can easily manage your luggage and create a travel plan that suits your needs. Whether you're seeking outdoor adventures, romantic getaways, or family-friendly activities, having a car opens up a world of possibilities. You can visit the August A. Busch Memorial Conservation Area for a day in nature, or head to nearby Six Flags St. Louis, located just 10 miles away, for an exciting amusement park experience. Purina Farms, also 10 miles from Defiance, provides a unique farm experience that is sure to delight visitors. A rental car also allows for convenient trips to nearby cities, such as Chesterfield, 12 miles away, where you can explore attractions like the Sophia M. Sachs Butterfly House and Faust Park. Saint Albans, only 4 miles from Defiance, offers easy access to Six Flags St. Louis and Route 66 State Park. With a car, you can effortlessly navigate to these destinations and enjoy all that the region has to offer.

Where to stay around Defiance

  • Chesterfield: Located 12 miles away from Defiance, Chesterfield offers a family-friendly atmosphere with a variety of entertainment options. Visitors can explore the `Sophia M. Sachs Butterfly House`, a beautiful botanical garden, or enjoy the thrills at `Six Flags St. Louis`, an amusement park perfect for outdoor adventures. The historic `Faust Park` provides a glimpse into local culture. Chesterfield boasts numerous dining options, including wineries and restaurants, making it an excellent choice for a well-rounded stay.
  • O'Fallon: Situated 13 miles from Defiance, O'Fallon is ideal for those seeking a city-themed experience with family-friendly activities. Explore the vibrant `Westport Plaza` for shopping and dining, or take a stroll down `Historic Main Street` to enjoy local charm. The `August A. Busch Memorial Conservation Area` offers outdoor recreational opportunities. With its array of wineries and restaurants nearby, O'Fallon presents a welcoming environment for travelers looking to unwind.
  • Wentzville: Also 13 miles from Defiance, Wentzville is a great destination for families and outdoor enthusiasts. Visitors can enjoy the scenic `Innsbrook Lake`, perfect for relaxation and outdoor activities. The `August A. Busch Memorial Conservation Area` provides a chance to connect with nature. For those interested in history, the `Historic Daniel Boone Home and Heritage Center` offers cultural insights. With various wineries and restaurants available, Wentzville is a delightful place to stay.

10 tips to save on your car rental in and around Defiance

  1. Use filters to find the right car: Refine your search by selecting specific vehicle types and features. Whether you need an SUV for added space, a convertible for summer fun, or an economy car for cost savings, utilize the filters on Expedia to discover the best option for your journey.
  2. Book in advance to help lower costs: Rental prices can vary based on demand, so it's advisable to secure your car well ahead of your trip. By booking early, you’re more likely to obtain lower rates and better availability, especially during peak travel seasons.
  3. Consider a smaller car for savings: Smaller vehicles typically cost less to rent and are easier to park in crowded areas. Mid-size rentals strike a good balance between affordability, comfort, and fuel efficiency.
  4. Age guidelines: Drivers under 30 may encounter higher deposits or daily fees, and certain vehicle types—such as SUVs or premium models—might not be available. This can also apply to renters over 70 years old. Always verify the age requirements before making a reservation.
  5. Check fuel policies: Some rentals implement a full-to-full fuel policy, which means you must return the car with a full tank to avoid additional charges. This is often the most economical choice. Other options may include full-to-empty or prepaid fueling, which can work as well; just ensure you return the car empty in that scenario.
  6. Save on city and airport pickups: Picking up your rental car at airports often incurs a surcharge, but the convenience may justify the extra cost.
  7. Know your payment options: Most car rental companies exclusively accept credit cards for payment.
  8. Understand your insurance coverage: Car rental insurance can help you avoid unexpected expenses and offers peace of mind in case of unforeseen events during your trip. Adding car rental insurance is simple when booking through Expedia.
  9. Consider unlimited mileage: If you're planning long road trips, seek out rentals that offer unlimited mileage to prevent extra charges.
  10. Bring your driver's license and ID: A valid driver's license is necessary to rent a car.

Finding the cheapest car rentals in Defiance

Using our Search Wizard

If the deals that are available on our page do not suit your needs, then enter Defiance into the search wizard at the top of the page. We will compare all the best deals available for your car rental in Defiance and provide you with a list of the cheapest options, with no added fees.

Renting a car in Defiance

Pay at pickup is available, so you don’t have to worry about spending your money until you arrive at your vehicle in Defiance. We partner with reliable partners that guarantee an enjoyable experience for solo travelers, couples, and families. Package your car with a flight or hotel to unlock even more savings from Expedia.

Expected prices in Defiance

Prices are subject to seasonal change depending on when you decide to arrange your car rental but right now you can book from $45.

Flexibility & Cancellation

Most car suppliers offer penalty-free cancellations, so you don’t have to worry about losing money if your plans change. To cancel your booking log into your account through the Trips portal. Click manage booking and cancel this car. If you needed to alter your booking, then you can create a new one once you have canceled.

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One Key members save 10% or more on select hotels, cars, activities and vacation rentals. Not only that, earn OneKeyCash for every dollar spent on eligible hotels, vacation rentals, flights, car rentals, and more when you book across our family of brands: Expedia, Hotels.com and VRBO. Learn more and join today.

Car classes available from Expedia in 2026

The classes of vehicles available will change depending on your chosen location.

Car Rental Information

Popular car types
SUV, Full Size, Economy
Car suppliers available
Our best deal of the day
$45
Our second best deal of the day
$47
Our third best deal of the day
$52
From the airport to your hotel
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Frequently asked questions

How much is a rental car per day in Defiance?
Set your own course in Defiance, with car rental prices starting from $45 per day. That's based on prices found within the past seven days. With rates like this, it'll be a piece of cake to find a ride that meets your needs.
Can I rent a car from Lambert-St. Louis Intl. Airport (STL)?
Unfortunately, not from Lambert-St. Louis Intl. Airport (STL). But there is a good selection of car rental options close by. Find your perfect ride with a bit of help from Budget, Thrifty, National, Enterprise or Alamo.
What happens if I need to cancel my Defiance car reservation?
We have good news! You should get all of your money back if you advise us at least six hours before picking up the car. Your itinerary contains information about this, and so does our Customer Service Portal. Not all prepaid reservations qualify for a refund though, so it's a good idea to scan your car's cancellation policy.
Where can I go on a road trip from Defiance?
When you've ticked off the interesting attractions in Defiance, there's heaps more to see in the region. Collect the keys to a rental car, pack your bags in the trunk and get out there. Here are some drives we're confident you'll love:
  • You'll find Illinois State Fairgrounds and many more amazing attractions in Springfield. From Defiance, it's approximately 100 miles away.
  • Next stop? Consider Columbia, which is around 85 miles away. Mizzou Arena is one local draw card you won't want to miss.
  • Starved Rock State Park is around 210 miles from Defiance and is one of the region's most gorgeous nature spots. Stretch your legs and enjoy the fresh air.
How do I find the best car rental deals in Defiance with Expedia?
Scoring an amazing deal on your Defiance rental car is easy with Expedia. Choose your preferred car type, add in a few more details and compare the offers from big-name brands. Why not add hotels and flights to your booking? You'll unlock even more savings when you combine your bookings into a package.
How old do you have to be to rent a car in Defiance?
Rental vehicle rules in Defiance require drivers to be 21 and over. Are you a younger driver? Some surcharges and restrictions may apply. Many rental suppliers impose what is known as a young driver surcharge, which is an additional fee to the rental car cost. Restrictions often apply to the sorts of cars available to young people as well. Age limits may differ between providers, so check before booking.
What do you need to rent a car in Defiance?
Before you can hop behind the wheel in Defiance, you'll need a valid driver's license and a credit card that matches the name on your license. If you prefer not to take out the company's insurance policy, you may also have to show proof of other coverage. Rules can vary, so understand the policy terms and conditions before you choose a rental company.
What is the cheapest car rental in Defiance?
According to prices found within the past seven days, the lowest daily rate for a rental vehicle in Defiance was $45. The next best deal was $47 a day. These rates were available on Expedia, with a rental starting date within the next year. Prices and availability are subject to change and additional terms apply.
Can I rent a car for a month or longer in Defiance?
Whether you plan to stay in Defiance or explore what's beyond, it's easy to reserve a long-term rental with Expedia. Enter your trip information and pick-up/drop-off locations and we'll find you incredible long-term car rental deals.
Where can I find a Defiance car rental if I am younger than 25?
Some Defiance outlets will rent to drivers under 25, and others won't. Policies differ from supplier to supplier, so you'll want to do your homework. Also, find out if there are any extra costs. Some businesses will have a surcharge for customers between the ages of 21 and 24. Make sure you read through the terms and conditions to avoid any surprise fees.
What insurance should I choose for my car rental in Defiance?
Start your road trip right by purchasing Expedia's collision protection. While there are many types of car rental insurance, this is one you'll need to have. It provides primary coverage for vandalism, accident damage and theft up to $35,000, as well as 24-hour emergency help. Don't wait until you arrive at the rental counter to insure your precious wheels. Opt in to collision protection while booking your Defiance ride with Expedia and save money and time.

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